A possible association between rs7903146 (C/T) polymorphism of the transcription factor 7-like 2 gene and type 2 diabetes mellitus in Egyptians

2020 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
OlaH Elgaddar ◽  
Heba Ashraf ◽  
Ebtesam Abdalla ◽  
Hanan Mahrous ◽  
SaidA Ooda
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor

scholarly journals Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History

2016 ◽  
Vol 19 (2) ◽  
pp. 176
Author(s):  
Waode Astria Sahrani ◽  
Indwiani Astuti ◽  
Ahmad Hamim Sadewa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
Insulin Secretion ◽  
Family History ◽  
Model Assessment ◽  
Tcf7l2 Gene ◽  
Type 2 Dm

Family history has considered as a risk factor of type 2 diabetes. Transcription factor-7 like 2 (TCF7L2) hasrole to regulates insulin secretion and blood glucose homeostasis. The aim of current study was to determine thers7903146 polymorphism of TCF7L2 gene and homeostatic model assessment-β (HOMA-β) level on individual withand without type 2 Diabetes Mellitus (DM) family history. This work is a case-control study. Thirty six subjectswith type 2 DM family history and 36 subjects without type 2 DM family history were recruited. HOMA-βmeasure to analyze the insulin secretion. Polymorphisms of TCF7L2 gene was analyzed by using PCR-RFLPmethod. Statistical analysis was performed by using T-test, Mann-Whitney and Chi-square with signifi cancelevel 0.05. The frequency of the T allele of the cases were 4.2% and the controls were 2.8% (p=0.500). The oddratio was 0.649 (CI;95%:0.106-4.055). The HOMA-β levels of the cases were signifi cant low (132.56±62.48)compared with the controls (266.09±1.68) with p=0.000. The subjects with type 2 DM family history have asimilar frequency of having T alleles and CT/TT genotypes. The subjects with type 2 DM family history hassignifi cantly lower HOMA-β levels than subject without DM family history.

AACE2021-A-1073: Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 27 (12) ◽  
pp. S25
Author(s):  
Ahmed M. Bahaaeldin ◽  
Arig Aly Seif ◽  
Amira Ibrahim Hamed ◽  
Walaa Ahmed Yousry Kabiel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
Tcf7l2 Rs7903146

Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Arig Aly Seif ◽  
Amira Ibrahim Hamed ◽  
Ahmed Mohamed Bahaaeldin ◽  
Walaa Ahmed Yousry Kabiel ◽  
Mohamed Ahmed Abo El Azm
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
High Risk ◽  
Gene Polymorphism ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Tcf7l2 Rs7903146

Abstract Background Type 2 diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders characterized by the incapability of pancreatic beta cells to increase insulin secretion to compensate for insulin resistance in the peripheral tissues. T2DM is a multi-factorial disease including several environmental factors with the presence of genetic predisposition. The transcription factor 7-like-2 gene (TCF7L2) rs7903146 (C/T) polymorphism is one of the most susceptible genes to T2DM discovered to date, with contribution to the disease through the Wnt/β –catenin signaling pathway affecting pancreatic islet development, expression of several genes involved in insulin granules exocytosis and the incretin glucagon-like peptide 1 (GLP-1) gene. Aim of the Work In this study we aimed to investigate the potential association of the transcription factor 7-like-2 (TCF7L2) rs7903146 (C/T) gene polymorphism in patients with type 2 diabetes mellitus. Patients and Methods The study was a case- control study conducted on 70 T2DM patients recruited from the endocrinology clinic at Ain Shams University Hospitals, and 30 non diabetic healthy controls matched with the patients in age and sex. All subjects underwent full history taking, thorough clinical examination, routine laboratory investigations including haemoglobin A1c (HbA1c), lipid profile; total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) and determination of TCF7L2 gene polymorphism by real-time quantitative polymerase chain reaction (RT-PCR). Results The minor T allele of the rs7903146(C/T) SNP was associated with high risk of development of T2DM with an OR of 1.35 (95% CI: 0.68-2.6), the heterozygous genotype (CT) with an OR 1.16 (95% CI: 0.49-2.7) and the homozygous mutant genotype (TT) with OR of 3.16 (95% CI: 0.15-6.31), however, they were statistically insignificant (p-value >0.05). Conclusion Our study did not confirm the presence of significant association between the TCF7L2 rs7903146(C/T) polymorphism and T2DM, however, it pointed to the possibility of presence of high risk of development of T2DM in patients with TT genotype. Further studies with higher sample size are needed to clarify the association.

Transcription factor 7-like 2 gene, rs12255372 (G/T) variant and susceptibility to type 2 diabetes mellitus in North Indians

Gene Reports ◽  
2020 ◽  
Vol 19 ◽  
pp. 100595 ◽  
Author(s):  
Navneet Kaur ◽  
Gurjit Kaur Bhatti ◽  
Sumanpreet Kaur ◽  
Sanjay Kumar Bhadada ◽  
Samer Singh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
North Indians

scholarly journals Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 26 (3) ◽  
pp. 112-118
Author(s):  
Ahmed Mohamed Bahaaeldin ◽  
Arig Aly Seif ◽  
Amira Ibrahim Hamed ◽  
Walaa Ahmed Yousry Kabiel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Transcription Factor ◽  
High Risk ◽  
Gene Polymorphism ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Peripheral Tissues

<b><i>Introduction:</i></b> Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by the incapability of pancreas to increase insulin secretion to compensate for insulin resistance in the peripheral tissues. T2DM is a multifactorial disease including several environmental factors with the presence of genetic predisposition. The transcription factor 7-like-2 gene (<i>TCF7L2</i>) rs7903146 (C/T) polymorphism is one of the most susceptible genes to T2DM discovered to date, with contribution to the disease through the Wnt/β-catenin signaling pathway affecting pancreatic islet development, expression of several genes involved in insulin granules exocytosis, and the incretin glucagon-like peptide 1 (<i>GLP-1</i>) gene. Then, <i>TCF7L2</i> gene seems to affect diabetes susceptibility through B-cell dysfunction that is why we studied its association with T2DM in particular. <b><i>Objectives:</i></b> To investigate the potential association of the transcription factor 7-like-2 (<i>TCF7L2</i>) rs7903146 (C/T) gene polymorphism in patients with T2DM. <b><i>Methods:</i></b> A case-control study conducted on 70 T2DM patients recruited from the endocrinology clinic at Ain Shams University Hospitals, and 30 non-diabetic healthy controls age- and sex-matched with the patients. All subjects underwent full history taking; thorough clinical examination; routine laboratory investigations including hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol; and determination of <i>TCF7L2</i> gene polymorphism by qRT-PCR. <b><i>Results:</i></b> The minor T allele of the rs7903146(C/T) SNP was associated with high risk of development of T2DM with an OR of 1.35 (95% CI: 0.68–2.6) and the heterozygous genotype (CT) with an OR 1.16 (95% CI: 0.49–2.7); however, they were statistically insignificant (<i>p</i> value &#x3e;0.05). <b><i>Conclusion:</i></b> Our study did not confirm the presence of significant association between the <i>TCF7L2</i> rs7903146(C/T) polymorphism and T2DM; however, it pointed out the possibility of presence of high risk of development of T2DM in patients with TT genotype. Further studies with higher sample size are needed to clarify the association.

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