Growth and serum thyroid hormone and insulin-like growth factor I (IGF-I) responses to natural passive immunization against somatostatin in the lamb

1993 ◽  
Vol 73 (3) ◽  
pp. 509-516 ◽  
Author(s):  
A. G. Van Kessel ◽  
R. S. Korchinski ◽  
B. Laarveld
Keyword(s):  
Growth Rate ◽  
Growth Factor ◽  
Thyroid Hormone ◽  
Serum Insulin ◽  
Passive Immunization ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Ad Libitum ◽  
Growth Factor I

The colostral transfer of maternal humoral immunity against somatostatin (SRIF) was examined as a mechanism of improving growth performance of the lamb. Lambs were the offspring of 15 ewes actively immunized against an SRIF-ovalbumin conjugate (SI; 14 male, 7 female) and of 13 ewes actively immunized against ovalbumin (C; 10 male, 5 female). At 5 d of age, lambs were removed from the ewes and received a 50:50 mixture of whole cow's milk and milk replacer ad libitum. At 46 d of age lambs were weaned and provided with an 18% crude protein pelleted grower ration ad libitum. Lamb weight was recorded and blood samples were obtained at regular intervals from 5 to 46 d of age and at 102 d of age. From 5 to 46 d of age, immunization increased growth rate of male (P < 0.001) but not female lambs. Serum thyroxine (T4) was lower (P < 0.001) in male than in female lambs. Serum triiodothyronine (T3) was higher (P < 0.05) in SI male than in C male lambs. SI female lambs initially demonstrated higher serum T3 levels than C female lambs, but this effect reversed after 19 d of age. Serum insulin-like growth factor I (IGF-I) levels were higher (P = 0.08) in SI than in C lambs without significant influence of sex. From 46 to 102 d of age, somatostatin immunization increased growth rate of male (P = 0.08) but not female lambs. Serum levels of T4, T3 and IGF-I at 102 d of age were not affected by immunization. Passive immunization against SRIF through colostral transfer of immunity may improve growth rate of the lamb via an influence on thyroid hormone metabolism. Key words: Sheep, somatostatin, immunoneutralization. growth, thyroid, IGF-I

scholarly journals Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I

2006 ◽  
Vol 26 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Philip Hanlon ◽  
William Andrew Lorenz ◽  
Zhihong Shao ◽  
James M. Harper ◽  
Andrzej T. Galecki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Genome Scan ◽  
Chromosome 17 ◽  
Insulin Like Growth Factor ◽  
Mouse Population ◽  
Factor I ◽  
A Genome ◽  
Igf I ◽  
Growth Factor I

A previous analysis of serum insulin-like growth factor I (IGF-I) levels in a mouse population ( n = 961) derived from a cross of (BALB/cJ × C57BL/6J) F1 females and (C3H/HeJ × DBA/2J) F1 males documented quantitative trait loci (QTL) on chromosomes 1, 10, and 17. We employed a newly developed, random walk-based method to search for three- and four-way allelic combinations that might influence IGF-I levels through nonadditive (conditional or epistatic) interactions among 185 genotyped biallelic loci and with significance defined by experiment-wide permutation ( P < 0.05). We documented a three-locus combination in which an epistatic interaction between QTL on paternal-derived chromosomes 5 and 18 had an opposite effect on the phenotype based on the allele inherited at a third locus on maternal-derived chromosome 17. The search also revealed three four-locus combinations that influence IGF-I levels through nonadditive genetic interactions. In two cases, the four-allele combinations were associated with animals having high levels of IGF-I, and, in the third case, a four-allele combination was associated with animals having low IGF-I levels. The multiple-locus genome scan algorithm revealed new IGF-I QTL on chromosomes 2, 4, 5, 7, 8, and 12 that had not been detected in the single-locus genome search and showed that levels of this hormone can be regulated by complex, nonadditive interactions among multiple loci. The analysis method can detect multilocus interactions in a genome scan experiment and may provide new ways to explore the genetic architecture of complex physiological phenotypes.

scholarly journals Serum Insulin-Like Growth Factor-I (IGF-I) in Normal Japanese Adults.

1995 ◽  
Vol 42 (6) ◽  
pp. 767-770 ◽  
Author(s):  
MICHIE KITANO ◽  
TAEKO SHIMIZU ◽  
YUKO YAMAZAKI ◽  
YOSHIE UMEZU ◽  
YUKIKO ARAKAWA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Japanese Adults ◽  
Igf I ◽  
Growth Factor I ◽  
Normal Japanese

SERUM INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF BINDING PROTEIN (BP)-1, -3 ADAPTATIONS TO TRAINING

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 173
Author(s):  
R. C. Hickson ◽  
L. P. Koziris ◽  
R. T. Chatterton ◽  
R. T. Groseth ◽  
J. M. Christie ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
Growth Factor I ◽  
Igf Binding Protein

P-75 SERUM INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS IN ACROMEGALIC PATIENTS WITH APPARENTLY NORMAL GH LEVELS

2006 ◽  
Vol 16 ◽  
pp. S38
Author(s):  
Junko Morita ◽  
Naomi Hizuka ◽  
Izumi Fukuda ◽  
Makiko Kurimoto ◽  
Akira Sata ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
P 75 ◽  
Igf I ◽  
Growth Factor I

Passive immunization against circulating insulin-like growth factor-I (IGF-I) increases protein catabolism in lambs: evidence for a physiological role for circulating IGF-I

1992 ◽  
Vol 135 (2) ◽  
pp. 279-284 ◽  
Author(s):  
J. B. Koea ◽  
B. W. Gallaher ◽  
B. H. Breier ◽  
R. G. Douglas ◽  
S. Hodgkinson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Turnover ◽  
Passive Immunization ◽  
Physiological Role ◽  
Whole Body ◽  
Insulin Like Growth Factor ◽  
Protein Catabolism ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

ABSTRACT Primed constant infusions of [14C]urea were used to determine the acute effect of passive immunization against circulating free and protein-bound insulin-like growth factor-I (IGF-I) on the rate of net protein catabolism (NPC) in castrated male lambs fasted for 48 h. Following an intravenous bolus of 50 ml IGF-I antiserum, the rate of NPC increased to a peak 30 min after injection of 1·69 ± 0·16 g/kg per day from a baseline value of 1·45±0·22 g/kg per day (P<0·05, n = 4). In three animals given 50 ml equivalents of the purified immunoglobulin fraction, NPC increased from 1·31 ±0·20 to 1·59±0·16 g/kg per day (P<0·05). A similar trend was observed in animals given 25 ml antiserum (n = 4). The rate of NPC did not increase following a bolus of non-immune serum in control animals and the rate of NPC in the treated lambs returned to control levels within 60 min of antibody injection. Plasma insulin and glucose concentrations in both the treated and control groups were unchanged throughout the study. These data suggest that circulating IGF-I has a physiological role in regulating whole body protein turnover during starvation and possibly other catabolic states. The effect of immunoneutralization of circulating IGF-I is transient and this suggests that while IGF-I has an endocrine role in the regulation of protein turnover, other regulatory mechanisms are involved. Journal of Endocrinology (1992) 135, 279–284

scholarly journals Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185561 ◽  
Author(s):  
Huijuan Zhu ◽  
Yuan Xu ◽  
Fengying Gong ◽  
Guangliang Shan ◽  
Hongbo Yang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Reference Ranges ◽  
Insulin Like Growth Factor ◽  
Chinese Adults ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Healthy Chinese

(−)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level

1997 ◽  
Vol 327 (2-3) ◽  
pp. 215-220 ◽  
Author(s):  
Cristina P De la Cruz ◽  
Elisa Revilla ◽  
Jose A Rodrı́guez-Gómez ◽  
Marı́a Luisa Vizuete ◽  
Josefina Cano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Aged Rats ◽  
Factor I ◽  
Igf I ◽  
Young Rat ◽  
Growth Factor I
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