scholarly journals Dosimetric analysis and acute toxicity comparison of bone marrow sparing intensity-modulated radiation therapy versus three-Dimensional conformal therapy with concurrent chemotherapy for the treatment of cervical carcinoma: A prospective single institutional study

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Ghritashee Bora ◽  
ApurbaKumar Kalita ◽  
Mouchumee Bhattacharyya ◽  
MoirangthemNara Singh ◽  
ParthaPratim Medhi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Radiation Therapy ◽  
Acute Toxicity ◽  
Three Dimensional ◽  
Intensity Modulated Radiation Therapy ◽  
Concurrent Chemotherapy ◽  
Intensity Modulated ◽  
Conformal Therapy ◽  
Bone Marrow Sparing ◽  
Dosimetric Analysis

Four-dimensional computed tomography-based respiratory-gated whole-abdominal intensity-modulated radiation therapy for ovarian cancer: a feasibility study

2007 ◽  
Vol 17 (1) ◽  
pp. 55-60 ◽  
Author(s):  
A. A. Garsa ◽  
R. S. Andrade ◽  
D. E. Heron ◽  
S. Beriwal ◽  
H. Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Bone Marrow ◽  
Radiation Therapy ◽  
Three Dimensional ◽  
Intensity Modulated Radiation Therapy ◽  
Target Volume ◽  
Subacute Toxicity ◽  
Intensity Modulated ◽  
The Mean ◽  
Grade 3

This study assesses the feasibility and implementation of respiratory-gated whole-abdominal intensity-modulated radiation therapy (RG-WAIMRT). Three patients were treated with RG-WAIMRT. The planning target volume (PTV1) included the entire peritoneal cavity and a pelvic boost field was created (PTV2). The dose prescribed was 30 Gy to PTV1 and 14.4 Gy to PTV2. For comparison, a conventional three-dimensional (3D) plan was generated for each patient. In the WAIMRT plan, an average of 90% of PTV1 received 30 Gy compared to 70% for the conventional 3D plan. The percent volume receiving 30 Gy (V30) for liver averaged 54% (WAIMRT) vs 43% (3D). The percent volume receiving 20 Gy (V20) for kidneys averaged 19% vs 0%, and the mean V20 for bone marrow was 74% vs 83%, respectively. Major acute toxicities were anemia (grade 2: 1/3), leukopenia (grade 3: 2/3 patients), and thrombocytopenia (grade 2: 1/3 patients, grade 3: 1/3 patients). One patient could not complete the whole-abdomen field after 19.5 Gy because of persistent nausea. No major subacute toxicity has been reported. WAIMRT demonstrated superior target coverage and reduced dose to bone marrow, with a slightly increased dose to liver and kidneys. WAIMRT is a novel and feasible technique for ovarian cancer treatment.

scholarly journals Feasibility of atlas-based active bone marrow sparing intensity modulated radiation therapy for cervical cancer

2017 ◽  
Vol 123 (2) ◽  
pp. 325-330 ◽  
Author(s):  
Nan Li ◽  
Sonal S. Noticewala ◽  
Casey W. Williamson ◽  
Hanjie Shen ◽  
Igor Sirak ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Bone Marrow ◽  
Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Intensity Modulated ◽  
Bone Marrow Sparing
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