scholarly journals Anti-annexin V Antibodies in Women with Recurrent Miscarriage

2010 ◽  
Vol 4 ◽  
pp. CMRH.S5835
Author(s):  
M.N. EL-Gharib ◽  
T.M. Elhawary ◽  
S.H. Elshourbagy ◽  
M.A. Morad
Keyword(s):  
Pregnant Women ◽  
Recurrent Miscarriage ◽  
Characteristic Curve ◽  
Annexin V ◽  
Mean Value ◽  
Control Group ◽  
Etiologic Factor ◽  
Group I ◽  
History Of ◽  
The Mean

Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results The mean value of a-A5 was 11.37 ± 6.78, 7.7 ± 1.40 and 6.20 ± 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ± 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage.

scholarly journals Thyroid Autoimmunity is a Risk Factor for Recurrent Pregnancy Loss

2018 ◽  
Vol 30 (1) ◽  
pp. 49-55
Author(s):  
Sharmin Sultana ◽  
Mosammat Nargis Shamima ◽  
Sahela Jesmin ◽  
Nargis Zahan ◽  
Md Abu Zahid ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Control Group ◽  
Genital Organ ◽  
Thyroid Antibodies ◽  
History Of ◽  
The Mean

This was a hospital based case control study. The study included patients attending in outdoor and indoor Department of Obstetrics and Gynaecology of Rajshahi Medical College, Hospital since July 2014 to June 2016. The aim of this study was to determine thyroid antibodies is a risk factor for recurrent pregnancy loss. Sixty seven pregnant or non pregnant women with history of recurrent miscarriage during 1st trimester were selected as case group and another sixty seven pregnant women who reached their 12 weeks uneventfully with no history of recurrent miscarriage were selected as control group. Patients with other cause of recurrent miscarriage such as metabolic or endocrinologic disorders, genital organ anomaly, uterine fibroid were excluded from the study. Thyroid function test and thyroid antibodies (FT4, TSH and TPO-Ab) were measured for the two groups. The result of this study showed that the percentage of positive TPO-Ab in target and control group is 67.16% and 5.95% respectively. The study observed that the mean serum concentrations of FT4 in the control subject was significantly higher than the mean of the target group (p-value <0.05). The TSH concentration was increased in miscarriage women with positive antibodies compared with the concentration of TSH in the control group with positive antibodies. The conclusions are that there is a deficiency in thyroid hormones or thyroid’s functional capacity is unable to meet the extra demands of pregnancy which may be one of the causes of recurrent miscarriage. Moreover positive thyroid antibodies pregnant women can reach term and have babies when the concentration of TSH is low during the first trimester, so the risk of miscarriage could be high in positive thyroid antibodies.TAJ 2017; 30(1): 49-55

Role of CD20 + IL-10 + B-lymphocytes in immunoregulatory processes in women with reccurent miscarriage

2021 ◽  
Vol 66 (8) ◽  
pp. 485-488
Author(s):  
A. V. Kust ◽  
N. Y. Sotnikova ◽  
A. I. Malyshkina ◽  
D. N. Voronin
Keyword(s):  
Pregnant Women ◽  
B Lymphocytes ◽  
Recurrent Miscarriage ◽  
Sharp Decrease ◽  
Main Group ◽  
Relative Content ◽  
Control Group ◽  
Becton Dickinson ◽  
Spontaneous Miscarriage ◽  
History Of

To determine the level of CD20 + IL-10 + B-lymphocytes in pregnant women with the threat of termination of pregnancy at 5-12 weeks and recurrent miscarriage in history and compare the data obtained with the end of gestation. A survey of 65 women at a gestational age of 5-12 weeks was carried out. The main group consisted of 33 women with a threatening recurrent miscarriage at the time of the examination, the comparison group consisted of 10 pre-pregnant women with a threatening sporadic miscarriage at the time of the examination, the control group consisted of 22 pregnant women without signs of a threatening miscarriage. The main group, depending on the outcomes of pregnancy, is divided into 2 subgroups: subgroup A - pregnancy ended in undeveloped pregnancy or miscarriage (9 women), subgroup B - pregnancy ended in childbirth (24 women). The relative content of CD20 + IL-10 + B-lymphocytes was determined by flow cytometry on FACSCanto II (Becton Dickinson, USA). Women in the main group had a significantly lower level of CD20 + IL-10 + B-lymphocytes in comparison with the rest of the surveyed. A retrospective analysis revealed that among women of subgroup A there was a sharp decrease in CD20 + IL-10 + cells compared with subgroup B. Prediction of a non-developing pregnancy and spontaneous miscarriage up to 22 weeks of gestation in pregnant women with threatened spontaneous miscarriage and a history of recurrent miscarriage is possible with the relative content of CD20 + IL-10 + equal to or less than 4.5% (sensitivity 100%, specificity 82.6%, accuracy 87.9%).

Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage

2021 ◽  
Vol 70 (4) ◽  
pp. 73-79
Author(s):  
Anna I. Malyshkina ◽  
Natalia Y. Sotnikova ◽  
Dmitriy N. Voronin ◽  
Alena V. Kust
Keyword(s):  
Pregnant Women ◽  
Mrna Expression ◽  
B Lymphocytes ◽  
Functional Activity ◽  
Recurrent Miscarriage ◽  
Quantitative Polymerase Chain Reaction ◽  
Main Group ◽  
Control Group ◽  
Spontaneous Miscarriage ◽  
History Of

BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage. AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage. MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestation period of 5-12 weeks. The main group consisted of 36 patients with threatened spontaneous miscarriage at the time of examination and a history of habitual miscarriage. The control group included 28 women with uncomplicated pregnancy. The comparison group consisted of 24 primary pregnant patients with threatened spontaneous abortion at the time of examination. BAFF and APRIL levels in the blood serum were determined by enzyme immunoassay. The content of CD19+BAFFR+B lymphocytes in the lymphocyte gate was evaluated in the peripheral blood by flow cytometry using monoclonal antibodies. Akt mRNA expression was assessed using real-time reverse-transcription quantitative polymerase chain reaction. CD19+В lymphocytes were isolated by direct magnetic separation. RESULTS:In the main group, there was an increase in expression of BAFF receptors on peripheral CD19+B lymphocytes and a decrease in the serum BAFF concentration compared to the parameters in the other study groups. We also found a pronounced trend towards a decrease in the serum APRIL level in the main and comparison groups of patients compared to healthy pregnant women. Besides, Akt mRNA expression in peripheral CD19+B lymphocytes was increased in the main group. CONCLUSIONS:Threatened habitual abortion is associated with the deficit of the regulatory influence of BAFF and APRIL, which is expressed in the disruption of B cell homeostasis and the weakening of humoral effector mechanisms.

Impacts of Covid-19 Pandemic on the Early Trimester Pregnancies

2021 ◽  
Vol 15 (8) ◽  
pp. 2508-2511
Author(s):  
Fatima Khosa ◽  
Masooda Naeem ◽  
Zahra Sultan ◽  
Aesha Sadaf Rizwan ◽  
Shazia Jang Sher ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Ethical Review ◽  
Control Group ◽  
Trimester Pregnancy ◽  
Ethical Approval ◽  
History Of ◽  
Global Health Care ◽  
Keywords Pregnancy ◽  
The Mean

Background and Aim: The COVID-19 pandemic caused by severe acute respiratory syndrome (SAR-CoV-2) had severe consequences and complications on the global health care system. Recent medical studies have been focused on the effect of COVID-19 pandemic on pregnancies outcomes especially early pregnancies. The present study aimed to investigate the impacts of the COVID-19 pandemic early-trimester pregnancies. Materials and Methods: This retrospective study was carried out on 76 women who visited Obstetrics and Gynecology department for the first and second-trimester viability scan at Government Hospital, Samnabad Lahore from 1st January 2021 to 30th June 2021. Individuals of age between 19 years and 40 years with a diagnosis of spontaneous miscarriage were enrolled in this study. Ethical approval was taken from the respective hospital's ethical review committee. Patients with recurrent pregnancy loss, induced miscarriage, and other co-morbidities were excluded. All the demographic details were taken from the hospital medical record. All the patients underwent routine baseline tests to confirm the COVID-19 history and its impacts on the early trimester of pregnancy. The outcomes of early trimester pregnancy were viable pregnancy, miscarriage, pregnancy loss, and ectopic pregnancy were calculated in terms of frequency and percentage. SPSS version 20 was used for data analysis. Results: The overall mean age study group patients was 28.72± 3.63 years. The control group comprised 57 pregnant women with a gestational age of 5 weeks to 11 weeks, and the mean maternal age was 34.83±4.91 years. Out of total pregnant women, 31 (40.7%) were of age 19-25 years old, 29 (38.2%) had age 25 to 30 years, and 31 to 40 years were 16 (21.1%). Of the total 76 pregnant women, about 41 (54%) had a miscarriage with positive COVID-19 tests and 24 (31.6%) had spouses who had COVID-19 positive tests. History of both spouse and personal positive COVID tests were eleven patients (14.4%). The incidence of miscarriage among control group was 10 (17.5%). Conclusion: Our study found that the COVID-19 pandemic significantly affects the rate of pregnancy loss during the early trimester (first and second pregnancy). The maternal viremia or vertical transmission caused early trimester pregnancy loss and maternal infection during COVID-19. Keywords: Pregnancy, Miscarriage, COVID-19 Pandemic

Obstetric and perinatal outcomes in women with threatened interruption of pregnancy, living in the armed conflict zone

2020 ◽  
pp. 21-24
Author(s):  
I.Yu. Romanenko ◽  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Operative Delivery ◽  
Pregnancy And Childbirth ◽  
Group I ◽  
History Of ◽  
Complicated Course ◽  
Female Genital

The objective: was to evaluate the course of pregnancy, childbirth and perinatal outcomes of delivery of women with threatened interruption of pregnancy (TIP), living in the Lugansk region, to improve treatment and preventive measures and prevent obstetric and perinatal complications in such women. Materials and methods. A prospective clinical and statistical analysis of the course of pregnancy and childbirth of 86 pregnant women in first and second trimesters of pregnancy were hospitalized regarding TIP in the hospitals located in the Luhansk region was performed (group I). The control group consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Results. In women of group I, a history of female genital inflammatory diseases was significantly more frequent, and a complicated course of pregnancy and childbirth was registered. The number of cases of acute respiratory viral infection (ARVI) was in 4, isthmic-cervical insufficiency (ICI) was in 3 times more often than in healthy pregnant women, asymptomatic bacteriuria, recurring TIP, gestational pyelonephritis and ureaplasma infection were found only in pregnant women of group I, the number of cases of anemia there was no significant difference. 13 (15.12%) of women of group I and 3 (4.69%) of group II (p=0.041) had spontaneous preterm birth at 33–37 weeks of gestation; operative delivery was registered in 23 (26.74%) and 8 (12.50%) cases, respectively (p=0.033). It was established that recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis are statistically significant risk factors for preterm delivery and operative delivery. Premature rupture of the membranes was found in 1.58, weakness of labor – in 2.2, premature detachment of a normally located placenta – in 6, fetal distress – in 1.9 times more often in women of group I, central placenta previa was noted only in group I. Conclusions. The complicated course of the first and second trimesters of pregnancy, in particular, recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis, had a direct effect on frequency increase of premature termination of pregnancy and operative delivery in patients of the main group compared with women of the control group. The presence of a history of chronic female genital inflammatory diseases, sexually transmitted infections, ARVI during this pregnancy, TIP in the first and second trimesters, allows pregnant women to be at high risk of developing gestational complications in order to conduct timely treatment. Key words: pregnancy, the threat of abortion, childbirth, the condition of newborns.

Gene-gene interactions and prevalence of gene polymorphism associated with disorders of hemostasis and folate metabolism in patients with recurrent miscarriage

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 18-22
Author(s):  
Nataly I Frolova ◽  
Tatiana E Belokrinitskaya ◽  
Nataliya N Strambovskaya ◽  
Evgeniya P Belozertseva
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Early Pregnancy ◽  
Gene Polymorphisms ◽  
Recurrent Miscarriage ◽  
Gene Interaction ◽  
Control Group ◽  
Minor Alleles ◽  
History Of ◽  
Pai 1

Aim. To assess the association between polymorphisms of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G and their combinations in patients with recurrent early pregnancy losses (RPL). Materials and methods. This study included two groups of women (age range 20-35 years): 50 currently non-pregnant women with a history of 2-5 unexplained recurrent early spontaneous abortion and unknown causes of miscarriages (RPL group), and 50 currently non-pregnant women with a history of having given birth to at least one live baby and without a history of spontaneous abortion, preterm labor, stillbirth, preeclampsia and other pregnancy complications (control group). Gene polymorphisms were detected by the technique of polymerase chain reaction-real time. We have analyzed the frequencies, Hardy-Weinberg equilibrium, V-Kramer test, χ2 test, odds ratio (OR) and its 95% confidence interval (95% CI). General (χ2 test, df=2) and multiplicative (χ2 test, df=1) models of inheritance have been used to assess the presence of gene polymorphisms. Results. Significant association between heterozygotes genotype PAI-1-5G4G (72% vs 32%, p=0.000; OR 5.46; 95% CI 2.32-12.87) and RPL was found. Heterozygous genotype FII-20210GA was detected only in RPL group (4% vs 0%). Combinations of genetic polymorphisms of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G increase the risk of RPL by 2.4 times (56% vs 20%; χ2=29.20, р=0.000; OR 3.69, 95% CI 1.52-8.97; strong V-Kramer association). The combination of two heterozygotes variants of minor alleles was found to be a risk factor for RPL (34% vs 10%; χ2=8.73, р=0.004; OR 4.64, 95% CI 1.55-3.84). Combined PAI-1-5G4G + FVL-1691GA genotypes was detected only in RPL group of women (2% vs 0%). No significant association between the combination of three heterozygotes variants of minor alleles and RPL. Conclusion. Our data suggest significant gene-gene interaction of the heterozygotes variants of minor alleles of FVL-1691G>A, FII-20210G>A, MTHFR-677C>T, MTHFR-1298А>C, РАІ-1-6755G>4G polymorphisms in patients with recurrent miscarriage. Combined genotypes FVL-1691GA/PAI-1-5G4G can be considered as a genetic molecular predictor of recurrent early pregnancy losses.

scholarly journals The effect of vitamin D3 supplements on the 25(OH)D levels in the II and III trimester of pregnant women in Sleman, Indonesia: randomized controlled trial

2020 ◽  
Vol 9 (1) ◽  
pp. 22
Author(s):  
Amalina T. Susilani ◽  
Hertanto W. Subagio ◽  
Noor Pramono ◽  
Martha I. Kartasurya
Keyword(s):  
Pregnant Women ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Significant Difference ◽  
The Mean ◽  
Vitamin D3 Deficiency

Background: Pregnant women are among the groups at high risk of vitamin D3 deficiency due to the increased need for micro and macro nutrients during pregnancy. Vitamin D3 deficiency is associated with pregnancy complications, namely preterm birth, pre-eclampsia, gestational diabetes, and babies born small according to their gestational age.Methods: The study involved a randomized pretest-posttest control group design. Subjects selected include 80 pregnant women in second trimester. Data were collected in June 2020 to September 2020. The respondents were then randomly divided into 2 groups, comprising 40 each, where the first received 400 IU/day vitamin D3 supplementation for 12 weeks, and the second served as a control. Furthermore, 25 (OH) D were measured by using the ELISA method.Results: The mean value of the 25(OH)D levels after D3 supplementation and statistically showed a significant difference with a significance value of p<0.05 (0.01), compared to the control group.  Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00, compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00.Conclusions: Vitamin D3 supplement of 400 IU per day can increase the levels of 25(OH)D in the II and III trimester of pregnant women in antenatal care (ANC), Sleman Regency, Yogyakarta.

scholarly journals Pathogenetically justified tactics of management of pregnancy with retrochorial hematoma

2021 ◽  
Vol 15 (5) ◽  
pp. 548-561
Author(s):  
K. G. Sultangadzhieva ◽  
N. N. Babaeva ◽  
E. S. Egorova ◽  
J. Kh. Khizroeva ◽  
M. G. Sultangadzhiev
Keyword(s):  
Pregnant Women ◽  
Viral Infections ◽  
Randomized Study ◽  
Annexin V ◽  
Control Group ◽  
Blood Levels ◽  
Therapy Regimen ◽  
Inflammatory Status ◽  
Group I ◽  
Group Ii

Introduction. Retrochorial hematoma (RH) often detected during routine ultrasound examination represents one of the multiple causes resulting in early pregnancy loss. RH results from the detachment of the chorionic plate from the vertebrae of the uterine decidual membrane and may lead to complicated course of pregnancy.Aim: to develop a differential approach to diagnose and manage pregnancy with RH.Materials and Methods. A prospective open-ended interventional non-randomized study was conducted by enrolling 170 women. The main group consisted of 85 pregnant women with RH, which were divided into 2 groups: group I (n = 45) – patients with RH and burdened obstetric history; and group II (n = 40) – pregnant women with RH without a history of obstetric complications. The control group included 85 women with uncomplicated pregnancy. The incidence of hereditary thrombophilia was assessed by measuring rate of high thrombogenic risk mutations in the genes of factor (F) V Leiden and prothrombin (FII) G20210A; blood levels of lupus anticoagulant (LA) and anti-cardiolipin antibodies (aCL), β2-glycoprotein 1 (β2-GP1), annexin V and prothrombin; ADAMTS-13; rate of low thrombogenic risk polymorphisms, prevalence and spectrum of bacterial-viral infections.Results. It was revealed that women with RH had occasional genetic and acquired hemostasis defects as well as impaired florocenosis of the urogenital tract. Defects in the fibrinolysis system prevailed among the hereditary hemostasis defects: 75.5 % in group I, 32.2 % in group II, and 4.7 % in the control group. No decrease in the activity of natural anticoagulants – antithrombin and protein C was found. Among the acquired thrombophilic conditions, a large proportion of circulating antiphospholipid antibodies (APA) was found: 46.6 % in group I, 27.5 % in group II, and 2.3 % in the control group. Cervicitis of nonspecific etiology prevailed among dysbiosis signs: 53.3 % in group I, 47.5 % in group II and 11.7 % in the control group.Conclusion. RG formation is a multifactorial process, which pathogenesis involves both genetic and acquired factors such as APA, especially in combination with genetic thrombophilia (FV Leiden and FII G20210A), as well as inflammatory or pro-inflammatory status. We consider that all patients with RG as well as those with former RG are indicated to undergo the above-mentioned studies. It is advisable to include tranexamic acid, progesterone, low molecular weight heparins and antibiotics in the therapy regimen if indicated. 

Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage

2007 ◽  
Vol 97 (04) ◽  
pp. 552-557 ◽  
Author(s):  
Ysabel Ramirez ◽  
Chandrasekaran Nagaswami ◽  
Leona Masova ◽  
Anibal Pulido ◽  
José Mora ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Recurrent Miscarriage ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Polymerization Process ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Fibrin Network ◽  
History Of ◽  
Pregnant State

SummaryWe have studied some biophysical properties of the fibrin network during the normal state of pregnancy and in patients with recurrent miscarriage (RM), in the first trimester of pregnancy. The fibrin polymerization process, followed by turbidity, showed that the rate of fibrin monomer assembly and the final turbidity was increased in the pregnant group (normal and with history of RM) compared to non-pregnant women (normal and RM), which is consistent with the increased fibrinogen concentration during pregancy. No changes were observed in the Darcy constant (Ks) of RM clots, pregnant or not; however, in pregnant control subjects the Ks increased (p=0.03).The fibrin lysis rate was increased in pregnant women compared to non-pregnant, being faster in women with RM. The rheological properties of the fibrin network in the non-pregnant group (control and RM patients) were similar; in the pregnant state, the fibrin network of the control group was 1.3 times stiffer compared to the control non-pregnant women, and almost unchanged in RM patients. In this study we have found changes in the clot structure that seem to be related to normal pregnancy and an increased rate of the fibrin lysis process in the RM patients, which may have clinical relevance.

scholarly journals Assessment of Sub-endometrial Blood Flow Parameters Following Oral Dydrogesterone versus Micronized Vaginal Progesterone in Women with Idiopathic Recurrent Miscarriage

2021 ◽  
pp. 69-83
Author(s):  
Magda I. Nasr ◽  
Mona K. Omar ◽  
Walid M. Ataallah ◽  
Amal E. Mahfouz
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Recurrent Miscarriage ◽  
Study Groups ◽  
Control Group ◽  
Flow Parameters ◽  
Vaginal Progesterone ◽  
Uteroplacental Blood Flow ◽  
Group A ◽  
The Mean

Background: Recurrent pregnancy loss is an important reproductive health issue, affecting 2%–5% of couples. An unsupportive endometrium, leading to abnormal implantation, is considered to be one of the key factors contributing to idiopathic recurrent spontaneous miscarriage (IRSM). The aim of this work was to evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage (IRSM) following administration of micronized vaginal progesterone versus oral dydrogesteron. Materials and Methods: This prospective, randomized-controlled study comprised 90 pregnant women who came to outpatient clinic of obstetrics  .All women had a singleton pregnancy with active cardiac pulsations at gestational age between 5-8 weeks Pregnant women in the study group were randomly distributed into: Group {A}: 30 pregnant women received 10 mg of oral dydrogesterone (Duphaston; Abbott Company) twice daily.Group {B}: 30 pregnant women received 200 mg micronized vaginal progesterone (Prontogest) twice-daily. Control group:30 pregnant women without history of recurrent miscarriage served as controls and they received folic acid as placebo. Results: comparing the Doppler indices before progesterone supplementation, the mean resistance index (RI) was statistically significant less in the control group compared with both study groups (A&B) (P=0.012, P=0.005 respectively) .Moreover, pulsatility index (PI) was statistically significant less in the control group compared with both study groups (A&B) (P=0.026, P=0.05 respectively) .Paralleled to that, the S/D ratio was statistically significant less in control group compared with both group A &B (P=0.43, & P=0.019respectively) .In addition, the mean PSV was significantly higher in control group  compared to group B (P=0.047) and was higher in control group than group A with nearly significant P value. Conclusion: Considerable improvement in uteroplacental blood flow parameters of pregnant women with IRSM is evident with progesterone supplementation.

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