DIALLEL CROSSES OF REPLICATE SELECTED LINES OF RATS

1975 ◽  
Vol 55 (4) ◽  
pp. 479-486 ◽  
Author(s):  
J. J. RUTLEDGE ◽  
A. B. CHAPMAN

A 6 × 6 diallel experiment was conducted with two control lines (Ri), two lines (Ui) selected for increased and two lines (Di) selected for decreased 3- to 9-wk body weight gain. Traits studied were 2-, 3-, 6- and 9-wk body weights and 3- to 9-wk body weight gain. For all traits, marginal means for dams or sires ranked in the order U > R > D. There was good agreement between replicate dam lines and between replicate sire lines for general combining ability. There was no clear evidence of any specific combining ability (non-additive gene effects) from crosses of lines within or between selection treatments.

Author(s):  
Pooja Sadana ◽  
Harpreet Kaur ◽  
Vishal Verma

Background: Wasting is a common feature in tuberculosis and treatment is aimed at achieving weight gain in pulmonary tuberculosis patients. The aims and objectives of the study were to study the extent of body weight gain during treatment and to identify the effect of different factors on weight gain among TB patients.Methods: The study was conducted on a total of 326 patients residing in the area of PHC Verka and registered with District Tuberculosis Centre, Amritsar. Weight change was assessed by taking the difference of weight at initial diagnosis and after completion of continuation phase therapy.Results: A total of 228 patients participated in the study. The mean (±SD) body weights (in kg) for the patients were 44.92±12.7 at diagnosis and 48.79±12.9 at the end of treatment. The mean (±SD) weight gain was 3.86±4.55 kgs at the end of treatment. The gain in weight at the end of treatment was associated with supervision of treatment and outcome of the TB patient.Conclusions: The findings showed that there is an association between gain in weight with supervision of treatment and outcome of the TB patient.


Author(s):  
Vidya Pradeep Kumar ◽  
Ramya G. Rao ◽  
A. Dhali ◽  
Vandana Thammiaha ◽  
Manpal Sridhar

Background: Fungal laccases have widespread application in a number of biotechnological processes including the biodegradation of lignin. Their low yield in the native state limits their practical use in the deconstruction of lignocellulosic biomass for feeding ruminants. Enzymes in bulk quantities are required to treat biomass which has got greater product consistency and less lot to lot variations. The present study was an attempt to evaluate the effect of feeding finger millet straw treated with exogenous laccases in heifers.Methods: The effect of feeding exogenous laccases obtained from immobilized Schizophyllum commune (MTCC 11893) on body weight gain, dry matter intake and nutrient digestibility in heifers was evaluated in three groups of heifers (4-each) with body weights ranging between 275 ± 47.12 to 276.75 ± 64.48kg. The control group received ad lib. finger millet straw treated with only production media (GI). Test group 1 (GII) received ad lib. straw treated with laccase rich media in a 3:5 (w/v) ratio, while test group 2 (GIII) received ad lib. straw treated in a 4:5 (w/v) ratio. Result: After 14- days of feeding, gain in body weights for GI, GII and GIII were 277.9 ± 68.47; 277.50 ± 46.43 and 278.85 ± 37.22 respectively with an overall increase of 1.15, 4.25 and 3.60 kgs. No significant variation (P greater than 0.05) was observed with regard to DMD (%) between the groups which was 46 ± 5.8 for the control animals and 41±13.0 and 41± 3.4 in G2 and G3 groups. Though significant variations were observed digestibility studies proved inconclusive. Though preliminary results indicate that applying lignin degrading enzymes as feed supplements could enhance digestibility of crop residues in ruminants.


2021 ◽  
Author(s):  
Yu Nie ◽  
Bo Huang ◽  
An-Ling Hu ◽  
Yun-Yan Xu ◽  
Yan Zou ◽  
...  

Abstract Background: Cadmium (Cd) is reported to have antitumor effects against chemical-induced liver tumors. Antitumor effects of Cd are not completely understood, but may be related to metallothionein-deficiency in tumors, which makes tumor vulnerable to necrotic effects of Cd. Methods: Eight-week old male C57BL/6 mice were given injections of diethylnitrosamine (DEN, 90 mg/kg, and 50 mg/kg two weeks later), followed by promotion with CCl4. CdCl2 was administered in the drinking water (500 ppm) from 21-40 weeks after DEN initiation. Body weights were recorded and liver tumor formation was monitored via ultrasound. At the end of experiments, livers were removed, weighed, and the tumor incidence, tumor numbers and tumor size scores were recorded. Liver histology and metallothionein immunostaining were performed. Results: After DEN injection, animal body weight decreased, and slowly recovered afterwards. Cd treatment did not affect animal body weight gain. Ultrasounds detected liver tumors 35 weeks after DEN injection. Animals were necropsied at 40 weeks. Liver/body weight ratios increased in DEN and DEN+Cd groups. Cd treatment decreased tumor incidence (71% vs 17%), tumor numbers (15 vs 2), and tumor scores (22 vs 3). Histopathology showed hepatocyte degeneration in all groups, and immunohistochemistry showed metallothionein-deficiency in liver tumors, while metallothionein stain was intensified in tumor surrounding tissues. RT-qPCR showed increases of alpha-fetoprotein in DEN-treated livers, and increases of metallionein-2 and TNFα in Cd-treated livers. Conclusion: Cd is effective in suppression of DEN-induced liver tumors, and the mechanisms may be related to metallothionein-deficiency in tumors and induction of TNFα to kill tumor cells.


1976 ◽  
Vol 81 (1) ◽  
pp. 215-224 ◽  
Author(s):  
Paul U. Dubuc

ABSTRACT Neonatal testosterone treatment of female rats led to an increase in body weight and skeletal growth and produced evidence of altered ovarian function over a 76 day period following treatment. Bilateral ovariectomy performed eleven weeks after neonatal treatment increased the rate of body weight gain of both testosterone propionate- and oil-treated groups, but no differences in the increased rates of weight gain were evident between groups over a five week post-ovex observation period. Subsequently, long-term oestrogen replacement therapy, via subcutaneous Silastic implants, produced equal reductions in the rates of body weight gain and somatic growth of both early testosterone- and oil-treated ovariectomized groups. In spite of the marked effects of these manipulations on body weight and skeletal growth, no significant differences were noted in the Lee Index of obesity between androgenized and the appropriate non-androgenized control rats at any interval of the experimental period. These results indicate that neither ovarian hormones nor an altered sensitivity to oestrogen of body weight regulatory mechanisms are important in the increased body weight that follows perinatal testosterone treatment. Additionally, the present data add support to previous work which has suggested that a general increase of somatic growth rather than 'obesity' provides the major contribution to the elevated body weights of androgenized female rats.


2012 ◽  
Vol 3 (1) ◽  
pp. 33-37
Author(s):  
SA Islam ◽  
MM Rahman ◽  
MA Hossain ◽  
MGA Chowdhury ◽  
M Mostafa

A twenty five calves of naturally infected with ascarid parasites were treated with different modern anthelmintics and pineapple leaves to study the comparative efficacy during the period from January to September 1997. The calves were divided into five groups. Groups A, B, C, D were treated with ivermectin (200 ?g / kg SC), albendazole (7.5 mg / kg orally), piperazine citrate (200 mg / kg orally) and pineapple leaves extract (1g / kg orally) respectively and group E was kept as untreated control. On the basis of faecal egg count of ascaris in calves, ivermectin was found to be more effective (100%), followed by piperazine citrate (100% at 28th day of post-treatment), albendazole (92.95% at 28th day of post-treatment) and pineapple leaves extract (51.21% at 7th day). Total erythrocyte count (TEC), haemoglobin (Hb) and packed cell volume (PCV) values significantly (p < 0.05) increased while erythrocyte sedimentation rate (ESR) significantly (p < 0.05) decreased following treatment. Body weights of treated calves were significantly (p < 0.05) increased in treated calves than the control. Therefore, ivermectin, albendazole and piperazine citate could be used against ascariasis in calves. Although efficacy of pineapple leaves was not encouraging but it may be used as a substitute for other anthelmintics.


2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.


2018 ◽  
Vol 16 (2) ◽  
pp. 201-210
Author(s):  
Muryanto Muryanto ◽  
Pita Sudrajad ◽  
Amrih Prasetyo

The aim of the study was to determine the development of ramie plants (Boehmeria nivea L. Gaud) and the effect of using ramie leaves on feed on the body weight gain of Wonosobo Sheep (Dombos). Research on the development of ramie plants using survey methods in the area of ramie plant development in Wonosobo Regency. While the research on the use of ramie leaves for fattening was carried out in Butuh Village, Kalikajar District, Wonosobo Regency in 2018. 21 male Dombos were divided into 3 feed treatments with forage proportions of 70%, 50% and 30 ramie leaves respectively. %. The results showed that currently ramie plants were being developed in Wonosobo Regency by CV. Ramindo Berkah Persada Sejahtera in Gandok Village, Kalikajar District, Wonosobo Regency, Central Java. Until now the area of the crop has reached 13 ha. Of this area will produce ramie leaves 195,000 kg / year. If one sheep needs 4 kg of ramie / tail / day leaves, then the potential capacity of sheep is 135 heads / year, if the given one is 50% then the Jurnal Litbang Provinsi Jawa Tengah, Volume 16 202 Nomor 2 – Desember 2018potential capacity is 270 heads / year and if it is reduced again to 25% of ramie leaves then the potential capacity 440 heads / year. The use of ramie leaves as a feed for Wonosobo Sheep fattening can be given as much as 30% in fresh form.


2010 ◽  
Vol 15 (4) ◽  
pp. 262-266 ◽  
Author(s):  
Won-Hee Choi ◽  
Ji-Yun Ahn ◽  
Sun-A Kim ◽  
Tae-Wan Kim ◽  
Tae-Youl Ha

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