scholarly journals The effects of riboflavin/ultraviolet: A corneal cross-linking on the signs and symptoms of bullous keratopathy

2011 ◽  
Vol 18 (1) ◽  
pp. 58 ◽  
Author(s):  
Mohammad-RezaAnsari Astaneh ◽  
Fatemeh Armanfar ◽  
Hamid Gharaee
Keyword(s):  
Signs And Symptoms ◽  
Cross Linking ◽  
Bullous Keratopathy ◽  
Ultraviolet A

scholarly journals ZDRAVLJENJE OKUŽB ROŽENICE S PREČNIM POVEZOVANJEM KOLAGENIH VLAKEN

2016 ◽  
Vol 85 (3) ◽  
Author(s):  
Mirna Štabuc Šilih
Keyword(s):  
Antimicrobial Treatment ◽  
Current Data ◽  
Cross Linking ◽  
Bullous Keratopathy ◽  
Ultraviolet A ◽  
Initial Management ◽  
Cross Links ◽  
The Stability ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Corneal collagen cross-linking increases the stability of the cornea through the use of the photosensitive material - riboflavin (vitamin B2) and ultraviolet A radiation. Progressive keratoconus is the most common indication and the frequency of these procedures is increasing worldwide. As cross-links in the cornea are a physiological principle of all connective tissue, additional indications were proposed. These include postrefractive surgery ectasia, bullous keratopathy, and, infectious keratitis.Infectious keratitis can lead to blindness without proper antimicrobial therapy. But even prompt initial management, with appropriate antimicrobial treatment, can be subjected to microorganism sensitivity and resistance.This article presents current data regarding the use of corneal collagen cross-linking in the treatment of corneal infections. This treatment modality may become important, but unanswered questions remain. Larger, prospective comparative studies should give the answers.

scholarly journals Corneal Cross-Linking: The Evolution of Treatment for Corneal Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Duoduo Wu ◽  
Dawn Ka-Ann Lim ◽  
Blanche Xiao Hong Lim ◽  
Nathan Wong ◽  
Farhad Hafezi ◽  
...  
Keyword(s):  
Ethylenediaminetetraacetic Acid ◽  
Cross Linking ◽  
Bullous Keratopathy ◽  
Ultraviolet A ◽  
Clinical Scenarios ◽  
Uva Light ◽  
Integral Role ◽  
Delivery Options ◽  
Topical Medications ◽  
Corneal Penetration

Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light has become a useful treatment option for not only corneal ectasias, such as keratoconus, but also a number of other corneal diseases. Riboflavin is a photoactivated chromophore that plays an integral role in facilitating collagen crosslinking. Modifications to its formulation and administration have been proposed to overcome shortcomings of the original epithelium-off Dresden CXL protocol and increase its applicability across various clinical scenarios. Hypoosmolar riboflavin formulations have been used to artificially thicken thin corneas prior to cross-linking to mitigate safety concerns regarding the corneal endothelium, whereas hyperosmolar formulations have been used to reduce corneal oedema when treating bullous keratopathy. Transepithelial protocols incorporate supplementary topical medications such as tetracaine, benzalkonium chloride, ethylenediaminetetraacetic acid and trometamol to disrupt the corneal epithelium and improve corneal penetration of riboflavin. Further assistive techniques include use of iontophoresis and other wearable adjuncts to facilitate epithelium-on riboflavin administration. Recent advances include, Photoactivated Chromophore for Keratitis-Corneal Cross-linking (PACK-CXL) for treatment of infectious keratitis, customised protocols (CurV) utilising riboflavin coupled with customised UVA shapes to induce targeted stiffening have further induced interest in the field. This review aims to examine the latest advances in riboflavin and UVA administration, and their efficacy and safety in treating a range of corneal diseases. With such diverse riboflavin delivery options, CXL is well primed to complement the armamentarium of therapeutic options available for the treatment of a variety of corneal diseases.

Corneal Wound Healing After Ultraviolet-A/Riboflavin Collagen Cross-Linking: A Rabbit Study

2010 ◽  
Vol 27 (6) ◽  
pp. 401-407 ◽  
Author(s):  
Marcella Q. Salomão ◽  
Shyam S. Chaurasia ◽  
Abhijit Sinha-Roy ◽  
Renato Ambrósio ◽  
Andrew Esposito ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cross Linking ◽  
Ultraviolet A ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
Collagen Cross Linking
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