Mesalamine-loaded mucoadhesive microsphere for colon drug delivery system: Effect of process variables and in vitro characterization

2018 ◽  
Vol 8 (2) ◽  
pp. 74 ◽  
Author(s):  
Anup Patil ◽  
Pravin Pawar ◽  
Varsha Gharge ◽  
Ujjwala Doltade ◽  
Rajendra Doijad
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Process Variables ◽  
System Effect ◽  
In Vitro Characterization ◽  
Colon Drug Delivery ◽  
Mucoadhesive Microsphere

scholarly journals Formulation and in Vitro Characterization of a Novel Solid Lipid-Based Drug Delivery System

2014 ◽  
Vol 62 (12) ◽  
pp. 1173-1179 ◽  
Author(s):  
Hongxing Ma ◽  
Mingjuan Chu ◽  
Kiyoshi Itagaki ◽  
Ping Xin ◽  
Xuegang Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid ◽  
In Vitro Characterization

scholarly journals Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma

2018 ◽  
Vol 19 (11) ◽  
pp. 3670 ◽  
Author(s):  
Elisa Martella ◽  
Claudia Ferroni ◽  
Andrea Guerrini ◽  
Marco Ballestri ◽  
Marta Columbaro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Physicochemical Characterization ◽  
Model Systems ◽  
Drug Induced ◽  
In Vitro Characterization ◽  
Superior Effect ◽  
Induced Aggregation

Osteosarcoma therapy might be moving toward nanotechnology-based drug delivery systems to reduce the cytotoxicity of antineoplastic drugs and improve their pharmacokinetics. In this paper, we present, for the first time, an extensive chemical and in vitro characterization of dual-loaded photo- and chemo-active keratin nanoparticles as a novel drug delivery system to treat osteosarcoma. The nanoparticles are prepared from high molecular weight and hydrosoluble keratin, suitably functionalized with the photosensitizer Chlorin-e6 (Ce6) and then loaded with the chemotherapeutic drug Paclitaxel (PTX). This multi-modal PTX-Ce6@Ker nanoformulation is prepared by both drug-induced aggregation and desolvation methods, and a comprehensive physicochemical characterization is performed. PTX-Ce6@Ker efficacy is tested on osteosarcoma tumor cell lines, including chemo-resistant cells, using 2D and 3D model systems. The single and combined contributions of PTX and Ce6 is evaluated, and results show that PTX retains its activity while being vehiculated through keratin. Moreover, PTX and Ce6 act in an additive manner, demonstrating that the combination of the cytostatic blockage of PTX and the oxidative damage of ROS upon light irradiation have a far superior effect compared to singularly administered PTX or Ce6. Our findings provide the proof of principle for the development of a novel, nanotechnology-based drug delivery system for the treatment of osteosarcoma.

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