scholarly journals Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats

2019 ◽  
Vol 18 (1) ◽  
pp. 4
Author(s):  
GayathriM Rao ◽  
Shyamala Nayak ◽  
Aradhana Marathe ◽  
M Vyshnavi
Keyword(s):  
Wistar Rats ◽  
Gastrointestinal Toxicity ◽  
Annona Muricata ◽  
Fruit Pulp

scholarly journals The Analgesic Effect of Ethanol Extract Soursop (Annona muricata L.) Leaves in Wistar Rats

2018 ◽  
Vol 5 (4) ◽  
pp. 196-200
Author(s):  
Kuswinarti Kuswinarti ◽  
Kendry Savira ◽  
Reno Rudiman
Keyword(s):  
Analgesic Effect ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Annona Muricata

1 H qNMR Quantification of Annonaceous Acetogenins in Crude Extracts of Annona muricata L. Fruit Pulp

2017 ◽  
Vol 28 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Natacha Bonneau ◽  
Timothé Cynober ◽  
Jean-Christophe Jullian ◽  
Pierre Champy
Keyword(s):  
Annona Muricata ◽  
Fruit Pulp ◽  
Annonaceous Acetogenins ◽  
Crude Extracts

scholarly journals Evaluating the Anticancer Potentials of Methanol Extracted Annona muricata Fruit Pulp and Seed(s) Phytochemicals

2020 ◽  
pp. 1-8
Author(s):  
D. Devananda ◽  
Shashanka K Prasad ◽  
D. Devananda
Keyword(s):  
Traditional Medicine ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antioxidant Activities ◽  
Annona Muricata ◽  
Fruit Pulp ◽  
Hct 116 ◽  
Mcf 7

Annona muricata L. has been widely used in traditional medicine for the treatment of various diseases ranging from fever to cancer. In this study, we evaluate the in vitro anticancer potential of methanol extracted A. muricata fruit pulp (AMPM) and seeds (AMSM) phytochemicals against breast (MCF-7), cervical (HeLa), prostate (PC-3) and colorectal (HCT-116) cancer cell lines. Additionally, the in vitro antiinflammatory and antioxidant activities of the extracts have been carried. The findings suggest that the AMSM is the most potent among the either extracts. Notwithstanding, both AMPM and AMSM showed significant dose and cell line-dependent anticancer potential(s).

scholarly journals Annona muricata Linn leaves or Curcuma longa Linn Rhizomes Ameliorates Oxidative Stress Associated with Hypertension in Uninephrectomized Wistar Rats Daily Loaded with Sodium Chloride

2019 ◽  
pp. 1-13
Author(s):  
Olayinka A. Oridupa ◽  
Folusho B. Falade ◽  
Ademola A. Oyagbemi ◽  
Bukola A. Abegunde ◽  
Precious C. Ekwem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Sodium Chloride ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Curcuma Longa ◽  
Antioxidant Properties ◽  
Annona Muricata ◽  
Hypertensive Rats ◽  
Animal House

Aims: Oxidative stress sequel to hypertension exacerbates the clinical condition and accelerates associated organopathies, therefore prevention is important. Traditionally in Nigeria, hypertension is treated with Annona muricata L. leaves or Curcuma longa L. rhizomes, two medicinal plants with antioxidant properties. Study Design:  This study assessed the effect of these plants on hypertension-induced oxidative stress in uninephrectomized Wistar rats daily loaded with 1% sodium chloride. Place and Duration of Study: Department of Veterinary Pharmacology and Toxicology Experimental Animal House, University of Ibadan, Nigeria, between August and November 2017. Methodology: Hypertensive rats were treated with methanol extracts of the plants for 42days. Two other groups of hypertensive rats were treated with lisinopril or chlorothiazide. Blood pressure was monitored by non-invasive tail plethysmography using an electro-sphygmomanometer. Oxidative stress markers were determined in blood and tissue (heart, kidney and liver); GPX, GST, GSH, SOD, MDA and NO. Results: Treatment of uninephrectomized rats with A. muricata or C. longa significantly (p<0.0001) decreased blood pressure and MDA, while elevating enzymatic and non-enzymatic antioxidant defense mechanisms of GST, GSH, GPx and SOD, comparable to normotensive rats. NO, the ubiquitous molecule required for basal vascular tone, myocardial contractility regulation and platelet adhesion prevention, was restored in the extract-treated rats. However, hypertensive untreated rats showed evidence of oxidative damages with significant increase in MDA, especially in the heart and liver, with decreases in the antioxidant defense system. Conclusion: Results of this study justified the traditional use of A. muricata or C. longa for management of hypertension in Nigeria and showed that the extracts ameliorated oxidative damage that accompanied hypertension, thus also preventing complications of hypertension.

scholarly journals ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

2020 ◽  
Vol 18 (1) ◽  
pp. 166-175
Author(s):  
O. E. ADELEYE ◽  
N. A. ABOAJAH ◽  
A. I. ADELEYE ◽  
E. A.O. SOGEBI ◽  
F. M. MSHELBWALA ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Sperm Count ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Annona Muricata ◽  
Major Health Problem ◽  
Ethanolic Leaf Extract

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.    

scholarly journals Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of Annona muricata L. (Soursop) from Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Joseph Nana Gyesi ◽  
Rita Opoku ◽  
Lawrence Sheringham Borquaye
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Moderate Activity ◽  
Annona Muricata ◽  
Fruit Pulp ◽  
Leaf Essential Oil

Annona muricata, also called soursop, is widespread in many tropical countries, and various parts of the plant have been shown to possess very good pharmacological properties. This work evaluated the chemical composition and antioxidant activities of essential oils obtained from the fruit pulp and leaves of soursop. Essential oils were obtained via hydrodistillation and characterized by gas chromatography-mass spectrometry. Antioxidant potential was evaluated via the phosphomolybdenum, hydrogen peroxide scavenging, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. In the leaf essential oil, a total of 31 compounds were identified with δ-cadinene (22.58%) and α-muurolene (10.64%) being the most abundant. Thirty-two compounds were identified in the fruit pulp essential oil with Ç-sitosterol (19.82%) and 2-hydroxy-1-(hydroxymethyl) ethyl ester (13.48%) being present in high amounts. Both essential oils showed very good total antioxidant capacities (49.03 gAAE/100 g and 50.88 gAAE/100 g for fruit pulp and leaf essential oils, respectively). The IC50 values from the DPPH assay were 244.8 ± 3.2 μg/mL for leaf essential oil and 512 ± 5.1 μg/mL for the fruit pulp essential oil. At 1 mg/mL, hydrogen peroxide scavenged was below 50% for both leaf and fruit pulp essential oils, indicating moderate activity. These results suggest possible application of the essential oils of Annona muricata in food preservation and processing.

Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar rats

2018 ◽  
Vol 17 (1) ◽  
pp. 1
Author(s):  
AbelNosereme Agbon ◽  
MustaphaTosin Issa ◽  
SadiyaUfeli Balogun ◽  
Onesimus Mahdi ◽  
KhadijatAbubakar Bobbo ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Hepatoprotective Effect ◽  
Fruit Pulp ◽  
Musa Paradisiaca
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