scholarly journals The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study

2015 ◽  
Vol 16 (2) ◽  
pp. 225 ◽  
Author(s):  
Jian Huang ◽  
Di Zhang ◽  
Fuqiang Xie ◽  
Degui Lin
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Mammary Tumor ◽  
Potential Role ◽  
Immunohistochemical Study ◽  
Tumor Initiation ◽  
Canine Mammary Tumor ◽  
Cox 2

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

2010 ◽  
Vol 134 (12) ◽  
pp. 1740-1749
Author(s):  
Yunyi Kong ◽  
Suresh M. Kumar ◽  
Xiaowei Xu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Molecular Basis ◽  
Potential Role ◽  
Genetic Alterations ◽  
Stem Cell Biology ◽  
Prevalent Disease

Abstract Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

Evaluation of the role of CD44 as a cancer stem cell marker in colorectal carcinoma: immunohistochemical study

2017 ◽  
Vol 30 (1) ◽  
pp. 174 ◽  
Author(s):  
AyatG Lasheen ◽  
NanisS Holah ◽  
HayamA Aiad ◽  
NancyY Asaad ◽  
EnasA. B. Elkhouly
Keyword(s):  
Stem Cell ◽  
Colorectal Carcinoma ◽  
Cancer Stem Cell ◽  
Immunohistochemical Study ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

T1150 Role of Cyclooxygenase-2 in Cancer Stem Cell Biology and Effect of COX-2 Inhibitors in Anti-Cancer Therapy Targeting Cancer Stem Cells

2010 ◽  
Vol 138 (5) ◽  
pp. S-499
Author(s):  
Masahiko Tsujii ◽  
Jumpei Kondo ◽  
Tomofumi Akasaka ◽  
Ying Jin ◽  
Yoshito Hayashi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Anti Cancer ◽  
Cox 2 ◽  
Cox 2 Inhibitors

scholarly journals Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Lisa Y. Pang ◽  
Emma A. Hurst ◽  
David J. Argyle
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Cell Biology ◽  
Tumour Growth ◽  
Cyclooxygenase 2 ◽  
Conventional Chemotherapy ◽  
Normal Tissues ◽  
Cox 2

Cyclooxygenase-2 (COX-2) is an inducible form of the enzyme that catalyses the synthesis of prostanoids, including prostaglandin E2 (PGE2), a major mediator of inflammation and angiogenesis. COX-2 is overexpressed in cancer cells and is associated with progressive tumour growth, as well as resistance of cancer cells to conventional chemotherapy and radiotherapy. These therapies are often delivered in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during treatment intervals, leading to repopulation of the tumour and limiting the effectiveness of the treatment. Tumour cell repopulation is a major cause of treatment failure. The central dogma is that conventional chemotherapy and radiotherapy selects resistant cancer cells that are able to reinitiate tumour growth. However, there is compelling evidence of an active proliferative response, driven by increased COX-2 expression and downstream PGE2release, which contribute to the repopulation of tumours and poor patient outcome. In this review, we will examine the evidence for a role of COX-2 in cancer stem cell biology and as a mediator of tumour repopulation that can be molecularly targeted to overcome resistance to therapy.

The Antioxidant Effects of Isorhamnetin Contribute to Inhibit COX-2 Expression in Response to Inflammation: A Potential Role of HO-1

Inflammation ◽  
2013 ◽  
Vol 37 (3) ◽  
pp. 712-722 ◽  
Author(s):  
Kyuhwa Seo ◽  
Ji Hye Yang ◽  
Sang Chan Kim ◽  
Sae Kwang Ku ◽  
Sung Hwan Ki ◽  
...  
Keyword(s):  
Potential Role ◽  
Cox 2 ◽  
Antioxidant Effects

Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 109-118 ◽  
Author(s):  
Lorenz Kadletz ◽  
Dietmar Thurnher ◽  
Robert Wiebringhaus ◽  
Boban M. Erovic ◽  
Ulana Kotowski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker
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