EMBRYONIC MORTALITY AND DEVELOPMENT DURING EARLY PREGNANCY IN THREE BREEDS OF SWINE WITH PUREBRED AND CROSSBRED LITTERS

1975 ◽  
Vol 55 (1) ◽  
pp. 9-15 ◽  
Author(s):  
J. J. DUFOUR ◽  
M. H. FAHMY
Keyword(s):  
Litter Size ◽  
Early Pregnancy ◽  
Uterine Horn ◽  
Embryonic Mortality ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Placental Membranes

Data on ovulation rate, litter size, fetal and placental weights and weight and length of uterine horns were taken at 23, 42 or 63 days of pregnancy on 138 Yorkshire, Landrace and Lacombe multiparous sows bred to Yorkshire, Landrace and Hampshire boars to produce purebred and crossbred litters. Of the 53 Yorkshire sows slaughtered, 13.2% were non-pregnant, compared to 7.5 and 8.5% for the Landrace and Lacombe sows, respectively. The average number of corpora lutea was 15.1 in Landrace, one more than in Lacombe and Yorkshire sows. Embryonic mortality in crossbred litters was 7.5 and 6.0% higher in Landrace sows than in Yorkshire and Lacombe sows, respectively. In purebred litters, it was 8.4% higher in Landrace than in Yorkshire. Litters sired by Yorkshire boars were 7.8% larger in number than those sired by Landrace or Hampshire boars. At 23 days of pregnancy, 19% of the ova released in the three breeds were lost. A further loss of 4% was noted at later stages. The weights of Landrace and Lacombe embryos were significantly (P < 0.05) heavier than those of Yorkshire at the 3 days of pregnancy studied. Crossbred embryos of Yorkshire and Landrace were heavier than purebreds by 27, 8 and 6% at the 23, 42 and 63 days of pregnancy, respectively. Weights of the uterine horns and placental membranes were heavier in Landrace and Lacombe than in Yorkshire sows. Little difference was found between Landrace and Lacombe breeds in embryonic, placental and uterine weights. Highly significant correlations (r = 0.65, 0.57 and 0.76) were found between placental and embryonic weights at the 3 days of pregnancy. Correlation between number of viable embryos and length of uterine horn was 0.30 and that with weight of horn was 0.10.

scholarly journals Embryonic Mortality in Relation to Ovulation Rate in the House Mouse

1958 ◽  
Vol 35 (1) ◽  
pp. 138-143
Author(s):  
J. C. BOWMAN ◽  
R. C. ROBERTS
Keyword(s):  
House Mouse ◽  
Linear Trend ◽  
Uterine Horn ◽  
Embryonic Mortality ◽  
Ovulation Rate ◽  
Corpora Lutea

1. Two series of observations were made to determine the time and amount of loss of eggs in relation to the number shed per ovary and per mouse. 2. The correlations between sides within mice for eggs shed was -0.528, for corpora lutea counts -0.436 for implantations -0.300 and for live embryos -0.111. 3. A positive linear trend of loss of fertilized eggs with increasing numbers of eggs per uterine horn has been shown to occur before implantation. 4. Possible causative mechanisms for the loss are discussed in relation to observations on embryonic mortality previously reported by other workers.

scholarly journals Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice

Reproduction ◽  
2012 ◽  
Vol 143 (2) ◽  
pp. 195-201 ◽  
Author(s):  
C Joy McIntosh ◽  
Steve Lawrence ◽  
Peter Smith ◽  
Jennifer L Juengel ◽  
Kenneth P McNatty
Keyword(s):  
Litter Size ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cross Reactivity ◽  
Full Length ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Immunization Group

The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility. Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion. In this study, we have actively immunized mice against these proregions to test the potential in vivo roles on fertility. Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH). For each immunization group, ovaries were collected from ten mice for histology after immunization, while a further 20 mice were allowed to breed and litter sizes were counted. To link the ovulation and fertility data of these two experimental end points, mice were joined during the time period identified by histology as being the ovulatory period resulting in to the corpora lutea (CL) counted. Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens. Compared with KLH controls, mice immunized with the N-terminus BMP15 proregion peptide had ovaries with fewer CL (P<0.05) and produced smaller litters (P<0.05). In contrast, mice immunized with the full-length GDF9 proregion not only had more CL (P<0.01) but also had significantly smaller litter sizes (P<0.01). None of the treatments affected the number of antral follicles per ovary. These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.

The effect of melatonin treatment during the seasonal anoestrus on the superovulatory response and embryo production of high-prolificacy Rasa Aragonesa ewes before culling

2003 ◽  
Vol 2003 ◽  
pp. 82-82
Author(s):  
F. Forcada ◽  
J.A. Abecia ◽  
J.A. Valares
Keyword(s):  
Embryonic Development ◽  
Breeding Season ◽  
Litter Size ◽  
Direct Effect ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Melatonin Treatment ◽  
Embryo Production ◽  
Spring Equinox

The efficacy of melatonin implants inserted around the spring equinox to improve fertility and ovulation rate or litter size in Mediterranean ewes has been previously reported (Chemineau et al., 1996; Forcada et al., 2002a.), indicating the ability of the hormone to regulate the hypothalamic activity (Viguié et al., 1995). Moreover, a direct effect of melatonin on corpora lutea and embryonic development has been also reported (Wallace et al., 1988; Abecia et al., 2002). The use of prolific Rasa Aragonesa (RA) ewes (a Mediterranean breed) before culling as embryo donors has been previously tested in the breeding season (Forcada et al., 2002b.). The aim of this experiment was to improve embryo production during the seasonal anoestrus period in selected superovulated RA ewes at the end of their reproductive lives through the use of melatonin.

scholarly journals Litter size components traits in two Algerian rabbit lines

2021 ◽  
Vol 29 (1) ◽  
pp. 51
Author(s):  
Rafik Belabbas ◽  
Maria de la Luz García ◽  
Hacina AinBaziz ◽  
Ali Berbar ◽  
Maria José Argente
Keyword(s):  
Body Weight ◽  
Litter Size ◽  
Principal Components ◽  
Local Population ◽  
The Body ◽  
Ovulation Rate ◽  
Phenotypic Correlation ◽  
Limiting Factor ◽  
Corpora Lutea ◽  
Synthetic Line

<p>The aim of this study was to estimate the limiting litter size components in rabbit females from a Synthetic line (n=32) and a Local population (n=34). Ovulation rate, number of implanted and live embryos were counted by laparoscopy at 12 d after mating. Prolificacy (total newborn, number born alive and mortality) and embryonic, foetal and prenatal survival at day of birth of the 3<sup>rd</sup> gestation were measured. The analysed traits were body weight of the female at mating, ovulation rate, implanted, live and resorbed embryos, embryonic, foetal and prenatal survival, as well as total newborn, number born alive and mortality at birth. Synthetic line females had a higher ovulation rate compared to the Local population (11.03±0.23 vs. 8.41±0.23 corpora lutea; <em>P</em>&lt;0.0001). Synthetic line displayed a higher number of implanted embryos (10.00±0.25 vs. 7.85±0.25 embryos; <em>P</em>&lt;0.0001). No difference was found between groups for number of resorbed embryos. Similar embryonic, foetal and prenatal survival rates were reported between the Synthetic line and the Local population. Additionally, total newborn was higher in the Synthetic line than in the Local population (+1.46 kits; <em>P</em>&lt;0.05). A principal components analysis was performed. The first four principal components (PC) explained more than 90% of the total variation in both lines. Total newborn, number born alive and live embryos were the main variables defining the 1<sup>st</sup> PC. Resorbed embryos and foetal survival were located in the 2<sup>nd</sup> PC. Ovulation rate and embryonic survival were the predominant variables defining the 3<sup>rd</sup> PC. The body weight of females was located in the 4<sup>th</sup> PC. The phenotypic correlation between total newborn and its components were high and positive in both lines, except for ovulation rate and total newborn, where it was moderate in Synthetic line. In conclusion, the females from Synthetic line have a higher total newborn than those from Local population, as a consequence of a higher number of released oocytes and embryos that successfully reach implantation. However, a higher uterine crowding in Synthetic line seems to limit survival of foetuses that reach term of gestation, while ovulation rate is the principal limiting factor of total newborn in Local population.</p>

THE RELATIONSHIP BETWEEN THE UTERUS AND OVARIES DURING EARLY PREGNANCY IN THE GUINEA-PIG

1972 ◽  
Vol 53 (2) ◽  
pp. 295-301 ◽  
Author(s):  
F. R. BLATCHLEY ◽  
B. T. DONOVAN
Keyword(s):  
Guinea Pig ◽  
Early Pregnancy ◽  
Guinea Pigs ◽  
Uterine Horn ◽  
Vaginal Smear ◽  
Corpora Lutea ◽  
Luteal Regression ◽  
Experimental Animals ◽  
Decidual Reaction ◽  
The Relationship

SUMMARY In mated guinea-pigs one uterine horn was rendered sterile by ligation of the oviduct 2 or 3 days after finding spermatozoa in the vaginal smear. Two glass beads were inserted into the sterile horn on each of days 3–12 and on day 14 in experimental animals but not in controls. At autopsy on day 20 large corpora lutea were present in both ovaries of the control animals. The presence of beads that had been introduced on days 3 and 4 and on days 10–14 resulted in marked regression of the corpora lutea in the adjacent ovary, in the absence of a decidual reaction in the uterus, while luteal enlargement typical of pregnancy occurred in the contralateral ovary. Beads inserted on days 5–8 caused decidualization in the sterile horn but did not induce premature luteal regression in the ipsilateral ovary.

A note on ovulation rate and embryonic survival in D'man ewes

1981 ◽  
Vol 32 (2) ◽  
pp. 227-229 ◽  
Author(s):  
A. Lahlou-Kassi ◽  
M. Marie
Keyword(s):  
Litter Size ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Embryonic Survival ◽  
Average Litter Size ◽  
Simultaneous Activity

ABSTRACTThe elements of prolificacy have been analysed for the D'man sheep, a prolific Moroccan breed, by laparotomy on 38 animals. The average ovulation rate was 2·50 (s.e.0·45); a slight difference was observed between nulliparous and multiparous ewes due to high simultaneous activity by both ovaries in the latter group. Embryonic survival (42% overall) was 94% (87 to 100%) for multiparous and 44% (36 to 52%) for the nulliparous ewes at one ovulation, decreasing with increasing numbers of corpora lutea. The average litter size showed an optimum at four ovulations.

scholarly journals The effects of inbreeding on the components of litter size in mice

1967 ◽  
Vol 10 (1) ◽  
pp. 73-80 ◽  
Author(s):  
J. C. McCarthy
Keyword(s):  
Litter Size ◽  
Inbreeding Depression ◽  
First Generation ◽  
Inbreeding Coefficient ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Base Population ◽  
Pregnant Females ◽  
Sib Mating ◽  
Size At Birth

Twenty-four lines were bred from a base population of outbred Q mice by continued full-sib mating. Inbreeding depression in litter size at birth was observed. This decline in litter size was analysed in terms of ovulation rate, the incidence of preimplantation mortality and the incidence of postimplantation mortality. Pregnant females were dissected at 17½ days' gestation and the numbers of corpora lutea, or eggs, and of live and dead embryos were counted. Matings were arranged so that separate estimates of the effects of inbreeding in the mother and in the litter on the components of litter size could be obtained.In the first generation of inbreeding when the inbreeding coefficient of the litter was raised from 0 to 25% decline in litter size was attributable to an increased incidence of preimplantation mortality.In the second and fourth generations decline in litter size was attributable to (1) a reduction in the number of eggs ovulated by the inbred mothers, (2) an increased incidence of preimplantation mortality which resulted from inbreeding in the mother. No evidence of significant effects on mortality of inbreeding in the litter was obtained in the later generation of inbreeding.These findings are discussed in the context of previous work on the effects of inbreeding and crossing on litter size and its components in mice and pigs.

Studies on reproduction in prolific ewes:7. Variability in the growth of individual foetuses in relation to intra-uterine factors

1981 ◽  
Vol 96 (1) ◽  
pp. 187-194 ◽  
Author(s):  
I. McDonald ◽  
J. J. Robinson ◽  
C. Fraser
Keyword(s):  
Litter Size ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Ovulation Rate ◽  
Placental Development ◽  
Embryo Mortality ◽  
The Difference ◽  
Placental Structure

SUMMARYThe weights of 44 twin foetuses, 99 triplets and 44 quadruplets, varying in gestational age from 55 to 145 days, were studied in relation to age, sex, litter size, uterine position, placental structure and weight, and ovulation rate. Triplet and quadruplet foetuses were more variable in weight, within litters, than were twins. The difference increased with foetal age and was attributed to increased competition between foetuses which were located within the same horn of the uterus. The effect was largely associated with differences in placental development, i.e. numbers of cotyledons and weight, but those differences did not entirely account for the reduction in foetal weight with increasing litter size. Differences in placental development, arising from embryo mortality, also accounted for the reduction in foetal weight when ovulation rate exceeded litter size. In contrast, differences in foetal weight associated with the sex of the foetuses were only partly mediated by differences in cotyledon weight. Foetuses in the larger litters are thus not only lighter in weight but are more variable in weight, the increased variability being controlled by events in early pregnancy.

Pre- and peri-pubertal feed intake: effects on age at puberty and potential litter size of replacement gilts

2017 ◽  
Vol 57 (6) ◽  
pp. 1040
Author(s):  
W. H. E. J. van Wettere ◽  
M. Mitchell ◽  
D. K. Revell ◽  
P. E. Hughes
Keyword(s):  
Litter Size ◽  
Dietary Restriction ◽  
Feed Intake ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Short Term ◽  
Large White ◽  
Embryo Number ◽  
Age At Puberty

The effect of moderate restriction of pre- and peri-pubertal liveweight gain on puberty attainment and potential litter size was investigated. At 69 days of age, 48 Large White/Landrace crossbred gilts (28.3 ± 0.3 kg), were fed to attain a liveweight of 70 kg (LIGHT) or 100 kg (HEAVY) at 161 days of age (n = 24 gilts/treatment). At 161 days of age, half the gilts in each group were fed to gain liveweight at 0.5 (LOW) or 1.0 (HIGH) kg/day until puberty (n = 12 gilts/treatment). From 175 days of age, gilts received 20 min/day of full, physical boar contact. Gilts were artificially inseminated at the pubertal oestrus, with reproductive tracts collected 22 ± 0.1 days later, and the number of corpora lutea and viable embryos recorded. LIGHT-LOW gilts were older (P < 0.05) at puberty compared with LIGHT-HIGH, HEAVY-LOW and HEAVY-HIGH gilts; 207.7 ± 3.50 versus 191.7 ± 3.65, 193.1 ± 3.50 and 192.5 ± 3.65, respectively. Treatment (HIGH vs LOW) increased (P < 0.05) pubertal ovulation rate (15.2 ± 0.43 vs 13.1 ± 0.47), oestradiol at oestrus (13.4 ± 1.87 vs 9.1 ± 1.22 pg/mL) and progesterone 72 h post-oestrus (7.1 ± 0.48 vs 4.6 ± 0.50 ng/mL). Embryo number (10.8 ± 0.46) and survival (77.0 ± 3.21) were unaffected (P > 0.05) by treatment. To conclude, puberty was delayed by chronic, but not acute, dietary restriction. Although short-term, moderate increases in feed intake increased pubertal ovulation rates, embryo numbers and survival were unaffected.

scholarly journals Effects of flush feeding strategy before breeding on reproductive performance of modern replacement gilts: impacts on ovulation rate and litter traits

2020 ◽  
Vol 98 (6) ◽  
Author(s):  
André L Mallmann ◽  
Lidia S Arend ◽  
Gabriela S Oliveira ◽  
Ana P G Mellagi ◽  
Rafael R Ulguim ◽  
...  
Keyword(s):  
Litter Size ◽  
Reproductive Performance ◽  
Feeding Strategy ◽  
Early Embryo ◽  
Ovulation Rate ◽  
Breeding Cycle ◽  
Corpora Lutea ◽  
Embryo Survival ◽  
Estrous Cycles ◽  
Litter Traits

Abstract AbstractThe effects of two feed levels offered during two estrous cycles before insemination were evaluated on the reproductive performance of gilts. A total of 93 gilts (PIC Hendersonville, TN) were individually housed and manually fed twice a day with 2.1 or 3.6 kg/d of a corn and soybean meal-based diet (3.15 Mcal ME/kg and 0.64% standardized ileal digestible lysine), during two estrous cycles before breeding (cycle 1, between first and second estrus; cycle 2, between second and third estrus). Gilts were weighed at the beginning of the experiment, at second and third estrus, and at slaughter (30.2 ± 1.2 d of gestation). Follicles were counted at second estrus, and the embryo-placental units and the corpora lutea were individually counted, measured, and weighed at slaughter. Gilts fed 3.6 kg/d had greater BW gain during cycle 1 and cycle 2 (P &lt; 0.001; + 9.8 kg and + 10.0 kg, respectively) becoming heavier at second and third estrus (P &lt; 0.001). At second estrus, gilts fed 3.6 kg/d had 1.6 more medium-large follicles (P = 0.074) but no difference in follicle size (P = 0.530) was observed. Gilts fed 3.6 kg/d in cycle 1 or cycle 2 had a greater ovulation rate at third estrus (P &lt; 0.016) than those receiving 2.1 kg/d. Also, 3.6 kg/d in cycle 2 increased early embryo mortality (P = 0.006; 2.3 vs. 1.1 dead embryos) and consequently reduced total embryo survival (P = 0.002; 84.6 vs. 90.1%). Gilts fed 3.6 kg/d during cycle 1 had two more total embryos (P &lt; 0.001; 17.2 vs. 15.1) and two more vital embryos on day 30 (P &lt; 0.001; 16.7 vs. 14.5) in comparison with gilts fed 2.1 kg/d. The coefficient of variation for placental length was greater for gilts fed 3.6 kg/d during cycle 1 (P = 0.003). No further significant effects of feeding levels were observed on embryo and placental traits (P ≥ 0.063). These results suggest that the feeding level during the first cycle after pubertal estrus is crucial to set ovulation rate and potential litter size for breeding at next estrus. However, flush feeding gilts before insemination can negatively impact litter size by reducing embryo survival when breeding at third estrus.

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