scholarly journals Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen

2007 ◽  
Vol 8 (1) ◽  
pp. 27 ◽  
Author(s):  
Yoot Mo Lee ◽  
Min Jae Seong ◽  
Jae Woong Lee ◽  
Yong Kyung Lee ◽  
Tae Myoung Kim ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Environmental Estrogen

scholarly journals Estrogen receptor 1 expression and methylation of Esr1 promoter in mouse fetal prostate mesenchymal cells induced by gestational exposure to bisphenol A or ethinylestradiol

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Ramji K Bhandari ◽  
Julia A Taylor ◽  
Jennifer Sommerfeld-Sager ◽  
Donald E Tillitt ◽  
William A Ricke ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Oral Contraceptives ◽  
Primary Cultures ◽  
Prostate Gland ◽  
Mesenchymal Cells ◽  
Urogenital Sinus ◽  
Environmental Estrogen ◽  
Mouse Prostate

Abstract Fetal/neonatal environmental estrogen exposures alter developmental programing of the prostate gland causing onset of diseases later in life. We have previously shown in vitro that exposures to 17β-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor α (Esr1) mRNA in primary cultures of fetal mouse prostate mesenchymal cells; a similar result was observed in the fetal rat urogenital sinus. Effects of these chemicals on prostate mesenchyme in vivo are not well understood. Here we show effects in mice of fetal exposure to the estrogenic drug in mixed oral contraceptives, 17α-ethinylestradiol (EE2), at a concentration of EE2 encountered by human embryos/fetuses whose mothers become pregnant while on EE2-containing oral contraceptives, or bisphenol A at a concentration relevant to exposures observed in human fetuses in vivo. Expression of Esr1 was elevated by bisphenol A or EE2 exposures, which decreased the global expression of DNA methyltransferase 3A (Dnmt3a), while methylation of Esr1 promoter was significantly increased. These results show that exposures to the environmental estrogen bisphenol A and drug EE2 cause transcriptional and epigenetic alterations to expression of estrogen receptors in developing prostate mesenchyme in vivo.

Exposure to the environmental estrogen bisphenol A differentially modulated estrogen receptor-α and -β immunoreactivity and mRNA in male mouse testis

Life Sciences ◽  
2003 ◽  
Vol 72 (10) ◽  
pp. 1159-1169 ◽  
Author(s):  
Toshihiro Takao ◽  
Wakako Nanamiya ◽  
Hossein Pournajafi Nazarloo ◽  
Reiko Matsumoto ◽  
Koichi Asaba ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Male Mouse ◽  
Estrogen Receptor Α ◽  
Mouse Testis ◽  
Environmental Estrogen

scholarly journals Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2).

2002 ◽  
Vol 110 (suppl 3) ◽  
pp. 397-402 ◽  
Author(s):  
Rosa Maria Facciolo ◽  
Raffaella Alò ◽  
Maria Madeo ◽  
Marcello Canonaco ◽  
Francesco Dessì-Fulgheri
Keyword(s):  
Bisphenol A ◽  
Somatostatin Receptor ◽  
Receptor Subtype ◽  
Environmental Estrogen

Environmental estrogen bisphenol A and autoimmunity

Lupus ◽  
2015 ◽  
Vol 24 (4-5) ◽  
pp. 392-399 ◽  
Author(s):  
I Jochmanová ◽  
Z Lazúrová ◽  
M Rudnay ◽  
I Bačová ◽  
M Mareková ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Environmental Estrogen

Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy

Life Sciences ◽  
2001 ◽  
Vol 69 (22) ◽  
pp. 2611-2625 ◽  
Author(s):  
Jong-Choon Kim ◽  
Ho-Chul Shin ◽  
Shin-Woo Cha ◽  
Woo-Suk Koh ◽  
Moon-Koo Chung ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Developmental Toxicity ◽  
Environmental Estrogen

Synthesis of bio-based epoxy monomers from natural allyl- and vinyl phenols and the estimation of their affinity to the estrogen receptor α by molecular docking

2016 ◽  
Vol 40 (9) ◽  
pp. 7701-7710 ◽  
Author(s):  
Erika Zago ◽  
Eric Dubreucq ◽  
Jérôme Lecomte ◽  
Pierre Villeneuve ◽  
Frédéric Fine ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Molecular Docking ◽  
Phenolic Compounds ◽  
Bisphenol A ◽  
Estrogen Receptor Α ◽  
Diglycidyl Ether ◽  
Metathesis Reaction

Potential substitutes of diglycidyl ether of bisphenol A (DGEBA) were synthesized by the metathesis reaction of glycidylated biobased phenolic compounds.

scholarly journals Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells

2019 ◽  
Vol 8 (1) ◽  
pp. 169-184 ◽  
Author(s):  
Victoria Lloyd ◽  
Mia Morse ◽  
Betsy Purakal ◽  
Jordan Parker ◽  
Paige Benard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha
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