scholarly journals Biological Responses to New Advanced Surface Modifications of Endosseous Medical Implants

2009 ◽  
Vol 2 ◽  
pp. BTRI.S3150 ◽  
Author(s):  
Weerachai Singhatanadgit
Keyword(s):  
Surface Modifications ◽  
Modern Medicine ◽  
Medical Implants ◽  
Implant Surface ◽  
Implantable Medical Devices ◽  
Implant Placement ◽  
Biological Responses ◽  
Wide Range ◽  
Tissue Responses ◽  
Surface Modification Techniques

Implantable medical devices are increasingly important in the practice of modern medicine. However, patients with severely poor bone quality and quantity require highest implant osseointegration for the long-term success. A number of newly-developed advanced surface modifications of medical implants have recently been introduced to the medical implant system. Understanding the mechanisms by which osteogenic cells respond to such materials is therefore of major importance in developing the most effective materials to promote functional osseointegration. Diverse studies using materials with a wide range of new surface modification techniques have demonstrated the pivotal role of surface treatments in cell adhesion, proliferation and lineage specific differentiation. These events underlie the tissue responses required for bone healing following implant placement, with the interaction between adsorbed proteins on the implant surface and surrounding cells eliciting body responses to the treated implant surface. This review illustrates tissue responses to the implant material following implant placement and highlights cellular responses to new advanced implant surface modifications. Such information is of utmost importance to further develop several new advanced surface modifications to be used in the new era medical implantable devices.

scholarly journals The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

2021 ◽  
Vol 10 (8) ◽  
pp. 1641
Author(s):  
Stefanie Kligman ◽  
Zhi Ren ◽  
Chun-Hsi Chung ◽  
Michael Angelo Perillo ◽  
Yu-Cheng Chang ◽  
...  
Keyword(s):  
Dental Implant ◽  
Biofilm Formation ◽  
Bacterial Colonization ◽  
Surface Modifications ◽  
Implant Surface ◽  
Oral Rehabilitation ◽  
Surface Design ◽  
Polyether Ether Ketone ◽  
Dental Implant Surface ◽  
The Impact

Implant surface design has evolved to meet oral rehabilitation challenges in both healthy and compromised bone. For example, to conquer the most common dental implant-related complications, peri-implantitis, and subsequent implant loss, implant surfaces have been modified to introduce desired properties to a dental implant and thus increase the implant success rate and expand their indications. Until now, a diversity of implant surface modifications, including different physical, chemical, and biological techniques, have been applied to a broad range of materials, such as titanium, zirconia, and polyether ether ketone, to achieve these goals. Ideal modifications enhance the interaction between the implant’s surface and its surrounding bone which will facilitate osseointegration while minimizing the bacterial colonization to reduce the risk of biofilm formation. This review article aims to comprehensively discuss currently available implant surface modifications commonly used in implantology in terms of their impact on osseointegration and biofilm formation, which is critical for clinicians to choose the most suitable materials to improve the success and survival of implantation.

Heparin-mediated antibiotic delivery from an electrochemically-aligned collagen sheet

2021 ◽  
pp. 1-12
Author(s):  
Olivia T. Cheng ◽  
Andrew P. Stein ◽  
Eric Babajanian ◽  
Kathryn R. Hoppe ◽  
Shawn Li ◽  
...  
Keyword(s):  
High Performance ◽  
Inhibitory Concentration ◽  
Medical Implants ◽  
Implantable Medical Devices ◽  
Antibiotic Solution ◽  
Inhibition Zones ◽  
Antibiotic Release ◽  
Local Antibiotic ◽  
Antibiotic Delivery

BACKGROUND: Implantable medical devices and hardware are prolific in medicine, but hardware associated infections remain a major issue. OBJECTIVE: To develop and evaluate a novel, biologic antimicrobial coating for medical implants. METHODS: Electrochemically compacted collagen sheets with and without crosslinked heparin were synthesized per protocol developed by our group. Sheets were incubated in antibiotic solution (gentamicin or moxifloxacin) overnight, and in vitro activity was assessed with five-day diffusion assays against Pseudomonas aeruginosa. Antibiotic release overtime from gentamicin infused sheets was determined using in vitro elution and high performance liquid chromatography (HPLC). RESULTS: Collagen-heparin-antibiotic sheets demonstrated larger growth inhibition zones against P. aeruginosa compared to collagen-antibiotic alone sheets. This activity persisted for five days and was not impacted by rinsing sheets prior to evaluation. Rinsed collagen-antibiotic sheets did not show any inhibition zones. Elution of gentamicin from collagen-heparin-gentamicin sheets was slow and remained above the minimal inhibitory concentration for gentamicin sensitive organisms for 29 days. Conversely, collagen-gentamicin sheets eluted their antibiotic payload within 24 hours. Overall, heparin associated sheets demonstrated larger inhibition zones against P. aeruginosa and prolonged elution profile via HPLC. CONCLUSION: We developed a novel, local antibiotic delivery system that could be used to coat medical implants/hardware in the future and reduce post-operative infections.

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020 ◽  
Vol 61 (6) ◽  
pp. 177-187
Author(s):  
Till Kämmerer ◽  
Tony Lesmeister ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Statistical Difference ◽  
Surface Modifications ◽  
Titanium Implants ◽  
In Vivo Model ◽  
Implant Surface ◽  
Press Fit ◽  
Endosseous Implant ◽  
Bone To Implant Contact

Introduction: We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. Materials and Methods: A total of 36 cylindrical press-fit implants with two different surfaces (CaP, n = 18; SA, n = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). Results: After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. Conclusion: Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.

scholarly journals Erratum to: Biomechanical and histological evaluation of four different titanium implant surface modifications: an experimental study in the rabbit tibia

2015 ◽  
Vol 19 (7) ◽  
pp. 1699-1699 ◽  
Author(s):  
José Luis Calvo-Guirado ◽  
Marta Satorres ◽  
Bruno Negri ◽  
Piedad Ramirez-Fernandez ◽  
Jose Eduardo Maté-Sánchez de Val ◽  
...  
Keyword(s):  
Experimental Study ◽  
Titanium Implant ◽  
Surface Modifications ◽  
Histological Evaluation ◽  
Implant Surface ◽  
Rabbit Tibia ◽  
Titanium Implant Surface

scholarly journals Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Matthew E Cockman ◽  
Kerstin Lippl ◽  
Ya-Min Tian ◽  
Hamish B Pegg ◽  
William D Figg ◽  
...  
Keyword(s):  
Oxygen Sensors ◽  
Prolyl Hydroxylase ◽  
Hydroxylase Activity ◽  
Recombinant Enzymes ◽  
Animal Cells ◽  
Prolyl Hydroxylases ◽  
Biological Responses ◽  
Wide Range ◽  
Prolyl Hydroxylation ◽  
Hif Prolyl Hydroxylase

Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enzymes as oxygen sensors raises a key question as to the existence and nature of non-HIF substrates, potentially transducing other biological responses to hypoxia. Over 20 such substrates are reported. We therefore sought to characterise their reactivity with recombinant PHD enzymes. Unexpectedly, we did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide, using conditions supporting robust HIF-α hydroxylation. We cannot exclude PHD-catalysed prolyl hydroxylation occurring under conditions other than those we have examined. However, our findings using recombinant enzymes provide no support for the wide range of non-HIF PHD substrates that have been reported.

scholarly journals Immediate Implant Placement in Infected Sockets: A Consecutive Cohort Study

2020 ◽  
Vol 11 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Ashish Kakar ◽  
Kanupriya Kakar ◽  
Minas D. Leventis ◽  
Gaurav Jain
Keyword(s):  
Bone Graft ◽  
Clinical Results ◽  
Bone Graft Substitute ◽  
Graft Material ◽  
Success Rates ◽  
Implant Surface ◽  
Implant Placement ◽  
Immediate Placement ◽  
Immediate Implant

Introduction: Immediate placement of implants in a fresh post-extraction socket is an increasingly popular and established treatment option. However, active infection in the extraction site may adversely affect the outcome of this procedure. This study was designed to assess the clinical results of immediate placement of dental implants in infected extraction sockets using a standardized protocol, which included (a) the use of an Er,Cr:YSGG laser for the decontamination of the infected socket prior to implant insertion, and (b) the utilization of an in situ hardening alloplastic bone graft substitute to augment the gap between the implant surface and the labial plate of bone. Patients and Methods: A retrospective record review was used to identify 68 patients who had implants placed as per the described protocol. A total of 126 implants were placed in 68 patients (65 implants in the maxilla, 61 implants in the mandible). The implants were loaded 136 ± 73 days (mean ± standard deviation; range: 37–400 days) after implant placement. Eight patients (16 implants) were subsequently lost to follow up. Results: 105 of the 110 implants (95.45%) placed immediately in the infected sites using the described protocol survived after prosthetic loading. Conclusion: Immediate implant placement in previously infected sites using the protocols mentioned in our study with laser decontamination of the socket, grafting with an in situ hardening alloplastic bone graft material and non-submerged healing shows a similar survival rate to the published success rates for immediate implants placed in non-infected sites.

Influence of conventional and extended CT scale range on quantification of Hounsfield units of medical implants and metallic objects

2018 ◽  
Vol 85 (5) ◽  
pp. 343-350 ◽  
Author(s):  
Zehra Ese ◽  
Marcel Kressmann ◽  
Jakob Kreutner ◽  
Gregor Schaefers ◽  
Daniel Erni ◽  
...  
Keyword(s):  
Artifact Reduction ◽  
Metal Artifact Reduction ◽  
Metallic Materials ◽  
Dose Calculations ◽  
Medical Implants ◽  
Hounsfield Units ◽  
Implantable Medical Devices ◽  
Cardioverter Defibrillator ◽  
Accurate Dose ◽  
Scale Range

Abstract We report on the suitability of two different ranges of Hounsfield units (HU) in computed tomography (CT) for the quantification of metallic components of active implantable medical devices (AIMD). The conventional Hounsfield units (CHU) range, which is traditionally used in radiology, is well suited for tissue but suspected inappropriate for metallic materials. Precise HU values are notably beneficial in radiotherapy (RT) for accurate dose calculations, thus for the safety of patient carrying implants. Some of today’s CT machines offers an extended Hounsfield units (EHU) range. This study presents CT acquisitions of a water phantom containing various metallic discs and an implantable-cardioverter defibrillator (IPG). We show that the comparison of HU values at EHU and CHU ranges clearly reveals the superiority and accuracy of EHU. Some geometrical discrepancies perpendicular to slices are observed. At EHU metal artifact reduction algorithms (MAR) underestimates HU values rendering MAR potentially inappropriate for RT.

Biological and medicinal application of Cucumis sativus Linn. – review of current status with future possibilities

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anayatullah Khan ◽  
Anuradha Mishra ◽  
Syed Misbahul Hasan ◽  
Afreen Usmani ◽  
Mohd Ubaid ◽  
...  
Keyword(s):  
Cucumis Sativus ◽  
Cost Effective ◽  
Pharmacological Action ◽  
Modern Medicine ◽  
Current Status ◽  
Synthetic Drugs ◽  
Wide Range ◽  
Increasing Demand ◽  
Calcium Iron ◽  
Whole Plants

Abstract Objectives The increasing demand for herbal drugs for the human application is causing a growing demand for the cultivation of Medicinal Plants. This demand has developed because of cost-effective, plant-derived products rather than commercially available synthetic drugs. Cucumis sativus Linn. (Ver. Kheera) is a vegetable climber, species belongs to family Cucurbitaceae This species has a wide range of medicinal and biological applications thanks to its richness in carbohydrate, proteins, minerals (calcium, iron, magnesium, phosphorus, potassium, zinc) and secondary metabolites like alkaloids, tannins, flavonoids, saponins, and phenolic compounds These phytoconstituents may be responsible for allied therapeutic application. So, C. sativus possess wider applications for preventing certain ailments. Content The literature in various national and international journals and reports pertaining to the medicinal and nutritional uses were reviewed. The result revealed the current therapeutic applications of C. sativus whole plants other than the nutritional value. C. sativus pharmacological action includes antioxidant, anti-diabetic, UV protectant, hepatoprotective, gastroprotective, anti-helminthic, wound healing, antimicrobial, and anticancer. So, it could be useful for both preventive and additive therapy along with modern medicine for the better management of certain disorders. Summary and Outlook This review furnishes updated information about the phytoconstituents and their medicinal applications so that it can pose a path for the young researchers to do future findings.

Laser Additive Manufacturing of Titanium-Based Implants

2016 ◽  
pp. 236-247
Author(s):  
Martin Ruthandi Maina
Keyword(s):  
Physical And Mechanical Properties ◽  
Additive Manufacture ◽  
Medical Implants ◽  
Unique Combination ◽  
Manufacture Process ◽  
Wide Range ◽  
Biomedical Industry ◽  
Manufacturing Techniques ◽  
Biological Performance ◽  
Selective Addition

Titanium and its alloys exhibit a unique combination of mechanical, physical properties and corrosion resistance behaviour which makes them desirable for aerospace, industrial, chemical, medical and energy industries. The selective addition of alloying elements to titanium enables a wide range of physical and mechanical properties to be obtained. Ti-based alloys are finding ever-increasing applications in biomaterials due to their excellent mechanical, physical and biological performance. Intense researches are being pursued in the development of new Ti-based alloys with bio-functionalization closer to human bone, owing to their excellent mechanical strength and resilience when compared to alternative biomaterials, such as polymers and ceramics. Several manufacturing techniques are capable of producing porous materials. There is a need to control pore size, shape, orientation and distribution. This work reviews the application of Ti-based alloys in the biomedical industry and also proposes laser additive manufacture process for the manufacture of medical implants.

scholarly journals An Overview on the Tribological Performance of Titanium Alloys with Surface Modifications for Biomedical Applications

Lubricants ◽  
2019 ◽  
Vol 7 (8) ◽  
pp. 65 ◽  
Author(s):  
Kaur ◽  
Ghadirinejad ◽  
Oskouei
Keyword(s):  
Wear Resistance ◽  
Corrosion Resistance ◽  
Titanium Alloys ◽  
Weight Ratio ◽  
High Strength ◽  
Surface Modifications ◽  
Tribological Performance ◽  
The Body ◽  
High Wear Resistance ◽  
Medical Implants

The need for metallic biomaterials will always remain high with their growing demand in joint replacement in the aging population. This creates need for the market and researchers to focus on the development and advancement of the biometals. Desirable characteristics such as excellent biocompatibility, high strength, comparable elastic modulus with bones, good corrosion resistance, and high wear resistance are the significant issues to address for medical implants, particularly load-bearing orthopedic implants. The widespread use of titanium alloys in biomedical implants create a big demand to identify and assess the behavior and performance of these alloys when used in the human body. Being the most commonly used metal alloy in the fabrication of medical implants, mainly because of its good biocompatibility and corrosion resistance together with its high strength to weight ratio, the tribological behavior of these alloys have always been an important subject for study. Titanium alloys with improved wear resistance will of course enhance the longevity of implants in the body. In this paper, tribological performance of titanium alloys (medical grades) is reviewed. Various methods of surface modifications employed for titanium alloys are also discussed in the context of wear behavior.

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