THE ANTI-ESTROGENIC ACTIVITY OF CERTAIN LEGUMES AND GRASSES

1964 ◽  
Vol 44 (3) ◽  
pp. 297-302 ◽  
Author(s):  
Jennia Biely ◽  
W. D. Kitts
Keyword(s):  
Estrogenic Activity ◽  
Ovariectomized Rats ◽  
Plant Materials ◽  
Wide Range

The anti-estrogenic activity of 13 legumes and grasses has been assayed by use of weanling ovariectomized rats. The results display a wide range of anti-estrogenic activity depending on the species, the date of harvest, and the stage of growth. The existence of a relationship between the anti-estrogenic and estrogenic activities of the plant materials examined is discussed.

scholarly journals Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1608
Author(s):  
Stephen Lo ◽  
Euphemia Leung ◽  
Bruno Fedrizzi ◽  
David Barker
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Breast Cancer Cell Lines ◽  
Scavenging Activity ◽  
Plant Materials ◽  
Wide Range ◽  
Derivatives Of ◽  
Acyl Derivatives

Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.

scholarly journals Estradiol Replacement Alters Expression of Genes Related to Neurotransmission and Immune Surveillance in the Frontal Cortex of Middle-Aged, Ovariectomized Rats

Endocrinology ◽  
2010 ◽  
Vol 151 (8) ◽  
pp. 3847-3862 ◽  
Author(s):  
Miklós Sárvári ◽  
Imre Kalló ◽  
Erik Hrabovszky ◽  
Norbert Solymosi ◽  
Kinga Tóth ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Frontal Cortex ◽  
Expression Profiling ◽  
Hormone Replacement ◽  
Immune Surveillance ◽  
Ovariectomized Rats ◽  
Middle Aged ◽  
Wide Range ◽  
Frontal Cerebral Cortex ◽  
Genomic Effects

Estradiol (E2) modulates a wide range of functions of the frontal cerebral cortex. From the onset of menopause, declining levels of E2 can cause cognitive disturbances and changes in behavior that can be counterbalanced by hormone replacement. To study the effect of E2 replacement on the cortical transcriptome in a rodent model with low serum E2 level, we treated middle-aged, ovariectomized rats with E2 or vehicle using osmotic minipumps for 4 wk. Six animals for each group were selected, and samples of their frontal cortex were subjected to expression profiling using oligonucleotide microarrays. The explored E2-regulated genes were related to neurotransmission (Adora2a, Cartpt, Drd1a, Drd2, Gjb2, Nts, and Tac1), immunity (C3, C4b, Cd74, Fcgr2b, Mpeg1, and RT1-Aw2), signal transduction (Igf2, Igfbp2, Igfbp6, Rgs9, and Sncg), transport (Abca1, Hba-a2, Slc13a3, and Slc22a8), extracellular matrix (Col1a2, Col3a1, Fmod, and Lum), and transcription (Irf7 and Nupr1). Seventy-four percent of the transcriptional changes identified by microarray were confirmed by quantitative real-time PCR. The genes identified by expression profiling indicated that chronic E2 replacement significantly altered the transcriptome of the frontal cortex. The genomic effects of E2 influenced dopaminergic and peptidergic neurotransmission, immune surveillance, adenosine and insulin-like growth factor signaling and transport processes, among other functions. Identification of these novel E2-regulated mechanisms highlights the wide range of genomic responses of the aging female frontal cerebral cortex subjected to hormone replacement. Some of the genomic effects identified in this study may underlie the beneficial effects of E2 on cognition, behavior, and neuroprotection.

Determination of effective standards for the introduction of fodder additive Aquatan in the diet of rainbow trut with a biological assessment of the influence on fisheries

2021 ◽  
pp. 66-78
Author(s):  
Dmitry Dmitrievich Zekov ◽  
Mikhail Vladimirovich Ulyanov ◽  
Daniil Veniaminovich Mikryakov ◽  
Tatyana Alexandrovna Suvorova
Keyword(s):  
Rainbow Trout ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Nuclear Power ◽  
Feed Additive ◽  
Average Weight ◽  
Leningrad Region ◽  
Plant Materials ◽  
Wide Range ◽  
Mass Accumulation

In connection with the global tendency to prohibit the use of antibiotics in animal husbandry, the prospect of using in ichthyopathological practice preparations from plant materials, which are mostly non-toxic, rarely cause side effects, have an antibacterial effect against a wide range of pathogens of bacterial diseases, opens up. One of these preparations is the feed additive Aquatan (Farmatan Aqua) based on ellagitannins from sweet chestnut wood manufactured by Tanin Sevnica (Slovenia). The aim of this work was to study the effect of different dosages of Aquatan on the survival rate, the rate of mass accumulation and the growth rate of rainbow trout reared in the industrial conditions of the cage farm on the waste warm waters of the nuclear power plant and to assess the production and economic efficiency of the application. The tests were carried out for 34 days in February-March 2021 on the basis of an aquaculture cage farm of LLC “Fish Federation”, located in the water area of the waste canal of warm waste water of the Leningrad nuclear power plant (LNPP) in the area of the LNPP-2 industrial zone in the city of Sosnovy Bor, Leningrad Region. The object of the study is rainbow trout yearlings brought from different fish farms. A total of 247,131 specimens were planted, with an average weight of 156.5–235.7 g and a total weight of 43 950.67 kg. The main hydrochemical indicators of water at the enterprise for the trial period met the water quality requirements for growing salmon fish OST 15.372-87. The feeding was carried out with the production compound feed for salmonids of the firm Alltech® Coppens Supreme-22. In experimental cages, fish were fed with compound feed with the addition of the preparation Aquatan at various concentrations (1, 2, and 3 g/kg of feed); in the control, feed without additive was used. As a result of the experiment, a positive effect of the Aquatan additive in dosages of 2–3 g / 1 kg of feed on growth, mass accumulation, survival and feed costs was established, while when adding 1 g / 1 kg of feed, such an effect was not recorded.

Estrogenic activity of adrenal transplants to the uterus of ovariectomized rats

1950 ◽  
Vol 108 (3) ◽  
pp. 441-455 ◽  
Author(s):  
Marvin J. Weinstein ◽  
Joseph Schiller ◽  
Harry A. Charipper
Keyword(s):  
Estrogenic Activity ◽  
Ovariectomized Rats

scholarly journals Biologically Active Substances of Siberian Medical Plants in Functional Wgey-Based Drinks

2019 ◽  
Vol 49 (1) ◽  
pp. 14-22
Author(s):  
Светлана Иванова ◽  
Svetlana Ivanova ◽  
Ирина Милентьева ◽  
Irina Milenteva ◽  
Людмила Асякина ◽  
...  
Keyword(s):  
Callus Cultures ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Rhodiola Rosea ◽  
Plant Materials ◽  
Rhaponticum Carthamoides ◽  
Wide Range ◽  
Mountain Ash ◽  
Active Substances ◽  
Mineral Base

The use of infusions and extracts from domestic plant materials is a promising direction in the development of functional beverages since they contain a wide range of substances of various pharmacological properties. Drinks fortified with physiologically active natural components maintain a certain level of this content in human body. They can have a healing or prophylactic effect. However, there is a lack of technologies for the effective production of biologically active substances from plant materials. Moreover, the development of cultivated botanical medicinal plant species remains quite poor. The present study features the qualitative and quantitative composition of biologically active substances of medicinal plants that are endemics of Siberia. They are Rhodiola rosea (Rhodiola rosea L.) and maral root (Rhaponticum carthamoides). The paper introduces a method for increasing their biosynthetic activity. An experiment helped to select a composition of the nutrient medium for the cultivation of callus cultures of Rhodiola rosea (Rhodiola rosea L.) and maral root (Rhaponticum carthamoides) in vitro, which contributed to an increase in the biosynthesis of biologically active substances. For callus cultures of Rhodiola Rosea (line R.r-1k) the following composition was used: mineral base – MS; sucrose – 30 g; inositol – 100 mg; thiamine – 1.0 mg; pyridoxine – 1.0 mg; Ca-panthetonate – 10 mg; kinetin – 0.05 g; naphthyl acetic acid – 0.1 g; 2.4-D – 0.5. For callus cultures of maral root (line R.c -2k): mineral base – SH; sucrose – 30 g; inositol – 100 mg; thiamine – 5.0 mg; pyridoxine – 0.5 mg; nicotinic acid – 5.0 mg; kinetin – 0.1 g; indoleacetic acid – 1.0 g. The authors developed a technology for the production of functional whey-based tonic drink fortified with extract of carotenoids isolated from the fruits of mountain ash and the extract of biologically active substances Rhodiola rosea and maral root. The presence of biologically active substances in the plant and medicinal raw materials gives the drink antioxidant and bactericidal properties, as well as helps to raise the overall state of the organizm and strengthen the immune system.

scholarly journals Writing Assignments for Horticulture Courses

1993 ◽  
Vol 3 (4) ◽  
pp. 456-459
Author(s):  
David J. Wehner
Keyword(s):  
Subject Matter ◽  
General Public ◽  
Plant Materials ◽  
Writing Assignments ◽  
Wide Range ◽  
The Subject ◽  
Answering Questions

Writing in horticulture courses helps students develop a better understanding of the subject matter and prepares them for careers where they must communicate with the general public. Three writing assignments that can be modified for use in a wide range of horticulture courses are presented, along with grading sheets. The writing assignments simulate situations that horticulturists encounter frequently; i.e., answering questions about plant materials and their utilization and maintenance or proposing site improvements or additional expenditures for maintenance programs.

scholarly journals DNA barcoding identifies cryptic animal tool materials

2021 ◽  
Vol 118 (29) ◽  
pp. e2020699118
Author(s):  
Matthew P. Steele ◽  
Linda E. Neaves ◽  
Barbara C. Klump ◽  
James J. H. St Clair ◽  
Joana R. S. M. Fernandes ◽  
...  
Keyword(s):  
Dna Barcoding ◽  
Raw Materials ◽  
Camera Traps ◽  
Behavioral Experiments ◽  
Plant Materials ◽  
Long Term Study ◽  
Fitness Consequences ◽  
Wide Range ◽  
Significant Research ◽  
New Caledonian Crows

Some animals fashion tools or constructions out of plant materials to aid foraging, reproduction, self-maintenance, or protection. Their choice of raw materials can affect the structure and properties of the resulting artifacts, with considerable fitness consequences. Documenting animals’ material preferences is challenging, however, as manufacture behavior is often difficult to observe directly, and materials may be processed so heavily that they lack identifying features. Here, we use DNA barcoding to identify, from just a few recovered tool specimens, the plant species New Caledonian crows (Corvus moneduloides) use for crafting elaborate hooked stick tools in one of our long-term study populations. The method succeeded where extensive fieldwork using an array of conventional approaches—including targeted observations, camera traps, radio-tracking, bird-mounted video cameras, and behavioral experiments with wild and temporarily captive subjects—had failed. We believe that DNA barcoding will prove useful for investigating many other tool and construction behaviors, helping to unlock significant research potential across a wide range of study systems.

scholarly journals Estrogenic Activity of Ethanolic Extract of Papaya Peels (Carica Papaya L.) on Uterine Weight and Mammae Gland Proliferation on Ovariectomy Rats

2018 ◽  
Vol 9 (2) ◽  
pp. 86 ◽  
Author(s):  
Dhania Novitasari ◽  
Devyanto Hadi Triutomo ◽  
Fitriana Hayyu Arifah ◽  
Anselma Ivanawati ◽  
Zahrotul Ulum ◽  
...  
Keyword(s):  
Estrogenic Activity ◽  
Ethanolic Extract ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Uterine Weight ◽  
Sprague Dawley ◽  
In Vivo Test ◽  
Female Reproductive Health ◽  
Agnor Staining

Papaya bark is one of Indonesia's natural wealth that contains flavonoid compounds such as myricetin and kaempferol that included in the phytoestrogen compounds. The aim of this study is to examine the estrogenic effects of ethanolic extract of papaya peels (EEPP), on the development of mammae gland and the increasing of uterine weight. The in vivo test was performed with ovariectomy in Sprague Dawley female rats that caused the rats to be in an estrogen deficiency state. After 30 days of treatment, animals are sacrificed to take the uterus and mammae glands. Measurement of uterine weight and mammae gland are observed by hematoxylin-eosin staining method to know the lobulus development and AgNOR staining to determine the proliferation level of mammae gland epithelial cells. The test results showed that EEPP concentration of 500 and 1000 mg/kgBW were able to increase uterine weight and proliferation of mammae gland. From the results of this study, papaya bark has the potential to be one of the phytoestrogens compound to maintain female reproductive health and woman beauty.Keyword: ethanolic extract of papaya peels (EEPP), phytoestrogen, ovariectomized rats, uterine weight, mammae proliferation

scholarly journals Rapid high throughput template preparation (rHTTP) method: a novel cost effective method of direct PCR for a wide range of plants

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Prassan Choudhary ◽  
Sudipta Das ◽  
Hillol Chakdar ◽  
Arjun Singh ◽  
Sanjay Kumar Goswami ◽  
...  
Keyword(s):  
Ssr Markers ◽  
High Throughput ◽  
Field Experiments ◽  
Dna Isolation ◽  
Cost Effective ◽  
Direct Pcr ◽  
Rice Varieties ◽  
Plant Materials ◽  
Wide Range ◽  
Commercial Kits

Abstract Background Conventional plant DNA isolation methods are complex, time consuming and require technical expertise. These limitations were overcome using the DNA isolation kits which, however significantly add to the research costs. Hence the present study was aimed to develop a high throughput, rapid and inexpensive method of PCR ready DNA template preparation from plant materials. Methods Concentration of SDS in lysis buffer, amount of starting material, period and temperature for lysis were optimized for obtaining PCR ready templates from plant materials. The method was tested using RAPD and ITS specific primers for different plant species like rice, wheat, mustard, pea, soybean, pigeonpea, tomato, maize, march lilly, bougainvillea, Indian blanket flower, nerium, petunia, purple pirouette petunia, moses-in-the-cradle, golden cane palm, duranta, periwinkle, chrysanthemum and two xerophytes viz. Dipterygium glaucum and Crotaleria burhia. SSR markers RM18398 and RM26108 showed successful amplification in rice varieties Improved Pusa Basmati 1 and KS Dev 12. The effectiveness of the method was tested using fresh as well as 1 year old tissues. The storability of the lysate was also tested. Results In this report, we developed a novel method called rapid high throughput template preparation (rHTTP) method to prepare PCR ready DNA templates. Most striking feature of this technique is that it can be done anywhere where water can be boiled by any means. Using rHTTP method, PCR ready templates can be prepared in just 10 min. Robust and reproducible amplification for all the test plants were recorded with RAPD, plant ITS primers and SSR markers following this method. rHTTP methods works well for both fresh as well as old plant tissues. The lysates had a shelf life of 1 month when stored at 4 °C and 3 days when stored at room temperature. Conclusions rHTTP method has several advantages over the other protocols like ease of execution, no requirement of tissue grinding/liquid nitrogen/hazardous chemicals and above all, equally effective for both fresh and old samples. Using this method, costs per prep comes down ~ 10–50 times as compared to most commercial kits. This method can be used for on-field experiments like molecular diagnostics, varietal identification etc.

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