scholarly journals Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

2020 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
GhadaH El-Osaily ◽  
RehamI Amer ◽  
SamehS Gad
Keyword(s):  
Factorial Design ◽  
Full Factorial Design ◽  
In Vivo Evaluation ◽  
Design And Optimization ◽  
Terbinafine Hydrochloride ◽  
Full Factorial

Design and Optimization of Curcumin–HPβCD Bioadhesive Vaginal Tablets by 23 Factorial Design: In Vitro and In Vivo Evaluation

2014 ◽  
Vol 10 (1) ◽  
pp. 21-35 ◽  
Author(s):  
Umme Hani ◽  
H. G. Shivakumar ◽  
Atul Srivastava ◽  
Nawaz Mahammed ◽  
Shailesh Thirumaleshwar ◽  
...  
Keyword(s):  
Factorial Design ◽  
In Vivo Evaluation ◽  
Design And Optimization ◽  
23 Factorial Design

Full Factorial Design, Optimization, In vitro and Ex vivo Studies of Ocular Timolol-Loaded Microsponges

2019 ◽  
Vol 15 (4) ◽  
pp. 651-663
Author(s):  
Radwa M. A. Abd-Elal ◽  
Ghada H. Elosaily ◽  
Shadeed Gad ◽  
El-Sayed Khafagy ◽  
Yasser Mostafa
Keyword(s):  
Design Optimization ◽  
Factorial Design ◽  
Ex Vivo ◽  
Full Factorial Design ◽  
Full Factorial

Cerebral effect of optimized Allium sativum oil-loaded chitosan nanorods: GC-MS analysis and in vitro/in vivo evaluation

2020 ◽  
Vol 11 (6) ◽  
pp. 5357-5376
Author(s):  
Rabab Kamel ◽  
Abeer Salama ◽  
Nermine M. Shaffie ◽  
Nesma M. Salah
Keyword(s):  
Factorial Design ◽  
Allium Sativum ◽  
Biological Effects ◽  
In Vivo Evaluation ◽  
Promising Strategy ◽  
Ms Analysis

Two-level orthogonal factorial design was used to optimize GO-loaded chitosan nanorods. This study proves that the nanoencapsulation of GO is a promising strategy which overcomes its limitations and improves its biological effects.

scholarly journals IMPLEMENTATION OF QUALITY BY DESIGN (QBD) APPROACH IN FORMULATION AND DEVELOPMENT OF RITONAVIR PELLETS USING EXTRUSION SPHERONIZATION METHOD

2019 ◽  
pp. 139-146
Author(s):  
SATISH K. MANDLIK ◽  
PAYAL P. AGARWAL ◽  
HARSHAL P. DANDGAVHAL
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Factorial Design ◽  
Quality By Design ◽  
Research Work ◽  
Full Factorial Design ◽  
Extrusion Speed ◽  
Full Factorial ◽  
Extrusion Spheronization

Objective: Ritonavir is an antiretroviral drug used for HIV-AIDS treatment. The purpose of this research work was to implement the quality by design (QbD) approach in formulation of ritonavir sustained-release pellets by industrially applied extrusion spheronization technique. Methods: Pellets were prepared by extrusion spheronization method and evaluated for their physicochemical properties. Initially, on the basis of prior knowledge Quality Target Product Profile (QTTP) element was identified and further Critical Quality Attributes (CQA) elements were defined. Risk assessment (RA) was done by two tools as failure mode and effect analysis (FMEA) and fishbone diagram (Ishikawa plot). Placket Burman design was implemented as a screening design using seven high-risk factors (spheronization speed, spheronization time, extrusion speed, drying method, PVP K 30, cross povidone, and solvent). Optimization study was done by 23 full factorial design with three critical factors as (spheronization speed, extrusion speed and PVP K 30). The in vitro drug release was studied in both gastric and intestinal fluids for 12 h using USP Ι apparatus. Control space was established for the sustained release pellets. Results: Among all batches obtained in 23 full factorial design, batch R7 was found to be effective with carr’s index value of 5.281, percentage yield of 69.6%, time required to release 50% drug was 8 h and percent drug release after 12 h was found 83.132 %, R7 batch was selected as optimized batch. Statistical analysis showed model terms were significant. Conclusion: We can conclude that; sustained-release pellets of ritonavir were successfully designed using QbD approach.

PLGA nanoparticles for nose to brain delivery of Clonazepam: formulation, optimization by 32 Factorial design, in vitro and in vivo evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Pranav Shah ◽  
Jayant Sarolia ◽  
Bhavin Vyas ◽  
Priti Wagh ◽  
Kaul Ankur ◽  
...  
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Intranasal Administration ◽  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Rabbit Brain ◽  
Histopathological Study ◽  
In Vivo Evaluation

Background: Intranasal administration of biodegradable nanoparticles has been extensively studied for targeting the drug directly to CNS through olfactory or trigeminal route bypassing blood brain barrier. Objective: The objective of the present study was to optimize Clonazepam loaded PLGA nanoparticles (CLO-PNPs) by investigating the effect of process variables on the responses using 32 full factorial design. Methods: Effect of two independent factors-amount of PLGA and concentration of Poloxamer 188, were studied at low, medium and high levels on three dependent responses-%Entrapment efficiency, Particle size (nm) and %cumulative drug release at 24hr. Results: %EE, Particle size and %CDR at 24hr of optimized batch was 63.7%, 165.1 nm and 86.96% respectively. Nanoparticles were radiolabeled with 99mTc and biodistribution was investigated in BALB/c mice after intranasal & intravenous administrations. Significantly higher brain/blood uptake ratios and AUC values in brain following intranasal administration of CLO-PNPs indicated more effective brain targeting of CLO. Higher brain uptake of intranasal CLO-PNPs was confirmed by rabbit brain scintigraphy imaging. Histopathological study performed on goat nasal mucosa revealed no adverse response of nanoparticles. TEM image exhibited spherical shaped particles in nano range. DSC and XRD studies suggested Clonazepam encapsulation within PLGA matrix. The onset of occurrence of PTZ-induced seizures in rats was significantly delayed by intranasal nanoparticles as compared to intranasal & intravenous CLO-SOL. Conclusion: This investigation exhibits rapid rate and higher extent of CLO transport in brain with intranasal CLO-PNPs suggesting a better option as compared to oral & parenteral route in management of acute status epilepticus.

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