scholarly journals Candidal species identification in malignant and potentially malignant oral lesions with antifungal resistance patterns

2018 ◽  
Vol 9 (6) ◽  
pp. 309 ◽  
Author(s):  
Rahul Bansal ◽  
Shambulingappa Pallagatti ◽  
Soheyl Sheikh ◽  
Amit Aggarwal ◽  
Deepak Gupta ◽  
...  
Keyword(s):  
Species Identification ◽  
Antifungal Resistance ◽  
Oral Lesions ◽  
Resistance Patterns ◽  
Potentially Malignant ◽  
Candidal Species

scholarly journals ‘Cytology-on-a-chip’ based sensors for monitoring of potentially malignant oral lesions

Oral Oncology ◽  
2016 ◽  
Vol 60 ◽  
pp. 103-111 ◽  
Author(s):  
Timothy J. Abram ◽  
Pierre N. Floriano ◽  
Nicolaos Christodoulides ◽  
Robert James ◽  
A. Ross Kerr ◽  
...  
Keyword(s):  
Oral Lesions ◽  
Potentially Malignant

scholarly journals A importância do acompanhamento clínico de lesões brancas potencialmente malignas em mucosa labial: relato de caso

2020 ◽  
Vol 8 (12) ◽  
Author(s):  
Vanessa Einsfeld ◽  
Ana Claudia Ramos ◽  
Beatriz Barbosa ◽  
Alberto Zen ◽  
Grasieli de Oliveira Ramos ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Precancerous Lesion ◽  
Oral Leukoplakia ◽  
World Health ◽  
Oral Lesions ◽  
Actinic Cheilitis ◽  
Potentially Malignant

Introdução: Quando estamos frente às lesões potencialmente malignas, torna-se imprescindível o acompanhamento rigoroso dessas lesões, pois são lesões frequentes e com risco de transformação maligna consideravelmente relevante, a leucoplasia e a queilite actínica, são as lesões mais comuns encontradas na cavidade bucal. Objetivo: relatar um caso de lesão potencialmente maligna em mucosa labial. Relato de caso: Paciente sexo masculino compareceu à clínica de Diagnóstico VI da Universidade do Oeste de Santa Catarina, com a presença de lesão branca em lábio inferior, o mesmo já se encontrava em acompanhamento há seis anos, com diagnóstico prévio de queilite actínica sem atipia celular (duas biópsias prévias). Aposentado, trabalhava anteriormente como agricultor, ex-fumante e ex-etilista. Clinicamente observava-se lesão esbranquiçada, com aspecto verruciforme, localizada em lábio inferior, medindo 2 cm no maior diâmetro. Além disso, o lábio encontrava-se endurecido, com aspecto roliço. Duas hipóteses de diagnóstico foram levantadas: queilite actínica associada a leucoplasia e carcinoma verrucoso. O paciente foi submetido à nova biópsia incisional. No laudo constatou-se tratar de queilite actínica com displasia epitelial leve e o tratamento proposto foi o uso de protetor labial FPS30, além de acompanhamento clínico semestral. Conclusão: O acompanhamento desse caso clínico foi possível observar alteração no perfil citológico, onde nas primeiras biópsias não era possível observar atipia celular e na biópsia mais recente foi observado uma displasia epitelial leve, portanto o acompanhamento das lesões potencialmente malignas é fundamental para prevenir sua transformação maligna, e uma nova biópsia deve ser realizada sempre que for observada alteração no aspecto clínico da lesão.Descritores: Leucoplasia; Queilite; Biópsia; Lábio.ReferênciasPindborg JJ, Reichart PA, Smith CJ, Van der Waal I. World Health Organization International histological classification of tumours. Histological typing of câncer and precancer of the oral mucosa. Berlin: Springer; 1997.Marley JJ, Linden GJ, Cowan CG, Lamey PJ, Warnakulasuriya KAAS, Scully C. Management of potentially malignant oral mucosa lesions by consultant UK oral and maxillofacial surgeons.  Br J Oral Maxillofac Surg. 1996;34(1):28-36.Neville BW, Dam DD, Allen CM, Chi AC . Patologia oral e maxilofacial. 3. ed. Rio de Janeiro; 2016.Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575-80.Gupta PC, Murti PR, Bhonsle RB, Mehta FS, Pindborg JJ. Effect of cessation of tobacco use on the incidence of oral mucosal lesions in a 10-yr follow-up study of 12.212 users. Oral Dis. 1995;1(1):54-8.Maito FDM. Avaliação da expressão do PCNA no epitélio lingual de camundongos submetidos à ingestão e aplicação tópica de álcool a 40 GL [dissertação]. Porto Alegre: Faculdade de Odontologia – UFRGS;2001.Markopoulos A, Albanidou-Farmaki E, Kayavis I. Actinic cheilitis: clinical and pathologic characteristics in 65 cases. Oral Dis. 2004;10(4):212-16.Cintra JS, Torres SCM, Silva MBF, Manhães Júnior LRC, Silva Filho JP, Junqueira JLC. Queilite Actínica: estudo epidemiológico entre trabalhadores rurais no município de Paracaia– SP. Ver Assoc Paul Cir Dent. 2013;67(2):118-21.Greespan D, Jordan RCK. The white lesions that kills – aneuploide dysplastic oral leukoplakia. N Engl J Med. 2004;350(14):1382-84.Bánóczy J. Follow-up studies in oral leukoplakia. J Maxillofac Surg. 1977;5(1):69-75.Huber MA. White oral lesions, actinic cheilitis, and leukoplakia: confusions in terminology and definition: facts and controversies. Clin Dermatol. 2010;28(3):262-68.Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological and molecular biological characateristics. Crit Rev Oral Biol Med. 2003;14(1):47-62.Scheifele C, Reichart PA, Oral leukoplakia in manifest squamous epithelial carcinoma. A clinical prospective study of 101 patients, Mund Kiefer Gesichtschir. 1998;2(6):326-30.Schepman K, der Meij E, Smeele L, der Waal I. Concomitant leukoplakia in patients with oral squamous cell carcinoma. Oral Dis. 1999;5(3):206-9.Kaugars GE, Pillion T, Svirsky JA, Page DG, Burns JC, Abbey LM. Actinic cheilitis: a review of 152 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(2):181-86.Abreu MAMA, Silva OMP, Pimentel DRN, Hirata CHW, Weckx LLM, Alchorne MMA et al. Actinic cheilitis adjacent to squamous carcinoma of the lips as an indicator of prognosis. Braz J Otorhinolaryngol. 2006;72(6):767-71.Patrício JFC. Evolução das lesões pré-malignas orais: orientações para os médicos dentistas [dissertação]. Porto: Universidade do Porto; 2011.Shah AY, Doherty SD, Rosen T. Actinic cheilitis: a treatment review. Int J Dermatol. 2010; 49(11):1225-34.Pimenta FJ, Cordeiro GT, Pimenta LGGS, Viana MB, Lopes J, Gomez MV et al.  Molecular alterations in the tumor suppressor gene WWOX in oral Leukoplakias. Oral Oncol. 2008;44(8):753-58Paulo LFB, Rosa RR, Rocha MA, Durighetto Junior AF. Incidência e prevalência das lesões brancas associadas ao tabagismo atendidos no ambulatório da Unidade de Diagnóstico Estomatológico da Universidade Federal de Uberlândia no período de 1997 a 2008. Horizonte Cientifico. 2011;2:1-20.Gandolfo S, Pentenero M, Broccoletti R, Pagano M, Carrozzo M, Scully C. Toluidine blue uptake in potentially malignant oral lesions in vivo: clinical and histological assessment. Oral Oncol. 2006;42(1):89-95.Mashberg A, Samit A. Early diagnosis of asympomatic oral and oropharyngeal squamous cancers. CA Cancer J Clin. 1995;45(6):328-51.Mendes SF, Ramos GO, Rivero ERC, Modolo F, Grando LJ, Meurer MI. Techniques for precancerous lesion diagnosis. J Oncol. 2011. ID 326094.Dib LL, Kowalski LP, Curi MM. Lesões cancerizáveis de boca. In: Kowaski LP, Anelli A, Salvajoli JV, Lopes LF. Manual de condutas diagnosticas e terapêuticas em oncologia. 2.ed. São Paulo: Âmbito Editores; 2002.

scholarly journals Use of Convolutional Neural Networks in Smartphones for the Identification of Oral Diseases Using a Small Dataset

2021 ◽  
Vol 30 (55) ◽  
pp. e11846
Author(s):  
Jormany Quintero-Rojas ◽  
Jesús David González
Keyword(s):  
Neural Networks ◽  
Convolutional Neural Networks ◽  
Mobile Application ◽  
Oral Lesions ◽  
Oral Diseases ◽  
Machine Learning Methods ◽  
Potentially Malignant ◽  
Malignant Lesions ◽  
Simplex Virus

Image recognition and processing is a suitable tool in systems using machine learning methods. The addition of smartphones as complementary tools in the health area for diagnosis is a fact nowadays due to the advantages they present. Following the trend of providing tools for diagnosis, this research aimed to develop a prototype mobile application for the identification of oral lesions, including potentially malignant lesions, based on convolutional neural networks, as early detection of indications of possible types of cancer in the oral cavity. A mobile application was developed for the Android operating system that implemented the TensorFlow library and the Mobilenet V2 convolutional neural network model. The training of the model was performed by transfer learning with a database of 500 images distributed in five classes for recognition (Leukoplakia, Herpes Simplex Virus Type 1, Aphthous stomatitis, Nicotinic stomatitis, and No lesion). The 80% of the images were used for training and 20% for validation. It was obtained that the application presented at least 80% precision in the recognition of four class. The f1-score and area under curve metrics were used to evaluate performance. The developed mobile application presented an acceptable performance with metrics higher than 75% for the recognition of three lesions, on the other hand, it yielded an unfavorable performance lower than 70% for identifying nicotinic stomatitis cases with the chosen dataset.

scholarly journals Comparison of Cytogenetic and Static Cytometry Procedures in the Evaluation of Potentially Malignant Oral Lesions

2008 ◽  
Vol 2008 ◽  
pp. 1-7
Author(s):  
L. Montebugnoli ◽  
I. Grelli ◽  
F. Cervellati ◽  
D. Servidio ◽  
C. Marchetti ◽  
...  
Keyword(s):  
Oral Lesions ◽  
Potentially Malignant ◽  
Static Cytometry

scholarly journals ROLE OF PHYTOCHEMICALS IN ORAL POTENTIALLY MALIGNANT DISORDERS : A REVIEW

2014 ◽  
Vol 04 (04) ◽  
pp. 120-125
Author(s):  
Ananya Madiyal ◽  
Vidya Ajila ◽  
Subhas G Babu ◽  
Shruthi Hedge ◽  
Harini Keshavaiah ◽  
...  
Keyword(s):  
Free Radicals ◽  
Chemical Species ◽  
Healthcare Services ◽  
Health Concern ◽  
Oral Lesions ◽  
Oral Potentially Malignant Disorders ◽  
Naturally Occurring ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

AbstractOral cancer is a major global health concern and poses a challenge to diagnostic and therapeutic aspects of healthcare services. Various oral lesions like leukoplakia, erythroplakia, lichen planus and oral submucus fibrosis categorized as orally potential malignant disorders have shown increased incidence of malignant transformation. Free radicals are highly reactive chemical species with capacity to damage nucleic acids, proteins and lipids and bring about changes of clinical significance. Antioxidants help in scavenging these free radicals and prevent disease progression. Naturally occurring phytochemicals play an important role in preventing oxidative stress and protect the cells from damage by free radicals.

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