N -Alkylation of 4-Trichloromethylpyrimidinones: Synthesis of Some New and Interesting Modified Nucleoside Analogues

2009 ◽  
Vol 2 ◽  
pp. 7-14 ◽  
Keyword(s):  
Nucleoside Analogues ◽  
Modified Nucleoside

scholarly journals Synthesis, Structure and Biological Activity of 6-R3Si(Ge, Sn)-Substituted 5-Fluorouracils

1994 ◽  
Vol 1 (1) ◽  
pp. 65-72 ◽  
Author(s):  
E. Lukevics ◽  
L. Ignatovich ◽  
N. Shilina ◽  
A. Kemme ◽  
N. Sjakste
Keyword(s):  
Biological Activity ◽  
Silicon Germanium ◽  
Nucleoside Analogues ◽  
Lithium Diisopropylamide ◽  
Biological Investigation ◽  
Modified Nucleoside ◽  
Derivatives Of ◽  
Transcription And Replication

Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at –70℃ in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin derivatives of ftorafur. The results of biological investigation indicate the ability of germanium–modified nucleoside analogues to interfere with transcription and replication processes.

New Nucleoside-Based Polymeric Supports for the Solid Phase Synthesis of Ribose-Modified Nucleoside Analogues

Synlett ◽  
2004 ◽  
Vol 2004 (11) ◽  
pp. 1975-1979 ◽  
Author(s):  
Giovanni Di Fabio ◽  
Lorenzo De Napoli ◽  
Jennifer D’Onofrio ◽  
Daniela Montesarchio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Nucleoside Analogues ◽  
Phase Synthesis ◽  
Modified Nucleoside ◽  
Polymeric Supports

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA

2015 ◽  
Vol 41 (08) ◽  
Author(s):  
C Klein ◽  
CT Bock ◽  
H Wedemeyer ◽  
T Wüstefeld ◽  
S Locarnini ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Nucleoside Analogues ◽  
B Virus

Nucleosides and Nucleoside Analogues as Emerging Antiviral Drugs

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamed Ibrahim Elzagheid
Keyword(s):  
Significant Role ◽  
Mode Of Action ◽  
Crucial Role ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Nucleoside Analogues ◽  
The Past ◽  
Nucleoside Drugs

: Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play. Given that a significant amount of research and literature has been documented regarding nucleoside analogues, this review article mainly focuses the discussion on nucleosides and nucleoside analogous that have proven to play significant role or be emerging in the treatment of known viral infections. This covers the names, structures, applications, toxicity, and mode of action of relevant nucleoside analogues.

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