Subcutaneous adipose tissue as a biomarker of pancreatic cancer: A pilot study in male patients

2019 ◽  
Vol 8 (3) ◽  
pp. 114 ◽  
Author(s):  
Federico Greco ◽  
CarloAugusto Mallio ◽  
Vincenzo Cirimele ◽  
RosarioFrancesco Grasso ◽  
BrunoBeomonte Zobel
Keyword(s):  
Pancreatic Cancer ◽  
Adipose Tissue ◽  
Pilot Study ◽  
Subcutaneous Adipose Tissue ◽  
Male Patients ◽  
Subcutaneous Adipose

scholarly journals Visceral Adiposity Associates With Malnutrition Risk Determined by Royal Free Hospital-Nutritional Prioritizing Tool in Cirrhosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyu Wang ◽  
Yifan Li ◽  
Mingyu Sun ◽  
Gaoyue Guo ◽  
Wanting Yang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Statistical Significance ◽  
Visceral Adiposity ◽  
Royal Free Hospital ◽  
Significant Difference ◽  
Total Adipose Tissue ◽  
Male Patients ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

Mounting evidence has suggested the clinical significance of body composition abnormalities in the context of cirrhosis. Herein, we aimed to investigate the association between visceral adiposity and malnutrition risk in 176 hospitalized patients with cirrhosis. The adiposity parameters were obtained by computed tomography (CT) as follows: total adipose tissue index (TATI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR). Malnutrition risk was screened using Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT). Visceral adiposity was determined given a higher VSR based on our previously established cutoffs. Multivariate analysis implicated that male gender (OR = 2.884, 95% CI: 1.360–6.115, p = 0.006), BMI (OR = 0.879, 95% CI: 0.812–0.951, P = 0.001), albumin (OR = 0.934, 95% CI: 0.882–0.989, P = 0.019), and visceral adiposity (OR = 3.413, 95% CI: 1.344–8.670, P = 0.010) were independent risk factors of malnutrition risk. No significant difference was observed regarding TATI, SATI, and VATI among patients with low or moderate and high risk of malnutrition. In contrast, the proportion of male patients embracing visceral adiposity was higher in high malnutrition risk group compared with that in low or moderate group (47.27 vs. 17.86%, p = 0.009). Moreover, this disparity was of borderline statistical significance in women (19.05 vs. 5.88%, p = 0.061). Assessing adipose tissue distribution might potentiate the estimation of malnutrition risk in cirrhotics. It is pivotal to recognize visceral adiposity and develop targeted therapeutic strategies.

scholarly journals The Effect of Fat Distribution on the Inflammatory Response of Multiple Trauma Patients—A Retrospective Study

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1243
Author(s):  
Zhaoxiong Chen ◽  
Silvan Wittenberg ◽  
Timo Alexander Auer ◽  
Maxim Bashkuev ◽  
Pimrapat Gebert ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Retrospective Study ◽  
Inflammatory Response ◽  
Hospital Stay ◽  
Subcutaneous Adipose Tissue ◽  
Fat Distribution ◽  
Independent Factor ◽  
Polytrauma Patients ◽  
Male Patients ◽  
Subcutaneous Adipose

Objectives In recent years; increasing evidence pointed out the clinical importance of adipose tissue (AT) distribution in various patient populations. In particular, visceral adipose tissue (VAT), when compared to subcutaneous adipose tissue (SAT), was found to play a pivotal role in the development of inflammatory reaction. The aim of the present study was to examine whether body fat distribution has an impact on the development of systemic inflammatory response syndrome (SIRS) in patients with polytrauma. Methods In our retrospective study; we filtered our institution records of the German Trauma Registry (Trauma Register DGU) from November 2018 to April 2021 and included 132 adult polytrauma patients with injury severity score (ISS) >16. Subsequently; we measured the visceral and subcutaneous adipose tissue area based on whole-body CT scan and calculated the ratio of VAT to SAT (VSr). Thereafter, the patient population was evenly divided into three groups; respectively VSr value less than 0.4 for the first group (low ratio), 0.4–0.84 for the second group (intermediate ratio), and greater than 0.84 for the third group (high ratio). Considering the other influencing factors; the groups were further divided into subgroups in the respective analysis according to gender (male/female), BMI (<25 or ≥25), and ISS (<26 or ≥26). Result VSr was an independent factor from body mass index (BMI) (r2 = 0.003; p = 0.553). VSr in male patients was significantly higher (p < 0.001). Patients with low VSr had higher ISS scores (p = 0.028). Polytrauma patients with higher VSr tended to have lower SIRS scores and significant differences of SIRS score were found on multiple days during the whole hospitalization period. In the low VAT/SAT group, male patients, and patients with BMI greater than 25, both exhibited higher SIRS scores during hospital stay (day 16: p = 0.01; day 22: p = 0.048 and p = 0.011; respectively). During hospitalization, patients with higher ISS score (≥26) in the low VSr group was found to have higher SIRS score (day 16; p = 0.007). Over the hospital stay; serum markers of CRP; CK; and leukocyte in patients with low VSr were higher than those in patients in the intermediate and high VSr groups; with significant difference discovered on multiple days (day 16: 0.014; day 22: p = 0.048). Conclusion Lower VSr is associated with increased inflammatory response and worse clinical outcome in patients with polytrauma. Furthermore; VSr is an independent factor providing additional information to BMI.

scholarly journals A Pilot Study of Sampling Subcutaneous Adipose Tissue to Examine Biomarkers of Cancer Risk

2009 ◽  
Vol 2 (1) ◽  
pp. 37-42 ◽  
Author(s):  
K. L. Campbell ◽  
K. W. Makar ◽  
M. Kratz ◽  
K. E. Foster-Schubert ◽  
A. McTiernan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Pilot Study ◽  
Cancer Risk ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Karen L. Herbst ◽  
Christopher Ussery ◽  
Alyna Eekema
Keyword(s):  
Adipose Tissue ◽  
Pilot Study ◽  
Side Effects ◽  
Metabolic Rate ◽  
Subcutaneous Adipose Tissue ◽  
Resting Metabolic Rate ◽  
Whole Body ◽  
Tissue Quality ◽  
Total Body ◽  
Subcutaneous Adipose

AbstractBackgroundLipedema is a common painful subcutaneous adipose tissue (SAT) disorder in women affecting the limbs. SAT therapy is a manual therapy to improve soft tissue quality.ObjectiveDetermine if SAT therapy improves pain and structure of lipedema SAT.DesignSingle arm prospective pilot study.SettingAcademic medical center.PatientsSeven women, 46 ± 5 years, weight 90 ± 19 kg, with lipedema.InterventionTwelve 90-min SAT therapy sessions over 4 weeks.OutcomesDual X-ray absorptiometry (DXA) scans, SAT ultrasound (Vevo 2100), leg volumetrics, skin caliper assessment, tissue exam, weight, resting metabolic rate, pain assessment, lower extremity functional scale (LEFS) and body shape questionnaire (BSQ) at baseline and end of study.ResultsWeight, resting metabolic rate and BSQ did not change significantly. Limb fat over total body fat mass (p = 0.08) and trunk fat over total body mass trended down from baseline (p = 0.08) by DXA. Leg volume and caliper assessments in eight of nine areas (p < 0.007), LEFS (p = 0.002) and average pain (p = 0.007) significantly decreased from baseline. Fibrosis significantly decreased in the nodules, hips and groin. Ultrasound showed improved SAT structure in some subjects. Side effects included pain, bruising, itching, swelling and gastroesophageal reflux disease. All women said they would recommend SAT therapy to other women with lipedema.LimitationsSmall number of subjects.ConclusionSAT therapy in 4 weeks improved tissue structure, perceived leg function, and volume although shape was not affected. While side effects of SAT therapy were common, all women felt the therapy was beneficial.

Insulin resistance, systemic and regional inflammation in subcutaneous adipose tissue during weight loss in a population with obesity

2019 ◽  
Author(s):  
Frederique Van de Velde ◽  
Margriet Ouwens ◽  
Arsene-Helene Batens ◽  
Samyah Shadid ◽  
Bruno Lapauw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose
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