scholarly journals Comparison of the Protective Effects of Radix Astragali, α-Lipoic Acid, and Vitamin E on Acute Acoustic Trauma

2012 ◽  
Vol 5 ◽  
pp. CMENT.S10711 ◽  
Author(s):  
Min Xiong ◽  
Huangwen Lai ◽  
Chuanhong Yang ◽  
Weiyi Huang ◽  
Jian Wang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Vitamin E ◽  
Lipoic Acid ◽  
Impulse Noise ◽  
Cell Damage ◽  
Acoustic Trauma ◽  
Protective Effects ◽  
Radix Astragali ◽  
Hair Cell Damage ◽  
Acute Acoustic Trauma

Objective Oxidative damage is a critical role which involves hearing loss induced by impulse noise. That exogenous antioxidant agents reduce noise induced hearing loss (NIHL) has been well demonstrated in both animal studies and clinical practices. Choosing a stronger and more effective antioxidant is very important for treatment of NIHL. Vitamin E, α-lipoic acid, and radix astragali are the most commonly used anti-oxidants for cochlear oxidative damage from acoustic trauma. In this study, the protective effects of radix astragali, α-lipoic acid, and vitamin E on acute acoustic trauma are investigated. Methods Guinea pigs in the experimental groups were intragastrically administered vitamin E, α-lipoic acid, and radix astragali. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) at click and tone bursts of 8, 16 and 32 kHz, 24 hours before and 72 hours after exposure to impulse noise. Cochlear malondialdehyde (MDA) concentrations were detected. Hair cell damage was analyzed by scanning electron microscopy. Results Vitamin E, α-lipoic acid, and radix astragali significantly reduced ABR deficits, reduced hair cell damage, and decreased the concentrations of MDA. α-lipoic acid and radix astragali were better than vitamin E, and there were no significant differences between α-lipoic acid and radix astragali. Conclusions α-lipoic acid or radix astragali are recommended for treatment of NIHL.

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss

2015 ◽  
Vol 166 (5) ◽  
pp. 440-450 ◽  
Author(s):  
Maki Niihori ◽  
Terry Platto ◽  
Suzu Igarashi ◽  
Audriana Hurbon ◽  
Allison M. Dunn ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Development ◽  
Hair Cell ◽  
High Throughput ◽  
Cell Damage ◽  
Swimming Behavior ◽  
Development Platform ◽  
Hair Cell Damage

Early Evidence of Cochlear Damage in a Large Sample of Percussionists

2005 ◽  
Vol 20 (3) ◽  
pp. 135-139
Author(s):  
Jodee A Pride ◽  
David R Cunningham
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Cell Damage ◽  
Normal Hearing ◽  
Outer Hair Cells ◽  
Sensory Loss ◽  
Distortion Product ◽  
Hair Cell Damage

Percussionists can be exposed to intermittent sound stimuli that exceed 145 dB SPL, although damage may occur to the outer hair cells at levels of 120 dB SPL. The present study measured distortion-product otoacoustic emissions (DPOAEs) in a group of 86 normal-hearing percussionists and 39 normal-hearing nonpercussionists. Results indicate that normal-hearing percussionists have lower DPOAE amplitudes than normal-hearing nonpercussionists. DPOAE amplitudes were significantly lower at 6000 Hz in both the left and right ears for percussionists. Percussionists also more frequently had absent DPOAEs, with the greatest differences occurring at 6000 Hz (absent DPOAEs in 25% of percussionists vs 10% of nonpercussionists). When all frequencies are considered as a group, 33% of the percussionists had an absent DPOAE in either ear at some frequency, compared to only 23% of the nonpercussionists. Otoacoustic emissions are more sensitive to outer hair cell damage than pure-tone threshold measurements and can serve as an important measurement of sensory loss (i.e., outer hair cell damage) in musicians before the person perceives the hearing loss. DPOAE monitoring for musicians, along with appropriate education and intervention, might help prevent or minimize music-induced hearing loss.

A Randomized, Double-blind, Placebo-controlled Study of Dextran/Pentoxifylline Medication in Acute Acoustic Trauma and Sudden Hearing Loss

1992 ◽  
Vol 112 (3) ◽  
pp. 435-443 ◽  
Author(s):  
Rudolf Probst ◽  
Kurt Tschopp ◽  
Eric Lodin ◽  
Bernhard Kellerhals ◽  
Michael Podvinec ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sudden Hearing Loss ◽  
Acoustic Trauma ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Acute Acoustic Trauma

Automobile Airbag Impulse Noise: Otologic Symptoms in Six Patients

1998 ◽  
Vol 118 (2) ◽  
pp. 228-234 ◽  
Author(s):  
James E. Saunders ◽  
William H. Slattery ◽  
William M. Luxford
Keyword(s):  
Hearing Loss ◽  
Automobile Industry ◽  
Impulse Noise ◽  
Motor Vehicle ◽  
High Amplitude ◽  
Acoustic Trauma ◽  
Vehicle Accidents ◽  
Patient Reported ◽  
Occupant Injuries ◽  
Safety Systems

Automobile airbag safety systems have successfully reduced the number of occupant injuries from motor vehicle accidents. Unfortunately, airbags are also associated with some inherent risk, including a high-amplitude, short-duration noise from airbag deployment. A review of the available research in the automobile industry indicates that the peak amplitude of this noise may exceed 170 dB sound pressure level. Despite the increasingly wide application of airbags in automobiles, there have been no previous reports of airbag-related otologic injuries. We have encountered six patients with otologic symptoms that appear to be related to airbag impulse noise. Five of these patients have documented hearing loss, one patient reported persistent tinnitus, and two patients have significant dysequilibrium. Although permanent hearing loss from airbag noise appears to be rare, temporary threshold shifts are probably much more common. It is important, therefore, that the clinician be aware of the noise associated with airbag inflation and the possibility of acoustic trauma from these safety devices.

Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish

2013 ◽  
Vol 77 (6) ◽  
pp. 1025-1031 ◽  
Author(s):  
Seok Jin Hong ◽  
Gi Jung Im ◽  
Jiwon Chang ◽  
Sung Won Chae ◽  
Seung Hoon Lee ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Protective Effects ◽  
Hair Cell Damage

scholarly journals The Role of Nrf2 in Hearing Loss

2021 ◽  
Vol 12 ◽  
Author(s):  
Dafei Li ◽  
Haiyan Zhao ◽  
Zhong-Kai Cui ◽  
Guangyong Tian
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Cell Damage ◽  
Hearing Protection ◽  
Related Factor ◽  
Nuclear Factor ◽  
The World ◽  
Hair Cell Damage ◽  
Heavy Burden

Hearing loss is a major unresolved problem in the world, which has brought a heavy burden to society, economy, and families. Hair cell damage and loss mediated by oxidative stress are considered to be important causes of hearing loss. The nuclear factor erythroid 2–related factor 2 (Nrf2) is a major regulator of antioxidant capacity and is involved in the occurrence and development of a series of toxic and chronic diseases associated with oxidative stress. In recent years, studies on the correlation between hearing loss and Nrf2 target have continuously broadened our knowledge, and Nrf2 has become a new strategic target for the development and reuse of hearing protection drugs. This review summarized the correlation of Nrf2 in various types of hearing loss, and the role of drugs in hearing protection through Nrf2 from the literature.

scholarly journals Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

2019 ◽  
Vol 29 (6) ◽  
pp. 739-743 ◽  
Author(s):  
SeonJu Park ◽  
Youn Hee Nam ◽  
Isabel Rodriguez ◽  
Jun Hyung Park ◽  
Hee Jae Kwak ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Chemical Constituents ◽  
Persea Americana ◽  
Protective Effects ◽  
Hair Cell Damage

scholarly journals Utility of Hyperbaric Oxygen Therapy for Acute Acoustic Trauma: 20 years' Experience at the Japan Maritime Self-Defense Force Undersea Medical Center

2019 ◽  
Vol 23 (04) ◽  
pp. e408-e414
Author(s):  
Morihiko Oya ◽  
Yutaka Tadano ◽  
Yasuhiro Takihata ◽  
Fumitaka Ikomi ◽  
Tetsuji Tokunaga
Keyword(s):  
Hearing Loss ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Medical Center ◽  
Acoustic Trauma ◽  
Symptom Improvement ◽  
Subjective Symptoms ◽  
Self Defense ◽  
Acute Acoustic Trauma

Introduction Acute acoustic trauma, which is a kind of sensorineural hearing loss, is caused by acoustic overstimulation. Hyperbaric oxygen therapy (HBOT) is reported to be effective against acute acoustic trauma. Objective We aimed to evaluate the efficacy of HBOT against acoustic hearing loss based on our 20 years of experience with such cases. Methods Patients who were treated with HBOT for acute acoustic trauma between April 1997 and August 2017 were evaluated in this study. Thirty-five patients with a mean age of 25.7 ± 9.2 (range: 16–48) years were included. Thirty-nine out of 70 ears (35 patients) were damaged. We investigated the initial level of hearing loss; the extent to which hearing recovered; subjective symptoms, such as tinnitus and aural fullness; and the treatment administered. Results The planned HBOT was completed in 37 of 39 ears. Twenty-six of the 37 ears (70.2%) displayed improved hearing, and 31 of the 37 ears (83.9%) exhibited symptom improvement. Twenty-three (76.7%) and 26 (86.7%) of the 30 ears treated with steroids demonstrated improvements in hearing and subjective symptoms, respectively. Conclusion A combination of HBOT and steroids should be considered as a treatment for acute acoustic trauma in cases involving symptoms such as tinnitus and aural fullness.

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