scholarly journals Wall shear stress and local plaque development in stenosed carotid arteries of hypercholesterolemic minipigs

2012 ◽  
Vol 3 (2) ◽  
pp. 76-83 ◽  
Author(s):  
Troels Thim ◽  
Mette Kallestrup Hagensen ◽  
Erling Falk ◽  
Arne Hørlyck ◽  
Won Yong Kim ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Carotid Arteries ◽  
Plaque Development ◽  
Wall Shear

Hemodynamics of the Rat Aortic Arch

2012 ◽  
Author(s):  
David S. Molony ◽  
Andrew Nencka ◽  
Zhixin Li ◽  
Ming Zhao ◽  
Don P. Giddens
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Vascular Disease ◽  
Molecular Level ◽  
In Vivo Studies ◽  
Mechanical Stimuli ◽  
Model Studies ◽  
Plaque Development ◽  
Wall Shear

Hemodynamics have been linked to the genesis and progress of vascular disease in humans and animals1. Disturbed flow patterns such as stagnant flow or flow reversal lead to low or oscillating wall shear stress (WSS). Several in-vivo studies have correlated these types of WSS with disease formation1, 2. The desire to find correlations between markers of vascular disease and mechanical stimuli and because of their easier availability has led to an increasing number of animal model studies. The mouse, in particular, is a commonly used animal for investigating vascular disease formation and progression. Suo et al., were one of the first to relate findings on the molecular level with WSS1. They found increased VCAM and ICAM expression in areas of low WSS. More recently Hoi et al.2, have shown a correlation between atherosclerotic plaque development and hemodynamic parameters such as low time averaged wall shear stress (TAWSS) and Oscillatory Shear Index (OSI).

Association Between Intima-Media Thickness and Wall Shear Stress in Common Carotid Arteries in Healthy Male Subjects

Circulation ◽  
1996 ◽  
Vol 94 (12) ◽  
pp. 3257-3262 ◽  
Author(s):  
Agostino Gnasso ◽  
Claudio Carallo ◽  
Concetta Irace ◽  
Vitaliano Spagnuolo ◽  
Giuseppina De Novara ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Healthy Male ◽  
Media Thickness ◽  
Wall Shear ◽  
Male Subjects ◽  
Common Carotid Arteries

scholarly journals Study of correlation between wall shear stress and elasticity in atherosclerotic carotid arteries

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Bo Zhang ◽  
Junyi Gu ◽  
Ming Qian ◽  
Lili Niu ◽  
Dhanjoo Ghista
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Carotid Arteries ◽  
Wall Shear

P3109Coronary vulnerable plaque development is promoted by multidirectional wall shear stress

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Hoogendoorn ◽  
A M Kok ◽  
E M J Hartman ◽  
C Chiastra ◽  
L Casadonte ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Flow Index ◽  
Local Flow ◽  
Predictive Values ◽  
Plaque Development ◽  
Relative Residence Time ◽  
Plaque Growth ◽  
Wall Shear

Abstract Aim Wall shear stress (WSS) has been widely associated with plaque development and destabilization. However, the multidirectionality of WSS, induced by the pulsatile nature of blood flow in combination with the arterial geometry, is rarely taken into account. The purpose of this study was to investigate the influence and predictive value of five (multidirectional) WSS parameters for coronary plaque progression and composition. Methods Familial hypercholesterolemic pigs (n=10, castrated male, 3 years old) were put on a high-fat diet and underwent imaging (near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), optical coherence tomography (OCT) and CT) of the three main coronary arteries at baseline and 10/12 months follow-up. IVUS-based lumen contours were combined with the centerline of artery as extracted from CT to obtain a 3D reconstruction of the coronary artery. Local flow velocity measurements were combined with the 3D-geometry of the coronary arterial lumen to calculate five multidirectional WSS parameters including: time average wall shear stress (TAWSS), oscilatory shear index (OSI), relative residence time (RRT), trans wall shear stress (TransWSS), cross flow index (CFI). For the analysis, arteries were divided into 3mm/45° sectors (n=3627). Per vessel each segment was classified as low, mid or high for each WSS metric based on the average value in the sector. Changes in wall thickness (WT) and plaque composition were assessed with NIRS-IVUS and OCT, and histology and related to the local (multidirectional) WSS. Results Half of the pigs developed lumen intruding, complex, lipid-rich plaques. In these pigs, coronary segments exposed to low baseline levels of TAWSS exhibited a significantly larger plaque growth per month compared to regions with either mid or high TAWSS (p<0.05, see figure). Furthermore, plaque growth correlated positively with the multidirectional WSS metrics OSI, RRT and CFI, with high multidirectionality resulting in the largest plaque growth (see figure). The positive predictive values (PPV) of the WSS metrics for plaque presence (WT>0.5mm) at follow up were 50% (low TAWSS), 48% (high OSI), 49% (high RRT), 47% (high CFI) and 43% (high transWSS). The PPVs for the presence of a fibroatheroma observed with histology were 61% (low TAWSS), 58% (high OSI), 61% (high RRT), 59% (high CFI) and 49% (high transWSS). Plaque growth vs. multidirectional WSS Conclusions This study shows that both low and multidirectional WSS promote the development of large and complex coronary atherosclerotic plaques with vulnerable characteristics. The high predictive values for fibrous cap atheroma development demonstrate the potential of multidirectional WSS metrics as a predictive clinical marker for vulnerable disease. Acknowledgement/Funding ERC- starter grant (grant agreement 310457)

Coronary Vulnerable Plaque Development Is Promoted By Multidirectional Wall Shear Stress – A Pre-Clinical Imaging Study

2019 ◽  
Vol 287 ◽  
pp. e105
Author(s):  
A. Hoogendoorn ◽  
A.M. Kok ◽  
E.M.J. Hartman ◽  
C. Chiastra ◽  
L. Casadonte ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Vulnerable Plaque ◽  
Imaging Study ◽  
Clinical Imaging ◽  
Plaque Development ◽  
Wall Shear
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