EFFECTS OF COLD EXPOSURE ON PANCREATIC EXOCRINE SECRETIONS IN SHEEP

1984 ◽  
Vol 64 (5) ◽  
pp. 263-264 ◽  
Author(s):  
S. KATO ◽  
B. A. YOUNG
Keyword(s):  
Bile Duct ◽  
Food Intake ◽  
Enzymatic Activity ◽  
Pancreatic Juice ◽  
Cold Exposure ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Daily Output ◽  
Exocrine Secretions ◽  
Pancreatic Exocrine

The effect of cold exposure (0–3 °C vs. 18–21 °C) on pancreatic exocrine secretion was investigated in sheep with chronically implanted bile duct catheters. At comparable feeding levels, cold exposure enhanced pancreatic juice flow by more than 50%, but its protein content and enzymatic activity were reduced. Only in cold-exposed sheep with increased food intake was there an increased daily output of pancreatic protein and enzymes. Key words: Pancreatic juice, protein, enzymes, cold exposure.

Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats

1996 ◽  
Vol 270 (1) ◽  
pp. G128-G135 ◽  
Author(s):  
A. W. Spannagel ◽  
I. Nakano ◽  
T. Tawil ◽  
W. Y. Chey ◽  
R. A. Liddle ◽  
...  
Keyword(s):  
Small Intestine ◽  
Pancreatic Juice ◽  
Lipolytic Activity ◽  
Exocrine Secretion ◽  
Secretory Response ◽  
Pancreatic Exocrine Secretion ◽  
High Fat ◽  
Functional Consequences ◽  
Pancreatic Exocrine ◽  
Cck Release

Exposure to higher levels of fat in the diet increases the secretion of fat-digesting enzymes in pancreatic juice. This study examines the functional consequences of this phenomenon and demonstrates that adapting rats to high fat (triglyceride) loads increases the release of cholecystokinin (CCK) and the pancreatic secretory response to intraduodenal fat. Lipolytic activity in the small intestine was also higher in adapted rats. Exchanging pancreatic juice from unadapted rats with pancreatic juice from adapted rats decreased the response to fat in adapted rats and increased the response to fat in unadapted rats. Infusing oleic acid into unadapted rats stimulated CCK secretion and pancreatic exocrine secretion to levels observed with triglycerides in adapted rats. Pancreatic exocrine secretion in response to intraduodenal fat in rats adapted to a high-fat (20%) diet were significantly higher than the responses seen in rats fed a low-fat (5%) diet. Adaptation to fat increases the pancreatic secretory and plasma CCK responses to fat, apparently by increasing the efficiency of triglyceride digestion and thereby increasing CCK release.

Neurohormonal mechanism of pancreatic exocrine secretion stimulated by sodium oleate and L-tryptophan in dogs

1992 ◽  
Vol 263 (1) ◽  
pp. G12-G16 ◽  
Author(s):  
Y. H. Jo ◽  
Y. L. Lee ◽  
K. Y. Lee ◽  
T. M. Chang ◽  
W. Y. Chey
Keyword(s):  
Pancreatic Juice ◽  
Sodium Oleate ◽  
Pancreatic Secretion ◽  
Exocrine Secretion ◽  
Dependent Manner ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine ◽  
Protein Output ◽  
Dose Dependent ◽  
Cck Release

In the present investigation, we have studied the effect of atropine on the pancreatic secretion stimulated by intraduodenal administration of either sodium oleate or exogenous cholecystokinin (CCK). In four dogs prepared with gastric and Thomas duodenal cannulas, pancreatic juice was collected for measurement of volume, bicarbonate, and protein output, and peripheral venous blood samples were obtained for radioimmunoassay of both secretin and CCK. Volume, bicarbonate, and protein output of the pancreatic juice increased significantly in response to sodium oleate (1-4 mmol/h) in a dose-dependent manner. The increase in pancreatic secretion paralleled the increments in both plasma CCK and secretin. Atropine given intravenously suppressed completely both pancreatic secretion and release of CCK stimulated by sodium oleate, whereas the release of secretin was not affected. Pancreatic secretion was significantly increased in a dose-dependent manner by exogenous CCK octapeptide (CCK-8) at 16, 32, and 64 micrograms (14, 28, and 56 pmol).kg-1.h-1. Atropine inhibited protein output only partially, but it did not influence bicarbonate output. In five additional dogs, the effect of atropine on L-tryptophan-stimulated pancreatic secretion was studied. Interestingly, atropine failed to influence the CCK release and pancreatic secretion of volume and bicarbonate, except for protein secretion, which was significantly inhibited. It was shown previously that atropine inhibited significantly the pancreatic secretion of bicarbonate stimulated by secretin in physiological doses. Thus we conclude that the inhibition by atropine of the pancreatic exocrine secretion stimulated by sodium oleate is mediated by both suppression of CCK release and inhibition of action of secretin on the exocrine pancreas.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Pancreatic phospholipase A2 from the small intestine is a secretin-releasing factor in rats

2001 ◽  
Vol 281 (2) ◽  
pp. G526-G532 ◽  
Author(s):  
James P. Li ◽  
Ta-Min Chang ◽  
David Wagner ◽  
William Y. Chey
Keyword(s):  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Pancreatic Juice ◽  
Duodenal Mucosa ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Phospholipase ◽  
Group I ◽  
Duodenal Acidification ◽  
Pancreatic Exocrine

A secretin-releasing activity exists in the upper small intestine and pancreatic juice in the rat and the dog. Group I pancreatic phospholipase A2(PLA2) in canine pancreatic juice and porcine pancreatic PLA2 stimulate the release of secretin from both STC-1 cells and a secretin-producing cell (S cell)-enriched preparation isolated from rat duodenal mucosa. We investigated the distribution and release of pancreatic PLA2-like immunoreactivity in the gastrointestinal tract and the role of PLA2 on the release of secretin and pancreatic exocrine secretion in response to duodenal acidification in anesthetized rats. PLA2-like immunoreactivity was detected in the mucosa throughout the gastrointestinal tract. High concentrations of PLA2 were found in both the small intestine and the pancreas. Duodenal acidification significantly increased the release of PLA2from the upper small intestine (385% over basal secretion). Intravenous infusion of an anti-PLA2 serum (anti-PLA2) dose-dependently inhibited the release of secretin and pancreatic exocrine secretion in response to duodenal acid perfusion. Preincubation of the concentrate of intestinal acid perfusate (10-fold) from donor rats with the anti-PLA2significantly suppressed its stimulation of secretin release and pancreatic exocrine secretion in recipient rats. We conclude that pancreatic PLA2 also functions as a secretin-releasing factor in the small intestine that mediates acid-stimulated release of secretin in rats.

Surgical preparation for the study of pancreatic exocrine secretion in the conscious preruminant goat

1986 ◽  
Vol 20 (3) ◽  
pp. 231-233 ◽  
Author(s):  
J. A. Naranjo ◽  
A. Valverde ◽  
E. Martinez De Victoria ◽  
M. Mañas ◽  
M. Moreno
Keyword(s):  
Pancreatic Juice ◽  
Pancreatic Secretion ◽  
Surgical Procedure ◽  
Sphincter Of Oddi ◽  
Exocrine Secretion ◽  
Normal Function ◽  
Pancreatic Exocrine Secretion ◽  
Surgical Preparation ◽  
Pancreatic Exocrine

A new surgical procedure for the study of pancreatic secretion in the conscious preruminant goat, under conditions which approach physiological normality, is described. The bile and pancreatic juice retain their natural route and preserve the normal function of the sphincter of Oddi. Experiments could be started 3 days after surgery.

The effect of AFMK (N 1 -acetyl-N 2 -formyl-5-methoxykynuramine) on pancreatic exocrine secretion in the rats

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S28
Author(s):  
Katarzyna Nawrot-Porabka ◽  
Anna Leja-Szpak ◽  
Joanna Szklarczyk ◽  
Joanna Bonior ◽  
Marta Góralska ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Effect of Ethanol Intake on Pancreatic Exocrine Secretion in Mice

1992 ◽  
Vol 27 (9) ◽  
pp. 783-786 ◽  
Author(s):  
M. I. Vaccaro ◽  
O. M. Tiscornia ◽  
E. L. Calvo ◽  
M. A. Cresta ◽  
D. Celener
Keyword(s):  
Exocrine Secretion ◽  
Ethanol Intake ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Sow milk feeding vs. pancreatic exocrine secretion in pigs

1997 ◽  
Vol 50 (1-2) ◽  
pp. 151-152 ◽  
Author(s):  
S.G. Pierzynowski ◽  
B.R. Weström ◽  
B.W. Karlsson
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine ◽  
Milk Feeding

Feedback Regulation of Pancreatic Exocrine Secretion in Minipigs

1997 ◽  
Vol 32 (4) ◽  
pp. 374-379 ◽  
Author(s):  
T. Houe ◽  
S. S. Sætre ◽  
P. Svendsen ◽  
O. Olsen ◽  
J. F. Rehfeld ◽  
...  
Keyword(s):  
Feedback Regulation ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine
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