scholarly journals From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol

2016 ◽  
Vol 10 ◽  
pp. JEN.S25099 ◽  
Author(s):  
Alessandra T. Peana ◽  
Michela Rosas ◽  
Simona Porru ◽  
Elio Acquas
Keyword(s):  
Mechanism Of Action ◽  
Active Ingredient ◽  
Parent Compound ◽  
Ethanol Metabolism ◽  
Central Effects ◽  
Single Receptor ◽  
Alcoholic Drinks ◽  
Ethanol Metabolites ◽  
Robust Evidence

In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects.

Ethanol Metabolism in Vivo and the Role of Hepatic Microsomal Ethanol Oxidation

1972 ◽  
Vol 33 (3) ◽  
pp. 751-755 ◽  
Author(s):  
Mary K. Roach ◽  
Myrna Khan ◽  
Marguerite Knapp ◽  
W. N. Reese
Keyword(s):  
Ethanol Oxidation ◽  
Ethanol Metabolism

SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION

1965 ◽  
Vol 49 (1) ◽  
pp. 28-38
Author(s):  
M. Grönroos ◽  
E. Mäkinen ◽  
K. Lahtinen ◽  
R. Tirri
Keyword(s):  
Mechanism Of Action ◽  
Biological Effect ◽  
Female Rats ◽  
Histological Picture ◽  
Peripheral Effect ◽  
Pituitary Secretion

ABSTRACT The effect of reserpine on the secretion of FSH and LH was studied as well as the role of the peripheral effect of reserpine after hypophysectomy. The results in the unoperated animals suggest that reserpine inhibits the pituitary secretion of both FSH and LH. Both these hormones combined with reserpine had a very different biological effect than was seen without reserpine. HCG (LH-like) and particularly PMS (FSH-like) hormones combined with reserpine caused definite enlargement of the ovaries. In the hypophysectomized groups, the effect of the PMS and HCG hormones administered together with reserpine or without it was the same with regard to the weight of the ovaries, but not with regard to their histological picture. On the basis of these results, reserpine may be said to have a peripheral effect although the nature of its mechanism of action is difficult to state. Reserpine probably affects the ovaries by inhibiting the follicular cycle and, consequently, the formation of new and more mature follicles.

Role of Flavonoids in Neurodegenerative Disorders with Special Emphasis on Tangeritin

2019 ◽  
Vol 18 (8) ◽  
pp. 581-597 ◽  
Author(s):  
Ambreen Fatima ◽  
Yasir Hasan Siddique
Keyword(s):  
Medicinal Plants ◽  
Mechanism Of Action ◽  
Neurodegenerative Disorders ◽  
Treatment Strategies ◽  
Dietary Supplementation ◽  
Plant Polyphenols ◽  
Promising Candidate ◽  
Naturally Occurring ◽  
The Brain

Flavonoids are naturally occurring plant polyphenols found universally in all fruits, vegetables and medicinal plants. They have emerged as a promising candidate in the formulation of treatment strategies for various neurodegenerative disorders. The use of flavonoid rich plant extracts and food in dietary supplementation have shown favourable outcomes. The present review describes the types, properties and metabolism of flavonoids. Neuroprotective role of various flavonoids and the possible mechanism of action in the brain against the neurodegeneration have been described in detail with special emphasis on the tangeritin.

scholarly journals The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

2021 ◽  
pp. 107916
Author(s):  
Brandán Pedre ◽  
Uladzimir Barayeu ◽  
Daria Ezeriņa ◽  
Tobias P. Dick
Keyword(s):  
Mechanism Of Action ◽  
Sulfur Species ◽  
Sulfane Sulfur

Role of cyclic nucleotides in the mechanism of action of enkephalins

1982 ◽  
Vol 93 (3) ◽  
pp. 265-267
Author(s):  
M. Ya. Maizelis ◽  
A. L. Zabludovskii ◽  
S. N. Shikhov
Keyword(s):  
Mechanism Of Action ◽  
Cyclic Nucleotides

The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs

2001 ◽  
Vol 50 (11) ◽  
pp. 856-872 ◽  
Author(s):  
Elisabeth B Binder ◽  
Becky Kinkead ◽  
Michael J Owens ◽  
Charles B Nemeroff
Keyword(s):  
Mechanism Of Action ◽  
Antipsychotic Drugs

The role of soil and active ingredient properties in degradation of pesticides: A preliminary assessment

Chemosphere ◽  
1995 ◽  
Vol 30 (12) ◽  
pp. 2375-2386 ◽  
Author(s):  
R. Diaz Diaz ◽  
C. Gaggi ◽  
J.C. Sánchez-Hernández ◽  
E. Bacci
Keyword(s):  
Active Ingredient ◽  
Preliminary Assessment
Sign in / Sign up

Export Citation Format

Share Document