Vitamin D3, L-Arginine, L-Citrulline, and antioxidant supplementation enhances nitric oxide bioavailability and reduces oxidative stress in the vascular endothelium – Clinical implications for cardiovascular system

2020 ◽  
Vol 12 (1) ◽  
pp. 17
Author(s):  
Tadeusz Malinski ◽  
Hazem Dawoud
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular System ◽  
Vitamin D3 ◽  
Vascular Endothelium ◽  
Clinical Implications ◽  
Antioxidant Supplementation ◽  
Nitric Oxide Bioavailability

Mercury Exposure and Endothelial Dysfunction

2015 ◽  
Vol 34 (4) ◽  
pp. 300-307 ◽  
Author(s):  
Swati Omanwar ◽  
M. Fahim
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Vascular Endothelium ◽  
Circulatory System ◽  
Vital Role ◽  
Mercury Exposure ◽  
And Function ◽  
The Impact ◽  
And Oxidative Stress

Vascular endothelium plays a vital role in the organization and function of the blood vessel and maintains homeostasis of the circulatory system and normal arterial function. Functional disruption of the endothelium is recognized as the beginning event that triggers the development of consequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. There is a growing data associating mercury exposure with endothelial dysfunction and higher risk of CVD. This review explores and evaluates the impact of mercury exposure on CVD and endothelial function, highlighting the interplay of nitric oxide and oxidative stress.

Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats

Alcohol ◽  
2015 ◽  
Vol 49 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Natalia A. Gonzaga ◽  
André S. Mecawi ◽  
José Antunes-Rodrigues ◽  
Bruno S. De Martinis ◽  
Claudia M. Padovan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Ethanol Withdrawal ◽  
Nitric Oxide Bioavailability

Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability

Life Sciences ◽  
2015 ◽  
Vol 143 ◽  
pp. 89-97 ◽  
Author(s):  
Vinicius Bermond Marques ◽  
Tatiani Botelho Nascimento ◽  
Rogério Faustino Ribeiro ◽  
Gilson Brás Broseghini-Filho ◽  
Emilly Martinelly Rossi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Iron Overload ◽  
Vascular Reactivity ◽  
Nitric Oxide Bioavailability

scholarly journals Nitric Oxide and Oxidative Stress-Mediated Cardiovascular Functionality: From Molecular Mechanism to Cardiovascular Disease

2020 ◽  
Author(s):  
Weilue He ◽  
Maria Paula Kwesiga ◽  
Eyerusalem Gebreyesus ◽  
Sijia Liu
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular System ◽  
Molecular Mechanism ◽  
Molecular Mechanisms ◽  
Contractile Function ◽  
Muscle Relaxation ◽  
Redox Balance ◽  
Heart Infarction ◽  
Artery Disease

The underlying pathology of most cardiovascular diseases (CVDs) such as coronary artery disease, high blood pressure, and stroke involves decreased cardiovascular contractility and anatomic alterations in cardiovascular structures. Nitric oxide (NO) regulates vascular tone and contractile function of myocardium and maintains blood vessel homeostasis. Interestingly, the effect of NO is like a double-edged sword in the body. Insufficient NO causes hypertension and atherosclerosis, while an overproduction of NO may foster inflammation and cause heart infarction and shock. In addition, growing evidences have shown that oxidative stress plays pivotal roles in the initiation and progression of CVDs. This chapter will discuss in detail the roles NO plays in the cardiovascular system under both physiological and pathological conditions. We will focus on: (1) the molecular mechanism of cardiovascular contraction, (2) NO/Ca2+-induced muscle relaxation, (3) NO-related structural change in blood vessels, and (4) redox balance in the cardiovascular system. The relationships between these molecular mechanisms and the characteristics of CVDs will be highlighted.

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