THE EFFECT OF ADDED DIETARY SELENIUM ON THE SELENIUM CONTENT OF MILK, URINE AND FECES

1980 ◽  
Vol 60 (1) ◽  
pp. 79-86 ◽  
Author(s):  
L. J. FISHER ◽  
J. MONTEMURRO ◽  
C. HOOGENDOORN
Keyword(s):  
Dietary Intake ◽  
Treatment Period ◽  
Sodium Selenite ◽  
Normal Values ◽  
Fold Increase ◽  
Selenium Supplementation ◽  
Identical Twin ◽  
Selenium Content ◽  
Variable Response ◽  
Dietary Selenium

Three sets of identical twin cows were used to quantitate the excretion of selenium in feces, urine and milk in response to increments of dietary selenium. The first trial consisted of three test periods, each 8 days long, separated by recovery periods of 5 days. A solution of sodium selenite was applied to the grain portion of the ration to provide 0, 6.0, 12.0, 24.0 and 48.0 or 100.0 mg of sodium selenite per day. Samples of milk, urine and feces were collected on the last 2 days of each treatment period and analyzed for selenium. There was a significant, positive linear (P < 0.05) response between excretion of selenium in feces and increments of dietary selenium. There was a marked but variable response in selenium content of urine to dietary intake but selenium levels in milk were not increased above those of control animals. In a second trial, sodium selenite was fed at the rate of 170 and 260 mg per day for 10 days. These theoretically toxic levels resulted in 10- and 40-fold increases in the selenium levels of feces and urine, respectively, but only a 3-fold increase in selenium content of milk. At these high levels of selenium supplementation the amounts of selenium in the kidney and liver were increased above the normal values. This study shows that selenium in the form of sodium selenite would have to be fed at levels toxic to the cow before there would be any measurable increase of selenium in milk.

scholarly journals Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

2018 ◽  
Author(s):  
Lenka Urbankova ◽  
Pavel Horky ◽  
Jiri Skladanka ◽  
Magdalena Pribilova ◽  
Vendula Smolikova ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Sodium Selenite ◽  
Model Organism ◽  
Selenium Nanoparticles ◽  
Control Group ◽  
Selenium Content ◽  
Blood Samples ◽  
Dietary Selenium ◽  
Animal Organism ◽  
Total Selenium

Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats. Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days. Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism.

Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit

2009 ◽  
Vol 28 (8) ◽  
pp. 461-467 ◽  
Author(s):  
W. Manati ◽  
F. Vaillant ◽  
M. Bost ◽  
V. Maffre ◽  
D. Belhani ◽  
...  
Keyword(s):  
Treatment Period ◽  
Sodium Selenite ◽  
Histopathological Examination ◽  
Psychiatric Patients ◽  
Protective Role ◽  
Selenium Supplementation ◽  
Blood Samples ◽  
Cardiac Lesions ◽  
Se Deficiency

Neuroleptics are a suspected cause of sudden death in psychiatric patients, especially in those with pre-existing cardiac lesions. As these lesions were previously shown to be associated with selenium (Se) deficiency, the aim of the present study was to evidence the possible protective effect of Se supplementation against cardiac lesions induced by the combination of the neuroleptic drugs levomepromazine and risperidone in the rabbit. Two groups of 6 rabbits were treated with 3 mg/kg of levomepromazine daily intramuscularly combined with 1 mg/kg of risperidone intramuscularly every other week for 3 consecutive months, and one group additionally received a solution of sodium selenite (2 μg/kg/day) intramuscularly during the whole treatment period. Furthermore, one group of six untreated animals was given the Se supplementation and another group of six control animals received saline daily. Blood samples were drawn before and at the end of the treatment period for the measurement of serum Se levels. At the end of the study, all animals were sacrificed and their hearts were removed for the measurement of tissue Se concentrations. In addition, the hearts were prepared for histopathological examination. A variety of cardiac lesions was found in the neuroleptics-treated animals without supplementation and to a lesser extent in the control and Se-supplemented untreated animals. Importantly, only rare cardiac lesions were observed in neuroleptics-Se-treated animals. The most striking differences in Se concentrations were noted in the myocardium: as compared to controls, there was a 43% reduction in neuroleptics-treated, but non-Se-supplemented animals (p < .01), at the end of the treatment period, whereas only a 14% reduction (p < .05) was noted in the neuroleptics-Se-treated animals. These results confirm that neuroleptics induce cardiac lesions associated with Se deficiency. Selenium supplementation markedly decreased the incidence and severity of neuroleptics-induced cardiac lesions and these findings may serve as a basis for further evaluation of the protective role of Se supplementation in neuroleptics-treated patients. However, Se supplementation in normal animals without Se deficiency was also shown to be cardiotoxic.

scholarly journals Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

2018 ◽  
Author(s):  
Lenka Urbankova ◽  
Pavel Horky ◽  
Jiri Skladanka ◽  
Magdalena Pribilova ◽  
Vendula Smolikova ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Sodium Selenite ◽  
Model Organism ◽  
Selenium Nanoparticles ◽  
Control Group ◽  
Selenium Content ◽  
Blood Samples ◽  
Dietary Selenium ◽  
Animal Organism ◽  
Total Selenium

Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats. Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days. Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism.

Effect of selenium supplementation on survival, liveweight and wool weight of young sheep on Kangaroo Island, South Australia

1979 ◽  
Vol 19 (101) ◽  
pp. 689 ◽  
Author(s):  
SK Walker ◽  
GP Hall ◽  
DH Smith ◽  
RW Ponzoni ◽  
GJ Judson
Keyword(s):  
Total Dose ◽  
Whole Blood ◽  
Sodium Selenite ◽  
South Australia ◽  
Selenium Concentration ◽  
Mortality Rates ◽  
Selenium Supplementation ◽  
First Year ◽  
Weaning Weight ◽  
Fleece Weight

The responses in liveweight, wool weight and survival, to selenium supplementation, were studied in young sheep from weaning to yearling age. The experiment was conducted over three years. In the first year, one sodium selenite supplementation rate was used (total dose 46.5 mg). During the following two years two supplementation rates were administered (total doses 46.5 mg and 93 mg). Mean concentrations of selenium in whole blood in unsupplemented sheep varied from 0.19-0.56 pmol l-l and from 0.20-0.44 pmol l-1 in the two years in which concentrations were measured. Supplementation, which commenced at lamb marking, increased the selenium concentration in sheep at weaning and thereafter. Selenium supplementation improved the break-of-season weight (P < 0.01) and yearling weight (P < 0.01 ) but not weaning weight (0.05 < P < 0.1 ). Hogget fleece weight was improved (P < 0.01 ) and mortality reduced (P < 0.01) by selenium supplementation. There was a treatment x year interaction in mortality rates (P < 0.01 ). There were no significant differences between the two supplementation rates

scholarly journals Influence of selenium bio-fortification on nutritional compositions, bioactive compounds content and anti-oxidative properties of young ricegrass (Oryza sativa L.)

2017 ◽  
Vol 7 (3) ◽  
pp. 195 ◽  
Author(s):  
Rattanamanee Chomchan ◽  
Sunisa Siripongvutikorn ◽  
Panupong Puttarak ◽  
Rungtip Rattanapon
Keyword(s):  
Oryza Sativa ◽  
Bioactive Compounds ◽  
Functional Food ◽  
Sodium Selenite ◽  
Antioxidant Activities ◽  
Oryza Sativa L ◽  
Food Product ◽  
Growth Characteristics ◽  
Selenium Content

Background: Young ricegrass (Oryza sativa L.) can be introduced as one of functional food product since sprouts have been much interested in this era due to their high nutritive values. Bio-fortification of selenium is one strategy to enhance plant bioactivity. However, the level of selenium used is varied among species of plants, hence, the proper level needs to be explored.Objective: To investigate the influence of selenium bio-fortification on nutritional compositions, bioactive compounds content and anti-oxidative properties of young ricegrass.Methods: Sodium selenite ranging 0, 10, 20, 30 and 40 mg Se/L has been hydroponically bio-fortified into ricegrass then grown for 8 d and investigated the changes of growth characteristics, selenium content, accumulation of bioactive compounds and anti-oxidative properties.Results:  Results revealed that selenium bio-fortified exogenously increased the accumulation of selenium in ricegrass by 529% at 40 mg Se/L treatment without negatively changes in leaves biomass at the day of harvesting. However, root part weight slightly decreased when increased selenium level. Selenium at concentration of 10 and 20 mg Se/L can stimulate the production of phenolic compounds and antioxidant activities in young ricegrass as measured by DPPH, ABTS, FRAP and chelating assay. Conversely, higher level of selenium fortification reduced the accumulation of phenolics in ricegrass may due to pro-oxidant expression.Conclusion: Selenium bio-fortification can be used as a useful technique to improve quality of ricegrass plantation. 10 mg Se/L treatment was an ideal to trigger the synthesis of phenolics which exhibited high antioxidant activities. While, 40 mg Se/L treatment was ultimate for the production of Se plant foods.Keywords: Antioxidant activities; Bio-fortification; Ricegrass; Selenium

scholarly journals Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e017883 ◽  
Author(s):  
Dongmei Xie ◽  
Yulin Liao ◽  
Jirong Yue ◽  
Chao Zhang ◽  
Yanyan Wang ◽  
...  
Keyword(s):  
Sodium Selenite ◽  
Meta Analysis ◽  
Selenium Supplementation ◽  
Assessment Development ◽  
Registration Number ◽  
Selenium Supplements ◽  
Randomised Controlled ◽  
Meta Analyses ◽  
Beck Disease

ObjectiveTo compare the effectiveness of five kinds of selenium supplementation for the treatment of patients with Kashin-Beck disease, and rank these selenium supplementations based on their performance.DesignWe searched for all publications between 1 January 1966 and 31 March 2017 using seven electronic databases. GRADE system to network meta-analyses (NMAs) was applied to rate the quality of the evidence. We conducted a random effects model NMA in STATA 12.1 to determine comparative effectiveness of each intervention. Rankings were obtained by using the surface under the cumulative ranking curve (SUCRA) values and mean ranks.ResultsA total of 15 randomised controlled trials involving 2931 patients were included. After assessment of the overall quality of the evidence, we downgraded our primary outcomes from high to low or very low quality. NMAs showed that all five kinds of selenium supplementation had higher metaphysis X-ray improvement which were superior to placebo. Ranking on efficacy indicated that selenium salt was ranked the highest, followed by sodium selenite + vitamin E, selenium enriched yeast, sodium selenite and then sodium selenite + vitamin C.ConclusionsBased on the results of NMA, all five types of selenium supplements are more effective than placebo and so that selenium supplementation is of help in repairing metaphyseal lesions. Since the overall quality of the evidence was low or very low, the SUCRA values may be misleading and should be considered jointly with the The Grading of Recommendations Assessment, Development and Evaluation (GRADE) confidence in the estimates for each comparison. The quality of the evidence is insufficient to draw a conclusion about what method of selenium supplementation is most effective.PROSPERO registration numberCRD42016051874.

Dietary selenium supplementation alleviates immune toxicity in the hearts of chickens with lead-added drinking water

2019 ◽  
Vol 48 (3) ◽  
pp. 230-237 ◽  
Author(s):  
He Huang ◽  
Xiaoyan Jiao ◽  
Yanmin Xu ◽  
Qi Han ◽  
Wanying Jiao ◽  
...  
Keyword(s):  
Drinking Water ◽  
Selenium Supplementation ◽  
Dietary Selenium ◽  
Immune Toxicity

scholarly journals PSIV-B-36 Late-Breaking: Selenium content and speciation in muscle of pigs fed diets supplemented with different selenium sources and doses

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 326-327
Author(s):  
Junmin Zhang ◽  
Chaohua Tang ◽  
Kai Zhang
Keyword(s):  
Essential Element ◽  
Basal Diet ◽  
Speciation Analysis ◽  
Deposition Efficiency ◽  
Dose Effect ◽  
Selenium Speciation ◽  
Selenium Content ◽  
Dietary Selenium ◽  
Selenium Species ◽  
Different Sources

Abstract Selenium (Se) is an essential element for pigs with diet being the major source of intake, while the metabolic process of different sources and doses of dietary Se in pigs muscle remains unclear. In this study, a reliable HPLC-ICP-MS approach was developed for analyzing selenium speciation in the muscle of pigs, which could analyze seven selenium speciation in ten minutes. This approach was used to study the metabolism of different sources and doses of dietary selenium in pigs muscle. In total, 108 castrated male pigs (Duroc × Landrace × Yorkshire, 61.3 ± 3.3 kg) were randomly assigned to six treatment groups with six replicates of three pigs per replicate. These six treatments received the same basal diet (0.1 mg Se/kg) without any Se supplement (BD-0.1), or basal diet supplemented with sodium selenite (0.25 mg Se/kg, SSe-0.25), methylselenocysteine (0.25 mg Se/kg, MeSeCys-0.25), or selenomethionine (0.25, 0.50, and 2.5 mg Se/kg, SeMet-0.25, SeMet-0.5, and SeMet-2.5) for 60 days. At the end of the experiment, six pigs from each group (one pig per replicate) were slaughtered and the longissimus dorsi muscle was collected for total Se and Se speciation analysis. The results showed that the selenium sources deposition efficiency was ranked as: selenomethionine &gt; methylselenocysteine &gt; selenite, and the muscle selenium content had a dose effect with selenomethionine supplementation (Figure 1). Four species of selenium were detected in the muscles of pigs, and the distribution of these selenium species were greatly affected by the dietary selenium supplementation forms and levels (Figure 2). Selenomethionine (&gt; 70% of total selenium) and selenocystine (&gt; 11%) were the major selenium species, followed by methylselenocysteine and selenourea. These findings could be advantageous for rational use of selenium supplements, as well as for selenium-enriched pork production.

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