scholarly journals Decreased serum Ou/Zn sOD in children with Autism

2009 ◽  
Vol 2 ◽  
pp. NMI.S3733 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Small Bowel ◽  
Digestive Disease ◽  
Children With Autism ◽  
Serum Levels ◽  
Autistic Children ◽  
Gi Symptoms ◽  
Nodular Hyperplasia ◽  
Lymphoid Nodular Hyperplasia

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in autistic children and evaluate its possible relationship to GI Symptoms. Subjects and Methods Serum from 50 autistic children (31 with chronic digestive disease (most with ileo-colonic lymphoid nodular hyperplasia (LNH) and inflammation of the colorectal, small bowel and/or stomach) and 19 autistic children without GI disease), and 29 non autistic controls (20 age matched non autistic children with no GI disease and 9 age matched non autistic children with GI disease) were tested for Cu/Zn SOD using ELISAs. Results Serum Cu/Zn SOD levels of autistic children were significantly lower than all non autistic controls (p < 0.0001). Serum Cu/Zn SOD of autistic children with severe GI disease was significantly lower than autistic children with no GI disease (p < 0.0001), non autistic children without GI disease (<0.0001) and non autistic children with GI disease (p = 0.0003). Discussion These results suggest an association between Cu/Zn SOD serum levels and autism, particularly autistic children with GI disease, and that the concentration of serum Cu/Zn SOD may be a useful biomarker for autistic children with severe GI disease.

scholarly journals Low serum Alpha-1 Antitrypsin Associated with Anti-PR-3 AncA in Autistic Children with GI Disease

2009 ◽  
Vol 2 ◽  
pp. GEI.S2918 ◽  
Author(s):  
A.J. Russo ◽  
A. Krigsman ◽  
B. Jepson ◽  
Andrew Wakefield
Keyword(s):  
Digestive Disease ◽  
Serum Levels ◽  
High Serum ◽  
Autistic Children ◽  
Severity Of Disease ◽  
High Severity ◽  
Nodular Hyperplasia ◽  
Alpha 1 Antitrypsin ◽  
Lymphoid Nodular Hyperplasia ◽  
Low Serum

Aim To assess the possible relationship between serum alpha-1 antitrypsin (AAT) levels and anti-neutrophil cytoplasmic antibodies (ANCA) in autistic children with severe GI disease and to test the hypothesis that there is an association between low serum AAT levels, the presence of ANCA and inflammatory GI disease seen in some autistic children. Subjects and Methods Serum from 40 autistic children with chronic digestive disease (many with ileo-colonic lymphoid nodular hyperplasia (LNH) and inflammation of the colorectum, small bowel and/or stomach), and 41 controls (21 age matched autistic children with no GI disease and 20 age matched children without autism or GI disease) were tested using ELISAs designed to quantitate ANCA (anti-PR3), AAT and PR3 levels. Results We found that a significant number of autistic children with chronic digestive disease had anti-PR3 ANCA, high serum PR3 and high severity of disease when compared to controls. This same group of autistic children had low serum levels of AAT compared to controls, which also correlated with the presence of anti-PR3 ANCA, high serum PR3, as well as the severity of intestinal disease, particularly LNH and severe erythema. Discussion These results suggest a relationship between low AAT levels, ANCA and severity of GI disease seen in a subpopulation of ASD individuals. We suggest that low AAT levels may result in high levels of PR3, which may, in turn be associated with the presence of ANCA.

scholarly journals RELATIONSHIP OF SERUM DIPEPTIDYL PEPTIDASE-IV ACTIVITY AND ANTI-CASEIN ANTIBODIES TO GASTROINTESTINAL SYMPTOMS AMONG CHILDREN WITH AUTISM SPECTRUM DISORDER: AN EGYPTIAN STUDY

2018 ◽  
Vol 11 (4) ◽  
pp. 370
Author(s):  
Inas R El-alameey ◽  
Hanaa H Ahmed ◽  
Ihab M Eid ◽  
Ghada El-dory ◽  
Manal Gameel
Keyword(s):  
Autism Spectrum Disorder ◽  
Enzyme Activity ◽  
Abdominal Pain ◽  
Children With Autism ◽  
Serum Levels ◽  
Autism Spectrum ◽  
Food Selectivity ◽  
Autistic Children ◽  
Dpp Iv ◽  
Gi Symptoms

 Objectives: The objectives of the study were to assess serum dipeptidyl peptidase-IV (DPP-IV) activity in autistic children suffering from severe gastrointestinal (GI) disorder and to examine the hypothesis that there is a link between DPP-IV activity in serum and GI disorder in a subgroup of children with autism spectrum disorder (ASD).Subjects and Methods: Serum levels of casein antibodies and DPP-IV enzyme activity from 40 autistic children with chronic GI symptoms, and 40 of age-matched children without autism or gastrointestinal (GI) symptoms were assayed using enzyme-linked immunosorbent assay kits.Results: In comparison with controls, developmental milestones were delayed among autistic children. The serum DPP-IV activity was significantly lower in the studied patients (p<0.05), while the mean serum levels of casein antibodies were statistically significantly higher in the studied patients (p<0.01). Multiple logistic regression analysis recorded significant association between the high serum level of antibodies to casein, food selectivity and recurrent attacks of abdominal pain (p<0.05), while the low serum DPP-IV enzyme activity was associated with recurrent attacks of abdominal pain in the studied patients with a prediction of 95% (p<0.05).Conclusions: Serum levels of casein antibodies were higher in children with ASD, and maybe contributes to their abdominal pain, and food selectivity. Serum DPP-IV enzyme activity was lower and associated with recurrent attacks of abdominal pain in the studied patients. They may benefit from a supplemental digestive enzyme formula.

scholarly journals Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with severe Gastrointestinal Disease

2009 ◽  
Vol 4 ◽  
pp. BMI.S3656 ◽  
Author(s):  
A.J. Russo ◽  
A. Krigsman ◽  
B. Jepson ◽  
Andrew Wakefield
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Gastrointestinal Disease ◽  
Serum Levels ◽  
Autistic Children ◽  
Functional Connection ◽  
Disease Symptoms ◽  
Lymphoid Nodular Hyperplasia ◽  
Lymphoid Nodules ◽  
Hepatocyte Growth

Aim To assess serum Hepatocyte Growth Factor (HGF) levels in autistic children with severe gastrointestinal (GI) disease and to test the hypothesis that there is a relationship between GI pathology and HGF concentration. Subjects and Methods Serum from 29 autistic children with chronic digestive disease (symptoms for a minimum of 6–12 months), most with ileo-colonic lymphoid nodular hyperplasia (LNH—markedly enlarged lymphoid nodules) and inflammation of the colorectum, small bowel and/or stomach), and 31 controls (11 age matched autistic children with no GI disease, 11 age matched non autistic children without GI disease and 9 age matched non autistic children with GI disease) were tested for HGF using ELISAs. HGF concentration of autistic children with GI disease was compared to GI disease severity. Results Autistic children with GI disease had significantly lower serum levels of HGF compared to controls (autistic without GI disease; p = 0.0005, non autistic with no GI disease; p = 0.0001, and non autistic with GI disease; p = 0.001). Collectively, all autistic children had significantly lower HGF levels when compared to non autistic children (p < 0.0001). We did not find any relationship between severity of GI disease and HGF concentration in autistic children with GI disease. Discussion These results suggest an association between HGF serum levels and the presence of GI disease in autistic children and explain a potential functional connection between the Met gene and autism. The concentration of serum HGF may be a useful biomarker for autistic children, especially those with severe GI disease.

scholarly journals SERUM ANTIGLIADIN ANTIBODIES IN EGYPTIAN CHILDREN WITH AUTISM SPECTRUM DISORDER: RELATIONSHIP TO GASTROINTESTINAL SYMPTOMS, BEHAVIORAL AND SOCIAL COMMUNICATIONS

2018 ◽  
Vol 11 (4) ◽  
pp. 355
Author(s):  
Inas R El-alameey ◽  
Hanaa H Ahmed ◽  
Ihab M Eid ◽  
Ghada El-dory ◽  
Manal Gameel
Keyword(s):  
Autism Spectrum Disorder ◽  
Gastrointestinal Symptoms ◽  
Children With Autism ◽  
Serum Levels ◽  
Autism Spectrum ◽  
High Serum ◽  
Spectrum Disorder ◽  
Gliadin Antibodies ◽  
Gi Symptoms ◽  
Egyptian Children

 Objectives: Gastrointestinal symptoms are major characteristic in children with autism spectrum disorder (ASD), drawing attention to a potent association with gluten sensitivity. The goal of this study was to evaluate anti-gliadin antibodies serum levels in a group of Egyptian children with ASDs and to address the potential link to gastrointestinal (GI) symptoms, behavioral, and social communications.Patients and Methods: This descriptive case–control study included 45 children diagnosed as ASD according to Diagnostic and Statistical Manual of Mental Disorders 5th Edition and a history of GI symptoms, compared with 45 apparently healthy children of matched age and sex. Serum anti-gliadin antibodies were measured using enzyme-linked immunosorbent assay kits.Results: Serum levels of IgM, IgA, and IgG class antibodies to gliadin showed a significant increase compared to healthy controls (p<0.000). Multiple logistic regression analysis showed a significant association between the high serum levels of IgA and IgM class antibodies to gliadin in the studied patients and GI symptoms (p<0.05). A significant association was detected between the high serum levels of IgG antibodies to gliadin and the behavior symptoms (p<0.05).Conclusions: The anti-gliadin antibody response and its association with GI symptoms indicated the involvement of abnormal immunologic intestinal permeability in affected children. Immune system of some autistic patients could be abnormally triggered by gluten assumption.

Hypogammaglobulinemia with Lymphoid Nodular Hyperplasia of the Small Bowel: Endoscopic Diagnosis of One Case

Endoscopy ◽  
1976 ◽  
Vol 08 (04) ◽  
pp. 214-216 ◽  
Author(s):  
J. Delamarre ◽  
J. Dupas ◽  
D. Chivrac ◽  
J. Capron ◽  
J. Messerschmitt
Keyword(s):  
Small Bowel ◽  
Endoscopic Diagnosis ◽  
Nodular Hyperplasia ◽  
Lymphoid Nodular Hyperplasia

STRATEGI KOPING ORANG TUA TERHADAP ANAK AUTIS DAN POLA ASUH ORANG TUA

2018 ◽  
Vol 11 (2) ◽  
pp. 196-204
Author(s):  
Asirotul Ma’rifah ◽  
Naning Puji Suryantini Suryantini ◽  
Rina Mardiyana
Keyword(s):  
Coping Strategies ◽  
Sampling Technique ◽  
Children With Autism ◽  
Adaptive Coping ◽  
Autistic Children ◽  
Cross Sectional ◽  
Authoritarian Parenting ◽  
Cross Tabulation ◽  
Relationship Of ◽  
The Relationship

Autism is still a nightmare for most parents. Parents with autism can be very stressful when dealing with a hyperactive child's behavior, aggressive and passive. Stress experienced by parents of children with autism will affect the ability of parents in the parenting role, especially in relation to coping strategies have in dealing with problems of children. The participation of parents is crucial the success of socializing with children with autism in the general population. This study aims to determine the relationship of coping strategies parents of autistic children and parenting parents. This type of research is an analytic correlation with cross sectional approach. The population in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto numbering 15 people. Samples in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto which totaled 15 people by using total sampling technique. Collecting data using questionnaires. Data analized use cross tabulation, presented in a frequency distribution. On cross-tabulation obtained results tend to use maladaptive coping strategies permissive parenting that is 8 (53.3%), there are also respondents who use adaptive coping strategies using authoritarian parenting as much as one person (16.7%), and adaptive coping strategies tend using democratic parenting style as much as 5 people (33.3%). Expected parents still seeking information to broaden their parents on coping strategies of parents of autistic children and parenting parents as well as parents to give special attention for children with autism to the development and advancement of their lives because they have the same rights as any other normal child.

Development of Virtual Reality Applications with the ADDIE Model for Prospective Educators of Children with Autism

2020 ◽  
Vol 4 (4) ◽  
pp. 672-681
Author(s):  
Dhomas Hatta Fudholi ◽  
Rahadian Kurniawan ◽  
Dimas Panji Eka Jalaputra ◽  
Izzati Muhimmah
Keyword(s):  
Virtual Reality ◽  
Special Needs ◽  
Prospective Teachers ◽  
Children With Autism ◽  
Children With Special Needs ◽  
Design Development ◽  
Autistic Children ◽  
Application Development ◽  
Addie Model ◽  
Prospective Educators

Knowledge is needed for children with special needs to support their quality of life. This is a challenge for prospective educators / prospective teachers. A deeper knowledge is needed to really understand children with special needs. This research is carried out to develop a skill simulator application for autistic child’s prospective educator using Virtual Reality technology. This application will be used as a teaching medium which incorporates motion sensor tools. The sensors will make the virtual application looks realistic. The application was developed using the ADDIE method (Analysis, Design, Development, Implementation and Evaluation). The application development begins with discovering the characteristic of autistic children. This is done to formulate the learning materials. The knowledge base of the autistic children was obtained from the Sekolah Luar Biasa (SLB). By using the obtained knowledge, storyboard was designed and implemented. The developed application has been evaluated by 16 prospective child educators with autism and two professional experts. In general, the application can help prospective educators understand the characteristics of children with autism. Moreover, it provides a safe and pleasant teaching skill practice for the prospective educators.  

PROSES KOMUNIKASI INTERPERSONAL ORANG TUA DENGAN ANAK AUTIS DALAM MEMBENTUK KEMANDIRIAN ANAK

Jurnal Common ◽  
2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Tina Rakhmatin ◽  
Dian Amilia
Keyword(s):  
Interpersonal Communication ◽  
Nonverbal Communication ◽  
Children With Autism ◽  
Verbal Communication ◽  
Communication Process ◽  
Image Method ◽  
Autistic Children ◽  
Normal Children ◽  
Inhibiting Factors ◽  
Parents And Children

Penelitian ini bertujuan untuk mengetahui proses komunikasi interpersonal orang tua kepada anak autis di Kota Bandung. Untuk menjawab dari tujuan penelitian tersebut, peneliti menetapkan sub fokus pada Komunikasi verbal, komunikasi nonverbal, dan faktor penghambat. Penelitian ini menggunakan metode kualitatif dengan studi deskriptif dimana informan yang terlibat dalam penelitian ini berjumlah lima orang yang terdiri dari empat informan kunci sebagai orang tua dan satu informan pendukung psikolog anak sebagai informan pendukung. Hasil penelitian ini menunjukkan bahwa proses komunikasi interpersonal yang dilakukan antara orang tua dengan anak autis tidak seperti melakukan komunikasi dengan anak normal dan sulit untuk melakukan komunikasi agar dapat dipahami oleh anak autis. Komunikasi verbal yang dilakukan dengan autis harus jelas, tegas, singkat dan juga dengan menggunakan metode gambar, serta adanya kata-kata perintah yang diberikan demi kemandirian anak autis. Komunikasi nonverbal dilakukan dengan gerakan-gerakan ketika orang tua memberikan larangan kepada anak dengan menggunakan gerakan jari telunjuk yang mengacung kemudian digoyangkan, mereka akan segera berhenti melakukan hal tersebut dan memahami bahwa hal tersebut dilarang. Faktor penghambat dalam berkomunikasi dengan anak autis yaitu sulitnya melakukan kontak mata, kurangnya respon yang diberikan, kesulitan berbicara yang dialami anak autis, serta gangguan pada bidang sensori. --------------------------------------------------------------------------------- This study aims to determine the parent's interpersonal communication process to autistic children in the city of Bandung. To answer the purpose of the study, the researcher established a sub focus on verbal communication, nonverbal communication, and inhibiting factors. This study uses qualitative methods with descriptive studies where the informants involved in this study amounted to five people consisting of four key informants as parents and one informant supporting child psychologists as supporting informants. The results of this study indicate that the process of interpersonal communication carried out between parents and children with autism is not like communicating with normal children and is difficult to communicate so that it can be understood by children with autism. Verbal communication done with autism must be clear, firm, concise and also by using the image method, as well as the words of the commands given for the independence of autistic children. Nonverbal communication is carried out with movements when parents give a prohibition to children by using the movement of the index finger that is raised and then shaken, they will immediately stop doing that and understand that it is prohibited. Inhibiting factors in communicating with children with autism are difficulty in making eye contact, lack of response given, speech difficulties experienced by autistic children, and disturbances in the sensory field.

RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

The Lancet ◽  
1998 ◽  
Vol 351 (9103) ◽  
pp. 637-641 ◽  
Author(s):  
AJ Wakefield ◽  
SH Murch ◽  
A Anthony ◽  
J Linnell ◽  
DM Casson ◽  
...  
Keyword(s):  
Pervasive Developmental Disorder ◽  
Developmental Disorder ◽  
Nodular Hyperplasia ◽  
Lymphoid Nodular Hyperplasia

scholarly journals POS0329 GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: PATHOGENETIC ROLE OF GUT MICROBIOME, CYTOKINES AND ADIPOKINES

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 392.1-392
Author(s):  
E. Pigatto ◽  
M. Schiesaro ◽  
M. Caputo ◽  
M. Beggio ◽  
P. Galozzi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Gut Microbiome ◽  
Serum Levels ◽  
High Serum ◽  
Healthy Population ◽  
Gastrointestinal Involvement ◽  
Degrading Bacteria ◽  
Gi Symptoms ◽  
Low Levels ◽  
The Impact

Background:Gastrointestinal (GI) involvement is very common in patients with Systemic Sclerosis (SSc). The pathophysiology of GI manifestations has not yet been defined. Cell-mediated immunological reactions appear to lead to endothelial damage resulting in fibrosis. The risk of developing malnutrition reinforces the need to better understand GI pathophysiology in these patients.Objectives:The study aimed to evaluate GI symptoms (GIT 2.0) and malnutrition status (MUST) and to determine specific bacterial changes in gut microbiome by investigating the possible presence of positive hot spots in bacterial species in SSc patients and their potential role in the disease progression. We also evaluated serum levels of adipokines and cytokines involved in the pathogenesis of SSc and their role, in addition to gut microbiome, in predicting the onset of GI involvement and malnutrition in SSc patients.Methods:We enrolled 25 scleroderma patients (EULAR/ACR 2013 criteria). UCLA-SCTC GIT 2.0 questionnaire to evaluate GI symptoms and MUST to investigate the risk of malnutrition were used. Gut microbiome was analyzed and the samples were subjected to extraction for the 16S rRNA gene (Earth Microbiome Project and the NIH-Human Microbiome Project). The microbiome was investigated at phenotypic and genotypic level. Serum levels of cytokines and adipokines (adiponectin and leptin) were evaluated by ELISA.Results:79.9% of patients had GERD and 63.5% abdominal distension at GIT 2.0 questionnaires. 48% of patients had moderate risk of malnutrition (MUST=2) and 12% had high risk (MUST=3). Gut microbioma: 19 patients (76%) had low similarity and 11 (44%) low diversity compared to the healthy population. The prevailing enterotypes of gut microbiome was Bacteroides (80%) and Prevotella (20%). The genotypic evaluation showed a reduced concentration of: gluten-digesting (Lactobacillus); lactose-digesting (Faecalibacterium); vitamin K-producing (Enterococcus, Desulfovibrio and Veillonella); acetaldehyde-degrading bacteria. 24 patients (96%) showed a reduction in bacteria devoted to maintaining weight control (Bifidobacterium and Ruminococcus). The patients had an altered intestinal permeability with less mucolytic bacteria (Bacteroides) and reduced production of LPS (Enterobacter and Escherichia). Low levels of butyrate (Eubacterium and Clostridium), acetate and propionate were found for SCFA-producing bacteria. Potentially pathogenic bacteria were also investigated: Salmonella was found in 14 (56%), Klebsiella in 9 (36%) and Enterococcus Faecalis in 3 (12%) patients. 11 (44%) patients had elevated serum levels of IL10 and IL12; 4 (16%) had high value of leptin. Correlation was found in patients who had a reduced concentration of gluten-digesting bacteria and MUST. Elevated MUST was correlated with serological increase in IL17A and IFN-α. Serum levels of IL12 and IL10 were found to correlate with specific bacteria alterations: high concentration of acetaldehyde-producing bacteria and low levels of acetaldehyde-degrade bacteria (also correlated with high serum levels of IL6), mucolytic bacteria and producers of hydrogen sulphide, acetate and propionate. Finally, reduced levels of mucolytic bacteria and acetate producing bacteria correlated with high serum leptin levels.Conclusion:The relationship between the gut microbiome and SSc seems to be multifactorial. In our study genotypic changes of gut microbioma might play a role in damaging the permeability of the mucosa and increasing risk of malnutrition. The evaluation of gut microbiome and cytokine profile is probably going to be of value in the follow-up of SSc. However, further studies are needed to clarify the impact of GI dysbiosis on the immune system in SSc.References:[1]Patrone V. et al. Gut microbiota profile in systemic sclerosis patients with and without clinical evidence of gastrointestinal involvement, Sci Rep. 2017; 7: 14874Disclosure of Interests:None declared

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