EFFECT ON CALF GROWTH AND BLOOD COMPOSITION OF PREPARTUM INJECTION OF VITAMIN D3 OR 25-HYDROXYVITAMIN D3 TO BEEF HEIFERS

1983 ◽  
Vol 63 (1) ◽  
pp. 251-254 ◽  
Author(s):  
M. HIDIROGLOU ◽  
J. G. PROULX
Keyword(s):  
Vitamin D ◽  
Key Words ◽  
Vitamin D3 ◽  
Plasma Calcium ◽  
Blood Composition ◽  
Beef Heifers ◽  
Calf Growth ◽  
Grass Silage ◽  
25 Hydroxycholecalciferol

Pregnant beef heifers, housed indoors and fed grass silage, were used as controls or treated prepartum with vitamin D3 or 25-hydroxycholecalciferol. Four months after birth, calves from treated dams were significantly heavier. Plasma calcium in calves was unaffected by treatments, while magnesium and phosphorus were only affected in the first week of life. Key words: Cattle, vitamin D, growth, blood composition

Effect of Phenobarbitone Treatment on Vitamin D Metabolism in Mammals

1974 ◽  
Vol 46 (4) ◽  
pp. 433-448 ◽  
Author(s):  
J. Silver ◽  
G. Neale ◽  
G. R. Thompson
Keyword(s):  
Vitamin D ◽  
Biological Activity ◽  
Silicic Acid ◽  
Vitamin D3 ◽  
Water Soluble ◽  
Prolonged Treatment ◽  
Vitamin D Metabolism ◽  
Silicic Acid Chromatography ◽  
Polar Metabolites ◽  
25 Hydroxycholecalciferol

1. The metabolism of radioactive cholecalciferol was studied in control and phenobarbitone-treated rats and pigs. 2. Treatment with phenobarbitone enhanced the appearance in plasma of 25-hydroxycholecalciferol (peak IV on silicic acid chromatography), and of more-polar metabolites (peak V), but not of the most-polar metabolites (peak VI). Peak IV had the chromatographic properties of authentic 25-hydroxycholecalciferol (25-HCC) and had biological activity. 3. There was no effect on the appearance of peaks V and VI in plasma after an injection of radioactive 25-HCC. 4. Treatment with phenobarbitone enhanced the excretion of metabolites of radioactive vitamin D3 in bile. These metabolites were largely water-soluble conjugates of peaks IV, V and VI, which included glucuronides. Peak IV in bile was not identical with 25-HCC. 5. Prolonged treatment with phenobarbitone depleted the tissue radioactivity of rats given radioactive vitamin D3.

Insensitivity to Vitamin D

PEDIATRICS ◽  
1956 ◽  
Vol 17 (2) ◽  
pp. 213-213
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Plasma Calcium ◽  
Related Substances

The authors observed that some patients being treated for postoperative tetany became insensitive to doses of vitamin D which had been adequate to maintain the plasma calcium levels and normal levels could no longer be maintained even with large doses of vitamin D. When a change was made from large doses of vitamin D to normal doses of A. T. 10 (dihydrotachysterol) or vitamin D3 the levels of calcium in the plasma could again be restored to normal. Thus there appeared to have developed an insensitvity to one form of vitamin D but not to closely related substances. This finding may have far-reaching implications in understanding other disorders such as vitamin D resistent rickets. The phenomenon appears to be unique as regards the action of vitamins.

Effect of vitamin D3 (cholecalciferol) on plasma calcium and intestinal 45calcium absorption in goldfish, Carassius auratus L.

1984 ◽  
Vol 62 (1) ◽  
pp. 34-36 ◽  
Author(s):  
James C. Fenwick
Keyword(s):  
Vitamin D ◽  
Food Deprivation ◽  
Vitamin D3 ◽  
Carassius Auratus ◽  
Calcium Absorption ◽  
Plasma Calcium ◽  
Intestinal Calcium Absorption ◽  
Total Calcium ◽  
Goldfish Carassius Auratus

Goldfish that were fed as well as not fed for 2 weeks had similar plasma total calcium levels, and vitamin D3 injections during the last 6 days had no significant effect on this parameter. When fish were fed for 1 day after 13 days of food deprivation, plasma calcium increased significantly and this increase was augmented by vitamin D3 injections. This latter group also showed a chlorpromazine-sensitive increase in 45calcium absorption from perfused everted gut sacs when compared with the controls. It was concluded that vitamin D3 stimulates intestinal calcium absorption in the goldfish.

The Effects of a Diphosphonate and Dietary Calcium on the Metabolism of Vitamin D3 (Cholecalciferol) in the Chick

1975 ◽  
Vol 49 (5) ◽  
pp. 391-400
Author(s):  
Carol M. Taylor ◽  
E. Barbara Mawer ◽  
A. Reeve
Keyword(s):  
Vitamin D ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Vitamin D3 ◽  
Dietary Calcium ◽  
No Inhibition ◽  
25 Hydroxycholecalciferol

1. Vitamin D-deficient chicks, maintained on a diet adequate in calcium and treated with ethane-1-hydroxy-1,1-diphosphonate for 2 days before a single oral dose of cholecalciferol (vitamin D3), converted the vitamin into 24,25-dihydroxycholecalciferol instead of into the normal metabolite 1,25-dihydroxycholecalciferol. 2. This inhibition of the renal 1-hydroxylase disappeared on withdrawal of the diphosphonate. 3. Kidneys from chicks given diphosphonate for 12 days converted 25-hydroxycholecalciferol into 24,25-dihydroxycholecalciferol on incubation in vitro. 4. The inhibition of the 1-hydroxylase was markedly accelerated by treating the birds with cholecalciferol. 5. No inhibition of renal 1-hydroxylation was observed in birds maintained on a diet low in calcium. 6. A possible mechanism producing this effect is discussed.

THE EFFECT ON THE GROWTH OF BEEF HEIFERS OF AVOPARCIN IN A FREE-CHOICE MINERAL MIXTURE

1984 ◽  
Vol 64 (1) ◽  
pp. 187-189 ◽  
Author(s):  
D. M. VEIRA ◽  
M. IVAN ◽  
G. BUTLER ◽  
J. PROULX
Keyword(s):  
Key Words ◽  
Free Choice ◽  
Beef Heifers ◽  
Apparent Effect ◽  
Grass Silage ◽  
Mineral Mixture ◽  
Ad Libitum

Twenty crossbred beef heifers (7–9 mo) were fed grass silage ad libitum for 90 days, with a free-choice mineral mixture containing avoparcin (8 g/kg) while 20 other heifers were fed similarly but without avoparcin. Heifers offered the supplement gained 27% faster (P < 0.01) than controls, with no apparent effect on silage intake. Key words: Avoparcin, administration, cattle, growth

scholarly journals Correlation of vitamin D3 and serum calcium level with left ventricular hypertrophy patients.

2020 ◽  
Vol 27 (06) ◽  
pp. 1143-1150
Author(s):  
Masood Nabi Noor ◽  
Anawar Ali Jamali ◽  
Hajra Naila Rahu ◽  
Ghulam Mustafa Jamali ◽  
Altaf Hussain Memon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Ventricular Hypertrophy ◽  
Serum Vitamin ◽  
Left Ventricular ◽  
Serum Vitamin D ◽  
25 Hydroxycholecalciferol

Extra cellular fluid (ECF) Ca++ performs vital functions such as blood clotting, cardiac muscle contraction, second messenger for hormone and neurotransmitter release. Total Ionized serum Ca++ is 4.65 to 5.25 mg/dl Ionized Ca++ performs vital physiological functions such as maintenance of plasma membrane integrity. Objectives: The present study is the first research being reporting on the association of LVH (left ventricular hypertrophy) due to essential hypertension with serum vitamin D3 and serum calcium levels. Study Design: Cross Sectional Research. Setting: Medicine/Cardiology department, Peoples Medical University Hospital, Nawabshah. Period: 1st January 2017 to 30th June 2017. Material & Methods: To assess the correlation of 25-hydroxycholecalciferol and serum calcium with left ventricular hypertrophy in essential hypertension. The thickness of inter ventricular septum (IVS) and posterior wall (PWT) on echocardiography were used to categorize LVH into mild, moderate and severe. Results: Male predominated in the present study. Male to female ratio was 1.65:1. Male and female comprised 62.33% and 37.67% respectively. Chi square value (X2-value) was 14.7 with significant p-value. Mean +SD of 25-hydroxycholecalciferol in mild moderate and severe LVH were noted as 30+7.8, 24.7+7.7 and 14.9+6.1 ng/dl respectively. Mean +SD of serum calcium in mild moderate and severe LVH were noted as 9.20+0.51, 8.93+0.72 and 8.678+0.44 mg/dl respectively. Conclusion: In subjects with left ventricular hypertrophy in essential hypertension the serum levels of vitamin D and calcium were low. There was a negative correlation with left ventricular hypertrophy and serum vitamin D and serum calcium. Thus it could be concluded that in subjects with left ventricular hypertrophy the low levels of serum vitamin D could be an independent modifiable risk factor.

Feedback Regulation of 25-Hydroxycholecalciferol Metabolism by Vitamin D3

1975 ◽  
Vol 48 (3) ◽  
pp. 227-230
Author(s):  
I. M. A. Evans ◽  
K. W. Colston ◽  
L. Galante ◽  
I. MacIntyre
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Actinomycin D ◽  
Feedback Regulation ◽  
Kidney Cells ◽  
Hydroxylase Activity ◽  
25 Hydroxycholecalciferol

1. In vitamin D-deficient chicks both vitamin D3 and 1α-hydroxycholecalciferol markedly decrease renal 1-hydroxylase activity and induce 24-hydroxylase activity. 2. Actinomycin D abolishes both effects. 3. These results are consistent with feedback regulation of vitamin D3 metabolism by a direct nuclear action of the vitamin or its metabolites on the kidney cells.

Intestinal CaBP: a new quantitive index of vitamin D deficiency in the rat

1975 ◽  
Vol 229 (3) ◽  
pp. 689-694 ◽  
Author(s):  
F Bronner ◽  
T Freund
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Calcium Intake ◽  
Calcium Binding ◽  
Plasma Calcium ◽  
Vitamin D Status ◽  
Calcium And Phosphorus ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
25 Hydroxycholecalciferol

Rats raised from weaning on regiments adequate in calcium and phosphorus but deficient in vitamin D will have no detectable intestinal calcium-binding proteins (CaBP), whether or not they show other signs of vitamin D deficiency, such as hypocalcemia. When hypocalcemic, vitamin D-deficient animals were treated with 25-hydroxycholecalciferol, a vitamin D metabolite, they showed a dose-dependent increase in plasma calcium and CaBP; both responses can be described by a single linear relationship, which appears to apply whether the metabolite is 25-hydroxycholecalciferol or dihydrotachysterol. Since vitamin D status is only one determinant of plasma calcium, whereas CaBP (or its expression) appears to depend on vitamin D quantitatively, CaBP may be used as an index of vitamin D status, provided calcium intake is controlled.

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