Incidental thyroid carcinoma after thyroidectomy for benign thyroid disease in Suez Canal region

2018 ◽  
Vol 37 (3) ◽  
pp. 361
Author(s):  
Mohammed Faisal ◽  
Hamada Fathy ◽  
Ahmed Risk ◽  
MahaM Atwa
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Suez Canal ◽  
Benign Thyroid Disease ◽  
Incidental Thyroid Carcinoma ◽  
Benign Thyroid

INCIDENTAL THYROID CARCINOMA IN A LARGE SERIES OF CONSECUTIVE PATIENTS OPERATED ON FOR BENIGN THYROID DISEASE

2006 ◽  
Vol 76 (3) ◽  
pp. 123-126 ◽  
Author(s):  
Paolo Miccoli ◽  
Michele N. Minuto ◽  
David Galleri ◽  
Jacopo D'Agostino ◽  
Fulvio Basolo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Large Series ◽  
Benign Thyroid Disease ◽  
Incidental Thyroid Carcinoma ◽  
Benign Thyroid

scholarly journals Incidental Thyroid Carcinoma in Benign Thyroid Disease: A Cohort Study

2018 ◽  
Vol 10 (3) ◽  
pp. 154-156
Author(s):  
Ranil Fernando ◽  
Diluka Pinto ◽  
Nalinda Munasinghe ◽  
Pramod C Chandrasinghe
Keyword(s):  
Cohort Study ◽  
Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Benign Thyroid Disease ◽  
Incidental Thyroid Carcinoma ◽  
Benign Thyroid

High Prevalence of Occult Papillary Thyroid Carcinoma in a Surgical Series for Benign Thyroid Disease

1990 ◽  
Vol 76 (3) ◽  
pp. 255-257 ◽  
Author(s):  
Maria Rosa Pelizzo ◽  
Andrea Piotto ◽  
Domenico Rubello ◽  
Dario Casara ◽  
Ambrogio Fassina ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Benign Thyroid Disease ◽  
Papillary Thyroid ◽  
High Prevalence ◽  
Benign Thyroid

Copper as Ancillary Diagnostic Tool in Preoperative Evaluation of Possible Papillary Thyroid Carcinoma in Patients with Benign Thyroid Disease

2014 ◽  
Vol 160 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Vesna V. Dragutinović ◽  
Svetislav B. Tatić ◽  
Snežana D. Nikolić-Mandić ◽  
Tatjana M. Tripković ◽  
Duško M. Dunđerović ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Tool ◽  
Thyroid Disease ◽  
Preoperative Evaluation ◽  
Benign Thyroid Disease ◽  
Papillary Thyroid ◽  
Benign Thyroid

lncRNA GAS8-AS1 genetic alterations in papillary thyroid carcinoma and their clinical significance

2020 ◽  
Vol 29 (2) ◽  
pp. 255-264
Author(s):  
Da-Lei Zhou ◽  
Qing Liu ◽  
Bo-Heng Xu ◽  
Yue Li ◽  
Xuan Su ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Healthy Volunteers ◽  
Thyroid Disease ◽  
Blood Cells ◽  
White Blood Cells ◽  
Genetic Alterations ◽  
Benign Thyroid Disease ◽  
Papillary Thyroid ◽  
Benign Thyroid

The long non-coding RNA (lncRNA) GAS8-AS1 is the second-most frequently altered gene, following the BRAF gene, in papillary thyroid carcinoma (PTC). We aimed to study the specificity and significance of genetic alterations in GAS8-AS1 in PTC. In this study, we reported the prevalence of genetic alterations of GAS8-AS1 in tissues of 48 nodular goiter, 573 papillary thyroid cancer, 95 colorectal cancer, 101 non-small cell lung cancer, 92 glioma, and 69 gastrointestinal stromal tumor patients, and in peripheral white blood cells of 286 healthy volunteers. We observed that the genomic sequence of GAS8-AS1 had a high frequency of genetic alterations in addition to the previously reported c.713A>G/714T>C substitution. Substitution of c.713A>G was completely linked with four other loci at c.714T>C, c.728A>G, c.737G>A, and c.752G>A. Two novel substitutions at c.749G>A and c.826A>G were also found. Interestingly, evidence from different samples indicated that these variations were not unique variants for PTC; they were also found in other malignant tissues and white blood cells of healthy volunteers. The c.713A>G substitution was associated with the T stage of PTC, while c.749G>A was more likely to occur in younger patients with PTC. PTC patients carrying heterozygous variants at the c.749 and c.826 loci had a higher risk of developing multiple lesions. These associations were also observed in patients with PTC and concomitant benign thyroid disease. Notably, the rare homozygous GG at the c.826 site conferred a higher risk of developing T2 PTC without benign thyroid disease, and a lower risk of developing T2 PTC with benign thyroid disease. Alterations of c.749G>A and c.826A>G had higher levels of serum TSH (thyroid stimulating hormone) in PTC subjects. Our study provides evidence that the detection of GAS8-AS1 genetic alterations would be useful in diagnostic screening and prognostic assessment of PTC.

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