scholarly journals What is the impact of traditional risk factors for vascular affection on Behcet’s disease vascular involvement: a retrospective cohort study

2019 ◽  
Vol 46 (4) ◽  
pp. 257
Author(s):  
Marwa Abdo ◽  
Alkhateeb Alkemary ◽  
Reem El Mallah
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Vascular Involvement ◽  
Behcet's Disease ◽  
Traditional Risk Factors ◽  
The Impact

scholarly journals Fatality and risk features for prognosis in COVID-19 according to the care approach – a retrospective cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248869
Author(s):  
Mariano Andrés ◽  
Jose-Manuel Leon-Ramirez ◽  
Oscar Moreno-Perez ◽  
José Sánchez-Payá ◽  
Ignacio Gayá ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Troponin T ◽  
Invasive Mechanical Ventilation ◽  
Academic Center ◽  
Care Approach ◽  
Independent Risk Factors ◽  
The Impact

Introduction This study analyzed the impact of a categorized approach, based on patients’ prognosis, on major outcomes and explanators in patients hospitalized for COVID-19 pneumonia in an academic center in Spain. Methods Retrospective cohort study (March 3 to May 2, 2020). Patients were categorized according to the followed clinical management, as maximum care or limited therapeutic effort (LTE). Main outcomes were all-cause mortality and need for invasive mechanical ventilation (IMV). Baseline factors associated with outcomes were analyzed by multiple logistic regression, estimating odds ratios (OR; 95%CI). Results Thirty-hundred and six patients were hospitalized, median age 65.0 years, 57.8% males, 53.3% Charlson index ≥3. The overall all-cause fatality rate was 15.0% (n = 46). Maximum care was provided in 238 (77.8%), IMV was used in 38 patients (16.0%), and 5.5% died. LTE was decided in 68 patients (22.2%), none received IMV and fatality was 48.5%. Independent risk factors of mortality under maximum care were lymphocytes <790/mm3, troponin T >15ng/L and hypotension. Advanced age, lymphocytes <790/mm3 and BNP >240pg/mL independently associated with IMV requirement. Conclusion Overall fatality in the cohort was 15% but markedly varied regarding the decided approach (maximum care versus LTE), translating into nine-fold higher mortality and different risk factors.

scholarly journals POS0339 PREDICTORS OF DEATH IN PATIENTS DIAGNOSED WITH GIANT CELL ARTERITIS IN WESTERN NORWAY 1972-2012

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 397.2-398
Author(s):  
L. K. Brekke ◽  
B. T. Svanes Fevang ◽  
J. Assmus
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Risk Of Death ◽  
Western Norway ◽  
Increased Risk ◽  
Traditional Risk Factors

Background:Giant cell arteritis (GCA) is the most common systemic vasculitis in adults, and the number of incident cases worldwide is projected to increase [1]. Evidence as to whether or not GCA confers a mortality risk is conflicting, and many studies have been limited by inadequate or lacking adjustment for confounders.Objectives:To investigate possible predictors of death in a large and well characterized Norwegian cohort of GCA-patients.Methods:This is a hospital-based retrospective cohort study including patients diagnosed with GCA during 1972-2012. Patients were identified through computerized hospital records using the International Classification of Diseases coding system. Clinical information was extracted from patients’ medical journals. Further details about the inclusion process have been published previously [2]. Information on time of death was obtained from the Norwegian Cause of Death Registry. We investigated predicting factors using Cox regression. Selected variables were first analyzed in univariate and block regression models (block 1: clinical features including histology, block 2: laboratory and treatment factors, block 3: demographic and traditional risk factors). Variables included in the final multivariate model were selected on the following basis: P-value <0.1 in univariate or block regression or otherwise deemed clinically significant.Results:881 patients were included of which 626 (71.1%) were females. Mean age was 73 years (SD 9). 490 patients (55.6%) died during the study period (1 January 1972 – 31 December 2012). Characteristics and mortality for the GCA-cohort compared to matched controls have been published previously [3]. Within the GCA-cohort we found that presenting with visual disturbance (any) or scalp necrosis was associated with increased risk of death in univariate analysis (Figure 1). However, in multivariate analysis the traditional risk factors (age, smoking, hypertension and previous cardiovascular disease) were more strongly associated with risk of death. Among laboratory parameters only Hemoglobin (Hb) levels were significantly associated with risk of death with increasing Hb-levels indicating decreased risk. Neither temporal artery biopsy result nor initial or maximal (before first tapering) Prednisolone dose were found to be associated with risk of death. Results from univariate and the final multivariate models are presented in Figure 1.Figure 1.Conclusion:In our large cohort of GCA-patients the risk of death was found to be predominantly predicted by age (HR 2.81) and traditional risk factors (smoking (HR 1.61), hypertension (HR 1.48) and previous cardiovascular disease (HR 1.26)). Visual disturbance (HR 1.40), visual loss in particular (HR 2.37), and scalp necrosis (HR 3.42) were found to be the clinical features most associated with risk of death. However, we note that our material lacked information about extra-cranial (large vessel) vasculitis, which may also carry increased risk of death.References:[1]De Smit E, Palmer AJ, Hewitt AW. Projected worldwide disease burden from giant cell arteritis by 2050. J Rheumatol 2015;42:119-25.[2]Brekke LK, Diamantopoulos AP, Fevang BTS, Assmus J, Esperø E, Gjesdal CG. Incidence of giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study. Arthritis Res Ther. 2017;19(1):278.[3]Brekke LK, Fevang BTS, Diamantopoulos AP, Assmus J, Esperø E, Gjesdal CG. Survival and death causes of patients with giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study. Arthritis Res Ther. 2019;21(1):154.Disclosure of Interests:Lene Kristin Brekke Grant/research support from: Unrestricted research grant from MSD, Bjørg Tilde Svanes Fevang Consultant of: Been part of advisory board for Lilly, Jörg Assmus: None declared

scholarly journals Impact of Multiple Factors on the Incidence of Developmental Dysplasia of the Hip

2021 ◽  
Author(s):  
Łukasz Pulik ◽  
Krzysztof Romaniuk ◽  
Aleksandra Sibilska ◽  
Andrzej Jedynak ◽  
Ignacy Tołowiński ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Positive Family History ◽  
Developmental Dysplasia ◽  
Risk Calculator ◽  
The Impact ◽  
Dysplasia Of The Hip

Abstract Introduction: Developmental dysplasia of the hip (DDH) is one of the most common musculoskeletal conditions in children. Not treated DDH leads to disability, gait abnormalities, limb shortening and chronic pain. Our study aims to determine the impact of multiple risk factors on the occurrence of DDH and develop an interactive risk assessment tool.Methods: We conducted a retrospective cohort study in the Outpatient Clinic for Children of University Hospital. The Graf classification system was used for ultrasonographic universal screening. In total, 4881 infants met the eligibility criteria (n = 9762 hip joints). Hypothesis testing was performed with χ² test and logistic regression.Results: The incidence of DDH was 4.57%. We have proven risk factors of DDH: female gender (OR=7.11), breech position (OR=3.65), Caesarean section (OR=1.43), positive family history in parent (OR=1.92) or sibling (OR=3.84). Preterm delivery decreased the risk (OR=0.17). Logistic regression was used to construct the interactive risk calculator.Conclusion: The DDH risk calculator was built but needs external validation in prospective study before being used in a clinical setting. We confirmed well-known DDH risk factors in the studied population. Our results support the recent hypothesis that preterm infants (37 < week) have lower rate of DDH.Level of Evidence:Retrospective cohort study: Level III

An Analysis of Dental Implants Survival and Success

2018 ◽  
Vol 69 (9) ◽  
pp. 2465-2466
Author(s):  
Iustin Olariu ◽  
Roxana Radu ◽  
Teodora Olariu ◽  
Andrada Christine Serafim ◽  
Ramona Amina Popovici ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Medical History ◽  
Retrospective Cohort Study ◽  
Odds Ratio ◽  
Retrospective Cohort ◽  
Demographic Data ◽  
Kaplan Meier ◽  
Number Of Patients ◽  
Health Related

Osseointegration of a dental implant may encounter a variety of problems caused by various factors, as prior health-related problems, patients� habits and the technique of the implant inserting. Retrospective cohort study of 70 patients who received implants between January 2011- April 2016 in one dental unit, with Kaplan-Meier method to calculate the probability of implants�s survival at 60 months. The analysis included demographic data, age, gender, medical history, behavior risk factors, type and location of the implant. For this cohort the implants�survival for the first 6 months was 92.86% compared to the number of patients and 97.56% compared to the number of total implants performed, with a cumulative failure rate of 2.43% after 60 months. Failures were focused exclusively on posterior mandible implants, on the percentage of 6.17%, odds ratio (OR) for these failures being 16.76 (P = 0.05) compared with other localisations of implants, exclusively in men with median age of 42 years.

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