RATE AND EFFICIENCY OF GAIN, FROM WEANING TO SLAUGHTER, OF STEERS GIVEN HAY, HAY SUPPLEMENTED WITH RUMTNAL UNDEGRADABLE PROTEIN, OR CONCENTRATE

1989 ◽  
Vol 69 (3) ◽  
pp. 691-705 ◽  
Author(s):  
C. B. BAILEY

Holstein steers were given milk from birth until they reached a weight of 100 kg. Beginning at 60 kg, they received gradually increasing amounts of one of three different diets and these became their sole diet after milk was withdrawn. The three diets were: (a) 85% grass hay and 15% concentrate (group 1); (b) the same diet with enough rumen undegradable protein (formaldehyde-treated canola meal) added to raise the crude protein content by 10 g kg−1 (group 2); and (c) 85% concentrate and 15% grass hay (group 3). The amounts of the three diets offered were designed to provide 0.95 MJ of digestible energy per day per unit of liveweight0.75. Steers were slaughtered at about 500 kg liveweight and the right sides of their carcasses were dissected into separable muscle, adipose tissue, and bone. This information was used to derive estimates of the daily gains of protein, fat, and energy in the empty bodies and the carcasses of the steers. Empty liveweight gain of group 3 steers exceeded that of group 1 steers by 42% and they required only 58% as much extra-maintenance energy per unit of gain. Daily gains of carcass muscle, adipose tissue, bone, protein, fat, and energy, and of empty body protein, fat, and energy, were greater in steers in group 3 than in those in group 1. The extra gain of group 3 steers, compared with group 1 steers, was due largely to gain of extra body fat. The overall efficiency of energy gain was 50% greater in steers in group 3 than in those in group 1. Supplementing the forage diet (group 1) with rumen undegradable protein (group 2) increased daily empty liveweight gains by 13% and reduced the extra-maintenance energy requirement per unit weight gain by 12%. Daily gains of carcass muscle, bone, and protein, and of empty body protein, were greater in steers in group 2 than in those in group 1. The extra gain of group 2 steers, compared with group 1 steers, was due largely to gain of extra body protein and its associated water. There were no differences between steers in these two groups in efficiency of energy gain (energy gain per unit extra-maintenance energy intake). It was concluded that the higher energetic efficiency of empty body weight gain of steers in group 2, as opposed to those in group 1, was due to a higher rate of net protein synthesis as a consequence of the increased amounts of protein absorbed from the intestine, and that the higher energetic efficiency of weight gain of steers given the concentrate diet (group 3), as opposed to those given the forage diet (group 1), was due to a higher efficiency of conversion of the energy-yielding products of digestion into fat. Key words: Energetic efficiency, steers, protein, undegradable, hay, concentrate

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S167-S167
Author(s):  
Moradi Hawar ◽  
Lars Helldin ◽  
Anna-Karin Olsson ◽  
Pontén Anna

Abstract Background Patients with schizophrenia spectrum disorder have a reduced life time expectancy with up to 20 years. Obesity and metabolic syndrome is highly prevalent and cardio vascular disease, CVD, remain the most common cause of the excess mortality. Despite studies showing the reduced life time expectancy and its causes the patients with schizophrenia spectrum disorder yet remain to benefit of the development of the healthcare. In this study we aim to focus on how the weight changes in different age groups and when do the cluster of conditions of metabolic syndrome start to occur. Methods In this naturalistic study we follow 71 patients, 47 man and 24 women diagnosed with schizophrenia spectrum disorder. We divided the patients into 5 different groups based on age. Group 1 aged 20–30 years, Group 2 aged 31–40 years, Group 3 aged 41–50 years, group 4 aged 51–60 years and Group 5 aged 61 years and elder. The longest time of observation was 18 years. Data on weight (kg) and disorders such as diabetes, hypertension and dyslipidemia were collected at baseline and then yearly thereafter. Data from baseline and the last yearly follow up were included in this study. Weight and the presence of the cluster of conditions that make up metabolic syndrome in the above-mentioned groups were analyzed. Results Patients in group 1 make the highest gain of weight with 0, 9 kg per year and group 2 with the least gain of weight only 0, 01 kg per year. Patients in group 3 have a weight loss of 0, 2 kg per year. At endpoint 9 out 19 patients in group 3 and 11 out of 21 patients in group 4 were treated for one, two or three conditions of the metabolic syndrome. Discussion In our study we show that weight gain appears at least 10 years before the development of metabolic syndrome. Despite the loss of weight that appear in group 3 the negative effects of the weight gained a decade earlier may be a factor that make patients aged 41 years and older to be at risk of developing metabolic syndrome.


1989 ◽  
Vol 69 (4) ◽  
pp. 905-909 ◽  
Author(s):  
C. B. BAILEY

Holstein steers (10 per group) were given either 85% grass hay and 15% concentrate (group 1), the same diet with added rumen undegradable protein to raise the overall protein level from 120 to 130 g kg−1 (group 2), or 85% concentrate and 15% grass hay (group 3) until they were slaughtered at 500 kg. Extractable fat in separable muscle was greatest for steers in group 3, least for steers in group 2, and intermediate for those in group 1. Loin-eye area was less for steers in groups 1 and 2 than for those in group 3. Carcasses were a larger proportion of empty liveweight in steers in group 3 than in those in groups 1 and 2 due primarily to increased adipose tissue in the front quarter. In comparison with steers on a mainly hay diet, a hay diet supplemented with rumen undegradable protein did not affect the composition of the carcass although it increased the rate of gain from weaning to slaughter. Key words: Carcass, composition, nondegradable, protein, steer


2020 ◽  
Vol 23 (18) ◽  
pp. 3304-3314
Author(s):  
Heng Yaw Yong ◽  
Zalilah Mohd Shariff ◽  
Geeta Appannah ◽  
Zulida Rejali ◽  
Barakatun Nisak Mohd Yusof ◽  
...  

AbstractObjective:To examine the gestational weight gain (GWG) trajectory and its possible association with pregnancy outcomes.Design:GWG trajectories were identified using the latent class growth model. Binary logistic regression was performed to examine the associations between adverse pregnancy outcomes and these trajectories.Setting:Negeri Sembilan, Malaysia.Participants:Two thousand one hundred ninety-three pregnant women.Results:Three GWG trajectories were identified: ‘Group 1 – slow initial GWG but followed by drastic GWG’, ‘Group 2 – maintaining rate of GWG at 0·58 kg/week’ and ‘Group 3 – maintaining rate of GWG at 0·38 kg/week’. Group 1 had higher risk of postpartum weight retention (PWR) (adjusted OR (AOR) 1·02, 95 % CI 1·01, 1·04), caesarean delivery (AOR 1·03, 95 % CI 1·01, 1·04) and having low birth weight (AOR 1·04, 95 % CI 1·02, 1·05) compared with group 3. Group 2 was at higher risk of PWR (AOR 1·18, 95 % CI 1·16, 1·21), preterm delivery (AOR 1·03, 95 % CI 1·01, 1·05) and caesarean delivery (AOR 1·02, 95 % CI 1·01, 1·03), but at lower risk of having small-for-gestational-age infants (AOR 0·97, 95 % CI 0·96, 0·99) compared with group 3. The significant associations between group 1 and PWR were observed among non-overweight/obese women; between group 1 and caesarean delivery among overweight/obese women; group 2 with preterm delivery and caesarean delivery were only found among overweight/obese women.Conclusions:Higher GWG as well as increasing GWG trajectories was associated with higher risk of adverse pregnancy outcomes. Promoting GWG within the recommended range should be emphasised in antenatal care to prevent the risk of adverse pregnancy outcomes.


Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1044-1044
Author(s):  
Sameer A Parikh ◽  
Hagop Kantarjian ◽  
Farhad Ravandi ◽  
Gautam Borthakur ◽  
Stefan Faderl ◽  
...  

Abstract Abstract 1044 Poster Board I-66 Background: Differentiation Syndrome (DS) in patients (pts) with acute promyelocytic leukemia (APL) remains a source of significant morbidity and mortality. DS is reported in 2-27% of pts with newly diagnosed APL treated with all-trans retinoic acid (ATRA) alone or in combination with idarubicin (IDA). More recently, arsenic trioxide (ATO) has been used in combination with ATRA as frontline therapy to improve rates of complete remission (CR) and overall survival (OS). It has been postulated that with the use of ATO, the risk of DS may decrease. Aim To describe the incidence, characteristics and outcome of differentiation syndrome with various modalities of ATRA-based therapy used for APL. Methods: We reviewed the records of 167 pts with newly diagnosed APL treated at our institution from 1992-2009 with three regimens: ATRA + IDA (Group 1), liposomal ATRA (Group 2) and ATRA plus ATO (Group 3). Patients in Group 1 (n=52; 1992-1997) received induction with ATRA 45mg/m2 orally daily in two divided doses until CR and IDA 12mg/m2 IV daily for 4 days. Group 2 (n=34; 1997-2000) received liposomal ATRA at 90mg/m2 IV every other day until CR. Patients in Group3 (n=82; 2002-2009) received 45mg/m2 ATRA orally daily in two divided doses, 9mg/m2 gemtuzumab ozogamicin if the WBC count exceeded 30 ×109/L in the first 4 weeks of therapy, ATO 0.15mg/kg/day IV starting on day 10 in 47 patients and on day 1 in 35 patients, and methylprednisolone (50 mg daily for 5 days) to prevent DS. A diagnosis of DS was made by the presence of: dyspnea, unexplained fever, weight gain, peripheral edema, unexplained hypotension, acute renal failure or congestive heart failure, and particularly by a chest radiograph demonstrating interstitial pulmonary infiltrates, or pleuropericardial effusion [Sanz MA, Blood. 2009;113(9):1875-91].Patients with ≥4 features were classified as having severe DS and those with ≤3 mild DS. No single sign or symptom was considered sufficient for diagnosis of DS. Patients with a final diagnosis of pneumonia, sepsis, diffuse alveolar hemorrhage and decompensated heart failure were not considered to have DS. Patients who developed DS ≤7 days of starting therapy with ATRA were classified as “early DS” and others as having “late DS”. Results: Forty one patients (24%) were diagnosed with DS: 14 (27%) in Group 1, 12 (35%) in Group 2, and 15 (18%) in Group 3. Baseline characteristics of patients with DS in each group are shown in Table. Dyspnea, weight gain and pulmonary infiltrates were the most common features of DS in all groups. The median number of days to develop DS after starting ATRA was 3 (1-15) in Group 1, 5 (2-18) in Group 2 and 10 (1-18) in Group 3. ATRA was held in 8 pts (57%) in Group 1, 9 pts (75%) in Group 2, and 8 pts (53%) in Group 3. Intravenous corticosteroids were used for treatment of all patients with DS. CR was achieved in 7 (50%) pts in group 1, 10 (83%) in Group 2 and 14 (93%) in Group 3. The number of patients who died during induction therapy was 6, 2 and 1 in Groups 1, 2 and 3 respectively. There were no deaths directly attributable to DS in any groups. Three-year survival was 65% for pts with DS and 83% for those without DS (p-value: 0.07). Conclusion: The incidence of DS is higher when ATRA alone is used as frontline therapy for APL. With ATRA + ATO (and prophylaxis with corticosteroids) there is a trend for decreased frequency and more delayed occurrence of DS. The severity of DS appears lower for patients not receiving chemotherapy with ATRA. With adequate management, a diagnosis of DS during induction therapy for APL does not influence outcomes independent of therapy. Disclosures: Ravandi: Cephalon: Consultancy, Honoraria.


1986 ◽  
Vol 251 (4) ◽  
pp. F642-F646
Author(s):  
D. C. Harris ◽  
P. A. Gabow ◽  
S. L. Linas ◽  
D. E. Rosendale ◽  
S. P. Guggenheim ◽  
...  

The mechanism of the concentrating defect of hypercalcemia is explored by examining the effect of concomitant phosphate restriction. Rats were pair fed a normal phosphorus diet, without (group 1) or with dihydrotachysterol (group 2), or a low-phosphorus diet (group 3). Hypercalcemia was comparable in groups 2 (12.1 +/- 0.6 mg/dl) and 3 (11.8 +/- 0.4 mg/dl), but serum phosphate was lower in group 3 than group 2 (3.8 +/- 0.7 vs. 7.1 +/- 1.1 mg/dl, P less than 0.005). Group 2 rats had impaired maximum urinary concentration after 24 h of fluid deprivation (2,441 +/- 450 mosmol/kg H2O, P less than 0.001) compared with group 1 (3,263 +/- 466 mosmol/kg H2O) or group 3 (3,332 +/- 515 mosmol/kg H2O) animals. Polydipsia and polyuria were found in group 2 rats only. Tubular calcium reabsorption was higher in group 2 (83.1 +/- 33.5 mg/24 h, P less than 0.001) than group 1 (47.0 +/- 26.1 mg/24 h) or group 3 (52.8 +/- 19.3 mg/24 h) animals, and medullary calcium concentration was higher in group 2 (7.57 +/- 3.08 nmol/mg dry wt, P less than 0.05) as compared to group 1 (5.04 +/- 1.37 nmol/mg dry wt) or group 3 (5.32 +/- 0.98 nmol/mg dry wt) rats. Total medullary solute concentration was significantly higher in group 3 than group 2 animals. Thus phosphate restriction prevents the defect of urinary concentrating ability of chronic hypercalcemia, probably by decreasing tubular uptake and tissue accumulation of calcium.


Fitoterapia ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 35-39
Author(s):  
A. P. Levitsky ◽  
◽  
A. V. Markov ◽  
T. I. Pupin ◽  
V. M. Zubachik ◽  
...  

Keywords: liver, phospholipids, essential fatty acids, palm oil, dysbiosis, herbal medicine. Aim. To study the effect of the phytopreparation kvertulin on the processes of biosynthesis of PUFA of liver phospholipids in rats treated with palm oil against the background of dysbiosis. Methods. Rats consumed a fat-free diet (group 1), a diet with 15 % palm oil (group 2), a diet with 15 % palm oil on the background of experimental dysbiosis (group 3) and a diet with 15 % palm oil on background of dysbiosis + kvertulin. The duration of the experiment is 40 days. The content of fatty acids in liver phospholipids was determined by gas chromatography. The ratio of the PUFA content was used to calculate the “activity” of ω-3-desaturase, the intensity of synthesis of arachidonic acid, and the intensity of synthesis of docosahexaenoic acid. Results: In rats of the 3rd group, which received palm oil against the background of dysbiosis, there was a decrease in the content of ω-3 PUFA, an increase in the ratio of ω-6 / ω-3 PUFA, and a decrease in the “activity” of ω-3-desaturase. In rats of the 4th group, which received kvertulin, the content of PUFA was completely restored and the “activity” of enzymes of their biosynthesis was normalized. Conclusion. The use of the phytopreparation kvertulin normalizes the endogenous biosynthesis of PUFA of liver phospholipids in rats consuming palm oil against the background of dysbiosis.


Parasitology ◽  
2006 ◽  
Vol 134 (1) ◽  
pp. 121-127 ◽  
Author(s):  
S. PETKEVIČIUS ◽  
L. E. THOMSEN ◽  
K. E. BACH KNUDSEN ◽  
K. D. MURRELL ◽  
A. ROEPSTORFF ◽  
...  

The objective of this experiment was to investigate the potential influence of inulin on the establishment of new and patent infections ofTrichuris suisin growing pigs. Two experimental diets were formulated based on barley flour with either added insoluble fibre from oat husk (Diet 1) or a pure inulin (16%) supplementation (Diet 2). Twenty-eight 10-week-old pigs were divided randomly into 4 groups (Groups 1–4) each of 7 pigs. After 3 weeks adaptation to the experimental diets all pigs were infected with a single dose of 2000 infectiveT. suiseggs. Group 1 was fed Diet 1 until 7 weeks post-infection (p.i.) and Group 3 until 9 weeks p.i., Group 2 was fed Diet 2 until 7 weeks p.i., Group 4 was fed Diet 1 until week 7 p.i. and was switched-over from Diet 1 to Diet 2 until week 9 p.i. Seven weeks p.i. pigs in Groups 1 and 2 were slaughtered, and pigs in Groups 3 and 4 were slaughtered at 9 weeks p.i.Trichuris suisworm burdens were determined for all pigs. Inulin-fed pigs (Group 2) exhibited an 87% reduction in EPG, compared to the pigs on standard diet (Group 1) (P<0·0001). The number of worms recovered at week 7 p.i. from pigs on the inulin diet (Group 2) was significantly reduced by 71%, compared to the pigs on standard diet (Group 1) (P<0·01). At week 9, worm recovery in pigs on the inulin diet switch protocol (Group 4) was reduced by 47% compared to the control pigs in Group 3 (P<0·01). Further, the inulin-fed pigs exhibited a significant reduction in female worm fecundity and worm large intestine location was more distal compared to those from pigs on standard diet. These results demonstrate that inclusion of the highly degradable fructose polymer inulin in the diet leads to significant reductions inT. suisestablishment, egg excretion, and female worm fecundity and can be used as a treatment for patent infections.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Naw Awn J-P ◽  
◽  
Marina Minami ◽  
Masamitsu Eitoku ◽  
Nagamasa Maeda ◽  
...  

Abstract Background Pregnant women in Japan express various reasons for limiting gestational weight gain (GWG). We aimed to identify and characterise groups where the women share common reasons to limit GWG and to examine how these groups are associated with inappropriate GWG and abnormal foetal size. Methods We prospectively studied information from the Japan Environment and Children’s Study (JECS) on 92,539 women who gave birth to live singletons from 2011 through 2014. Pregnant women were recruited during early pregnancy. Their reasons for limiting GWG and other information were collected through self-reported questionnaires and medical records. We applied latent class analysis to group the women based on their reported reasons. We used multinomial logistic regression to compare the risks of inappropriate (inadequate and excessive) GWG and abnormal foetal size (determined by new-born weight for gestational age) between the identified groups. Results We identified three groups: Group 1 (76.7%), concerned about delivery and new-born health (health-conscious women); Group 2 (14.5%), concerned about body shape, delivery, and new-born health (body-shape- and health-conscious women); and Group 3 (8.8%), women without strong reasons to limit GWG (women lacking body-shape and health consciousness). Compared with Group 1 members, Group 2 members tended to be younger, have lower pre-pregnancy weight, be unmarried, be nulliparous, have practiced weight loss before pregnancy, and not have chronic medical conditions. Group 3 members tended to be less educated, unmarried, multiparous, smokers, and have a higher prevalence of pre-pregnancy underweight and previous caesarean delivery. Relative to Group 1, Group 2 had a lower unadjusted risk for inadequate GWG (relative risk ratio [RRR] = 0.86, 95% CI: 0.81–0.90) and large-for-gestational-age birth (RRR = 0.91, 95% CI 0.86–0.97), whereas Group 3 had a higher unadjusted risk for excessive GWG (RRR = 1.36, 95% CI: 1.29–1.43) and small-for-gestational-age (SGA) births (RRR = 1.15, 95% CI: 1.05–1.25). Conclusions In this Japanese nationwide birth cohort study, pregnant women who were less conscious about body shape and health had complex risks for excessive GWG and SGA birth. Health care providers should consider a woman’s perception of GWG when addressing factors affecting GWG and foetal growth.


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S554-S554
Author(s):  
Michelle Fang ◽  
Ariel Ma ◽  
Scott T Johns ◽  
Jonathan Lacro

Abstract Background Recent studies have given rise to the concern that some integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy may lead to weight gain in PLWH. The objectives of this study were to compare the incidence of weight gain following initiation of bictegravir (BIC) compared to other INSTIs, and to assess whether any differences were associated with changes in metabolic indices. Methods Patients from the VA San Diego Healthcare System (VASDHS) were included in this retrospective cohort study if they were at least 18 years old and being treated for HIV with an INSTI that was started exclusively with FTC/TAF for at least 6 months. INSTI-containing regimens were excluded if initiated with non-FTC/TAF antiretroviral agents or if the patient was pregnant, using prescription weight loss drugs, or did not have weights recorded after the start of the studied regimen. The primary outcome was weight gain at 12 and 18 months after the start of the studied regimen. Secondary outcomes included changes in parameters used to define metabolic syndrome. Statistical analysis was performed using Mann-Whitney U, Chi-square, and Spearman’s Rho tests. Results 560 patients with 809 instances of new INSTI prescriptions from VASDHS during November 2015 to October 2019 were reviewed for inclusion. Raltegravir-based regimens were excluded from analysis due to the limited number of eligible regimens. Study groups included group 1 (BIC, n=265), group 2 (elvitegravir/cobicistat, n=123), and group 3 (dolutegravir, n=35). There were no significant differences in baseline weight between groups. Median weight change at 12 months was 2.8 lbs. in group 1, 4.4 lbs. in group 2 (p=0.328 vs. group 1), and 5.3 lbs. in group 3 (p=0.133 vs. group 1). At 18 months, median weight change was 4.5 lbs. in group 1, 3.4 lbs. in group 2 (p=0.597 vs. group 1), and 7.7 lbs. in group 3 (p=0.585 vs. group 1). Within group 1, there was a significant increase in weight at 3, 6, 12, and 18 months compared to index date. Conclusion These results support the growing body of evidence associating INSTI use with weight gain, which was persistent over 18 months in all groups and in the context of a consistent FTC/TAF backbone in this study. No significant differences in magnitude of weight gain were observed between INSTIs. Disclosures All Authors: No reported disclosures


VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.


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