scholarly journals A Case of Diffuse Alveolar Hemorrhage Associated with Tegafur plus Uracil and Warfarin Therapy

2011 ◽  
Vol 4 ◽  
pp. CCRep.S8522 ◽  
Author(s):  
Masayuki Itoh ◽  
Shuji Oh-ishi ◽  
Kenji Nemoto ◽  
Seitaro Senba ◽  
Hideki Adachi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Computed Tomography ◽  
Lung Cancer ◽  
Bronchoalveolar Lavage Fluid ◽  
Warfarin Therapy ◽  
Lavage Fluid ◽  
International Normalized Ratio ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
Sequential Samples

A 72-year-old man who received warfarin for myocardial infarction (prothrombin time-international normalized ratio [PT-INR] controlled between 2.2 and 2.5) for 2 years. He developed lung cancer, underwent surgery, and received tegafur plus uracil (UFT) after 1 month. After 2 months, he was admitted for hemoptysis and dyspnea. Chest radiography and computed tomography showed bilateral alveolar infiltration (PT-INR, 8.9). Bronchoalveolar lavage fluid (BALF) disclosed hemorrhagic features in sequential samples. And he was diagnosed with diffuse alveolar hemorrhage (DAH). A known interaction exists between fluoropyrimidines and warfarin. So, they were discontinued, and vitamin K was intravenously administered. One day later, the PT-INR returned to 1.14. The symptoms improved and, alveolar infiltration resolved after 2 weeks. Alveolar hemorrhage may be due to an interaction between UFT and warfarin. When fluoropyrimidines and warfarin are prescribed simultaneously, we recommend that PT-INR should be closely monitored.

scholarly journals Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Takashige Kiyota ◽  
Seiji Shiota ◽  
Ryosuke Hamanaka ◽  
Daisuke Tsutsumi ◽  
Takeshi Takakura ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Prothrombin Time ◽  
Persistent Infection ◽  
Warfarin Therapy ◽  
Anticoagulant Activity ◽  
International Normalized Ratio ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
High Resolution Computed Tomography

An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.

scholarly journals Actinomyces graevenitziiPulmonary Abscess Mimicking Tuberculosis in a Healthy Young Man

2014 ◽  
Vol 21 (6) ◽  
pp. e75-e77 ◽  
Author(s):  
Smaranda Gliga ◽  
Mathilde Devaux ◽  
Marine Gosset Woimant ◽  
Dominique Mompoint ◽  
Christian Perronne ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Clinical Samples ◽  
High Dose ◽  
Pulmonary Actinomycosis ◽  
History Of ◽  
Right Lobe

Pulmonary actinomycosis is a rare disease that is often misdiag-nosed as tuberculosis or lung cancer.Actinomyces graevenitziiis a relatively new recognizedActinomycesspecies isolated from various clinical samples. The authors report a case of pulmonary actinomycosis caused byA graevenitzii. A computed tomography examination revealed an excavated consolidation in the middle right lobe of a previously healthy young man who presented with a long history of moderate cough. Cultures of the bronchoalveolar lavage fluid confirmed the diagnosis of pulmonary abscess caused byA gravenitzii. At the three-month follow-up consultation and, after six weeks of high-dose amoxicillin, the pulmonary lesion had completely disappeared.

scholarly journals Metagenomic next-generation sequencing in the diagnosis of leptospirosis presenting as severe diffuse alveolar hemorrhage: a case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meiqin Chen ◽  
Weili Lu ◽  
Shugen Wu ◽  
Shun Wang ◽  
Tao Lu ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Complete Recovery ◽  
Lavage Fluid ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
Leptospira Interrogans ◽  
Next Generation ◽  
Generation Sequencing

Abstract Background Leptospirosis is a common infectious disease in tropical and semitropical regions, and it is typically neglected. Leptospirosis-associated acute diffuse alveolar hemorrhage is one of its fatal complications. The use of bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing in the diagnosis of Leptospira interrogans infection has rarely been reported. Case presentation We present the case of a 62-year-old female who was transferred to our hospital with dyspnea, and severe hemoptysis and was supported by a tracheal intubation ventilator. Bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) reported Leptospira interrogans. A diagnosis of diffuse alveolar hemorrhage caused by leptospirosis was made. After immediately receiving antibiotics and hormone therapy, the patient achieved a complete recovery upon discharge. Conclusion Leptospirosis presenting as severe diffuse alveolar hemorrhage is rare but should be considered in the differential diagnosis. mNGS can help identify pathogens and treat them early, which can improve prognosis.

scholarly journals Diffuse Alveolar Haemorrhage as Initial Presentation of Systemic Lupus Erythematosus

2018 ◽  
Vol 56 (214) ◽  
pp. 970-973
Author(s):  
Ashesh Dhungana ◽  
Prajowl Shrestha ◽  
Bhakta Dev Shrestha ◽  
Anil Baral ◽  
Gita Sayami
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
Alveolar Haemorrhage ◽  
Systemic Lupus ◽  
Fluid Analysis ◽  
Prompt Diagnosis

Diffuse alveolar hemorrhage results from accumulation of red blood cells in the alveolar space originating from alveolar capillaries. Alveolar hemorrhage in Systemic Lupus Erythematosus is rare but catastrophic and can rapidly progress to respiratory failure. We report a 22-year old lady who presented with dyspnoea on exertion, hemoptysis, bilateral leg swelling and oliguria. Diffuse alveolar hemorrhage was confirmed by bronchoalveolar lavage fluid analysis. Serologic tests and renal biopsy confirmed lupus nephritis. She was treated with systemic immunosuppressive therapy and plasma exchange, to which she had a favourable response. Lupus presenting as alveolar hemorrhage is rare which warrants prompt diagnosis and treatment to prevent complications.

scholarly journals Durvalumab-Induced Diffuse Alveolar Hemorrhage: An Autopsy Case Report

2020 ◽  
Vol 13 (2) ◽  
pp. 696-701
Author(s):  
Kensuke Kanaoka ◽  
Saori Ikebe ◽  
Shouichi Ihara ◽  
Hiromi Tsuji ◽  
Hironao Yasuoka ◽  
...  
Keyword(s):  
Lung Injury ◽  
Bronchoalveolar Lavage Fluid ◽  
Checkpoint Inhibitors ◽  
Diffuse Alveolar Damage ◽  
Ground Glass Opacity ◽  
Lavage Fluid ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
Rare Type ◽  
First Case

Durvalumab, a programmed cell death ligand 1 inhibitor, induces various immune-related adverse events (irAEs), including lung injury. However, diffuse alveolar hemorrhage (DAH) is a rare type of lung injury due to immune checkpoint inhibitors. A 76-year-old man with c-stage IIIA squamous cell carcinoma of the lung received maintenance durvalumab therapy after chemoradiotherapy. He developed dyspnea and malaise after 11 cycles of durvalumab. Chest computed tomography showed rapidly spreading bilateral ground-glass opacity in the lungs. We diagnosed DAH by hemosiderin-laden macrophages in bloody bronchoalveolar lavage fluid. Despite mechanical ventilation, steroids, and cyclophosphamide, he died of respiratory failure. The autopsy revealed that fresh and old bleeding areas coexisted, and neither pulmonary vasculitis nor diffuse alveolar damage was detected microscopically. Furthermore, CD3+ and CD8+ lymphocytes were observed in the lung interstitium, whereas CD20+ and CD4+ lymphocytes were scarcely detected. We report the first case of durvalumab-induced DAH. We should be alert to irAEs with DAH as a potential differential diagnosis of lung injury during durvalumab treatment.

52 The diagnosis value of neopterin measurement in serum and bronchoalveolar lavage fluid (BALF) in lung cancer

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S286
Author(s):  
Guzin Gursoy ◽  
Sibel Alpar ◽  
Nazire Ucar ◽  
Tulay Bakirci ◽  
Ahmet Aydin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid

A Case of Diffuse Alveolar Hemorrhage Due to Uncontrolled Warfarin Therapy

2012 ◽  
Vol 11 (2) ◽  
pp. 130-132 ◽  
Author(s):  
Turker Yardan ◽  
Ali Kemal Erenler ◽  
Selim Genc ◽  
Hizir Ufuk Akdemir
Keyword(s):  
Warfarin Therapy ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage
Sign in / Sign up

Export Citation Format

Share Document