Squamous cell carcinoma antigen reproducible marker and its clinicopathological correlation with preinvasive and invasive cervical cancer

2017 ◽  
Vol 6 (4) ◽  
pp. 184
Author(s):  
Rekha Sachan ◽  
Meenakshi Singh ◽  
Pushplata Sachan ◽  
MunnaLal Patel ◽  
Radhey Shyam
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Invasive Cervical Cancer ◽  
Clinicopathological Correlation ◽  
Squamous Cell Carcinoma Antigen

scholarly journals Invasive Cervical Cancer in Southampton and South West Hampshire: Effect of Introducing a Comprehensive Screening Programme

1996 ◽  
Vol 3 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Amanda Herbert ◽  
Catherine Breen ◽  
TN Bryant ◽  
A Hitchcock ◽  
H Macdonald ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Invasive Cervical Cancer ◽  
Depth Of Invasion ◽  
Inverse Association ◽  
Age Group ◽  
South West ◽  
Screening Coverage

A study of invasive cervical cancer in Southampton and South West Hampshire is reported, covering three consecutive three year periods during which the screening coverage increased from an estimated 60% to a recorded 87% of eligible women aged 20–64. From the first to the third periods of the study in that age group registrations of fully invasive squamous cell carcinoma (stage Ib and above) fell from 64 to 30 (53%), which was largely counteracted by an increase in microinvasive squamous cell carcinoma (linear trend: P<0–0001). In the same age group registrations of adenocarcinoma rose slightly, which resulted from an increase in the number diagnosed at a depth of invasion of less than 3 mm. There were no significant changes in the numbers of stage III and IV cancers or among cancers in women aged 65 and over. A strong inverse association was found between stage of both histological types of cancer and their likelihood of being screen detected rather than symptomatic: 91% of screen detected cancers were diagnosed at stage I compared with 38% of symptomatic cancers. There was a slight downward trend in the incidence of cancer per 100 000 total female population across the three periods of the study with a significant trend towards low stage disease, which is likely to reduce mortality in years to come. The trend towards screen detected cancers and cancers of less than 3 mm depth of invasion is presented as a positive outcome to be expected in early rounds of increasing the screening coverage.

scholarly journals The simultaneous detection of the squamous cell carcinoma antigen and cancer antigen 125 in the cervical cancer serum using nano-Ag polydopamine nanospheres in an SERS-based lateral flow immunoassay

RSC Advances ◽  
2020 ◽  
Vol 10 (49) ◽  
pp. 29156-29170
Author(s):  
Ji Xia ◽  
Yifan Liu ◽  
Menglin Ran ◽  
Wenbo Lu ◽  
Liyan Bi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Simultaneous Detection ◽  
Lateral Flow ◽  
Lateral Flow Immunoassay ◽  
Squamous Cell Carcinoma Antigen ◽  
Cancer Antigen 125 ◽  
Cancer Antigen

Based on SERS-based lateral flow immunoassay, nano-Ag polydopamine nanospheres was used for detecting squamous cell carcinoma antigen and cancer antigen 125 simultaneously in cervical cancer serum.

The curative role of radiotherapy in patients with isolated para-aortic node recurrence from cervical cancer and value of squamous cell carcinoma antigen for early detection

2005 ◽  
Vol 15 (4) ◽  
pp. 630-638 ◽  
Author(s):  
I. Ogino ◽  
H. Nakayama ◽  
T. Kitamura ◽  
N. Okamoto ◽  
T. Inoue
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Antigen ◽  
Radiotherapy Group ◽  
Number Of Patients ◽  
Primary Radiotherapy ◽  
Initial Sign ◽  
Group 2

The objective of this study was to examine the clinical benefits of routine squamous cell carcinoma antigen (SCC-ag) monitoring of patients with locally advanced cervical cancer. Recurrent disease occurred in 99 uterine cervical cancer patients with elevated pretreatment SCC-ag before primary radiotherapy. Elevated SCC-ag levels persisted in 23 patients after primary radiotherapy (group 1), and SCC-ag was normalized in 76 patients after primary radiotherapy (group 2). The overall survival (OS) rate was higher for patients with SCC-ag elevation as the first sign than for patients with recurrence predicted by other modalities for group 2 patients (P = 0.033). The prediction of isolated para-aortic node recurrence significantly correlated with SCC-ag elevation as an initial sign (P = 0.001). The SCC-ag level before primary radiotherapy (≥10.8 ng/mL) significantly affected recurrence predicted by SCC-ag elevation as an initial sign (P = 0.002). For multivariate analysis, the presence of para-aortic node recurrence was statistically significant in OS (P < 0.0001). Routine SCC-ag monitoring of patients with carcinoma of the uterine cervix can lead to the early diagnosis of isolated para-aortic lymph node recurrence, and prolonged survival can be achieved by applying radiation therapy to the para-aortic region. To reduce the number of patients monitored for SCC-ag, we recommend monitoring group 2 patients with pretreatment SCC-ag level before primary radiotherapy ≥10.8 ng/mL.

Detection of squamous cell carcinoma antigen in cervical cancer by surface-enhanced Raman scattering-based immunoassay

2019 ◽  
Vol 11 (21) ◽  
pp. 2809-2818 ◽  
Author(s):  
Dan Lu ◽  
Ji Xia ◽  
Zhuo Deng ◽  
Xiaowei Cao
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Raman Scattering ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surface Enhanced Raman Scattering ◽  
Squamous Cell Carcinoma Antigen ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this study, a highly specific, sensitive and reliable immunosensor has been developed for the quantitative detection of the squamous cell carcinoma antigen (SCCA) in cervical cancer, based on surface-enhanced Raman scattering (SERS).

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