scholarly journals Efficacy of parenteral administration of ivermectin in the control of strongylidosis in donkeys

2005 ◽  
Vol 76 (4) ◽  
Author(s):  
R. Binev ◽  
Z. Kirkova ◽  
J. Nikolov ◽  
A. Russenov ◽  
K. Stojanchev ◽  
...  
Keyword(s):  
Body Weight ◽  
Parenteral Administration ◽  
Larval Culture ◽  
Blood Samples ◽  
Complete Reduction ◽  
Weight One ◽  
Leukocyte Counts ◽  
Faecal Egg Counts ◽  
Eosinophil Leukocyte ◽  
Eosinophil Counts

Investigations into the efficacy of parenteral ivermectin (Pandex) administration for strongylidosis control in donkeys were carried out. The preparation was applied subcutaneously at a dose of 0.2 mg / kg (1mℓ / 50 kg body weight). One day prior to the treatment and 14 days post-treatment, individual coprological samples were obtained for faecal nematode egg counts and larval culture. The study was performed on 263 donkeys originating from different regions of Bulgaria. Prior to the treatment and 20 days after that, blood samples were obtained from 64 previously infected animals for monitoring of changes in eosinophil leukocyte counts. The subcutaneous application of ivermectin had an efficacy of 96 % in terms of reduction of faecal egg counts. In 92.2%of infected donkeys, a complete reduction of faecal eggs count occurred (0 eggs per gram of faeces epg), whereas in the remaining 7.8%of the infected donkeys, the egg counts were reduced by 72 %. The reduction in faecal egg counts did not result in changes in eosinophil counts. The results obtained as well as the lack of local changes after the subcutaneous application of ivermectin in donkeys allow us to recommend its use for control of strongyles in donkeys.

Central Histamine, the H3-Receptor and Obesity Therapy

2019 ◽  
Vol 18 (7) ◽  
pp. 516-522
Author(s):  
Néstor F. Díaz ◽  
Héctor Flores-Herrera ◽  
Guadalupe García-López ◽  
Anayansi Molina-Hernández
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Animal Studies ◽  
Energy Homeostasis ◽  
Receptor Activation ◽  
Receptor Ligands ◽  
Histaminergic System ◽  
H3 Receptor ◽  
Weight One ◽  
The Central Nervous System

The brain histaminergic system plays a pivotal role in energy homeostasis, through H1- receptor activation, it increases the hypothalamic release of histamine that decreases food intake and reduces body weight. One way to increase the release of hypothalamic histamine is through the use of antagonist/inverse agonist for the H3-receptor. Histamine H3-receptors are auto-receptors and heteroreceptors located on the presynaptic membranes and cell soma of neurons, where they negatively regulate the synthesis and release of histamine and other neurotransmitters in the central nervous system. Although several compounds acting as H3-receptor antagonist/inverse agonists have been developed, conflicting results have been reported and only one has been tested as anti-obesity in humans. Animal studies revealed the opposite effect in food intake, energy expeditor, and body weight, depending on the drug, spice, and route of administration, among others. The present review will explore the state of art on the effects of H3-receptor ligands on appetite and body-weight, going through the following: a brief overview of the circuit involved in the control of food intake and energy homeostasis, the participation of the histaminergic system in food intake and body weight, and the H3-receptor as a potential therapeutic target for obesity.

THE RELATIONSHIP BETWEEN SERUM TESTOSTERONE LEVELS, SEX AND TEAT-SEEKING ABILITY OF NEWBORN PIGLETS

1985 ◽  
Vol 65 (3) ◽  
pp. 627-630 ◽  
Author(s):  
L. A. BATE ◽  
R. R. HACKER ◽  
M. B. KREUKNIET
Keyword(s):  
Body Weight ◽  
Detrimental Effect ◽  
Serum Testosterone ◽  
Maternal Serum ◽  
Blood Samples ◽  
Male And Female ◽  
Newborn Piglets ◽  
Baseline Levels ◽  
Highly Correlated ◽  
The Relationship

Blood samples were collected from five pregnant sows from day 111 postbreeding to farrowing and from their piglets at regular intervals between birth and 48 h. The time between birth and first suckling (BTS) was recorded for each piglet. Maternal serum testosterone (T) levels were detectable only at the beginning of parturition and were highly correlated (r = 0.83) with litter BTS. Serum T levels of male and female piglets were similar at birth. In male piglets the T levels increased to a peak 2 h after birth and decreased gradually thereafter. In contrast, the T levels of female piglets declined rapidly after birth to baseline levels. The BTS of female piglets was shorter than that of male piglets. Body weight of males was higher than that of females and was influenced by litter size. These results suggest that the higher serum T levels of male piglets may have a detrimental effect on their teat-seeking ability. Key words: Serum testosterone, sex, piglets, teat-seeking ability, sow

scholarly journals Evaluation of Anthelmintic Efficacy of Ivermectin, Levamisole HCl and Albendazole Administered through Different Routes against Naturally Occuring Gastrointestinal Nematodiasis in Black Bengal Goat Inducing Hematological Parameters and Live Weight Indices

2016 ◽  
Vol 5 (1) ◽  
pp. 26-34 ◽  
Author(s):  
M Aktaruzzaman ◽  
MS Islam ◽  
MMI Hasan ◽  
MJU Bhuiyan ◽  
MM Hossain ◽  
...  
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Live Weight ◽  
Gastrointestinal Nematodes ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Counting Method ◽  
Blood Samples ◽  
Group A ◽  
Group D

This study aimed to evaluate the efficacy of ivermectin, levamisole HCl and albendazole against gastrointestinal nematodes in naturally infected goats of government goat development farm, Sylhet, Bangladesh. The study included 52 black Bengal breed of which 30 were naturally infected and randomly selected 20 on the basis of their weight and egg count. Twenty black Bengal goats of 12-13 month old irrespective of sex infested with gastrointestinal nematodes were selected for this experiment and randomly divided into four equal groups (group A, B, C and D) where each group consisted of 5 goats and goats of group D were kept as control group. One injectable ivermectin (200?gkg-1 body weight, S/C) preparations (Techno Drugs Ltd. Bangladesh) and two solid levamisole HCl, albendazole (7.5 mgkg-1 body weight, orally) preparations (The ACME Laboratories Ltd. and Square Pharmaceuticals Ltd. Bangladesh) were used for positive control of gastrointestinal nematodes as group A, B and C. Goats of group D was kept as control without giving any treatment. Before trials (day 0), total egg count, blood samples and initial body weight were recorded. During the study period the fecal and blood samples were collected directly from rectum and examined on 7th, 14th, 21st and 28th day using McMaster fecal egg counting method. Body weight was recorded on day 28 following the treatments. The results of the comparative efficacies of different anthelmintic of ivermectin was 86.75%, followed by levamisole HCl 85.07% and albendazole 92.81%. McMaster fecal egg counting method discloses the percentage of Haemonchus spp. (15.38%), with Trichostrongylus spp, Strongyloides spp., and Cooperia spp. also present. After treatment with ivermectin, levamisole HCl and albendazole, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p<0.01 and p>0.05) in goats but Erythrocyte Sedimentation Rate (ESR) and Total Leukocyte Count (TLC) were decreased significantly (p<0.05 and p>0.01) in all treated goat and body weight was increased significantly (p<0.01) on day 28.International Journal of Natural Sciences (2015), 5(1) 26-34

scholarly journals Intestinal microbiota, obesity and prebiotics

2015 ◽  
Vol 64 (2) ◽  
pp. 93-100 ◽  
Author(s):  
R. BARCZYNSKA ◽  
K. BANDURSKA ◽  
K. SLIZEWSKA ◽  
M. LITWIN ◽  
M. SZALECKI ◽  
...  
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
Disease Risk ◽  
Global Scale ◽  
Weight One ◽  
Prevalence Of Obesity ◽  
Normal Body Weight ◽  
Healthy Body Weight ◽  
Treatment Of Obesity

Over the past few decades there has been a significant increase in the prevalence of obesity in both children and adults. Obesity is a disease that has reached epidemic levels on a global scale. The development of obesity is associated with both environmental and genetic factors. Recent studies indicate that intestinal microorganisms play an important function in maintaining normal body weight. One of the objectives in the gut microbiota research is to determine the role it plays and can it be a reliable biomarker of disease risk, including the predisposition to obesity. This article discusses (1) the role of prebiotics and gut microbiota in maintaining a healthy body weight and (2) potential influence on the gut microbiota in the prevention and treatment of obesity.

scholarly journals Evidence of Regeneration of Testicular and Epididymal Tissue Structure and Function Following Withdrawal from Sub-chronic Khat Exposure: Studies in the Rabbit Animal Model

2020 ◽  
pp. 10-23
Author(s):  
Albert W. Nyongesaa ◽  
Esther M. Malukib ◽  
Jemimah A. Simbaunib
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Structure And Function ◽  
The Body ◽  
Endocrine Function ◽  
Eastern Africa ◽  
Blood Samples ◽  
Middle East Countries ◽  
Group I ◽  
And Function

Khat, Catha edulis, use is rampant in Eastern Africa and Middle East countries with associated reports of reproductive function impairment in the body of the user. Reports on recovery post long-term khat exposure are obscure. The present study investigated evidence of restoration of testicular and epididymal structure and function during withdrawal from cytotoxic damage caused by sub-chronic exposure of khat extract. Twenty-eight male rabbits were divided into 7 groups of 4 rabbits each. Group I (control) was administered normal saline while groups II, III and IV were administered 1.0 g/kg, 10 g/kg and 20 g/kg body weight of khat extract, respectively, via oral gavage on alternate days of the week for 12 weeks. Blood samples from animals were collected for hormonal assays followed by euthanasia using 26.4 mg/kg body weight of Sagatal sodium intramuscularly for testicular and epididymal histology. Group V, VI and VII were administered 1.0 g/kg, 10 g/kg and 20 g/kg body weight of khat extract, respectively, orally on alternate days of the week for 12 weeks followed by 1-month withdrawal period, blood samples collected for hormone assays and animals sacrificed for testicular and epididymal histology. High khat dose, 20 g/kg body weight, at sub-chronic exposure caused degeneration in spermatogenic cells with accompanying decrease in plasma FSH and testosterone. Histological output of Sertoli cells, Leydig cells and epididymal epithelium appeared unaffected in treatment groups. Post withdrawal data showed apparent regeneration of seminiferous epithelium and restoration of plasma FSH and testosterone comparable to control. It appears khat extract preferentially affected germ cell spermatogonia and subsequent daughter cells while stem cell spermatogonia were unaffected and contributed to regeneration of germinal epithelium and endocrine function.

scholarly journals Haematological parameters in relation to age, sex and body weight of free-range village chickens (Gallus gallus domesticus) in Maiduguri, Nigeria

2021 ◽  
pp. 78-84
Keyword(s):  
Body Weight ◽  
Haemoglobin Concentration ◽  
The Body ◽  
Haematological Parameters ◽  
Jugular Veins ◽  
Important Indicator ◽  
Free Range ◽  
Body Weights ◽  
Leukocyte Counts ◽  
Apparently Healthy

The haematology of animals including chickens is an important indicator of their health status. It is therefore considered a useful tool in clinical diagnosis. The aim of this study was to investigate the haematological parameters of apparently healthy free range domesticated chickens as influenced by their sex, age and body weights. Blood samples taken from the jugular veins were analysed using standard haematological protocols. PCV, haemoglobin concentration, TRBC, TWBC, differential leukocyte counts, erythrocytes indices (MCV, MCHC and MCH) were measured. The study showed that there were no significant (P>0.05) age-dependent variation in all the measured haematological parameters. However, sex had effect on PCV, TRBC and heterophil count. Male chickens had higher PCV value of (34.4%) and TRBC value of (2.4 × 1012/L) as compared to female chickens with PCV value of (30.5%) and TRBC value of (2.1 × 1012/L). On the other hand, female chickens had higher mean heterophil value of (22.0 × 109/L) and MCHC value of (29.5g/dl) as compared to male chickens with mean heterophil and MCHC values of (16.8 × 109/L) and (25.7g/dl) respectively. There was significant (P<0.05) increase in PCV with increasing body weights in males but not in females. The MCHC decreased significantly (P<0.05) as the body weight increased also in males but not in females. The results of the study indicate that sex and body weights influenced normal haematological parameters of apparently healthy free range domestic chickens in the study environment. Keywords: Age, body weight, haematology, sex, village chicken.

scholarly journals Effects of a Fusarium Toxin-Contaminated Maize Treated with Sodium Sulfite on Male Piglets in the Presence of an LPS-Induced Acute Inflammation

Toxins ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 419 ◽  
Author(s):  
Anh-Tuan Tran ◽  
Jeannette Kluess ◽  
Andreas Berk ◽  
Marleen Paulick ◽  
Jana Frahm ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Inflammation ◽  
Clinical Biochemistry ◽  
Sodium Sulfite ◽  
Clinical Chemistry ◽  
Redox Status ◽  
Blood Samples ◽  
Lps Challenge ◽  
Fusarium Toxin ◽  
Tnf Α

We investigated the effects of feeding sodium sulfite (SoS) treated uncontaminated and Fusarium contaminated maize in a porcine lipopolysaccharide (LPS) challenge model. Eighty piglets (7.59 ± 0.92 kg body weight [BW]) were equally assigned to one of four experimental diets containing 10% maize, either uncontaminated and untreated (CON−, 0.09 mg deoxynivalenol [DON]/kg diet) or uncontaminated and SoS-treated (CON+, wet-preserved with 5 g SoS/kg maize; 0.05 mg DON/kg diet), or prepared with 10% of a Fusarium contaminated maize containing mainly deoxynivalenol (DON), either contaminated and untreated (FUS−, 5.36 mg DON/kg diet), or contaminated and SoS-treated (FUS+, wet-preserved with 5 g SoS/kg maize; 0.83 mg DON/kg diet). At day 42 of experiment, ten pigs of each group were injected intraperitoneally with either 7.5 µg LPS/kg BW or placebo (0.9% NaCl). At 120 min after injection, blood samples were collected to analyse TNF-α, hematological profile, clinical biochemistry as well as the redox status. A significant increase in body temperature and cytokine TNF-α concentration was observed in the LPS-injected piglets. Results for hematology, clinical chemistry and redox status indicate no effects of SoS treatment, with exception of neutrophil counts being significantly more pronounced after feeding the SoS treated FUS maize. In conclusion, SoS treatment of maize did not modulate the LPS-induced acute inflammation.

Blood Volumes of Dairy Calves Comparing Cr51-Tagged Red Blood Cells and T-1824 Plasma Dilution Methods

1958 ◽  
Vol 193 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Perry Ruth Stahl ◽  
Homer E. Dale
Keyword(s):  
Body Weight ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Dairy Calves ◽  
Computation Method ◽  
Blood Samples ◽  
Whole Blood Samples ◽  
Blood Volumes

In a repeated study on 17 dairy calves, T-1824 dye plasma dilution showed significantly higher blood volumes than were found by any other technique or computation method using Cr51-tagged red blood cells. Five blood samples taken at 20-minute intervals after injection showed consistent decrease in radioactivity count from the first to the last sample, indicating greater accuracy in radioactivity dilution regressed to zero time figures than in average counts of several postinjection samples. In vitro studies suggest a loss of Cr51 from red blood cells to plasma after saline washings are Cr-free. Percentage blood volumes computed from whole blood samples of calves injected with Cr51-tagged red blood cells decreased in a straight line relationship with increase of body weight. Percentage plasma and whole blood volumes estimated with the T-1824 dye technique decreased regularly with body weight increase until a second determination was made when there was a rapid rise nearly to the level of the smallest calves, followed by another regular decrease with increase in weight. It is suggested that repeated dye injections do not always measure the same space. Regressed values of five whole blood samples taken at 20-minute intervals after injection of Cr51 tagged red blood cells gave more consistent blood volume determinations than either the weighed red cells or the plasma dye dilutions of the same samples.

Endocrine changes and their relationship with body weight in growing yaks

2002 ◽  
Vol 74 (1) ◽  
pp. 89-94
Author(s):  
Tian Yongqiang ◽  
Zhao Xingxu ◽  
Wang Minqiang ◽  
Lu Zhonglin ◽  
Zhang Rongchang
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Seasonal Change ◽  
Seasonal Changes ◽  
Significant Positive Correlation ◽  
The Body ◽  
Nutrition Status ◽  
Blood Samples ◽  
Different Seasons ◽  
Grass Growth

AbstractThe concentrations of growth hormone (GH), insulin (Ins), tri-iodothyronine (T3) and thyroxine (T4) in blood samples of growing yaks during different bimonthly seasons were determined by radioimmunoassay. The changes of body weight of growing yaks and composition of grass grazed were measured accordingly. The seasonal changes of hormones were significant (P < 0·01 or P < 0·05). Within season, the variances of hormones depended upon the different growing stages. The body-weight gains in the different groups varied in different seasons, increase being significant in May, July and September, decrease being significant from January to May. Correlation analysis indicated that T4 concentration had a significant positive correlation with the body weight of the growing yaks(r = 0·2509, P < 0·05) and other hormones did not have any significant correlation with body weight. The results showed that the annual cycle of weight loss and gain was attributed to the seasonal change of nutrition status. The seasonal change of the assayed hormones depended on the grass growth.

Use of Values for Calcium and Protein Serum, and of a Derived Index Obtained from a Probability Population Sample

1978 ◽  
Vol 24 (3) ◽  
pp. 506-506
Author(s):  
Anthea Kelly ◽  
Louis Munan ◽  
Claude PetitClerc ◽  
Kok Ping Ho ◽  
Bernard Billon
Keyword(s):  
Body Weight ◽  
Ursodeoxycholic Acid ◽  
Blood Sample ◽  
Cholic Acid ◽  
Amylase Activity ◽  
Population Sample ◽  
Blood Samples ◽  
Annual Index ◽  
Protein Serum

Abstract Volume 22 p 1726: In the footnote to Table 3, the last half of the sentence should read " for SI units, the index becomes (80 calcium - 120)/protein." Volume 23 p 1779: In column two of "corrections," the word "malate" should be substituted for "maleate." p 2127: In column two, last line, change "chinic" to "chenodeoxycholic." On the next page, change the last part of the sub-legend to Figure 7 to read "(5) ursodeoxycholic acid, (6) cholic acid." p 2205: col. two, line 32. For "mg/g body weight" read "mg/kg body weight." p 2288: In the last sentence of the abstract, change ".... 0.3 to 7.8 mole..." to "... 0.3 to 7.8 mmol...." p 2289: Table 1, footnote a should read: "Millimoles of 4NP injected/270 x 10-3 moles of 4NPP. This is calculated as if the 4NP were present in 270 nmol of 4NPP...." p 2290: In Table 2, in column A "7.76d" should read "7.76c" p 2356: The reader may incorrectly infer that the "Gamma-Coat Kit" (CA 535, 536; 555, 556) is intended for the analysis of dried blood samples on paper in screening for congenital hypothyroidism in infants. Actually, that kit is intended for serum thyroxine assay. A modified kit dedicated to dried blood-sample screening for hypothyroidism is currently under development and will be introduced shortly as CA-538, 558. Further, in Tables and text, the "3.5-mm" disks referred to should read "3.18 mm" (⅛''). This is of significance, because the error in diameter produces a 20% error in the apparent blood volume or thyroxine content per disk in the Tables. Inadvertent omissions from the list of invited reviewers (p 2360) and our annual index are, respectively: Jocelyn M. Hicks and Royden Rand and "Direct Spectrophotometric Determination of α-Amylase Activity in Saliva, with p-Nitrophenyl α-Maltoside as Substrate," by Baiba K. Gillard, Henry C. Markman, and Stephen A. Feig. (p 2279)

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