scholarly journals Primary Extraskeletal Ewing Sarcoma of the Thoracic Spinal Epidural Space: A Case Report

2007 ◽  
Vol 1 ◽  
pp. CMO.S332
Author(s):  
Yasuhiro Yamamoto ◽  
Osuke Washimi ◽  
Daisuke Ishimura ◽  
Harumoto Yamada ◽  
Makoto Kuroda ◽  
...  
Keyword(s):  
Epidural Space ◽  
Ewing Sarcoma ◽  
Chromosomal Translocation ◽  
Fusion Transcript ◽  
Complete Excision ◽  
Thoracic Spinal ◽  
Polymerase Chain ◽  
Spinal Epidural ◽  
Extraskeletal Ewing Sarcoma ◽  
Disease Free

Cases of extraskeletal Ewing sarcoma (EES) originating primarily within the spinal epidural space, are very rare and have a very poor prognosis. There is no standard therapy for this disease. We report the case of a 23-year-old man presenting with symptoms of back pain and numbness of both legs for 10 days. Imaging studies revealed a dorsal soft-tissue, extradural mass at the T8–9 vertebral level. The patient underwent a laminectomy and complete excision of the tumor. The EES diagnosis was confirmed by histologic analysis including immunohistochemistry and by presence of the EWS-ERG due to the t (21: 22) (q22: q12) chromosomal translocation by a reverse transcriptase-polymerase chain reaction (RT-PCR). This is the first report of spinal epidural EES with presence of the EWS-ERG fusion transcript. Post-operatively, the patient received aggressive adjuvant chemotherapy and radiotherapy. At 63 months after surgery, the patient is without clinical or radiological evidence of recurrent or metastatic disease. Early discovery of EES and a complete resection followed by the aggressive treatment with radiation and chemotherapy may improve disease-free and overall survival.

scholarly journals Solitary Spinal Epidural Metastasis from Gastric Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Taisei Sako ◽  
Yasuaki Iida ◽  
Yuichirou Yokoyama ◽  
Shintaro Tsuge ◽  
Keiji Hasegawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Epidural Space ◽  
Malignant Tumor ◽  
Metastatic Tumor ◽  
Spinal Tumor ◽  
Whole Body ◽  
Thoracic Spinal ◽  
Epidural Metastasis ◽  
Metastatic Spinal Tumor ◽  
Spinal Epidural

Solitary epidural space metastasis of a malignant tumor is rare. We encountered a 79-year-old male patient with solitary metastatic epidural tumor who developed paraplegia and dysuria. The patient had undergone total gastrectomy for gastric cancer followed by chemotherapy 8 months priorly. The whole body was examined for suspected metastatic spinal tumor, but no metastases of the spine or important organs were observed, and a solitary mass was present in the thoracic spinal epidural space. The mass was excised for diagnosis and treatment and was histopathologically diagnosed as metastasis from gastric cancer. No solitary metastatic epidural tumor from gastric cancer has been reported in English. Among the Japanese, 3 cases have been reported, in which the outcome was poor in all cases and no definite diagnosis could be made before surgery in any case. Our patient developed concomitant pneumonia after surgery and died shortly after the surgery. When a patient has a past medical history of malignant tumor, the possibility of a solitary metastatic tumor in the epidural space should be considered.

scholarly journals TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

Blood ◽  
1996 ◽  
Vol 88 (11) ◽  
pp. 4252-4258 ◽  
Author(s):  
TW McLean ◽  
S Ringold ◽  
D Neuberg ◽  
K Stegmaier ◽  
R Tantravahi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Chromosomal Translocation ◽  
Fusion Transcript ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Childhood All ◽  
Polymerase Chain ◽  
B Lineage

Abstract Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. The TEL/AML1 fusion results from a t(12;21)(p13;q22) chromosomal translocation, but was undetectable at the routine cytogenetic level. TEL/AML1-positive patients had exclusively B-lineage ALL, and most patients were between the ages of 2 and 9 years at diagnosis. Only 3/89 (3.4%) adult ALL patients were TEL/AML1-positive. Most importantly, TEL/AML1-positive children had a significantly lower rate of relapse compared with TEL/AML1-negative patients (0/22 v 16/54, P = .004). Co- immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together. The elucidation of the precise mechanism of transformation by TEL/AML1 and the role of TEL/AML1 testing in the treatment of childhood ALL will require additional studies.

scholarly journals Two cases of hemolymphangioma in the thoracic spinal canal and spinal epidural space on MRI

Medicine ◽  
2017 ◽  
Vol 96 (52) ◽  
pp. e9524
Author(s):  
Xingchen Pan ◽  
Yutong Dong ◽  
Tingting Yuan ◽  
Yuzhu Yan ◽  
Dan Tong
Keyword(s):  
Epidural Space ◽  
Spinal Canal ◽  
Thoracic Spinal ◽  
Spinal Epidural

scholarly journals TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

Blood ◽  
1996 ◽  
Vol 88 (11) ◽  
pp. 4252-4258 ◽  
Author(s):  
TW McLean ◽  
S Ringold ◽  
D Neuberg ◽  
K Stegmaier ◽  
R Tantravahi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Chromosomal Translocation ◽  
Fusion Transcript ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Childhood All ◽  
Polymerase Chain ◽  
B Lineage

Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. The TEL/AML1 fusion results from a t(12;21)(p13;q22) chromosomal translocation, but was undetectable at the routine cytogenetic level. TEL/AML1-positive patients had exclusively B-lineage ALL, and most patients were between the ages of 2 and 9 years at diagnosis. Only 3/89 (3.4%) adult ALL patients were TEL/AML1-positive. Most importantly, TEL/AML1-positive children had a significantly lower rate of relapse compared with TEL/AML1-negative patients (0/22 v 16/54, P = .004). Co- immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together. The elucidation of the precise mechanism of transformation by TEL/AML1 and the role of TEL/AML1 testing in the treatment of childhood ALL will require additional studies.

Spinal epidural extraskeletal Ewing sarcoma

2007 ◽  
Vol 34 (1) ◽  
pp. 63-67 ◽  
Author(s):  
E. Ozturk ◽  
H. Mutlu ◽  
G. Sonmez ◽  
F. Vardar Aker ◽  
C. Cinar Basekim ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Spinal Epidural ◽  
Extraskeletal Ewing Sarcoma

Extraskeletal Ewing Sarcoma in a 77-Year-Old Woman

2001 ◽  
Vol 125 (10) ◽  
pp. 1358-1360
Author(s):  
Carol C. Cheung ◽  
Rita A. Kandel ◽  
Robert S. Bell ◽  
Raymond E. Mathews ◽  
Danny M. D. Ghazarian
Keyword(s):  
Electron Microscopy ◽  
Ewing Sarcoma ◽  
Primitive Neuroectodermal Tumor ◽  
Young Patients ◽  
Fusion Transcript ◽  
Neuroectodermal Tumor ◽  
Histologic Analysis ◽  
Characteristic Features ◽  
Extraskeletal Ewing Sarcoma ◽  
Ewing Family Of Tumors

Abstract Extraskeletal Ewing sarcoma (EES) is a rare soft tissue tumor that is morphologically indistinguishable from Ewing sarcoma of bone. It is usually found in young people, but several cases have occurred in patients older than 50 years. The differential diagnoses include other small, blue round cell tumors (SBRCTs) and other members of the Ewing family of tumors such as the primitive neuroectodermal tumor. We present a case of EES in the left inguinal region of a 77-year-old woman. The tumor was distinguished from other SBRCTs by lack of immunoreactivity for epithelial, lymphoid, vascular, neuroendocrine, neural, histiocytic, and muscle markers. Primitive neuroectodermal tumor was excluded because of the lack of neural differentiation by histologic analysis, immunohistochemistry, and electron microscopy. Extraskeletal Ewing sarcoma was confirmed by characteristic features on histologic analysis, histochemistry, immunohistochemistry, and electron microscopy and by the presence of the t(11;22)(q24;q12) fusion transcript detected by reverse transcriptase–polymerase chain reaction. This case serves to remind the reader that EES is not a tumor that occurs exclusively in young patients.

SPINAL EPIDURAL EXTRASKELETAL EWING SARCOMA IN AN ADOLESCENT BOY: A Case Report

2006 ◽  
Vol 23 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Fani Athanassiadou ◽  
Athanassios Tragiannidis ◽  
Maria Kourti ◽  
Theodotis Papageorgiou ◽  
Vassiliki Kotoula ◽  
...  
Keyword(s):  
Case Report ◽  
Ewing Sarcoma ◽  
Spinal Epidural ◽  
Extraskeletal Ewing Sarcoma
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