Cons and Pros of Epidemiological Versus Experimental Approaches to Answer Questions About Risk and Protective Factors for Alzheimer’s Disease: A Personal Journey

2018 ◽  
Author(s):  
Krister Håkansson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protective Factors ◽  
Risk And Protective Factors ◽  
Personal Journey ◽  
Experimental Approaches

scholarly journals The Prevalence of Alzheimer’s Disease; its Risk and Protective Factors Among the Elderly Population in Iran

2017 ◽  
Vol 18 (9) ◽  
Author(s):  
Sakineh Gholamzadeh ◽  
Banafsheh Heshmati ◽  
Arash Mani ◽  
Peyman Petramfar ◽  
Zahra Baghery
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protective Factors ◽  
Elderly Population ◽  
The Elderly ◽  
Risk And Protective Factors

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

2018 ◽  
Vol 14 (9) ◽  
pp. 1126-1136 ◽  
Author(s):  
Stefan J. Teipel ◽  
Enrica Cavedo ◽  
Simone Lista ◽  
Marie-Odile Habert ◽  
Marie-Claude Potier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protective Factors ◽  
Disease Risk ◽  
Risk And Protective Factors ◽  
Subjective Memory

scholarly journals Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer’s Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia

2020 ◽  
Vol 17 (20) ◽  
pp. 7475
Author(s):  
Chih-Yun Kuo ◽  
Ivo Stachiv ◽  
Tomas Nikolai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protective Factors ◽  
Social Engagement ◽  
Late Life ◽  
Risk And Protective Factors ◽  
Late Life Depression ◽  
Prodromal Stage ◽  
Prevention And Treatment ◽  
Depressive Syndromes

The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease; depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied. It has been proposed that to understand mechanisms of dementia and Alzheimer’s disease pathogeneses require their multifactorial nature represented by these multiple factors to be considered. In this review, we first summarize the recent literature findings on roles of the late life depression and the other known (non-)modifiable risk and possibly protective factors in development of dementia and Alzheimer’s disease. Then, we provide evidences supporting hypotheses that (i) depressive syndromes in late life may indicate the prodromal stage of dementia (Alzheimer’s disease) and, (ii) the interplay among the multiple (non-)modifiable risk and protective factors should be considered to gain a better understanding of dementia and Alzheimer’s disease pathogeneses. We also discuss the evidences of recently established interventions considered to prevent or delay the prodromes of dementia and provide the prospective future directions in prevention and treatment of dementia and Alzheimer’s disease using both the single-domain and multidomain interventions.

scholarly journals Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population‐based longitudinal study

2021 ◽  
Vol 17 (2) ◽  
pp. 191-204
Author(s):  
Rui Wang ◽  
Chengxuan Qiu ◽  
Christina S. Dintica ◽  
Ying Shang ◽  
Amaia Calderón Larrañaga ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ischemic Stroke ◽  
Longitudinal Study ◽  
Protective Factors ◽  
Risk And Protective Factors ◽  
Population Based ◽  
Shared Risk

Smoking and oestrogen-replacement therapy as protective factors for Alzheimer's disease

The Lancet ◽  
1997 ◽  
Vol 349 (9049) ◽  
pp. 403-404 ◽  
Author(s):  
Alan Lerner ◽  
Elisabeth Koss ◽  
Sara Debanne ◽  
Douglas Rowland ◽  
Kathleen Smyth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protective Factors ◽  
Replacement Therapy ◽  
Oestrogen Replacement Therapy
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