Simultaneous determination of two diterpenoids, continentalic acid and kaurenoic acid, in the water extract of Aralia continentalis and their wound-healing activity

2020 ◽  
Vol 16 (72) ◽  
pp. 745
Author(s):  
SeungHyun Kim ◽  
Guijae Yoo ◽  
TaekHwan Lee ◽  
JaeHyuk Lee ◽  
KyoBin Kang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Simultaneous Determination ◽  
Water Extract ◽  
Aralia Continentalis ◽  
Kaurenoic Acid ◽  
Continentalic Acid ◽  
Wound Healing Activity

Determination of the wound-healing activity of a gel cream containing a synthetic selenoxanthene derivative

2021 ◽  
Vol 70 (5) ◽  
pp. 43-47
Author(s):  
Daniil Vladimirovich Zayats ◽  
Olga Vladimirovna Buyuklinskaya ◽  
Kenes Tagaevich Erimbetov ◽  
Olga Vladimirovna Khoreva ◽  
Nicolay Sergeevich Felenko
Keyword(s):  
Wound Healing ◽  
Wound Healing Activity

scholarly journals Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Sijia Gao ◽  
Xuelin Zhou ◽  
Liwei Lang ◽  
Honghong Liu ◽  
Jianyu Li ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Simultaneous Determination ◽  
Water Extract ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Interaction Study ◽  
Triple Quadrupole Mass Spectrometer ◽  
Drug Interaction Study ◽  
Limit Of Quantification

This study aimed to develop a selective, simple, and sensitive HPLC-MS/MS method for the simultaneous determination of schisandrin and promethazine (PMZ) with its metabolite in rat plasma, which was further used for a pharmacokinetic herb-drug interaction study. HPLC-MS/MS analyses were performed on an Agilent Technologies 1290 LC and a 6410 triple quadrupole mass spectrometer. The following parameters, the lower limit of quantification (LLOQ), calibration curve, accuracy, precision, stability, matrix effect, and recovery, were validated. The linear range of the developed method for PMZ, its metabolite promethazine sulfoxide (PMZSO), and schisandrin in rat plasma was 0.5–200 ng/mL (R2 > 0.995), with an LLOQ of 0.5 ng/mL, which completely met the determination requirements of biosamples. The intra- and interday precision (RSD, %) was below 13.31% (below 16.67% for the LLOQ) in various plasma, whose accuracy (bias, %) was from −8.52% to 11.40%, which were both within an acceptable range. This method was successfully applied to a pharmacokinetic herb-drug interaction study after oral administration of PMZ with or without S. chinensis water extract. The results demonstrated that coadministration with the S. chinensis water extract might affect the pharmacokinetic behaviors of PMZ. In turn, when taken together with PMZ, the pharmacokinetic parameters of schisandrin, the main active component of S. chinensis, were also affected. The method established in the current study was selective, simple, sensitive, and widely available with good linearity, high accuracy and precision, and a stable sample preparation process. Moreover, this analytical method provides a significant approach for the investigation of herb-drug interaction between S. chinensis and PMZ. The potential pharmacokinetic herb-drug interaction of PMZ- and schisandrin-containing preparations should be noted.

scholarly journals Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Sara H. Freiesleben ◽  
Jens Soelberg ◽  
Nils T. Nyberg ◽  
Anna K. Jäger
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Plant Species ◽  
Cold Water ◽  
Water Extract ◽  
Scratch Assay ◽  
3T3 Fibroblasts ◽  
Nih 3T3 ◽  
Wound Healing Activity

The present study was carried out to investigate the wound healing potentials of 17 medicinal plants historically used in Ghana for wound healing. Warm and cold water extracts were prepared from the 17 dried plant species and tested in vitro in the scratch assay with NIH 3T3 fibroblasts from mice. The wound healing scratch assay was used to evaluate the effect of the plants on cell proliferation and/or migration in vitro, as a test for potential wound healing properties. After 21 hours of incubation increased proliferation and/or migration of fibroblasts in the scratch assay was obtained for 5 out of the 17 plant species. HPLC separation of the most active plant extract, which was a warm water extract of Philenoptera cyanescens, revealed the wound healing activity to be attributed to rutin and a triglycoside of quercetin. The present study suggests that Allophylus spicatus, Philenoptera cyanescens, Melanthera scandens, Ocimum gratissimum, and Jasminum dichotomum have wound healing activity in vitro.

scholarly journals Determination of Wound Healing Activity of Shark Liver Oil using Burn Wound Model in Wistar Rats

2021 ◽  
Vol 13 (2) ◽  
pp. 113-117
Author(s):  
Samiullah Allahbaksh Auti ◽  
Rakesh Kumar Jat ◽  
Supriya Kumar Das ◽  
Shukla ST Shukla
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Burn Wound ◽  
Shark Liver Oil ◽  
Wound Model ◽  
Wound Healing Activity
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