Evaluation of the protective effect of ethanolic extract of seed kernel of Caesalpinia bonducella Flem (EECB) on forced swimming-induced chronic fatigue syndrome in mice

2019 ◽  
Vol 11 (3) ◽  
pp. 254
Author(s):  
Phulen Sarma ◽  
Mukundam Borah ◽  
Swarnamoni Das
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Chronic Fatigue ◽  
Forced Swimming ◽  
Seed Kernel ◽  
Fatigue Syndrome ◽  
Caesalpinia Bonducella

scholarly journals EVALUATION OF THE PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF LEAVES OF PUNICA GRANATUM LINN. ON FORCED SWIMMING INDUCED CHRONIC FATIGUE SYNDROME IN MICE

2016 ◽  
Vol 9 (1) ◽  
pp. 207
Author(s):  
Tarali Devi ◽  
Swarnamoni Das
Keyword(s):  
Locomotor Activity ◽  
Chronic Fatigue Syndrome ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Punica Granatum ◽  
Chronic Fatigue ◽  
Control Group ◽  
Stress Control ◽  
Fatigue Syndrome ◽  
Group A

<p><strong>Objective: </strong>To study the protective effect of ethanolic extract of leaves of <em>Punica granatum</em> Linn. (EEPG) on forced swimming induced chronic fatigue syndrome (CFS) in mice.</p><p><strong>Methods</strong>:<strong> </strong>Male albino mice of 25-40 grams were grouped into five groups taking 5 mice in each. Group A served as naïve control, Group B as stress control, Group C and D received EEPG at a dose of 100 mg/kg and 200 mg/kg respectively. Group E was given a standard drug (Imipramine 20 mg/kg). All animals received their respective agent orally daily for 7 d. Except for group A animals, animals in all other groups were subjected to force swimming 6 min daily for 7 d to induce a state of chronic fatigue. Animals were assessed for the duration of immobility on day 1<sup>st</sup>, 3<sup>rd</sup>, 5<sup>th</sup> and 7<sup>th</sup>. Level of anxiety (elevated plus maze and mirrored chamber test) and locomotor activity (open field test) were assessed 24 h after last force swimming which was followed by estimation of oxidative biomarkers in brain homogenate.</p><p><strong>Results</strong>:<strong> </strong>Treatment with EEPG (100 mg/kg and 200 mg/kg) and imipramine resulted in a statistically significant (p≤0.05) reduction in anxiety and duration of immobility and there was a significant increase in locomotor activity when compared to stress control group. Significant reduction in MDA level and increase in catalase level were seen in EEPG and imipramine-treated group compared to stress control group.<strong></strong></p><p><strong>Conclusion</strong>:<strong> </strong>The study confirmed that EEPG has protective action effect against experimentally induced CFS.</p>

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters

2020 ◽  
Vol 38 (2) ◽  
pp. 359-369
Author(s):  
Vandana Thakur ◽  
Sumit Jamwal ◽  
Mandeep Kumar ◽  
Vikrant Rahi ◽  
Puneet Kumar
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Protective Effect ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice

2019 ◽  
Vol 42 (7) ◽  
pp. 1140-1145 ◽  
Author(s):  
Takuya Ohba ◽  
Shinichi Domoto ◽  
Miyu Tanaka ◽  
Shinsuke Nakamura ◽  
Masamitsu Shimazawa ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Forced Swimming ◽  
Fatigue Syndrome

scholarly journals PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Fangnan Wu ◽  
Chaolu Huder ◽  
Zhenjun Tian
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Intervention Group ◽  
Tail Suspension Test ◽  
Serum Testosterone ◽  
Chronic Fatigue ◽  
Forced Swimming ◽  
Control Group ◽  
Stress System ◽  
Fatigue Syndrome ◽  
Antioxidant Stress

Objective To investigate the effects of exogenous VD3 on exercise-induced chronic fatigue syndrome (CFS) and its mechanism. Methods 80 male mice were randomly divided into 5 groups（n=16）. One group was named as quiet control group (C) while the other four were used to build CFS model by forced swimming. Among the four groups, three were selected for feeding VD3 1 h before exercise (bVD), 15 min after starting exercise (mVD) and 1 h after exercise (aVD) respectively, and the group without VD3 feeding was CFS model group (CFS). The behavior and condition of mice was observed during the whole process. After the training was completed totally, the tail suspension test and the forced swimming test were implemented, and then the blood and quadriceps were dissected. Serum testosterone and corticosterone content, as well as the antioxidant system indexes in the quadriceps, including malondialdehyde (MDA), total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD), were measured. Routine western blotting experimentation was used to measure signal pathway indicators, containing SIRT1, SIRT3, ERK1/2, p-ERK1/2 and MEK1/2. Results Compared with C group, CFS group appeared serious damage caused by fighting, and the concentration of serum testosterone decreased significantly (p<0.01 or p<0.05) while cortisol concentration increased significantly (p<0.01 or p<0.05). Regarding antioxidant stress system indexes, the expression of MDA, T-SOD and GSH-PX significantly increased (p<0.05). The concentration of MEK and SIRT3 decreased significantly (p<0.01 or p<0.05). Compared with CFS group, VD intervention group (bVD, mVD and aVD) showed less damage caused by fighting and significantly lighter body weight (p<0.05), and the concentration of serum testosterone increased significantly (p<0.05) while that of cortisol decreased significantly (p<0.01 or p<0.05). The expression of MDA decreased significantly (p<0.05), on the countrary, T-AOC, T-SOD and GSH-PX increased significantly (p<0.05). The expressions of MEK, p-ERK/ERK, SIRT1 and SIRT3 were significantly upregulated (p<0.01 or p<0.05). Conclusions Exogenous VD3 could alleviate CFS, which probably related to activate the MEKs/ERKs-SIRT1 signal transduction axis and hence regulate the expression of SIRT3.

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome
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