scholarly journals EFFECT OF REDUCED FEED INTAKE ON ZEARALENONE METABOLISM AND TOXICITY IN THE RAT

1987 ◽  
Vol 67 (2) ◽  
pp. 535-542 ◽  
Author(s):  
M. C. KIRITSY ◽  
M. J. LATTA ◽  
D. W. FITZPATRICK
Keyword(s):  
Feed Intake ◽  
Young Female ◽  
Female Rats ◽  
Feed Restriction ◽  
Standard Diet ◽  
Uridine Diphosphate ◽  
Metabolizing Enzymes ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Conjugated Metabolites

Three experiments were conducted to determine the effect of reduced feed intake on the metabolism and toxic expression of zearalenone. Young female rats were fed a standard diet either ad libitum or 75% of ad libitum intake. The enzyme activities of 3α-hydroxysteroid dehydrogenase (3α-HSD) and uridine diphosphate glucuronyl transferase (UDP-G), the zearalenone metabolizing enzymes, were determined after 14 d of feeding. When feed was restricted, 3α-HSD activity increased 28% while UDP-G activity increased 79% compared to fed controls. After 14 d of feeding, animals were orally dosed with 1 mg zearalenone kg−1 body weight; zearalenone and its metabolites were measured in urine and feces. Feed restriction resulted in more conjugated zearalenone being excreted in the urine, with a corresponding decrease in α- and β-zearalenols produced and fecal metabolites compared to fed animals. No conjugated metabolites were found in the feces. Animals were fed the same diet, but 0–150 ppm zearalenone were added for 3 wk and growth and organ weights were determined. Feed restriction ameliorated zearalenone's toxic expression. These results indicate that nutritional regimen effects zearalenone metabolism, excretion and toxicity. Key words: Mycotoxin, zearalenone, feed intake, toxicity

scholarly journals Effects of feeding level on efficiency of high- and low-residual feed intake beef steers

2020 ◽  
Vol 98 (10) ◽  
Author(s):  
Emily M Andreini ◽  
Sheyenne M Augenstein ◽  
Carrie S Fales ◽  
Roberto D Sainz ◽  
James W Oltjen
Keyword(s):  
Feed Intake ◽  
Energy Requirement ◽  
Average Daily Gain ◽  
Residual Feed Intake ◽  
Energy Requirements ◽  
Feed Restriction ◽  
Maintenance Energy ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Daily Intakes

Abstract Comparing heat production after ad libitum (ADLIB) and restricted (RESTRICT) feeding periods may offer insight into how residual feed intake (RFI) groups change their energy requirements based on previous feeding levels. In this study, the authors sought to explain the efficiency changes of high- and low-RFI steers after feed restriction. To determine RFI classification, 56 Angus-cross steers with initial body weight (BW) of 350 ± 28.7 kg were individually housed, offered ad libitum access to a total mixed ration, and daily intakes were recorded for 56 d. RFI was defined as the residual of the regression of dry matter intake on mid-test BW0.75 and average daily gain. High- and low-RFI groups were defined as >0.5 SD above or below the mean of zero, respectively. Fourteen steers from each high and low groups (n = 28) were selected for the subsequent 56-d RESTRICT period. During the RESTRICT period, intake was restricted to 75% of previous ad libitum intake on a BW0.75 basis, and all other conditions remained constant. After the RESTRICT period, both RFI groups had decreased maintenance energy requirements. However, the low-RFI group decreased maintenance energy requirements by 32% on a BW0.75 basis, more (P < 0.05) than the high-RFI group decreased maintenance requirements (18%). Thus, the low-RFI steers remained more efficient after a period of feed restriction. We conclude that feed restriction decreases maintenance energy requirement in both high- and low-RFI groups that are restricted to the same degree.

scholarly journals Effects of Soy Protein Intake on Low Bone Mass Caused by Energy Restriction in Young Female Rats

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 540-540
Author(s):  
Kazuki Kioka ◽  
Yuki Aikawa ◽  
Yusuke Wakasugi ◽  
Takahiro Narukawa ◽  
Tomoya Fukuyasu ◽  
...  
Keyword(s):  
Soy Protein ◽  
Young Female ◽  
Diet Group ◽  
Energy Restriction ◽  
Female Rats ◽  
Main Effect ◽  
Igf I ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Research Grant

Abstract Objectives Eating disorders, such as anorexia nervosa, in young adulthood have been shown to lower bone mineral density (BMD), possibly due to the dysfunction of growth and gonadal hormones caused by reduced energy intake, which leads to bone loss. Isoflavones in soy protein have estrogen-like effects and are used as an alternative treatment for a wide range of hormonal disorders such as osteoporosis. The purpose of this study was to determine the effect of soy protein intake on bone fragility caused by energy restriction in young female rats. Methods Six-week-old Sprague–Dawley female rats were acclimated for 1 week and then divided into four groups: (1) ad libitum intake and casein diet group (Cas: n = 8), (2) ad libitum intake and soy diet group (Soy: n = 8), (3) energy-restricted and casein diet group (ER-Cas: n = 8), and (4) energy-restricted and soy diet group (ER-Soy: n = 8). The animals were maintained under these feeding conditions for 10.5 weeks. In the energy-restricted groups, the calorific intake was reduced by 40%. After rearing, viscera, blood, muscle, and bone samples were collected. Bone samples were evaluated for BMD by the dual-energy x-ray absorptiometry method. Two-way analysis of variance and multiple comparison tests were used to evaluate the differences among the four groups. Results The bodyweight and uterine weight results revealed a significant main effect of energy restriction on bone mineral content (BMC), bone area, and BMD. BMC and BMD results revealed a significant interaction of soy protein and energy restriction. BMD was highest in the Soy group, followed by the Cas group, ER-Cas group, and ER-Soy group. There was no difference in estradiol among the four groups. Energy restriction had a significant main effect on insulin-like growth factor I (IGF-I), which was significantly reduced in the ER-Soy group compared with the two ad libitum groups. Conclusions Soy protein showed a tendency of having a positive effect on BMD and IGF-I under ad libitum conditions, whereas under energy restriction, it had a negative effect and did not suppress the effect of energy restriction. Funding Sources This work was supported by the Research Grant of Fuji Foundation for Protein Research and the Cooperative Research Grant of Advanced Research Initiative for Human High Performance, University of Tsukuba.

Diet Supplementation with Madagascar Cockroach Flour (Gromphadorhina portentosa) Improved Malnourished Mice Metabolism and Ameliorated Liver Inflammatory Markers

2021 ◽  
Vol 12 (2) ◽  
pp. 112-122
Author(s):  
Janaína Ribeiro Oliveira ◽  
Junio Cota ◽  
Bruna Mara Carvalho ◽  
Theles de Oliveira Costa ◽  
Diego Vicente da Costa ◽  
...  
Keyword(s):  
Body Weight ◽  
Inflammatory Markers ◽  
Food Sources ◽  
Feed Restriction ◽  
Standard Diet ◽  
Mice Model ◽  
Protein Food ◽  
High Quality Protein ◽  
Ad Libitum ◽  
Gromphadorhina Portentosa

Background: Malnutrition and accessible high-quality protein food sources are two of the world’s alimentary challenges. Edible insects are nowadays recognized as a possible functional food solution with lower environmental impacts and beneficial health effects. Objective: In this context, the aim of the present study is to evaluate Madagascar cockroach (Gromphadorhina portentosa) flour supplementation effects on a malnourished mice model, considering its effects on metabolism, adiposity, and inflammatory liver profiles. Method: Male Swiss mice are divided into five groups and fed with experimental diets for eight weeks, including a standard diet (ST) ad libitum, AIN93 ad libitum (AIN), insect flour-enriched AIN93 (AIN+IM), AIN-40% feed restriction (AIN-FR), and insect flour-enriched AIN-40% of feed restriction (AIN-FR+IM). The metabolic profiles, adipose tissue, biochemical parameters, and liver IL-6 and IL-10 expression are evaluated. Results: The main findings show a body weight and metabolism improvement followed by an increased recovery of the adipocyte area in the AIN-FR+IM group when compared to the AIN-FR malnourished group. Reduced hepatic IL-6 and increased IL-10 expression are also detected in the AIN-FR+IM group. Conclusion: The results show that insect flour supplementation enhances both body weight and adiposity gain/recovery. The results also show hepatic improvement of inflammatory markers.

scholarly journals Feed Restriction Reveals Distinct Serum Metabolome Profiles in Chickens Divergent in Feed Efficiency Traits

Metabolites ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 38 ◽  
Author(s):  
Barbara Metzler-Zebeli ◽  
Sina-Catherine Siegerstetter ◽  
Elizabeth Magowan ◽  
Peadar Lawlor ◽  
Niamh O’Connell ◽  
...  
Keyword(s):  
Feed Intake ◽  
Feed Efficiency ◽  
Energy Demand ◽  
Body Weight Gain ◽  
Serum Glucose ◽  
Arachidonic Acid Metabolism ◽  
Feed Restriction ◽  
Physiological Factors ◽  
Ad Libitum ◽  
Almost All

Restrictive feeding influences systemic metabolism of nutrients; however, this impact has not been evaluated in chickens of diverging feed efficiency. This study investigated the effect of ad libitum versus restrictive feeding (85% of ad libitum) on the serum metabolome and white blood cell composition in chickens of diverging residual feed intake (RFI; metric for feed efficiency). Blood samples were collected between days 33 and 37 post-hatch. While serum glucose was similar, serum uric acid and cholesterol were indicative of the nutritional status and chicken’s RFI, respectively. Feed restriction and RFI rank caused distinct serum metabolome profiles, whereby restrictive feeding also increased the blood lymphocyte proportion. Most importantly, 10 amino acids were associated with RFI rank in birds, whereas restrictive feeding affected almost all detected lysophosphatidylcholines, with 3 being higher and 6 being lower in restrictively compared to ad libitum fed chickens. As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively. Only for taurine, feed intake mostly explained the RFI-associated variation, whereas for most metabolites, other host physiological factors played a greater role for the RFI-associated differences, and was potentially related to insulin-signaling, phospholipase A2, and arachidonic acid metabolism. Alterations in the hepatic synthesis of long-chain fatty acids and the need for precursors for gluconeogenesis due to varying energy demand may explain the marked differences in serum metabolite profiles in ad libitum and restrictively fed birds.

393 Reproductive Parameters and Blood Metabolites in Young Female Rats Subjected to Feed Restriction and/or Ginger Administration.

2018 ◽  
Vol 96 (suppl_2) ◽  
pp. 211-211
Author(s):  
B Shdaifat ◽  
A Izbeidat ◽  
W Al-Khashroom ◽  
M Mayyas ◽  
H S Subih ◽  
...  
Keyword(s):  
Young Female ◽  
Female Rats ◽  
Blood Metabolites ◽  
Feed Restriction ◽  
Reproductive Parameters

Effect of residual feed intake phenotype–nutritional treatment interaction on the growth performance, plasma metabolic variables and somatotropic axis gene expression of growing ewes

2016 ◽  
Vol 56 (10) ◽  
pp. 1593 ◽  
Author(s):  
H. T. Nie ◽  
Z. Y. Wang ◽  
S. Lan ◽  
H. Zhang ◽  
Y. J. Wan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Growth Performance ◽  
Feed Intake ◽  
Mrna Abundance ◽  
Feed Restriction ◽  
Somatotropic Axis ◽  
Nutritional Treatment ◽  
Treatment Interaction ◽  
Ad Libitum

This study aimed to evaluate the effect of residual feed intake (RFI) phenotype and nutritional treatment interaction on the growth performance, plasma variables and gene expression levels within the somatotropic axis. Growing ewes [n = 52, initial bodyweight (BW) = 17.5 ± 0.5 kg, 2 months of age] were offered ad libitum access to diets for 63 days and ranked based on RFI phenotype. Thirty ewes with the highest and lowest RFI values were selected and randomly assigned to three nutritional treatments based on dry matter intake (DMI), which are ad libitum (AL), low restriction (LR) and high restriction (HR) groups, respectively. Each nutritional treatment group included ewes with high (n = 5) and low RFI (n = 5) values. During nutritional treatment (from Day 64 to Day 138), plasma samples were obtained to measure metabolite and hormone concentrations. Tissues of the hypothalamus, pituitary, liver, and Longissimus dorsi muscle (LM) were harvested at the end of the experiment (Day 138) to measure the gene expression level within the somatotropic axis. Muscle growth hormone receptor mRNA abundance of low RFI ewes tended to be greater (P = 0.09) under AL feeding, but this difference was abolished by underfeeding (P > 0.10). Low RFI ewes under HR treatment showed slightly greater growth performance, which was accompanied with lower pituitary somatostain receptor 2 mRNA abundance (P < 0.05), plasma non-esterified fatty acid concentration (P < 0.05), and greater concentration of triglyceride (P < 0.05), compared with ewes classified as high RFI group. Our results suggested that ewes categorised as low RFI showed higher resistance to the condition of high feed restriction, which might be attributed to less intensity of fat mobilisation under negative energy balance. The mechanism underlying resistance to such feed restriction was presumably through action of somatostain receptor 2 and was potentially mediated by inhibitory effects of somatostatin on growth hormone release but not basal growth hormone secretion.

Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats

1988 ◽  
Vol 254 (4) ◽  
pp. R616-R621 ◽  
Author(s):  
F. H. Bronson
Keyword(s):  
Food Restriction ◽  
Dark Period ◽  
Pubertal Development ◽  
Young Female ◽  
Female Rats ◽  
The Third ◽  
Feedback Sensitivity ◽  
Effect Of Food ◽  
Ad Libitum ◽  
Ad Libitum Feeding

Female rats were prevented from growing and developing reproductively by restricting their food intake from the time they reached 80-85 g (27-29 days of age) until they were 2 mo old. A return to ad libitum feeding then typically yielded the pubertal ovulation during the third or fourth dark period. Ad libitum feeding for 48 h increased the frequency of luteinizing hormone (LH) pulsing in ovariectomized females. This treatment also depressed the level of circulating estradiol in ovariectomized females implanted with Silastic capsules. It had no effect on the rate at which estradiol was cleared from the blood in a 1-h test, however, nor did it affect the pool of assayable gonadotropin-releasing hormone (GnRH) in the hypothalamus, the pool of assayable LH in the pituitary, the response of the pituitary to GnRH, or the rate at which LH was cleared from the blood. In toto, the present results suggest that food restriction inhibits pubertal development by acting rather specifically on GnRH secretion via an ovarian steroid-independent pathway. The presumed supplemental role for enhanced negative-feedback sensitivity could not be evaluated because of the aberrant results with encapsulated estradiol.

scholarly journals Performance and hormonal profile in broiler chickens fed with different energy levels during post restriction period

2003 ◽  
Vol 38 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Poliana Fernanda Giachetto ◽  
Erika Nomura Guerreiro ◽  
Jesus Aparecido Ferro ◽  
Maria Inês Tiraboschi Ferro ◽  
Renato Luis Furlan ◽  
...  
Keyword(s):  
Energy Level ◽  
Broiler Chickens ◽  
Energy Levels ◽  
High Energy ◽  
Feed Restriction ◽  
Feed Conversion ◽  
Feeding Program ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Metabolic Hormone

The aim of this work was to investigate the influence of diet energy level on performance and hormonal profiles of broilers during post restriction period. It was a split-plot experiment, and the main treatments were in a 2x2 factorial scheme. Birds were fed restricted to 30% of the ad libitum intake, from 7 to 14 days of age. After the restriction period, birds were fed ad libitum with diets containing low (2,900 kcal ME/kg) or high (3,200 kcal ME/kg) energy until 49 days of age. Broilers fed with high energy ration showed lower feed intake and better feed conversion and decreased carcass protein; however, abdominal fat pad, and total carcass fat were not affected by ration energy levels or feeding program. Neither diet energy level nor feed restriction program changed body weight at 49 days. The profile of insulin-like growth factor-1 (IGF-1) was reduced during the feed restriction period, but increased at refeeding period. Feeding program and ration energy level did not affect T3, T4 and growth hormone serum concentrations. Feed restriction at 30% of ad libitum intake is not enough to promote changes on carcass quality, related to fat deposition, and on metabolic hormone levels, except IGF-1 seric level that has rapid increase after feed restriction.

scholarly journals THE EFFECT OF FEED RESTRICTION AT THE STARTER PHASE ON PERFORMANCE OF BROILER CHICKENS

2021 ◽  
Vol 34 (1) ◽  
pp. 69-76
Author(s):  
M Tion ◽  
M. T. Orga ◽  
I. A. Adeka
Keyword(s):  
Weight Gain ◽  
Mortality Rate ◽  
Feed Intake ◽  
Broiler Chickens ◽  
Live Weight ◽  
Feed Restriction ◽  
Control Group ◽  
Broiler Chicks ◽  
Feed Conversion ◽  
Ad Libitum

Two hundred and twenty five day old straight run broiler chicks were utilized in completely randomized design to test the effect of restricting feed intake of four groups of chicks to 92.5% 85.0%, 77.5% and 70.0% of the unrestricted (control) group in the starter phase and following adlibitum feeding for all groups in the finisher phase. The treatments were simply designated as A, B, C, D and E. The starter phase in which the restriction was carried out lasted 28 days and the finisher phase 42 days. Parameters evaluated during the starter and finisher phases included; growth rate, feed conversion ration and mortality rate. Results show gain in weight among all groups while the group fed diet B and the control had comparable weight gain at the starter phase. The percentage weight difference between the control and each of the other dietary groups was: 4.4%, 8.4%, 8.6% and 10.4% for the treatments B, C, D and E respectively. Feed gain ration improved as the level of restriction became stricter. Following ad-libitum feeding of all grops at the finisher phase, the feed restricted groups at the starter phase voraciously increased their feed intake, thus, producing comparable performance values with the unrestricted (control) group in weight gain in the 8th week of the study. Although birds in all groups averaged more than 2000g final live weight in 10weeks, significant differences exist between groups that were fed diets C, D, and E that were restricted at the starter phase, an indication that complete compensatory growth was not obtainable. Feed gain ration improved for restricted groups. Mortality rate did not show any trend attributable to levels of feed restriction. This study shows that broiler chicks fed restricted levels of balanced diet at the starter phase but later fed ad-libitum at the finisher phase could attain a finished weight of about 2000g or more at a market age of 10 weeks (70 days) with an improvement in feed gain ration.

scholarly journals Influence of timing and duration of feed restriction on growth and economic performance of finisher broiler chickens

2012 ◽  
Vol 12 (55) ◽  
pp. 6976-6986
Author(s):  
OA Makinde ◽  
Keyword(s):  
Feed Intake ◽  
Crude Protein ◽  
Average Daily Gain ◽  
Live Weight ◽  
Feed Restriction ◽  
Meat Production ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Ad Libitum ◽  
Cost Of Production

The study investigated different feed restriction programs during an 8-week broiler chicken growing cycle as a management strategy for reducing cost of production. Initially, 90 Hubbard day-old chicks fed ad libitum a commercial starter feed supplying 24% crude protein and 3000 kcal of ME/kg for 4 weeks. Thereafter, they were randomly allotted to five different feed restriction programs (R0, R5, R56, R67 and R57) utilizing finisher diets supplying 19% crude protein and 2850 kcal of ME/kg from 5-8 weeks. Each program had three replicates and six birds per replicate. Unrestricted (R0) was the control where birds fed ad libitum. In R5, birds were restricted the 5th week; R56, 5th and 6th weeks; R67, 6th and 7th weeks, and R57, 5th and 7th weeks. However, all the feed-restricted birds fed ad libitum in the 8th week. Feed restriction involved feeding one-third feed intake of R0 birds starting from 14.00 to 18.00 h daily and performance parameters recorded. Feed restriction negatively affected growth performance as the severity of restriction increased. Final body weight, carcass weight, average daily gain and average daily feed intake were similar (P>0.05) for R0 and R5 but higher than R56, R67 and R57. However, feed restriction did not significantly affect (P>0.05) carcass and breast yields or feed conversion ratio except for R67, the least (P<0.05) feed efficient. Feed cost, cost of production and revenue declined as the period of restriction increased. However, profit or profit/kg live weight, economic efficiency (EE) of feed and relative EE of feed were highest for R0 followed by R5, R56, R57 and R67 in that order. Generally, birds restricted for 1 week performed better than those restricted for 2 weeks and birds restricted continuously for 2 weeks before the last week of re-alimentation and slaughter were inferior to others. These results suggest that the duration and timing of feed restriction can reduce cost in broiler meat production without seriously affecting performance or economics of production depending on the restriction program applied.

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