NIPPLE FEEDING OF SUPPLEMENTAL PROTEIN TO CALVES

1977 ◽  
Vol 57 (1) ◽  
pp. 181-186 ◽  
Author(s):  
P. H. ROBINSON ◽  
D. N. MOWAT ◽  
H. W. CHAPMAN ◽  
J. J. PARKINS
Keyword(s):  
Bottle Feeding ◽  
Wire Mesh ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Bull Calves ◽  
Lukewarm Water ◽  
High Level ◽  
Supplemental Protein ◽  
High Degree ◽  
Basal Ration

Forty-eight Holstein bull calves initially averaging 90 kg were used in a 2 × 2 factorial design to compare two levels and two methods of feeding supplemental protein. The basal ration, which was fed free choice, consisted of shelled corn, minerals, vitamins and urea and provided 10.5% CP on a DM basis. Supplemental protein as 50% CP soyaflour was fed at levels of 228 g (H) and 126 g (L) per day. The soyaflour was fed either with the basal ration (C) or twice per day (in equal amounts) from a nipple bottle (N) after being mixed with approximately 2 liters of lukewarm water. Calves were housed in individual pens with wire mesh floors and fed for 70 days. The soyaflour slurry was vigorously consumed by calves. No significant differences (P <.05) occurred in any of the performance parameters. However, a trend toward reduced weight gains and DM intake was observed among calves fed treatment LN. A nitrogen metabolism trial was conducted concurrently utilizing the same calves. Calves fed the high level of protein retained more (P <.05) nitrogen and excreted more (P <.05) urine urea nitrogen than calves fed the low level of protein. Increases in levels of plasma urea nitrogen following feeding were greater (P <.05) and occurred later (P <.05) in nipple-fed compared to conventionally fed calves. A subsequent trial was conducted with 10 calves to determine extent of closure of the reticular groove. Post-feeding levels of both blood glucose and rumen strontium indicated a high degree of groove closure with bottle feeding.

INFLUENCE OF HIGH-PROTEIN FEED ADDITIVE ON THE PRODUCTIVITY OF THE MEAT BULL-CALVES

2019 ◽  
Vol 2019 (3) ◽  
pp. 6-11
Author(s):  
Батырхан Абилов ◽  
Batyrkhan Abilov ◽  
Лариса Пашкова ◽  
Larisa Pashkova
Keyword(s):  
Hematological Parameters ◽  
Physiological State ◽  
Average Daily Gain ◽  
Live Weight ◽  
Feed Additive ◽  
North Caucasus ◽  
Agricultural Enterprise ◽  
Bull Calves ◽  
Economic Indices ◽  
High Level

The article presents the data obtained as a result of carrying by employees of the Research Institute of sheep and goat breeding, a branch of the FSBSI "North Caucasus FARC", the scientific and economic experience to study the efficiency of a new fodder additive "Organic" on the productive and physiological indices of bull-calves during the completion of growing in the conditions of the farm "Pata" agricultural enterprise in the Karachay-Cherkessia Republic. The statement of the experience and all researches were carried out according to generally accepted methods. In the course of the experiment, the following indices were studied: the chemical compound of forages, the dynamics of a live weight gain in the experimental stock, hematological parameters, control slaughter data, economic indices. Completed researches have shown positive result from the use of the fodder additive "Organic" in bull-calves diets: an increase in the average daily gain of live weight by 25%, a slaughter yield by 1% and a high level of profitability – 27%. Thus, the additional introduction of "Organic" in a diet of young horned cattle in the 2nd experimental group promoted more intensive metabolism, stabilization of a physiological state, increase in productivity and, as a consequence, profitability of beef production. Researches in this direction reveal the latent fodder reserves promoting increase in the productivity of agricultural animals.

ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

scholarly journals PSVII-6 Effects of heat stress on proteolysis in dairy cattle skeletal muscle

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 168-168
Author(s):  
Melissa S Roths ◽  
Megan A Abeyta ◽  
Tori Rudolph ◽  
Brittany Wilson ◽  
Matthew B Hudson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Dairy Cattle ◽  
Electric Heating ◽  
Economic Loss ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
E3 Ligases ◽  
Acclimation Period ◽  
Milk Urea

Abstract Heat stress (HS) occurs when internal body temperatures are elevated above a thermoneutral zone in response to extreme environmental temperatures. In the U.S. dairy industry, HS results in economic loss due to decreased feed intake, milk quality, and milk yield. Previous work has demonstrated increased plasma urea nitrogen in heat stressed dairy cattle which is thought to originate from increased skeletal muscle proteolysis, however this has not been empirically established. The objective of this investigation was to determine the extent to which HS promotes proteolysis in skeletal muscle of dairy cattle. We hypothesized HS would increase activation of the calpain and proteasome systems in skeletal muscle. To test this hypothesis, following a 3-d acclimation period in individual box stalls, all lactating dairy cows were held under thermoneutral (TN) conditions for 4-d for collection of baseline measures and then exposed to TN or HS conditions for 7-d followed by a biopsy of semitendinosus (n=8/group). To induce HS, cattle were fitted with electric heating blankets, which they wore for the duration of the heating period. This approach increased rectal temperature 1.1°C (P&lt; 0.05), respiratory rate by 33 bpm (P&lt; 0.05), plasma urea nitrogen by 19% (P=0.08) and milk urea nitrogen by 26% (P&lt; 0.05), and decreased dry matter intake by 32% (P&lt; 0.05) and milk production by 26% (P&lt; 0.05) confirming HS. Contrary to our expectations, we discovered that calpain I and II abundance and activation, and calpain activity were similar between groups. Likewise, protein expression of E3 ligases, MafBx and Murf1, were similar between groups as was total ubiquitinated proteins and proteasome activity. Collectively, and counter to our hypothesis, these results suggest skeletal muscle proteolysis is not increased following 7-d of HS. These data question the presumed dogma that increased blood urea nitrogen is due to elevated proteolysis in skeletal muscle.

CSim 2

2021 ◽  
Vol 43 (1) ◽  
pp. 1-46
Author(s):  
David Sanan ◽  
Yongwang Zhao ◽  
Shang-Wei Lin ◽  
Liu Yang
Keyword(s):  
Programming Languages ◽  
Concurrent Systems ◽  
Theorem Prover ◽  
Compositional Techniques ◽  
Machine Code ◽  
Top Down ◽  
Hol Theorem Prover ◽  
High Level ◽  
High Degree

To make feasible and scalable the verification of large and complex concurrent systems, it is necessary the use of compositional techniques even at the highest abstraction layers. When focusing on the lowest software abstraction layers, such as the implementation or the machine code, the high level of detail of those layers makes the direct verification of properties very difficult and expensive. It is therefore essential to use techniques allowing to simplify the verification on these layers. One technique to tackle this challenge is top-down verification where by means of simulation properties verified on top layers (representing abstract specifications of a system) are propagated down to the lowest layers (that are an implementation of the top layers). There is no need to say that simulation of concurrent systems implies a greater level of complexity, and having compositional techniques to check simulation between layers is also desirable when seeking for both feasibility and scalability of the refinement verification. In this article, we present CSim 2 a (compositional) rely-guarantee-based framework for the top-down verification of complex concurrent systems in the Isabelle/HOL theorem prover. CSim 2 uses CSimpl, a language with a high degree of expressiveness designed for the specification of concurrent programs. Thanks to its expressibility, CSimpl is able to model many of the features found in real world programming languages like exceptions, assertions, and procedures. CSim 2 provides a framework for the verification of rely-guarantee properties to compositionally reason on CSimpl specifications. Focusing on top-down verification, CSim 2 provides a simulation-based framework for the preservation of CSimpl rely-guarantee properties from specifications to implementations. By using the simulation framework, properties proven on the top layers (abstract specifications) are compositionally propagated down to the lowest layers (source or machine code) in each concurrent component of the system. Finally, we show the usability of CSim 2 by running a case study over two CSimpl specifications of an Arinc-653 communication service. In this case study, we prove a complex property on a specification, and we use CSim 2 to preserve the property on lower abstraction layers.

Addiction and schizophrenia

2000 ◽  
Vol 15 (2) ◽  
pp. 115-122 ◽  
Author(s):  
P. Batel
Keyword(s):  
Epidemiologic Studies ◽  
Self Medication ◽  
Addictive Disorders ◽  
Co Morbidity ◽  
Dependency Type ◽  
Active Research ◽  
Social Environmental ◽  
High Level ◽  
Environmental Hypothesis ◽  
High Degree

SummaryEpidemiologic studies in the general population and those based on the clinical assessment of schizophrenic populations have revealed a high degree of overlap between schizophrenia and addictive disorders. The abuse of psychoactive substances (including alcohol) throughout life is so frequent (50%) that the possibility of a specific link inevitably arises. Various hypotheses have been suggested to explain the high co-morbidity between schizophrenia and addiction: 1) The social-environmental hypothesis has been developed but studies have provided poor evidence to validate it. 2) The possible shared biological vulnerability between schizophrenia and addictions led researchers to explore common genetic determinants and study the involvement of the dopaminergic and opioid systems in the aetiology of both schizophrenia and the abuse of and dependence on psychoactive drugs. 3) Finally, the theory of self-medication suggests that schizophrenics may be attempting to counter the deficit linked to their disorders by using the substances they take or their dependency-type behaviour to cope with their emotional problems. The clinical profile of schizophrenic addicts does seem to display some distinctive features, such as the high level of depressive co-morbidity, very high nicotine and alcohol dependence, with a very poor prognosis. These patients are difficult to manage; the possibility of pharmacologic interactions between the substances they are taking and neuroleptic medication calls for prudence, and their compliance is also poor. Addictive disorders in schizophrenics are currently a topic of active research intended to lead to identifying specific treatments. The early identification of addictive disorders in schizophrenics should make it possible to limit their development and improve the prognosis.

Living in the end times: a short course addressing end of life issues for older people in an English parish church setting

2015 ◽  
Vol 19 (3) ◽  
pp. 140-149 ◽  
Author(s):  
Joanna Collicutt
Keyword(s):  
Older People ◽  
End Of Life ◽  
Group Dynamics ◽  
Death And Dying ◽  
Community Context ◽  
Content Type ◽  
End Of Life Issues ◽  
End Times ◽  
High Level ◽  
High Degree

Purpose – The purpose of this paper is to report a pilot study that evaluated an innovative practice in a faith community context designed to help older people live well at the end of life and prepare for death. Design/methodology/approach – A simple audit of the intervention using a contemporaneous journal kept by the author, and a follow up questionnaire completed by participants. Findings – Rich findings on the process are reported. These indicate a high degree of engagement by participants, the establishment of a high degree of group intimacy and trust, a high level of articulation of wisdom, the emergence of significant anxiety in some isolated cases, and the use made of tea and cake to manage the transition between the existentially demanding nature of the discussions and normal life. The outcome indicated very high levels of appreciation and increased confidence in relation to issues of death and dying. Practical implications – The findings of the pilot have been used to inform training of clergy in the principles of working in this area (e.g. in ways of managing group dynamics and anxiety, pacing, tuning in to archetypes and the natural symbols that people use to talk about death and dying, self-care and supervision of the programme leader/facilitator). Originality/value – The paper adds to knowledge in terms of an in depth description of processes at work in a group of older people working on spiritual and practical issues in relation to death, and offers ideas for supporting older people in this process, some of which are specific to the Christian tradition, and some of which are more widely applicable to people of all faiths and none. It gives a specific worked example of what “spiritual care” in this area might look like.

scholarly journals A High Level of Blood Urea Nitrogen Is a Significant Predictor for In-hospital Mortality in Patients with Acute Myocardial Infarction

2018 ◽  
Vol 59 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Yu Horiuchi ◽  
Jiro Aoki ◽  
Kengo Tanabe ◽  
Koichi Nakao ◽  
Yukio Ozaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Blood Urea Nitrogen ◽  
Urea Nitrogen ◽  
High Level

scholarly journals Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells

2018 ◽  
Vol 115 (50) ◽  
pp. 12811-12816 ◽  
Author(s):  
Chad Paul Grabner ◽  
Tobias Moser
Keyword(s):  
Hair Cells ◽  
Synaptic Vesicles ◽  
Basolateral Membrane ◽  
Mean Amplitude ◽  
Auditory Pathway ◽  
Inner Hair Cell ◽  
Excitatory Postsynaptic Currents ◽  
High Level ◽  
High Degree ◽  
Channel Type

Spontaneous excitatory postsynaptic currents (sEPSCs) measured from the first synapse in the mammalian auditory pathway reach a large mean amplitude with a high level of variance (CV between 0.3 and 1). This has led some to propose that each inner hair cell (IHC) ribbon-type active zone (AZ), on average, releases ∼6 synaptic vesicles (SVs) per sEPSC in a coordinated manner. If true, then the predicted change in membrane capacitance (Cm) for such multivesicular fusion events would equate to ∼300 attofarads (aF). Here, we performed cell-attached Cm measurements to directly examine the size of fusion events at the basolateral membrane of IHCs where the AZs are located. The frequency of events depended on the membrane potential and the expression of Cav1.3, the principal Ca2+-channel type of IHCs. Fusion events averaged 40 aF, which equates to a normal-sized SV with an estimated diameter of 37 nm. The calculated SV volumes showed a high degree of variance (CV > 0.6). These results indicate that SVs fused individually with the plasma membrane during spontaneous and evoked release and SV volume may contribute more variability in EPSC amplitude than previously assumed.

Time-response relationship of ractopamine feeding on growth performance, plasma urea nitrogen concentration, and carcass traits of finishing pigs1

2013 ◽  
Vol 91 (2) ◽  
pp. 811-818 ◽  
Author(s):  
V. V. Almeida ◽  
A. J. C. Nuñez ◽  
A. P. Schinckel ◽  
C. Andrade ◽  
J. C. C. Balieiro ◽  
...  
Keyword(s):  
Growth Performance ◽  
Nitrogen Concentration ◽  
Carcass Traits ◽  
Time Response ◽  
Response Relationship ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Relationship Of
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