Study the association among human papilloma virus subtypes 16 and 18, codon 72 P53 gene polymorphism, and oral squamous cell carcinoma in Upper Egypt: a case–control study

2020 ◽  
Vol 39 (2) ◽  
pp. 364
Author(s):  
HamdanS Abbas ◽  
Salah El-DeinG Shaltout ◽  
HebaM.S El-Dein ◽  
DaliaA Elsers ◽  
MohammedS Shahine ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Gene Polymorphism ◽  
Human Papilloma Virus ◽  
Case Control Study ◽  
P53 Gene ◽  
Case Control ◽  
Papilloma Virus ◽  
Codon 72 ◽  
Control Study

scholarly journals SCCA, TSGF, and the Long Non-Coding RNA AC007271.3 are Effective Biomarkers for Diagnosing Oral Squamous Cell Carcinoma

2018 ◽  
Vol 47 (1) ◽  
pp. 26-38 ◽  
Author(s):  
Tingru Shao ◽  
Jiaxin Huang ◽  
Zenan Zheng ◽  
Qingqing Wu ◽  
Tiancai Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Differentially Expressed ◽  
Normal Controls ◽  
Control Study ◽  
Potential Biomarkers

Background/Aims: Oral squamous cell carcinoma (OSCC) is one of the most lethal malignancies worldwide and the most common type of oral cancer, characterized by invasive growth, frequent regional metastases, high recurrence, and poor prognosis. In the current study, we investigated the use of long non-coding RNAs (lncRNAs), tumor-specific growth factor (TSGF), and squamous cell carcinoma antigen (SCCA) as potential biomarkers for OSCC screening. Methods: LncRNA expression was measured by microarray analysis in three sets of OSCC and paired normal mucosal tissues. The potential lncRNAs involved in OSCC development were investigated by bioinformatics and verification experiments. We also determined the expression of these potential biomarkers in tissue and serum samples in a case–control study of 80 OSCC cases and 70 controls. Receiver operating characteristics, decision curve analysis, and the combined detection of lncRNA AC007271.3, TSGF, and SCCA were carried out to screen for OSCC biomarkers. Results: A total of 691 lncRNAs (433 upregulated and 258 downregulated) were differentially expressed in OSCC tissues compared with normal controls (p< 0.05). Based on Gene Ontology and pathway analysis, we selected four differentially expressed lncRNAs (AC007271.3, AC007182.6, LOC283481, and RP11-893F2.9), and showed that aberrant AC007271.3 levels in OSCC patients were significantly associated with clinical stage, especially in early-stage disease, in an expanded case–control study. The combination of AC007271.3 and SCCA (AUC=0.902, p< 0.001) showed significantly better ability to discriminate between OSCC and controls compared with SCCA or AC007271.3 alone. Serum AC007271.3, SCCA, and TSGF levels could also discriminate between OSCC and normal controls with sensitivities of 77.6%, 55.0%, and 63.3%, and specificities of 84.5%, 93.3%, and 66.7%, respectively. Conclusions: These results suggest that AC007271.3, SCCA, and TSGF could be novel circulating biomarkers for the determination of OSCC. However, further validation in large-scale prospective studies is necessary.

Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study

The Lancet ◽  
2000 ◽  
Vol 355 (9222) ◽  
pp. 2189-2193 ◽  
Author(s):  
Agnetha M Josefsson ◽  
Patrik KE Magnusson ◽  
Nathalie Ylitalo ◽  
Per Sørensen ◽  
Pernilla Qwarforth-Tubbin ◽  
...  
Keyword(s):  
Viral Load ◽  
Human Papilloma Virus ◽  
Carcinoma In Situ ◽  
Case Control Study ◽  
Case Control ◽  
Papilloma Virus ◽  
Nested Case Control ◽  
Human Papilloma Virus 16 ◽  
Control Study

P179 High risk HPV infection is associated with oral squamous cell carcinoma in Mexican patients: a case control study

2007 ◽  
Vol 2 (1) ◽  
pp. 185
Author(s):  
G. Anaya-Saavedra ◽  
V.A. Ramírez-Amador ◽  
M.E. Irigoyen-Camacho ◽  
C.M. García-Cuellar ◽  
A. García-Cuellar
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Hpv Infection ◽  
Case Control ◽  
High Risk Hpv ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document