scholarly journals Granulocyte-colony stimulating factor and umbilical cord blood cell transplantation: Synergistic therapies for the treatment of traumatic brain injury

2017 ◽  
Vol 3 (3) ◽  
pp. 143 ◽  
Author(s):  
Ike dela Peña ◽  
MichaelG Liska
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Cord Blood Cell ◽  
Stimulating Factor

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

2015 ◽  
Vol 24 (3) ◽  
pp. 447-457 ◽  
Author(s):  
Ike De La Peña ◽  
Paul R. Sanberg ◽  
Sandra Acosta ◽  
Shinn-Zong Lin ◽  
Cesar V. Borlongan
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Cell ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Adjunctive Therapy ◽  
Cord Blood Cell ◽  
Umbilical Cord Blood Cell

Combined Transplantation of Bone Marrow and Umbilical Cord Blood of Same Sibling in Twenty Three Children with Beta-Thalassemia Major

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4506-4506
Author(s):  
Wu Xuedong ◽  
Li Chunfu ◽  
Xiaoqin Feng ◽  
Yuelin He ◽  
Xiaohui Zhou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Conflicts Of Interest ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

Abstract Abstract 4506 Objective: To investigate the effect of transplantation using bone marrow plus umbilical cord blood from same sibling in children with β-thalassemia major (TM). Methods: Twenty three TM patients undergoing transplantation of bone marrow and umbilical cord blood of same sibling aged from 4.0 to 12 years, 13 boys and 10 girls, were recruited at the Department of Pediatrics, Nanfang Hospital, Southern Medical University from January 2005 to June 2012. The patients were classified into three classes, class¢ñ to class ¢ò 22 cases and class ¢ó 1 case. Donors ranged 1–4 years received 10 Ìg/kg per day of subcutaneous granulocyte colony-stimulating factor (G-CSF) for 5 consecutive days. Bone marrow was harvested on the fifth day. Bone marrow and umbilical cord blood of the same sibling then were transfused into the patient. Results: Recovery of hematopoiesis was gained in all patients 4 weeks following transplantation. Seventeen patients suffered from infection of different degree. Six patients developed mild venous occlusive disease. Four patients developed grade¢ñacute graft-versus-host disease (GVHD), and one developed grade¢ñchronic GVHD. Of twenty three patients, twenty survived, three died of whom, one died of lung infection and heart failure 32 days following transplantation, one died of organ failue on 47days after transplantation, and the other one died of lung fugal infection 22 months after transplantation. Conclusion: Combined transplantation of granulocyte colony-stimulating factor primed bone marrow and umbilical cord blood of same sibling in children with β-thalassemia major is safe and effective with promising results. However, complications should be paid high attention following transplantation. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Enhancement of Umbilical Cord Blood Cell Hematopoiesis by Maitake Beta-Glucan Is Mediated by Granulocyte Colony-Stimulating Factor Production

2006 ◽  
Vol 14 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Hong Lin ◽  
Sandy W. Y. Cheung ◽  
Mirjana Nesin ◽  
Barrie R. Cassileth ◽  
Susanna Cunningham-Rundles
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Colony Formation ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Beta Glucan ◽  
Mouse Bone Marrow Cell ◽  
Hematopoietic Stem ◽  
Stimulating Factor

ABSTRACT Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to treat cancer in Asia. We have previously reported that MBG enhances mouse bone marrow cell (BMC) hematopoiesis in vitro and protects BMC from doxorubicin (DOX) toxicity. In the current study, we investigated the ability of MBG to enhance hematopoiesis and to reduce the toxic effects of DOX on fresh human umbilical cord blood (CB) cells. MBG treatment significantly enhanced the colony formation unit (CFU) response of granulocytes-macrophages (CFU-GM response) over the whole dose range of 12.5 to 100 μg/ml (P < 0.05). The addition of MBG to DOX-treated CB cells significantly protected granulocyte-macrophage colony formation from the toxicity of DOX, which otherwise produced strong hematopoietic repression. MBG also partially replaced recombinant human granulocyte colony-stimulating factor (rhG-CSF), as shown by a significant augmentation of the CFU-GM response in the absence of rhG-CSF. We found that MBG induces granulocyte colony-stimulating factor (G-CSF) production in CB CD33+ monocytes, as detected by intracellular cytokine flow cytometric assessment. In contrast, we found that adult peripheral blood monocytes did not produce a significant G-CSF response to MBG, whereas both adult and CB monocytes produced G-CSF in response to lipopolysaccharide. These studies provide the first evidence that MBG induces hematopoietic stem cell proliferation and differentiation of CFU-GM in umbilical CB cells and acts directly to induce G-CSF.

Umbilical cord blood cell-derived neurospheres differentiate into Schwann-like cells

Neuroreport ◽  
2009 ◽  
Vol 20 (4) ◽  
pp. 354-359 ◽  
Author(s):  
Hong-Tian Zhang ◽  
Hao-Yu Cheng ◽  
Liang Zhang ◽  
Juan Fan ◽  
Yi-Zhao Chen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Cell ◽  
Umbilical Cord Blood Cell
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