Triptans in the Treatment of Migraine

2009 ◽  
Vol 1 ◽  
pp. CMT.S2927
Author(s):  
Baburhan Guldiken
Keyword(s):  
Renal Impairment ◽  
Effective Treatment ◽  
Severe Headache ◽  
Acute Migraine ◽  
Financial Loss ◽  
Treatment Choices ◽  
Receptor Agonists ◽  
Abortive Treatment ◽  
Special Subgroup

Migraine is a neurovascular disease, which pathogenesis is still unclear. It causes a severe headache and a substantial financial loss due to absenteeism, therefore, its effective treatment is particularly valuable. Triptans, selective 5HT1B and D receptor agonists, are effective treatment choices of acute migraine attacks. Migraine patients, who bear special conditions such as hypertension, hepatic or renal impairment, constitute a special subgroup of patients whose treatment with triptans has to be individually arranged. The review of Kalanuria and Peterlin, regarding the metabolism and efficacy of zolmitriptan in the abortive treatment of migraine, highlights many details of the use of zolmitriptan in migraine patients.

Ayurveda in changing scenario of diabetes management for developing safe and effective treatment choices for the future

2015 ◽  
Vol 12 (2) ◽  
Author(s):  
Subhadip Banerjee ◽  
Parikshit Debnath ◽  
Prasanna N. Rao ◽  
Tapas Brata Tripathy ◽  
Anjan Adhikari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Effective Treatment ◽  
Diabetes Management ◽  
Treatment Choices ◽  
The Future

AbstractAyurveda described diabetes mellitus (DM) as

5-HT1F Receptor Agonists in Acute Migraine Treatment: A Hypothesis

Cephalalgia ◽  
2003 ◽  
Vol 23 (8) ◽  
pp. 776-785 ◽  
Author(s):  
NM Ramadan ◽  
V Skljarevski ◽  
LA Phebus ◽  
KW Johnson
Keyword(s):  
Glutamate Release ◽  
Trigeminal System ◽  
Migraine Treatment ◽  
Acute Migraine ◽  
Receptor Agonists ◽  
Protein Extravasation ◽  
Clinical Observations ◽  
Pain Transmission ◽  
Plasma Protein Extravasation ◽  
Potential Link

Serotonin-1F receptor (5-HT1F) agonists may relieve acute migraine without vasoconstriction. We conducted a review of preclinical and clinical data that assessed the potential link between migraine and 5-HT1F activation. (i) A high correlation exists between the potency of various 5-HT1 receptor agonists in the guinea pig dural plasma protein extravasation assay and their 5-HT1F receptor binding affinity. (ii) 5-HT1F receptors are on the trigeminal system, and may participate in blocking migraine pain transmission through the trigeminal ganglion and nucleus caudalis. (iii) 5-HT1F receptors are located on glutamate-containing neurones and their activation might inhibit glutamate release; glutamate excess may play a role in migraine. (iv) Selective 5-HT1F receptor agonists (LY334370; LY344864) are effective in preclinical migraine models and are non-vasoconstrictive. (v) LY334370 is effective in acute migraine, and does not cause any symptoms/signs of coronary vasoconstriction. Preclinical experiments and clinical observations argue for a role of selective 5-HT1F agonists in migraine.

Y-configured Stent with a Double Microcatheter Technique for Ruptured Complex Basilar Tip Aneurysm

2009 ◽  
Vol 22 (4) ◽  
pp. 476-481 ◽  
Author(s):  
Jh Ko ◽  
Yj Kim ◽  
Cs Cho
Keyword(s):  
Effective Treatment ◽  
Cerebral Angiography ◽  
Intracranial Aneurysms ◽  
Clinical Course ◽  
Sudden Onset ◽  
Severe Headache ◽  
Hemodynamic Stress ◽  
Basilar Tip Aneurysm ◽  
Neurological State

A 79-year-old woman had a sudden onset severe headache and became somnolent. On the first day in the hospital, diagnostic cerebral angiography revealed a small broad-necked basilar tip aneurysm with a bleb near the neck. Due to the unfavorable configuration of aneurysm, we decided to use a Y-configured stent with a double microcatheter technique. Although procedural rupture on the bleb near the neck occurred, perioperative neurological state was not changed and her clinical course was uneventful. Because of the stent, complete packing of the aneurysm was possible, hemodynamic stress at the inflow area was reduced and consequently the chance of rebleeding may decrease. Stenting with a double microcatheter technique can be an effective treatment for highly complex intracranial aneurysms.

scholarly journals COMPLICATED MIGRAINE

2021 ◽  
Vol 2 (2) ◽  
pp. 28-33
Author(s):  
Kadek Putri Paramita Abyuda ◽  
Shahdevi Nandar Kurniawan
Keyword(s):  
Genetic Disease ◽  
Severe Headache ◽  
Life Threatening ◽  
History Of ◽  
Complicated Migraine ◽  
Abortive Treatment ◽  
Migraine Pathophysiology ◽  
Systemic Symptoms ◽  
As Stress ◽  
The Brain

Migraine is a chronic paroxysmal neurological disease characterized by attacks of moderate or severe headache accompanied by reversible neurologic and systemic symptoms. Although not life threatening, migraine can cause disability in the productive population. Migraine sufferers generally have a family history of migraine so that migraine is considered a genetic disease. Endogenous psychological factors such as stress or fatigue are the main triggers for migraine. Migraine pathophysiology involves various parts of the brain so that migraine symptoms are complex. Management of acute migraine can be done pharmacologically and non-pharmacologically. Migraine preventive management is needed if the patient has a chronic migraine or does not respond to abortive treatment.

Ayurveda – Opportunities for Developing Safe and Effective Treatment Choices for the Future

2015 ◽  
pp. 427-454 ◽  
Author(s):  
Pratip K. Debnath ◽  
Subhadip Banerjee ◽  
Parikshit Debnath ◽  
Achintya Mitra ◽  
Pulok K. Mukherjee
Keyword(s):  
Effective Treatment ◽  
Treatment Choices ◽  
The Future
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