scholarly journals Molecular characterization of the feline T-cell receptor γ alternate reading frame protein (TARP) ortholog

2012 ◽  
Vol 13 (4) ◽  
pp. 345 ◽  
Author(s):  
Alexander Th. A. Weiss ◽  
Marie-Charlotte von Deetzen ◽  
Werner Hecht ◽  
Manfred Reinacher ◽  
Achim D. Gruber
Keyword(s):  
T Cell ◽  
Molecular Characterization ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

Mouse autoreactive γ/δ T cells II. Molecular characterization of the T cell receptor

1992 ◽  
Vol 22 (2) ◽  
pp. 491-498 ◽  
Author(s):  
Angel Ezquerra ◽  
David B. Wilde ◽  
Thomas J. McConnell ◽  
Knut Sturmhöfel ◽  
Robert B. Valas ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Molecular Characterization ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals Characterization of the Androgen-Regulated Prostate-Specific T Cell Receptor γ-Chain Alternate Reading Frame Protein (TARP) Promoter

Endocrinology ◽  
2003 ◽  
Vol 144 (8) ◽  
pp. 3433-3440 ◽  
Author(s):  
Wing-Shing Cheng ◽  
Valeria Giandomenico ◽  
Ira Pastan ◽  
Magnus Essand
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
T Cell ◽  
Cancer Cells ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Regulatory Sequence ◽  
Prostate Cancer Cells ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

Abstract TARP (T cell receptor γ-chain alternate reading frame protein) is uniquely expressed in males in prostate epithelial cells and prostate cancer cells. Here we demonstrate that TARP expression is regulated by testosterone at the transcriptional level through specific binding of androgen receptor to an androgen response element in the proximal TARP promoter. We further demonstrate that the promoter specifically initiates reporter gene expression in TARP-positive prostate cancer cell lines. To develop a regulatory sequence for prostate-specific gene expression, we constructed a chimeric sequence consisting of the TARP promoter and the prostate-specific antigen (PSA) enhancer. We found that in the prostatic adenocarcinoma cell line LNCaP, the transcriptional activity of the regulatory sequence consisting of a TARP promoter and PSA enhancer is 20 times higher than the activity of a regulatory sequence consisting of the PSA promoter and PSA enhancer. Thus, our studies define a regulatory sequence that may be used to restrict expression of therapeutic genes to prostate cancer cells and may therefore play a role in prostate cancer gene therapy.

Molecular characterization of human T cell receptor α chains including a Vδ1-encoded variable segment

1991 ◽  
Vol 21 (4) ◽  
pp. 1061-1064 ◽  
Author(s):  
Christine Miossec ◽  
Anne Caignard ◽  
Laurent Ferradini ◽  
Sergio Roman-Roman ◽  
Florence Faure ◽  
...  
Keyword(s):  
T Cell ◽  
Molecular Characterization ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
Variable Segment

Molecular characterization of the Di-leucine based internalization motif of the T cell receptor

1997 ◽  
Vol 56 ◽  
pp. 58
Author(s):  
Jes Dietrich ◽  
Jesper Kastrup ◽  
Niels Ødum ◽  
Carsten Geisler
Keyword(s):  
T Cell ◽  
Molecular Characterization ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals The T Cell Receptor γ Chain Alternate Reading Frame Protein (TARP), a Prostate-specific Protein Localized in Mitochondria

2004 ◽  
Vol 279 (23) ◽  
pp. 24561-24568 ◽  
Author(s):  
Hiroshi Maeda ◽  
Satoshi Nagata ◽  
Curt D. Wolfgang ◽  
Gary L. Bratthauer ◽  
Tapan K. Bera ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Specific Protein ◽  
Reading Frame ◽  
Alternate Reading Frame Protein
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