Combined Therapy in Dyslipidemia and Hyperglicemia of Diabetes Mellitus Type II

2010 ◽  
Vol 2 ◽  
pp. CMT.S5220
Author(s):  
Azhar S. Sulaiman ◽  
Nada F. Zaki ◽  
Wasif S. Gillani
Keyword(s):  
Type Ii Diabetes ◽  
Combined Therapy ◽  
Demographic Data ◽  
Therapeutic Monitoring ◽  
Type Ii ◽  
Clinical Practices ◽  
Research Committee ◽  
Therapeutic Goals ◽  
Significant Difference ◽  
Study Population

Today the world is facing a high prevalence of dyslipidemia among type II diabetes, and in matter of fact clinical practices against hyperglycemic and hyperlipidemia were quiet intrusive. Our aim was to determine the therapeutic compliance against the clinical practices of dyslipidemia with type II diabetes in a multiracial society. A three year retrospective cohort study was planned to achieve the above mentioned objectives of the study. Study was carried out in out-patient department of General Hospital Penang over a period of ten months (Jan–Oct 2008). Study data collection duration was from Jan 2005–Dec 2007. All the concerned approvals were obtained from Clinical Research Committee (CRC). Data was analyzed by using SPSS 15®. A total of all only 501 diabetes type 2 patients with dyslipidemia were included in this study. The demographic data showed that 55.9% (n = 280) were female patients and 44.1% (n = 221) were male patients. According to racial distribution, Chinese constituted 41.7% of the study population, Malay 34.3% and Indians 24%. The mean age was 62.2 ± 9.2 years. About 56.1% of patients were more and equal than 60 years old range, while 43.9% were in the less or equal range of 59 years. Lifestyle and social habits data demonstrated 86.2% non-smokers, 74.1% with uncontrolled diet and 78.4% on bad exercise. Patients on combination therapy of metformin with other antidiabetic agent were 79%, while 21% were on monotherapy. The test analysis revealed that there was a significant difference between Malay and Chinese in FPG levels, in which the Malay had higher mean FPG than Chinese (mean difference Malay/Chinese 0.75991, P = 0.007). This study showed that both metformin and lovastatin were effective in reducing elevated glucose and lipid values. However, for glucose levels, the values were still above the normal limit used by the hospital. Among the multiracial study population, Chinese had the most controlled HDL levels and Malay had the highest uncontrolled FPG levels. Recommendations were associated with more frequent follow- up and therapeutic monitoring for the patient's condition by the health practitioners to determine the appropriate compliance with therapy and to control diabetes and dyslipidemia as per needed with therapeutic goals.

scholarly journals PATTERN OF BIOCHEMICAL PARAMETERS IN OBESE AND NON-OBESE TYPE II DIABETIC PATIENTS ATTENDING MEDICINE OUTDOOR OF A TEACHING HOSPITAL IN KOLKATA: AN OBSERVATIONAL STUDY

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Dr. Agnihotri Bhattacharyya ◽  
Dr. Kaushik Kar
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Biochemical Parameters ◽  
Glycosylated Haemoglobin ◽  
Diabetic Patients ◽  
Type Ii ◽  
Mean Values ◽  
Significant Difference ◽  
Study Population

Introduction: The diagnostic parameters of diabetes in obese and non obese individuals might not be always same because the physiological basis of developing diabetes in them is not similar. Objectives: The present study has been done to assess any significant difference in the Clinical and Biochemical parameters of diabetes like Glycosylated Haemoglobin (HbA1C), Fasting and Post prandial Blood Sugar (FBS and PPBS) among obese and non obese Type II Diabetes patients. Methodology: The present study was undertaken in the Medicine Outdoor of Calcutta National Medical College during June to August 2018 among 100 Type II Diabetes Mellitus patients of both sexes and aged 18 or above prior to an informed consent. Any significant difference in the Clinical and Biochemical parameters of diabetes among different groups of Diabetic patients as per BMI and waist circumference was assessed. Data was analyzed by standard statistical software like SPSS version 20 with proportion and percentage and using parametric and non-parametric tests like Chi-squares and ANNOVA. Result: The study reveals that 30% of the study population has BMI 25-29.99 kg/m2, 9% has 30-34.99 kg/m2 and 3% have BMI between 35-39.99 kg/m2 and 83.67% of Males and 96.07% of females have increased Waist Circumference Complications like Diabetic Nephropathy, Retinopathy, Neuropathy and Foot ulcer etc was found in 61% of the study population. There is significant difference in mean values of Glycosylated Haemoglobin, fasting blood sugar and post prandial blood sugar in the different groups of BMI. 32.78% of patients with complications of Diabetes Mellitus have BMI>24.99 and this association is statistically significant. Conclusion: The present study has found significant difference of the mean values of diagnostic parameters of diabetes in different groups according to Body Mass Index.  However the study was performed with the population who were already on treatment for some duration, so there can be a variation of findings in the present study from other studies done in different settings like primary care hospitals or with patients at onset of diabetes. Key words: Diabetes, Glycosylated Haemoglobin, Fasting blood sugar, Post prandial blood sugar

scholarly journals Correlation of microalbuminuria with neuropathy in type-II diabetes mellitus patients

2018 ◽  
Vol 5 (5) ◽  
pp. 1143
Author(s):  
P. K. Bariha ◽  
K. M. Tudu ◽  
Shiny Thomas Kujur
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Motor Neuropathy ◽  
Type Ii ◽  
Study Population ◽  
Factor Evaluation ◽  
The Mean ◽  
Microvascular And Macrovascular Complications

Background: The microvascular and macrovascular complications in diabetes mellitus resulting in microalbuminuria and diabetic neuropathy in common in developing country like India. The aim of the study has been undertaken to emphasis upon the association of microalbuminuria with neuropathy.Methods: The study was undertaken among 124 Type-II diabetes patients in the Department of Medicine, VIMSAR, Burla, Odisha between October 2015 to September 2017. Detail history, clinical examination, BMI, laboratory investigation like FBS, PPBS, HbA1C, nerve conduction study was done, and data were analysed and compiled.Results: Out of 124 patients the mean age of male patients in the study was 49.75 years and that of female patients was 50.36 years. The mean age of the study population was 50.18 years. The mean BMI in patients with and without microalbuminuria was 23.95±2.04kg/m2 and 21.57±2.89kg/m2 respectively. The mean HbA1C value in patients with and without microalbuminuria was 9.96±3.380 and 8.75±3.25 respectively.Conclusions: Microalbuminuria is significantly associated with presence of neuropathy. The most common type of neuropathy observed in this study was distal symmetrical sensory motor neuropathy. Hence, microalbuminuria has an important role as a biochemical marker for risk factor evaluation of microvascular complications in type 2 diabetes mellitus.

scholarly journals Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia in Vitro and in Vivo

2017 ◽  
Author(s):  
Jirawat Riyaphan ◽  
Chien-Hung Jhong ◽  
May-Jwan Tsai ◽  
Der-Nan Lee ◽  
Max K. Leong ◽  
...  
Keyword(s):  
Type Ii Diabetes ◽  
Herbal Medicines ◽  
Alpha Amylase ◽  
Type Ii ◽  
Reference Drug ◽  
Significant Difference ◽  
Natural Inhibitors ◽  
Alpha Glucosidase

The inhibition of alpha-glucosidase and alpha-amylase is one of clinic strategies for remedy the type II diabetes. Herbal medicines are reported to alleviate hyperglycemia. However, the constituents from those sources whether are targeted to the alpha-glucosidase and alpha-amylase still unexplored. This study attempted to select the compounds for efficacy of hypoglycemia via cellular and mouse levels. The results illustrated that the cytotoxicity in all tested compounds at various concentrations except the concentration of 16-hydroxy-cleroda-3,13-dine-16,15-olide (HCD) at 30 µM were not significant difference (p > 0.05) when compared with the untreated control. Acarbose (reference drug), Antroquinonol, Catechin, Quercetin, Actinodaphnine, Curcumin, HCD, Docosanol, Tetracosanol, Berberine, and Rutin could effectively inhibit the alpha-glucosidase activity of Caco-2 cells when compared with the control (maltose). The compounds (Curcumin, HCD, Tetracosanol, Antroquinonol, Berberine, Catechin, Actinodaphnine, and Rutin) could reduce blood sugar level at 30 min in tested mice. The effects of tested compounds on area under curve (AUC) were significant (p < 0.05) among Acarbose, Tetracosanol, Antroquinonol, Catechin, Actinodaphnine, and Rutin along with Berberine and Quercetin. In in vitro (alpha-glucosidase) with in vivo (alpha-amylase) experiments suggest that bioactive compounds can be a potential inhibitor candidate of alpha-glucosidase and alpha-amylase for the alleviation of type II diabetes.

scholarly journals Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Muhammad Khalid ◽  
Muhammad Kashif Hanif ◽  
Qamar Ul Islam ◽  
Muhammad Asim Mehboob
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Type Ii Diabetes Mellitus ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Density ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference ◽  
Corneal Endothelial Cell Density ◽  
Study Population

Objective: To compare the mean change in Corneal Endothelial cell Density (CED), from baseline (pre-operative value), two months after phacoemulsification cataract surgery between type II diabetic patients and non-diabetic patients. Methods: This prospective stratified controlled study was conducted at PNS Shifa Hospital, Karachi. 80 eyes of 72 type II diabetic patients and 80 eyes of 77 non diabetic controls, having Nuclear Opalescence (NO) grades 2 and 3 on slit lamp examination underwent phacoemulsification surgery. CED was measured in cells/mm2, of concerned eye of each subject preoperatively and 2 months post operatively using specular microscope. The difference in mean CED change between the two groups after surgery was analyzed. Results: Mean age of study population was 61.41± 6.76 years. Out of study population, 92 (57.5%) were males and 68 (42.5%) were females. There was a statistically significant difference between both groups in terms of mean post-operative CED, mean change in CED and mean frequency change in CED (p <0.05). There was no statistically significant difference between both groups in age, gender, laterality of eyes and mean pre-operative CED, (p >0.05). Difference of pre-operative CED from post-operative CED in each group was statistically significant. Conclusion: There is a significant difference between diabetic population and normal population in terms of corneal endothelial loss after uneventful phacoemulsification cataract surgery. doi: https://doi.org/10.12669/pjms.35.5.596 How to cite this:Khalid M, Hanif MK, Qamar ul Islam, Mehboob MA. Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.596 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

2017 ◽  
Vol 2 (2) ◽  
pp. 26-34
Author(s):  
Hridaya Parajuli ◽  
Jyotsna Shakya ◽  
Bashu Dev Pardhe ◽  
Puspa Raj Khanal ◽  
Narayan Prasad Parajuli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

scholarly journals Prevalence, pattern and distribution of MIH defects in Sudanese children

2020 ◽  
Author(s):  
Hanna Elhassan Abdalla ◽  
Amal Hussein Abuaffan ◽  
Arthur Musakulu Kemoli
Keyword(s):  
Demographic Data ◽  
Rank Correlation ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Related Factors ◽  
Cross Sectional ◽  
Statistical Significant Difference ◽  
Tooth Structure ◽  
Significant Difference ◽  
Study Population

Abstract Background: Molar incisos hypomineralization (MIH) has serious impact on oral health-related quality of life for a child, due to its effects on tooth structure, aesthetics and behavior of the child. The current study was designed to determine the prevalence, pattern and distribution of MIH in school children in Sudan.Methods: This was a descriptive, cross-sectional study involving 568 children, aged 8-11 years from schools in Khartoum State. After collecting their socio-demographic data, the children were examined for hypomineralization on the 12 MIH indexed teeth, and assessed on the MIH pattern and distribution. The data collected were analyzed to obtain descriptive statstics, and the results related to the socio-demographic and other dental-related factors of the children using chi-square test and Spearman Rank Correlation, with the significant level set at p<0.05.Results: The prevalence of MIH in the study population was 20.1%. Majority of the affected teeth were permanent first molars (PFMs) (12.5%), but there was no statistical significant difference between the occurrence of hypomineralization on mandibular and maxillary molars (p=0.22). However, in the case of incisors, there was a statistical significant difference between the maxillary incisors that had higher hypomineralization rate when related to the mandibular incisors ( p=0.00). In terms of the pattern of hypomineralization, demarcated opacities were the commonest MIH defects (69.9%) in the study group.Conclusions: While the prevalence of MIH in the study population was 20.1%, both molars and incisor teeth were frequently affected in both dental arches, and the demarcated opacity type were the most frequent form of defect found in the teeth of the participants.

scholarly journals Diastolic dysfunction in cases with Type II diabetes mellitus.

2019 ◽  
Vol 26 (12) ◽  
pp. 2040-2043
Author(s):  
Munir Ahmed ◽  
Abdul Hayee ◽  
Shahla Afsheen Memon ◽  
Ismail Salim Memon ◽  
Abdul Qayoom Memon
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Female Gender ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type I ◽  
Type Ii ◽  
Cross Sectional ◽  
Significant Difference

Objectives: To determine the frequency of diastolic dysfunction in patients presenting with type II Diabetes Mellitus. Study Design: Cross sectional study. Setting: Sheikh Zayed Hospital, Rahim Yar Khan. Period: From 01-01-2017 to 30-06-2017. Material & Methods: In this study the cases were selected via non probability consecutive sampling of both male and female gender with age more than 40 years having type II DM of at least more than 2 years were included. The cases suffering from type I DM, gestational DM and those with HTN, end stage kidney and liver failure were excluded. Trans thoracic echocardiography was done to label diastolic dysfunction and was labelled as yes when the E/A ratio was <0.8. The data was analysed using chi square test and p value less than 0.05 was taken as significant. Results: In this study, 100 cases of type II DM were included with mean age of 51.31±7.89 years at presentation. There were 61% males and 39% females. Diastolic dysfunction was observed in 53% of the cases. There was no significant difference in terms of gender where it affected 56.41% of females with p= 0.92. Diastolic dysfunction was more in cases that had duration of DM more than 3 years affecting 48 (70.58%) cases with p= 0.001 and it was also significantly high in cases that had BMI more than 30 where it was seen in 40 (70.17%) of cases with p= 0.001. Conclusion: Diastolic dysfunction seen in half of the cases suffering from type II DM and it is significantly high in cases that had duration of DM more than 3 years and BMI more than 30.

scholarly journals 8-Isoprostane in chronic periodontitis and type II diabetes: Exploring the link

2018 ◽  
Vol 12 (4) ◽  
pp. 252-257
Author(s):  
Arati C Koregol ◽  
Nagaraj B Kalburgi ◽  
Sireesha kanniappa sadasivan ◽  
shivaraj warad ◽  
Apoorva kamat wagh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Chronic Periodontitis ◽  
Type Ii Diabetes ◽  
Cell Function ◽  
Periodontal Diseases ◽  
Clinical Parameters ◽  
Type Ii ◽  
Genetic Ablation ◽  
Significant Difference

Background. Reactive oxygen species (ROS) are associated with the pathogenesis of inflammatory diseases and have a direct or indirect role in tissue damage constituting oxidative stress. ROS are also involved in impairment of β-cell function during development of diabetes, which leads to genetic ablation of KATP channels, triggering up-regulation of antioxidant enzymes. Several markers of lipid peroxidation, protein oxidation and DNA damage induced by ROS can be measured. Over the last decade, isoprostanes have been considered as the best markers of lipid peroxidation. The aim of this study was to determine the presence of 8-isoprostane in healthy, chronic periodontitis and chronic periodontitis subjects with type II diabetes and to find the correlation between 8-isoprostane levels among groups and with clinical parameters like gingival index, probing depth and clinical attachment levels. Methods. Ninety subjects were selected and divided into 3 groups: healthy, chronic periodontitis and chronic periodontitis subjects with type II diabetes (n=30 each). Saliva was collected from these subjects after obtaining consent and analyzed for 8-isoprostane levels using ELISA kit. Statistical analysis was performed using Kruskal-Wallis test, Mann-Whitney U test and Spearman’s correlation coefficient (P<0.001). Results. Statistically significant difference was found in the levels of 8-isoprostane between healthy, chronic periodontitis and chronic periodontitis subjects with type II diabetes and with all clinical parameters. Conclusion. 8-isoprostane can be considered as a pathophysiological marker to measure oxidative stress in periodontal diseases.

Effect of Virtual Nutrition Training Based on the Health Belief Model on the Awareness of Patients with Type II Diabetes

2021 ◽  
Vol 7 (3) ◽  
Author(s):  
Mostafa Jafari ◽  
Hossein Ashtarian ◽  
Parvin Nokhasi
Keyword(s):  
Health Belief Model ◽  
Self Efficacy ◽  
Type Ii Diabetes ◽  
Health Belief ◽  
Diabetic Patients ◽  
Type Ii ◽  
Nutrition Training ◽  
Significant Difference ◽  
Belief Model ◽  
The Health Belief Model

Background: Various teaching methods could be used to reduce complications in diabetic patients. Objectives: The present study aimed to assess the effect of nutrition training based on the health belief model (HBM) and electronic methods on the awareness of patients with type II diabetes in Kermanshah, Iran in 2012. Methods: This quasi-experimental study was conducted at a diabetes clinic in Kermanshah City. In total, 60 patients were selected via convenience sampling and divided into three groups of 20, including SMS, blog, and collaborative blog. Data were collected before, immediately after, and three months after the educational intervention using a standard questionnaire. Data analysis was performed in SPSS version 16 using the Kruskal-Wallis test, Friedman’s test, and analysis of variance (ANOVA) at the significance level of 0.05. Results: The mean score of awareness was considered significant (P < 0.01). In addition, significant differences were observed in the perceived sensitivity and barriers, cue to action, and self-efficacy in the blog group (P < 0.05) before and three months after the intervention. In the collaborative blog group, a significant difference was denoted in the perceived severity and cue to action before and three months after the intervention (P < 0.05). Cue to action also differed significantly in the SMS group, and the self-efficacy score significantly changed only in the blog group after the intervention (P = 0.006). Conclusions: According to the results, using blogs, group/collaborative blogs, and SMS could effectively increase the awareness of the diabetic patients. Therefore, virtual training could enhance the structures of the HBM, with the exception of the perceived sensitivity domain.

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