FATTY ACID COMPOSITION OF BLOOD SERUM AND OVER IN BEEF CALVES AS INFLUENCED BY MATERNAL DIET AND INCIDENCE OF NUTRITIONAL MUSCULAR DYSTROPHY

1973 ◽  
Vol 53 (2) ◽  
pp. 297-305 ◽  
Author(s):  
M. HIDIROGLOU ◽  
K. J. JENKINS ◽  
R. R. MACKAY
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Muscular Dystrophy ◽  
Blood Serum ◽  
Acid Composition ◽  
Beef Calves ◽  
Group 2 ◽  
Nutritional Muscular Dystrophy ◽  
Group 1

Changes in the fatty acid composition of blood serum and liver from 28 beef calves were studied from birth to approximately 8 and 12 wk, respectively. The calves (purebred Shorthorn) were born from 14 cows fed alfalfa hay (group 1) and from 14 cows fed oat hay (group 2). The data indicate a pronounced effect of the dietary fat, with liver and serum of group 2 calves containing a higher proportion of C18:1 and C18:2 fatty acids than those of group 1. The serum of group 1 calves had higher proportions of C12:0, C14:0, C14:1, C15:0, C17:0, C18:3, and C20:1 than group 2. The proportion of C18:2 and C18:3 in the serum of both groups increased from birth until the calves were about 21 days of age, whereas the proportion of C18:1 declined during the same period. Proportionately more C17:1 and less C12:0 were found in the serum of the nondystrophic calves than those affected with nutritional muscular dystrophy. There was also a significant interaction between the nutritional muscular dystrophy incidence and the diet of calves for the C16:0, C18:2, and C18:3 fatty acids of serum. However, no such difference was found for the liver, which contained proportionally the highest concentrations of C18:0 compared with other fatty acids. In liver, high concentrations of the C16:0 and C18:1 acids were also found and appreciable levels of the C20 series.

Features of fatty acid composition of blood serum in vibration disease

2020 ◽  
pp. 59-63
Author(s):  
I. A. Potapova
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Blood Serum ◽  
Acid Composition ◽  
Metabolic Disorders ◽  
Clinical Manifestations ◽  
Level Shift ◽  
Vibration Disease ◽  
Concentration Levels

Vibration disease (VD) is one of the most common occupational diseases. It is characterized by complex symptoms of the clinical picture. The study of the features of the course of VD of different severity from the position of metabolic disorders is an urgent issue, since it will allow to establish the most significant prognostic indicators in the future. Production vibration early enough leads to a shift in serum levels of higher fatty acids (HFA). This is largely due to the fact that HFA are structural units of lipids of cell membranes and precursors of biologically active mediators, are actively involved in the processes of energy supply. At present, there is no information on whether there is a reliable relationship between this indicator and the severity of clinical manifestations of VD.The aim of the study was to study the dependence of changes in the concentration levels of fatty acids, reflecting the specifics of metabolic disorders in VD, on the severity of pathological manifestations.The study of blood serum of workers of vibration-dangerous professions with vibration disease established in the clinic was carried out. The fatty acid composition of blood serum was studied using a gas chromatographic complex equipped with a flame ionization detector and a capillary column with a polyethylene glycol phase modified with nitroterephthalic acid. It is established that the complication of the clinical picture of vibration pathology on the background of authentic level shift s HFA: eicosatrienoic and arachidonic in males, γ-linolenic and eicosatrienoic in women. In addition, men tend to increase the levels of nervonic, eicosapentaenoic and docosahexaenoic acids with worsening of the degree of VD. Compared with workers exposed to vibration, but without pathological disorders, men have high levels of nervonic and docosahexaenoic, women-nervonic and palmitoleic acids.With varying degrees of severity of clinical manifestations of vibration pathology, certain changes in the metabolism of the HFA are observed. The nature of shift s in their concentration levels reflects the depth of violations of energy exchange reactions, synthesis of Pro-and anti-inflammatory mediators, membrane-pathological processes. The study of fatty-acid composition of blood serum in VD has prognostic value of detected level shift s and HFA can be estimated, what the metabolic process in the body of the examinee was subjected to the most grave violations, and to adjust the complex of therapeutic measures.Funding. The study had no funding.Conflict of interests. The authors declare no conflict of interests.

scholarly journals Tissue lipids in calves suffering from muscular dystrophy

1966 ◽  
Vol 20 (2) ◽  
pp. 245-256 ◽  
Author(s):  
Ritva Poukka
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Muscular Dystrophy ◽  
Acid Composition ◽  
Acid Content ◽  
Monounsaturated Fatty Acids ◽  
Healthy Controls

1. Lipids of the heart muscle, skeletal muscle and liver were investigated in healthy calves and in calves suffering from enzootic muscular dystrophy with special regard to the fatty acid composition of the phospholipids and triglycerides. 2. Healthy young calves and older calves differed in the fatty acid composition of these tissues. The tissue phospholipids of healthy young calves contained less linoleic acid and more monounsaturated fatty acids than those of older calves. Of the saturated fatty acids, palmitic acid content tended to be higher in young calves and stearic acid content tended to be higher in older calves. 3. The stearic acid content of tissue triglycerides was lower in young calves than in older calves. 4. Fatty aldehydes were present in the phospholipid fraction of the heart muscle and of the skeletal muscle. Stearaldehyde content was higher in older calves than in young calves. 5. In calves with muscular dystrophy definite changes in the fatty acid composition of the phospholipids were found. In young calves the content of linoleic acid was higher and that of monounsaturated fatty acids lower in tissues of diseased animals than in the corresponding tissues of healthy controls. Both in young and older calves arachidonic acid content was higher in the degenerated areas of the skeletal muscle than in the healthy controls. 6. Possible relationships between the tocopherol and arachidonic acid contents of the tissues are discussed. 7. In the triglyceride fraction the differences between diseased and healthy tissues were less significant than in the phospholipid fraction in young calves. In older calves no significant differences were found. 8. An increase in lipid content was found in the degenerated areas of the skeletal muscle and a decrease in livers from diseased animals. An increase in free cholesterol was found in the degenerated areas of the skeletal muscle. The triglyceride content of livers from diseased animals was decreased. The relative proportion of phospholipids was less in skeletal muscle and higher in liver of diseased animals than in the corresponding tissues of healthy controls.

scholarly journals Fatty acids of lipids of blood serum and liver of rats with tetracyclin-induced hepatosis and at correction

2019 ◽  
Vol 10 (4) ◽  
pp. 520-525 ◽  
Author(s):  
V. Gryshchenko ◽  
S. Sуsoliatin ◽  
S. Midyk
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Blood Serum ◽  
Dietary Supplement ◽  
Acid Composition ◽  
Liver Tissue ◽  
New Drugs ◽  
Quantitative Composition ◽  
Corrective Effect

Irrational pharmacotherapy with tetracyclines can cause mitochondrial cytopathies of liver cells and the development of toxic dystrophy. The issue of violation of the qualitative and quantitative composition of fatty acids and their functional role in the development of liver dystrophy has not been studied enough. Therefore, the aim of the work was to determine the features of changes in the fatty acid composition of blood serum and liver lipids in rats with tetracycline-induced hepatosis and the corrective efficacy of the phospholipid-acceptable dietary supplement “FLP-MD”. It was experimentally established that, in the composition of blood serum lipids and liver tissue, key changes in modeling tetracycline-induced hepatosis in rats (250 mg/kg for 7 days) are primarily tested for polyene fatty acids (PUFAs). In blood serum this is manifested by a decrease in the level of docosadiienoic (22:2ω6) and docosahexaenoic acid (22:6ω3), as well as the total PUFA content due to representatives of the ω3 family, respectively, by 1.3 times. At the same time, a decrease in the content of eicosapentenoic (20:5ω3), docosapentaenoic (22:5ω3), docosahexaenoic (22:6ω3) acids and the saturated/unsaturated fatty acid (SFA/UFA) and ω3/ω6 PUFA ratios, respectively, are noted in the lipid fraction of the liver, respectively by 1.3 times. In contrast to these animals, the use of reparative action of a phospholipid-acceptable dietary supplement “FLP-MD” (13.5 mg/kg) in sick rats provides a significant increase in the level of these fatty acids both in blood serum and in the liver and the restoration of their profile for other representatives. Thus, the components of the “FLP-MD” dietary supplement show a corrective effect on the fatty acid composition of the lipid component of blood serum and liver tissue of animals with tetracycline-induced hepatosis. Indicators have been experimentally established for the diagnosis of toxic liver damage and preclinical trials of the hepatoprotective efficacy of new drugs, which is a promising area of research in veterinary hepatopathology.

scholarly journals INDICES OF FATTY ACIDS SPECTRUM OF LIPIDS IN THE BLOOD SERUM OF STERLET OF DIFFERENT AGE

2018 ◽  
Vol 2 ◽  
pp. 3-8 ◽  
Author(s):  
Roza Suleimanova ◽  
Dmytro Melnychuk ◽  
Liliia Kalachniuk
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Acid Composition ◽  
Moderate Increase ◽  
National Academy Of Sciences ◽  
Fa Composition ◽  
Lipid Fractions

As the only sturgeon living in freshwater, sterlet is important for breeding in industrial fish farms, where lately cases of early mortality of this species have been detected. Hence, in order to preserve the species, it is important to study the parameters of fatty acid (FA) composition of lipid fractions of the blood serum of sterlet. Here we present changes of fatty acid composition in different lipid fractions of the blood serum of sterlets of different age (namely two-, three- and nine-year-old) with the masses 0.3–0.4, 0.5–0.6 and 5–6 kgfor the age-groups of fish, respectively. Fatty acid (FA) composition was determined using gas-chromatography on HRGC 5300 (Italy) in Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU). Fatty acid composition of starlet blood serum is presented by saturated and unsaturated high-molecular weight carboxylic acids, mostly palmic, stearic, oleic and linoleic. In the phospholipids fraction, there was a moderate increase in saturated and monounsaturated fatty acids and a slight decrease in polyunsaturated fatty acids depending on the age of fish. As for free fatty acids, there was a drop in the saturated ones depending on the starlet age. Among the free fatty acids of sterlet blood serum, we identified 28 acids, of them 39 %, 35 % and 30 % were saturated in 2-, 3-year-old and mature fish, respectively. Monounsaturated FA content was 14 %, 23 % and 23 % in 2-, 3-year-old and adult sterlet fish, and polyunsaturated FA content –46 %, 41 % and 36 %, respectively. The data can be used for the theoretical verification of correcting supplementary feed and premixes.

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

scholarly journals A conjunction of sn-2 fatty acids and overall fatty acid composition combined with chemometric techniques increase the effectiveness of lard detection in fish feed

2021 ◽  
pp. 104308
Author(s):  
Mohamed Haniff Hanafy Idris ◽  
Yanty Noorzianna Manaf ◽  
Mohd Nasir Mohd Desa ◽  
Amalia Mohd Hashim ◽  
Muhamad Shirwan Abdullah Sani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Fish Feed ◽  
Chemometric Techniques

scholarly journals Effect of Nitrogen Fertilisation and Inoculation with Bradyrhizobium japonicum on the Fatty Acid Profile of Soybean (Glycine max (L.) Merrill) Seeds

Agronomy ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 941
Author(s):  
Ewa Szpunar-Krok ◽  
Anna Wondołowska-Grabowska ◽  
Dorota Bobrecka-Jamro ◽  
Marta Jańczak-Pieniążek ◽  
Andrzej Kotecki ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Bradyrhizobium Japonicum ◽  
Field Experiments ◽  
Fatty Acid Content ◽  
Soybean Seeds ◽  
Oilseed Crop ◽  
Soybean Cultivars

Soybean is a valuable protein and oilseed crop ranked among the most significant of the major crops. Field experiments were carried out in 2016–2019 in South-East Poland. The influence of soybean cultivars (Aldana, Annushka), nitrogen fertilizer (0, 30, 60 kg∙ha−1 N) and inoculation with B. japonicum (control, HiStick® Soy, Nitragina) on the content of fatty acids (FA) in soybean seeds was investigated in a three-factorial experiment. This study confirms the genetic determinants of fatty acid composition in soybean seeds and their differential accumulation levels for C16:0, C16:1, C18:1n9, C18:2, C18:3, and C20:0 as well saturated (SFA), monounsaturated (MUFA), and polyunsaturated (PUFA) fatty acids. Increasing the rate from 30 to 60 kg ha−1 N did not produce the expected changes, suggesting the use of only a “starter” rate of 30 kg ha−1 N. Inoculation of soybean seeds with a strain of Bradyrhizobium japonicum (HiStick® Soy, BASF, Littlehampton, UK and Nitragina, Institute of Soil Science and Plant Cultivation–State Research Institute, Puławy, Poland) is recommended as it will cause a decrease in SFA and C16:0 acid levels. This is considered nutritionally beneficial as its contribution to total fatty acids determines the hypercholesterolemic index, and it is the third most accumulated fatty acid in soybean seeds. The interaction of cultivars and inoculation formulation on fatty acid content of soybean seeds was demonstrated. An increase in the value of C16:0 content resulted in a decrease in the accumulation of C18:1, C18:2, and C18:3 acids. The content of each decreased by almost one unit for every 1% increase in C16:0 content. The dominant effect of weather conditions on the FA profile and C18:2n6/C18:3n3 ratio was demonstrated. This suggests a need for further evaluation of the genetic progress of soybean cultivars with respect to fatty acid composition and content under varying habitat conditions.

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