Egyptian consensus for the use of antimicrobial therapy in Preoperative prophylaxis, surgical site infections and diabetic foot infections

2020 ◽  
Vol 39 (1) ◽  
pp. 1
Author(s):  
AbdelM Hussein ◽  
Mohamed Farid
Keyword(s):  
Antimicrobial Therapy ◽  
Diabetic Foot ◽  
Surgical Site Infections ◽  
Diabetic Foot Infections ◽  
Preoperative Prophylaxis

scholarly journals Evaluation of antimicrobial therapy and patient adherence in diabetic foot infections

2019 ◽  
Vol 7 (3) ◽  
pp. 283-287
Author(s):  
Rahul Naresh Wasnik ◽  
Srujitha Marupuru ◽  
Zabiuddin Ahad Mohammed ◽  
Gabriel Sunil Rodrigues ◽  
Sonal Sekhar Miraj
Keyword(s):  
Antimicrobial Therapy ◽  
Diabetic Foot ◽  
Patient Adherence ◽  
Diabetic Foot Infections

Antimicrobial therapy in infectious complications of diabetic foot

2014 ◽  
Vol 21 (1) ◽  
pp. 55-62
Author(s):  
Ioan Marin ◽  
Roxana Zaharia ◽  
Leonard Lupu ◽  
Emilia Rusu ◽  
Gabriela Radulian
Keyword(s):  
Antimicrobial Therapy ◽  
Diabetic Foot ◽  
Arterial Disease ◽  
Infectious Complications ◽  
Wound Management ◽  
Successful Outcome ◽  
Surgical Interventions ◽  
Diabetic Foot Infections ◽  
Definitive Therapy ◽  
Peripheral Arterial

Abstract Background and aims: The treatment of diabetic foot complications is combined, surgical and medical. The aim of our study was to assess the results of antimicrobial therapy in diabetic foot infections. Material and methods: 100 patients with diabetic foot infections admitted in the Surgery Clinic “I. Juvara” between December 2010 and February 2011 were analyzed. Results: Mean age at presentation was 58.4±9.74 years for women and 63.2±10.53 years for men. Mean diabetes duration was 12.3 years in men and 15.7 years in women. Patients with peripheral arterial disease represented 45% of cases, patients with neuropathy represented 16% of cases and patients with both conditions 39% of the cases. 41 patients suffered minor surgical interventions, 36 patients experienced minor amputations and 23 major amputations (below or above the knee). Antibiotic treatment included cephalosporins, fluoroquinolones and combinations with Metronidazole. After treatment, 74% of patients had a good postoperative evolution. For 26 patients a change of the antibiotic was necessary but only in 10 cases this was made according to antibiogram. Conclusions: Surgical debridement and wound management, carefully chosen antimicrobial therapy and treatment of comorbidities are very important for a successful outcome. Initial empirical antibiotic selection should be followed by culture-guided definitive therapy.

scholarly journals Outpatient parenteral antimicrobial therapy (OPAT) versus inpatient care in the UK: a health economic assessment for six key diagnoses

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e049733
Author(s):  
Maria Dimitrova ◽  
Mark Gilchrist ◽  
R A Seaton
Keyword(s):  
Antimicrobial Therapy ◽  
Diabetic Foot ◽  
British Society ◽  
Oral Antibiotic ◽  
Self Administration ◽  
Outpatient Parenteral Antimicrobial Therapy ◽  
Diabetic Foot Infections ◽  
The Uk ◽  
Tract Infections ◽  
Delivery Models

ObjectivesTo compare costs associated with different models of outpatient parenteral antimicrobial therapy (OPAT) delivery with costs of inpatient (IP) care across key infection groups managed via OPAT in the UK.DesignA cost-minimisation design was used due to evidence of similarities in patient and treatment outcomes between OPAT and IP care. A bottom-up approach was undertaken for the evaluation of OPAT associated costs. The British Society of Antimicrobial Chemotherapy National Outcomes Registry System was used to determine key infection diagnoses, mean duration of treatment and most frequent antibiotics used.SettingSeveral OPAT delivery settings were considered and compared with IP care.InterventionsOPAT models considered were OP clinic model, nurse home visits, self (or carer)-administration by a bolus intravenous, self-administration by a commercially prefilled elastomeric device, continuous intravenous infusion of piperacillin with tazobactam or flucloxacillin with elastomeric device as OP once daily and, specifically for bone and joint and diabetic foot infections, complex outpatient oral antibiotic therapies.ResultsBase case and a range of scenario results showed all evaluated OPAT service delivery models to be less costly than IP stay of equivalent duration. The extent of savings varied by OPAT healthcare delivery models. Estimated OPAT costs as a proportion of IP costs were estimated at 0.23–0.53 (skin and soft-tissue infections), 0.34–0.46 (complex urinary tract infections), 0.23–0.51 (orthopaedic infections), 0.24–0.42 (diabetic foot infections) 0.40–0.56 (exacerbations of bronchiectasis) and 0.25–0.42 (intra-abdominal infections). Partial or full complex oral antibiotic therapies in orthopaedic or diabetic foot infections costs were estimated to be 0.13–0.26 of IP costs. Main OPAT costs were associated with staff time and antimicrobial medications.ConclusionsOPAT is a cost-effective use of National Health Service resources for the treatment of a range of infections in the UK in patients who can be safely managed in a non-IP setting.

Optimising Antimicrobial Therapy in Diabetic Foot Infections

Drugs ◽  
2007 ◽  
Vol 67 (2) ◽  
pp. 195-214 ◽  
Author(s):  
Nalini Rao ◽  
Benjamin A Lipsky
Keyword(s):  
Antimicrobial Therapy ◽  
Diabetic Foot ◽  
Diabetic Foot Infections
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