Effects of vertical sleeve gastrectomy on serum visfatin level and insulin resistance in obese diabetic and obese nondiabetic cases

2020 ◽  
Vol 39 (1) ◽  
pp. 147
Author(s):  
MohamedM Abouzeid ◽  
AhmedM.B El-Din ◽  
CarolineA Girgis ◽  
NihadS.M Shoeib ◽  
KhaledM Makboul ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sleeve Gastrectomy ◽  
Vertical Sleeve Gastrectomy ◽  
Visfatin Level

scholarly journals Insulin Resistance, Microbiota, and Fat Distribution Changes by a New Model of Vertical Sleeve Gastrectomy in Obese Rats

Diabetes ◽  
2016 ◽  
Vol 65 (10) ◽  
pp. 2990-3001 ◽  
Author(s):  
Nicola Basso ◽  
Emanuele Soricelli ◽  
Lidia Castagneto-Gissey ◽  
Giovanni Casella ◽  
Davide Albanese ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sleeve Gastrectomy ◽  
Fat Distribution ◽  
Vertical Sleeve Gastrectomy ◽  
New Model ◽  
Obese Rats

scholarly journals Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Hepatology ◽  
2016 ◽  
Vol 64 (3) ◽  
pp. 760-773 ◽  
Author(s):  
Lili Ding ◽  
Kyle M. Sousa ◽  
Lihua Jin ◽  
Bingning Dong ◽  
Byung‐Wook Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Fatty Liver ◽  
Vertical Sleeve Gastrectomy

scholarly journals Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jie Zhang ◽  
Min Feng ◽  
Lisha Pan ◽  
Feng Wang ◽  
Pengfei Wu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Vitamin D Deficiency ◽  
Hepatic Steatosis ◽  
Metabolic Disorders ◽  
Obese Mice ◽  
Vertical Sleeve Gastrectomy ◽  
Obesity And Diabetes

AbstractVertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vitamin D deficiency (VDD) is associated with many diseases, including obesity. To explore the role of vitamin D in metabolic disorders for patients with obesity after VSG. We established a murine model of diet-induced obesity + VDD, and we performed VSGs to investigate VDD's effects on the improvement of metabolic disorders present in post-VSG obese mice. We observed that in HFD mice, the concentration of VitD3 is four fold of HFD + VDD one. In the post-VSG obese mice, VDD attenuated the improvements of hepatic steatosis, insulin resistance, intestinal inflammation and permeability, the maintenance of weight loss, the reduction of fat loss, and the restoration of intestinal flora that were weakened. Our results suggest that in post-VSG obese mice, maintaining a normal level of vitamin D plays an important role in maintaining the improvement of metabolic disorders.

Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

2017 ◽  
Vol 68 (7) ◽  
pp. 1622-1627 ◽  
Author(s):  
Diana Simona Stefan ◽  
Andrada Mihai ◽  
Daiana Bajko ◽  
Daniela Lixandru ◽  
Laura Petcu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Control Group ◽  
Cell Dysfunction ◽  
Randomized Controlled

Metabolic surgery is the most efficacious method for the treatment of morbid obesity and was recently included among the antidiabetes treatments recommended in obese type 2 diabetes (T2D) patients. The aim of this study was to compare in a randomized controlled trial the effect of sleeve gastrectomy (SG) to that of intensive lifestyle intervention plus pharmacologic treatment on some markers of insulin resistance and beta cell function as well as some appetite controlling hormones in a group of male obese T2D subjects. The study groups comprised 20 subjects for SG and 21 control subjects. Fasting blood glucose, insulin, proinsulin, adiponectin, leptin, ghrelin, HOMA-IR, HOMA-%B, proinsulin-to-insulin ratio and proinsulin-to-adiponectin ratio were evaluated at baseline and after one year follow-up. Overall, patients in the SG group lost 78.98% of excess weight loss (%EWL) in comparison with 9.45% in the control group. This was accompanied by a significant improvement of insulin resistance markers, including increase of adiponectin and decrease of HOMA-IR, while no changes were recorded in the control group. Weight loss was also associated with a significant improvement of proinsulin-to-insulin and proinsulin-to-adiponectin ratio, both surrogate markers of beta cell dysfunction. These also improved in the control group, but were only marginally significant. Our findings suggest that improved insulin resistance and decreased beta cell dysfunction after sleeve gastrectomy might explain diabetes remission associated with metabolic surgery.

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