scholarly journals Hybrid therapy versus sequential therapy for eradication of Helicobacter pylori: A randomized controlled trial

2017 ◽  
Vol 8 (2) ◽  
pp. 62 ◽  
Author(s):  
Vikram Kate ◽  
Sahoo Ashokkumar ◽  
Sonia Agrawal ◽  
Jharna Mandal ◽  
Sathasivam Sureshkumar ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Helicobacter Pylori ◽  
Controlled Trial ◽  
Sequential Therapy ◽  
Hybrid Therapy ◽  
Randomized Controlled

scholarly journals Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting?

2017 ◽  
Vol 30 (3) ◽  
pp. 185 ◽  
Author(s):  
Pedro Boal Carvalho ◽  
Joana Magalhães ◽  
Francisca Dias de Castro ◽  
Bruno Rosa ◽  
José Cotter
Keyword(s):  
Randomized Controlled Trial ◽  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Eradication Rate ◽  
Controlled Trial ◽  
Sequential Therapy ◽  
First Line ◽  
Portuguese Population ◽  
Helicobacter Pylori Eradication ◽  
Randomized Controlled

Introduction: Helicobacter pylori eradication has become increasingly difficult as resistances to several antibiotics develop. We aimed to compare Helicobacter pylori eradication rates between triple therapy and sequential therapy in a naive Portuguese population.Material and Methods: Prospective randomized trial including consecutive patients referred for first-line Helicobacter pylori eradication treatment. Exclusion criteria: previous gastric surgery/neoplasia, pregnancy/lactancy, allergy to any of the drugs. The compared eradication regimens were triple therapy (pantoprazol, amoxicillin and clarithromycin 12/12 hours, 14 days) and sequential therapy (pantoprazol 12/12 hours for 10 days, amoxicillin 12/12 hours for days 1 - 5 and clarithromycin plus metronidazol 12/12 hours during days 6 - 10). Eradication success was confirmed with urea breath test. Statistical analysis was performed with SPSS v21.0 and a p-value < 0.05 was considered statistically significant.Results: Included 60 patients, 39 (65%) female with mean age 52 years (SD ± 14.3). Treatment groups were homogeneous for gender, age, indication for treatment and smoking status. No statistical differences were encountered between sequential and triple therapy eradication rates (86.2% vs 77.4%, p = 0.379), global eradication rate was 82%. Tobacco consumption was associated with a significantly lower eradication success (54.5 vs 87.8%, p = 0.022).Discussion: In this randomized controlled trial in a naive Portuguese population, we found a satisfactory global Helicobacter pylori eradication rate of 82%, with no statistical differences observed in the efficacy of the treatment between triple and sequential regimens.Conclusion: These results support the use of either therapy for the first-line eradication of Helicobacter pylori.

scholarly journals Efficacy of Helicobacter pylori eradication regimens in Rwanda: a randomized controlled trial

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jean Damascene Kabakambira ◽  
Celestin Hategeka ◽  
Cameron Page ◽  
Cyprien Ntirenganya ◽  
Vincent Dusabejambo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Helicobacter Pylori ◽  
Controlled Trial ◽  
Helicobacter Pylori Eradication ◽  
Randomized Controlled
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