scholarly journals Primary thin nodular melanoma: An early tumorigenic vertical growth phase melanoma

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Luca Roncati ◽  
Francesco Piscioli
Keyword(s):  
Growth Phase ◽  
Nodular Melanoma ◽  
Vertical Growth ◽  
Vertical Growth Phase

scholarly journals Immunophenotyping of Compound and Spitz Nevi and Vertical Growth-Phase Melanomas Using a Panel of Monoclonal Antibodies Reactive in Paraffin Sections

1993 ◽  
Vol 100 (3) ◽  
pp. S313-S317 ◽  
Author(s):  
Bette Lazzaro ◽  
David E. Elder ◽  
Ahlke Rebers ◽  
Laurie Power ◽  
Meenhard Herlyn ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Growth Phase ◽  
Paraffin Sections ◽  
Vertical Growth ◽  
Spitz Nevi ◽  
Vertical Growth Phase

Cerebellar Balloon-Cell Metastasis of a Melanoma

1982 ◽  
Vol 68 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Romano Ferracini ◽  
Valeria Manetto ◽  
Giuliano Minghetti ◽  
Giuseppe Lanzanova
Keyword(s):  
Growth Phase ◽  
Cutaneous Melanoma ◽  
Cellular Differentiation ◽  
Vertical Growth ◽  
Balloon Cell ◽  
Cell Metastasis ◽  
Vertical Growth Phase

The authors describe a cerebellar balloon-cell metastasis of a cutaneous melanoma. The authors explain this phenomenon according to the theory of cellular differentiation of the component vertical-growth phase of Clark.

scholarly journals Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?

2000 ◽  
Vol 13 (3) ◽  
pp. 217-222 ◽  
Author(s):  
Zahid Kaleem ◽  
Anne C Lind ◽  
Peter A Humphrey ◽  
Robert H Sueper ◽  
Paul E Swanson ◽  
...  
Keyword(s):  
Growth Phase ◽  
Ki 67 ◽  
Vertical Growth ◽  
Malignant Melanomas ◽  
Vertical Growth Phase

scholarly journals Antigenic Phenotype of Radial Growth Phase Melanomas with or without a Vertical Growth Phase Portion

1988 ◽  
Vol 74 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Laura Brogelli ◽  
Paolo Carli ◽  
Umberto Maria Reali ◽  
Nicola Pimpinelli ◽  
Silvia Moretti
Keyword(s):  
Monoclonal Antibodies ◽  
Growth Phase ◽  
Growth Pattern ◽  
Radial Growth ◽  
Hla Antigens ◽  
Antigen Expression ◽  
Superficial Spreading ◽  
Vertical Growth ◽  
Vertical Growth Phase ◽  
Vertical Growth Pattern

The expression of 4 melanoma-associated antigens and of class I and II HLA antigens was investigated in 12 superficial spreading melanomas (SSM) and in 8 SSM with a vertical growth pattern portion (SS + NM) by the use of monoclonal antibodies and an indirect immunoperoxidase procedure. Monoclonal antibodies 225.28, 763.74, CL. 203, VF19-LL217, Q5-13, W6-32 and anti-HLA-DR, were used. Each antigen was more frequently expressed by SS +NM on the whole than by SSM and also by the radial growth pattern portions of SS + NM than by SSM. Vertical growth pattern portions of SS + NM were not antigenically similar to radial growth pattern portions in the same tumors. The high frequency of antigen expression in radial growth pattern melanomas seems to be associated with the appearance of a more invasive cell population.

Cellular Heterogeneity in Vertical Growth Phase Melanoma

2010 ◽  
Vol 134 (12) ◽  
pp. 1750-1757 ◽  
Author(s):  
Alvaro C. Laga ◽  
George F. Murphy
Keyword(s):  
Growth Phase ◽  
Effective Means ◽  
Significant Risk ◽  
Cellular Heterogeneity ◽  
Melanoma Tumor ◽  
Vertical Growth ◽  
Vertical Growth Phase ◽  
And Function ◽  
Insight Into ◽  
Small Subpopulation

Abstract Context—Melanoma growing as a tumorigenic nodule is one of the most virulent neoplasms to which the flesh is heir. At a considerably small tumor size, it incurs significant risk for widespread metastatic dissemination. There are no effective means of surgical intervention, chemical therapy, or immunologic therapy for advanced and metastatic melanoma. Objective—To review the literature and highlight recent cardinal advances in the understanding of melanoma vertical growth, with specific emphasis on how its recognition and characterization may be applied to diagnostic practice and development of novel investigative approaches. Data Sources—Literature review, archival material, personal experience, and research collaborators. Conclusions—The study of tumorigenic melanoma, both in primary lesions and in metastases, is the key to the eventual eradication of this highly virulent neoplasm that may disseminate widely when only occupying the volume of a grain of rice. Morphology often provides the first insight into structure and function. A growing database using meticulous and inclusive criteria to define tumor stem cells in the context of clinically relevant models now indicates that the key to melanoma heterogeneity may reside in a small subpopulation with the ability to self-renew and form tumors despite most cells present being significantly less virulent. Hopefully, from these insights into melanoma tumor progression from radial growth phase to heterogeneous and tumorigenic vertical growth phase will come additional answers to how smart therapies may be developed that specifically target those vertical growth phase cells that most pertain to patient survival.

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