scholarly journals Mass spectrometry-based metabolomics in biomarker-assisted drug discovery and oxidative stress research

2017 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
V Sivaram ◽  
AKiran Kumar ◽  
Sagarika Devi
Keyword(s):  
Oxidative Stress ◽  
Mass Spectrometry ◽  
Drug Discovery ◽  
Stress Research ◽  
And Oxidative Stress

scholarly journals Isolation and Characterization of β-Sitosterol from Justicia gendarussa burm. F.-An Anti-Inflammatory Compound

2017 ◽  
Vol 9 (09) ◽  
Author(s):  
N. D. Phatangare ◽  
K. K. Deshmukh ◽  
V. D. Murade ◽  
P. H. Naikwadi ◽  
D. P. Hase ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mass Spectrometry ◽  
Acute Inflammation ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Isolation And Characterization ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Justicia gendarussa Burm.f. has become important source of β-sitosterol which is associated with other phenolic,terpenoids,alkaloids and steroids. Plant sterols show anti-inflammatory activity. β-sitosterol is one of phytosterol, in a mouse model of acute inflammation, and β-sitosterol effect on leukocyte recruitment, cytokines levels, and oxidative stress. The anti-inflammatory activities of β-sitosterol were assessed by measuring paw edema induced by different inflammatory agents. It separated from Justicia gendarussa burm.f. and characterization of β-sitosterol carried out by IR, NMR, and mass spectrometry. β-sitosterol shows potent as Anti-inflammatory activity by releasing histamine (30.07%), serotin and bradykinin (52.25%), and prostaglandin (69.43%) as compared to standard (Dicolfenac 5mg/kg). Objectives:To isolate, separate and characterization of β-sitosterol and to evaluate the anti-inflammatory activity of β-sitosterol extracted from Chloroform extract of Justicia Gendarussa Burm.f.

Glycosphingolipids and oxidative stress: Evaluation of hydroxyl radical oxidation of galactosyl and lactosylceramides using mass spectrometry

2015 ◽  
Vol 191 ◽  
pp. 106-114 ◽  
Author(s):  
Daniela Couto ◽  
Deolinda Santinha ◽  
Tânia Melo ◽  
Emanuel Ferreira-Fernandes ◽  
Romeu A. Videira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mass Spectrometry ◽  
Hydroxyl Radical ◽  
Stress Evaluation ◽  
Radical Oxidation ◽  
And Oxidative Stress

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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