scholarly journals A clinical study of severe cutaneous adverse drug reactions and role of corticosteroids in their management

2017 ◽  
Vol 3 (1) ◽  
pp. 20 ◽  
Author(s):  
Rohini Sharma ◽  
Naina Dogra ◽  
Devraj Dogra
Keyword(s):  
Clinical Study ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Adverse Drug Reactions Among Patients Enrolled in an Outpatient Parenteral Antimicrobial Therapy (OPAT) Program 2015–2016 at UNC Medical Center

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S341-S341
Author(s):  
Vahini Chundi ◽  
Anh Eichholz ◽  
Onyeka Nwankwo ◽  
Alan Kinlaw ◽  
Wesley Kufel ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Medical Center ◽  
Critical Role ◽  
Drug Reactions ◽  
Health Records ◽  
Outpatient Parenteral Antimicrobial Therapy ◽  
Initial Cohort ◽  
Recorded Data ◽  
Antimicrobial Regimen

Abstract Background The UNC Medical Center OPAT program was started in 2015 to provide multidisciplinary monitoring and management of patients discharged on parenteral antimicrobials. We examined characteristics of incident adverse drug reactions (ADRs) observed in our initial cohort of OPAT patients. Methods We abstracted electronic health records for the first 250 patients enrolled in the OPAT program. 223 patients with sufficient recorded data for entire OPAT course were included in the analysis. ADRs meeting criteria as detailed in Table 1 were collected and further stratified by antimicrobial regimen. Results 57 patients (26%) experienced at least one ADR during OPAT therapy. The frequency of specific ADRs associated with OPAT therapies are provided in Figure 1. Β-lactam regimens were most frequently associated with liver dysfunction, while combinations of β-lactams and vancomycin were associated with kidney dysfunction. Median days on OPAT regimen was 19 days (IQR: 10–29) for patients who experienced an ADR compared with 39 (IQR: 30–44) for patients who did not experience an ADR. Conclusion ADRs were most commonly observed within the first three weeks of therapy, particularly for patients receiving vancomycin and a β-lactam antimicrobial in combination. These results underscore the critical role of a multidisciplinary team in providing laboratory monitoring and response to abnormal results for OPAT patients. In addition, closer monitoring within the first three weeks of therapy may provide opportunities for regimen changes or dose adjustment to avoid toxicities. Disclosures All authors: No reported disclosures.

The role of pharmacogenomics in adverse drug reactions

2019 ◽  
Vol 12 (5) ◽  
pp. 407-442 ◽  
Author(s):  
Ramón Cacabelos ◽  
Natalia Cacabelos ◽  
Juan C. Carril
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals A CLINICAL STUDY ON CUTANEOUS ADVERSE DRUG REACTIONS

2017 ◽  
Vol 6 (49) ◽  
pp. 3757-3762
Author(s):  
Lakshmi Asokan ◽  
Abdul Samad K ◽  
Joan Felicita Samson
Keyword(s):  
Clinical Study ◽  
Adverse Drug Reactions ◽  
Drug Reactions

CP-227 Risk minimisation of adverse drug reactions: Role of the pharmacist

2016 ◽  
Vol 23 (Suppl 1) ◽  
pp. A100.2-A100
Author(s):  
M Benabbes ◽  
M Alami Chentoufi ◽  
B Meddah
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Risk Minimisation

The role of advanced technologies supplemented with traditional methods in pharmacovigilance sciences

2020 ◽  
Vol 14 ◽  
Author(s):  
M Vijaya Satwika Naidu ◽  
Dudala Sai Sushma ◽  
Varun Jaiswal ◽  
S. Asha ◽  
Tarun Pal
Keyword(s):  
Data Mining ◽  
Social Media ◽  
Adverse Drug Reactions ◽  
Mobile Apps ◽  
Health Sector ◽  
Early Developmental Stage ◽  
Drug Reactions ◽  
Traditional Methods ◽  
Advanced Technologies

Background: The immediate automatic systemic monitoring and reporting of adverse drug reaction, improving the efficacy is the utmost need of medical informatics community. The venturing of advanced digital technologies into the health sector has opened new avenues for rapid monitoring. In recent years, data shared through social media, mobile apps and on other social websites has increased manifolds requiring data mining techniques. Objective: The objective of this report is to highlight the role of advanced technologies together with traditional methods to proactively aid in early detection of adverse drug reactions concerned with drug safety and pharmacovigilance. Methods: A thorough search was conducted for papers and patents regarding pharmacivigilance. All articles with respect to relevant subject were explored and mined from public repositories such as Pubmed, Google Scholar, Springer, ScienceDirect (Elsevier), Web of Science, etc. Results: The European Union’s Innovative Medicines Initiative WEB-RADR project emphasized the development of mobile applications and social media data for reporting adverse effects. Only relevant data has to be captured through the data mining algorithms (DMAs) playing an important role in timely prediction of risk with high accuracy using two popular approaches the frequentist and Bayesian approach. The pharmacovigilance at premarketing stage is useful for the prediction of the adverse drug reactions in early developmental stage of a drug. Later postmarketing safety reports and clinical data reports are important to be monitored through electronic health records, prescription-event monitoring, spontaneous reporting databases, etc approaches. Conclusion: The advanced technologies supplemented with traditional technologies is the need of hour for evaluating product’s risk profile and reducing risk in population esp. with comorbid conditions and on concomitant medications.

The Role of Pharmacovigilance Center in Sudan in Reporting Adverse Drug Reactions

2012 ◽  
pp. 344-354
Author(s):  
Abdalla Omer Elkhawad
Keyword(s):  
Adverse Drug Reactions ◽  
International Organizations ◽  
Healthcare Professionals ◽  
Drug Reactions ◽  
Different Types ◽  
Large Populations ◽  
Pharmacovigilance Center

Pharmacovigilance is an active discipline, which is the study of structured mechanisms of the safety of medicines being used in clinical situations in large populations. In this chapter, the authors attempt to characterize the different types of Adverse Drug Reactions (ADRs) and related problems and mechanisms by which they cause harm to patients. They investigate the methods of detection of ADRs and various pharmacovigilance methods. The role and contributions of international organizations will be presented. The authors present the importance and need for education of healthcare professionals about pharmacovigilance and the proper reporting of ADRs for the purpose of efficient and safe use of medicines. The establishment of the Sudan pharmacovigilance center and how the system works will be discussed. Sources of data and actions taken since its inception are presented. The authors conclude by highlighting the problems and weaknesses of the system and ways to strengthen it.

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