scholarly journals Using Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins

2015 ◽  
Vol 11 ◽  
pp. EBO.S30594
Author(s):  
Sayaka Miura ◽  
Stephanie Tate ◽  
Sudhir Kumar
Keyword(s):  
Sequence Variation ◽  
Functional Compensation ◽  
Coding Sequence ◽  
Paralogous Proteins

scholarly journals Amino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideum

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e46150 ◽  
Author(s):  
Clea Scala ◽  
Xiangjun Tian ◽  
Natasha J. Mehdiabadi ◽  
Margaret H. Smith ◽  
Gerda Saxer ◽  
...  
Keyword(s):  
Amino Acid ◽  
Dictyostelium Discoideum ◽  
Sequence Variation ◽  
Social Amoeba ◽  
Coding Sequence ◽  
Amino Acid Repeats ◽  
The Social

Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci

2005 ◽  
Vol 26 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Unkyung Kim ◽  
Stephen Wooding ◽  
Dante Ricci ◽  
Lynn B. Jorde ◽  
Dennis Drayna
Keyword(s):  
Sequence Variation ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Haplotype Diversity ◽  
Bitter Taste Receptor ◽  
Coding Sequence

scholarly journals Functional interpretation of non‐coding sequence variation: Concepts and challenges

BioEssays ◽  
2013 ◽  
Vol 36 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Dirk S. Paul ◽  
Nicole Soranzo ◽  
Stephan Beck
Keyword(s):  
Sequence Variation ◽  
Functional Interpretation ◽  
Coding Sequence

Sub-Saharan African coding sequence variation and haplotype diversity at theNAT2gene

2006 ◽  
Vol 27 (7) ◽  
pp. 720-720 ◽  
Author(s):  
Etienne Patin ◽  
Christine Harmant ◽  
Ken K. Kidd ◽  
Judith Kidd ◽  
Alain Froment ◽  
...  
Keyword(s):  
Sequence Variation ◽  
Haplotype Diversity ◽  
Coding Sequence ◽  
Sub Saharan

scholarly journals Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Maria N. Timofeeva ◽  
Ben Kinnersley ◽  
Susan M. Farrington ◽  
Nicola Whiffin ◽  
Claire Palles ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Architecture ◽  
Sequence Variation ◽  
Coding Sequence

scholarly journals An integrative approach to predicting the functional effects of non-coding and coding sequence variation

2015 ◽  
Vol 31 (10) ◽  
pp. 1536-1543 ◽  
Author(s):  
Hashem A. Shihab ◽  
Mark F. Rogers ◽  
Julian Gough ◽  
Matthew Mort ◽  
David N. Cooper ◽  
...  
Keyword(s):  
Sequence Variation ◽  
Integrative Approach ◽  
Coding Sequence

scholarly journals Haplotypes at ATM Identify Coding-Sequence Variation and Indicate a Region of Extensive Linkage Disequilibrium

2000 ◽  
Vol 67 (6) ◽  
pp. 1437-1451 ◽  
Author(s):  
Penelope E. Bonnen ◽  
Michael D. Story ◽  
Cheryl L. Ashorn ◽  
Thomas A. Buchholz ◽  
Michael M. Weil ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Sequence Variation ◽  
Coding Sequence

scholarly journals Tandem repeats contribute to coding sequence variation in bumblebees (Hymenoptera: Apidae)

2017 ◽  
Author(s):  
Xiaomeng Zhao ◽  
Long Su ◽  
Sarah Schaack ◽  
Ben M. Sadd ◽  
Cheng Sun
Keyword(s):  
Genetic Variation ◽  
Sequence Variation ◽  
Molecular Mechanisms ◽  
Tandem Repeats ◽  
Sequence Length ◽  
Length Variation ◽  
Coding Sequence ◽  
Bumblebee Species ◽  
Coding Regions ◽  
Wide Range

AbstractTandem repeats (TRs) are highly dynamic regions of the genome. Mutations at these loci represent a significant source of genetic variation and can facilitate rapid adaptation. Bumblebees are important pollinating insects occupying a wide range of habitats. However, to date, molecular mechanisms underlying the potential adaptation of bumblebees to diverse habitats are largely unknown. In the present study, we investigate how TRs contribute to genetic variation in bumblebees, thus potentially facilitating adaptation. We identified 26,595 TRs in the buff-tailed bumblebee (Bombus terrestris) genome, 66.7% of which reside in genic regions. We also compared TRs found in B. terrestris with those present in the whole genome sequence of a congener, B. impatiens. We found that a total of 1,137 TRs were variable in length between the two sequenced bumblebee species, and further analysis reveals that 101 of them are located within coding regions. The 101 TRs were responsible for coding sequence variation and corresponded to protein sequence length variation between the two bumblebee species. The variability of identified TRs in coding regions between bumblebees was confirmed by PCR amplification of a subset of loci. Functional classification of bumblebee genes where coding sequences include variable-length TRs suggests that a majority of these genes are related to transcriptional regulation. Our results show that TRs contribute to coding sequence variation in bumblebees and TRs may facilitate the adaptation of bumblebees through diversifying proteins involved in controlling gene expression.

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